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1. Characterization of high-H2O2-tolerant bacterial cytochrome P450 CYP105D18: insights into papaverine N-oxidation

Author

Bashu Dev Pardhe, Hackwon Do, Chang-Sook Jeong, Ki-Hwa Kim, Jun Hyuck Lee, and Tae-Jin Oh

Subjects
cyp105d18, papaverine n-oxide, h2o2 tolerance, streptomyces laurentii, enzyme mechanisms, crystal morphology, co-crystals, Crystallography, QD901-999
Abstract

The bacterial CYP105 family is involved in secondary metabolite biosynthetic pathways and plays essential roles in the biotransformation of xenobiotics. This study investigates the newly identified H2O2-mediated CYP105D18 from Streptomyces laurentii as the first bacterial CYP for N-oxidation. The catalytic efficiency of CYP105D18 for papaverine N-oxidation was 1.43 s−1 µM−1. The heme oxidation rate (k) was low (

Published
2021
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