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3. Measurement of groomed event shape observables in deep-inelastic electron-proton scattering at HERA

Author

The H1 collaboration, Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contreras, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H. -U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reichelt, D., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Schumann, S., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Stöcker, L., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Acosta, F. Torales, Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., and Zomer, F.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

The H1 Collaboration at HERA reports the first measurement of groomed event shape observables in deep inelastic electron-proton scattering (DIS) at $\sqrt{s}=319$ GeV, using data recorded between the years 2003 and 2007 with an integrated luminosity of $351$ pb$^{-1}$. Event shapes provide incisive probes of perturbative and non-perturbative QCD. Grooming techniques have been used for jet measurements in hadronic collisions; this paper presents the first application of grooming to DIS data. The analysis is carried out in the Breit frame, utilizing the novel Centauro jet clustering algorithm that is designed for DIS event topologies. Events are required to have squared momentum-transfer $Q^2 > 150$ GeV$^2$ and inelasticity $ 0.2 < y < 0.7$. We report measurements of the production cross section of groomed event 1-jettiness and groomed invariant mass for several choices of grooming parameter. Monte Carlo model calculations and analytic calculations based on Soft Collinear Effective Theory are compared to the measurements., Comment: 32 pages, 17 tables, 7 figures, version as accepted by EPJ C

Published
2024
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4. Observation and differential cross section measurement of neutral current DIS events with an empty hemisphere in the Breit frame

Author

The H1 collaboration, Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contreras, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kluth, S., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H. -U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reichelt, D., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Schumann, S., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Stöcker, L., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Acosta, F. Torales, Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., and Zomer, F.

Subjects
High Energy Physics - Experiment, High Energy Physics - Phenomenology, Nuclear Experiment
Abstract

The Breit frame provides a natural frame to analyze lepton-proton scattering events. In this reference frame, the parton model hard interactions between a quark and an exchanged boson defines the coordinate system such that the struck quark is back-scattered along the virtual photon momentum direction. In Quantum Chromodynamics (QCD), higher order perturbative or non-perturbative effects can change this picture drastically. As Bjorken-$x$ decreases below one half, a rather peculiar event signature is predicted with increasing probability, where no radiation is present in one of the two Breit-frame hemispheres and all emissions are to be found in the other hemisphere. At higher orders in $\alpha_s$ or in the presence of soft QCD effects, predictions of the rate of these events are far from trivial, and that motivates measurements with real data. We report on the first observation of the empty current hemisphere events in electron-proton collisions at the HERA collider using data recorded with the H1 detector at a center-of-mass energy of 319 GeV. The fraction of inclusive neutral-current DIS events with an empty hemisphere is found to be $0.0112 \pm 3.9\,\%_\text{stat} \pm 4.5\,\%_\text{syst} \pm 1.6\,\%_\text{mod}$ in the selected kinematic region of $150< Q^2<1500$ GeV$^2$ and inelasticity $0.14< y<0.7$. The data sample corresponds to an integrated luminosity of 351.1 pb$^{-1}$, sufficient to enable differential cross section measurements of these events. The results show an enhanced discriminating power at lower Bjorken-$x$ among different Monte Carlo event generator predictions., Comment: 13 pages, 5 figures, 2 Tables. This version as accepted for publication

Published
2024
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10. Acute dose-dependent effects of mescaline in a double-blind placebo-controlled study in healthy subjects

Author

Aaron Klaiber, Yasmin Schmid, Anna M. Becker, Isabelle Straumann, Livio Erne, Alen Jelusic, Jan Thomann, Dino Luethi, and Matthias E. Liechti

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Classic psychedelics have regained interest in research and therapy. Despite the long tradition of the human use of mescaline, modern data on its dose-dependent acute effects and pharmacokinetics are lacking. Additionally, its mechanism of action has not been investigated in humans. We used a randomized, double-blind, placebo-controlled, crossover design in 16 healthy subjects (8 women) who received placebo, mescaline (100, 200, 400, and 800 mg), and 800 mg mescaline together with the serotonin 5-hydroxytryptamine-2A (5-HT2A) receptor antagonist ketanserin (40 mg) to assess subjective effects, autonomic effects, adverse effects, and pharmacokinetics up to 30 h after drug administration. Mescaline at doses >100 mg induced dose-dependent acute subjective effects. Mescaline increased systolic and diastolic blood pressure at doses >100 mg, with no difference between doses of 200-800 mg. Heart rate increased dose-dependently. Pharmacokinetics of mescaline were dose-proportional. Maximal concentrations were reached after approximately 2 h, and the plasma elimination half-life was approximately 3.5 h. The average duration of subjective effects increased from 6.4 to 14 h with increasing doses of 100-800 mg mescaline. Nausea and emesis were frequent adverse effects at the 800 mg dose. Co-administration of ketanserin attenuated and shortened acute effects of 800 mg mescaline to become comparable to the 100 and 200 mg doses. There were no ceiling effects of the subjective response within the investigated dose range, but tolerability was lower at the highest doses. These results may assist with dose finding for future research and suggest that acute effects of mescaline are primarily mediated by 5-HT2A receptors.

Published
2024
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11. Pharmacological and non-pharmacological predictors of the LSD experience in healthy participants

Author

Patrick Vizeli, Erich Studerus, Friederike Holze, Yasmin Schmid, Patrick C. Dolder, Laura Ley, Isabelle Straumann, Anna M. Becker, Felix Müller, Denis Arikci, and Matthias E. Liechti

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract The pharmacodynamic effects of lysergic acid diethylamide (LSD) are diverse and different in different individuals. Effects of other psychoactive substances have been shown to be critically influenced by non-pharmacological factors such as personality traits and mood states. The aim of this study was to determine pharmacological and psychological predictors of the LSD effects in healthy human subjects. This analysis is based on nine double-blind, placebo-controlled, cross-over studies with a total of 213 healthy subjects receiving between 25–200 µg LSD. The influence of sex, age, dose, body weight, pharmacogenetic, drug experience, personality, setting, and mood before drug intake on the peak autonomic and total subjective responses to LSD was investigated using multiple linear mixed effects models and Least Absolute Shrinkage and Selection Operator regression. Results were adjusted for LSD dose and corrected for multiple testing. LSD dose emerged as the most influential predictor, exhibiting a positive correlation with most response variables. Pre-drug mental states such as “Well-Being”, “Emotional Excitability”, and “Anxiety” were also important predictor for a range of subjective effects but also heart rate and body temperature. The trait “Openness to Experiences” was positively correlated with elevated ratings in “Oceanic Boundlessness” and mystical-type effects. Previous experiences with hallucinogens have been negatively associated with the overall altered state of consciousness and particularly with “Anxious Ego Dissolution”. Acute anxiety negatively correlated with the genetically determined functionality of the Cytochrome 2D6 enzyme. In summary, besides the amount of drug consumed, non-pharmacological factors such as personal traits and current mood also significantly predicted the subjective drug experience. Sex and body weight were not significant factors in influencing the drug experience.

Published
2024
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12. Measurement of the 1-jettiness event shape observable in deep-inelastic electron-proton scattering at HERA

Author

H1 Collaboration, V. Andreev, M. Arratia, A. Baghdasaryan, A. Baty, K. Begzsuren, A. Bolz, V. Boudry, G. Brandt, D. Britzger, A. Buniatyan, L. Bystritskaya, A. J. Campbell, K. B. Cantun Avila, K. Cerny, V. Chekelian, Z. Chen, J. G. Contreras, J. Cvach, J. B. Dainton, K. Daum, A. Deshpande, C. Diaconu, A. Drees, G. Eckerlin, S. Egli, E. Elsen, L. Favart, A. Fedotov, J. Feltesse, M. Fleischer, A. Fomenko, C. Gal, J. Gayler, L. Goerlich, N. Gogitidze, M. Gouzevitch, C. Grab, T. Greenshaw, G. Grindhammer, D. Haidt, R. C. W. Henderson, J. Hessler, J. Hladký, D. Hoffmann, R. Horisberger, T. Hreus, F. Huber, P. M. Jacobs, M. Jacquet, T. Janssen, A. W. Jung, J. Katzy, C. Kiesling, M. Klein, C. Kleinwort, H. T. Klest, S. Kluth, R. Kogler, P. Kostka, J. Kretzschmar, D. Krücker, K. Krüger, M. P. J. Landon, W. Lange, P. Laycock, S. H. Lee, S. Levonian, W. Li, J. Lin, K. Lipka, B. List, J. List, B. Lobodzinski, O. R. Long, E. Malinovski, H.-U. Martyn, S. J. Maxfield, A. Mehta, A. B. Meyer, J. Meyer, S. Mikocki, V. M. Mikuni, M. M. Mondal, K. Müller, B. Nachman, Th. Naumann, P. R. Newman, C. Niebuhr, G. Nowak, J. E. Olsson, D. Ozerov, S. Park, C. Pascaud, G. D. Patel, E. Perez, A. Petrukhin, I. Picuric, D. Pitzl, R. Polifka, S. Preins, V. Radescu, N. Raicevic, T. Ravdandorj, D. Reichelt, P. Reimer, E. Rizvi, P. Robmann, R. Roosen, A. Rostovtsev, M. Rotaru, D. P. C. Sankey, M. Sauter, E. Sauvan, S. Schmitt, B. A. Schmookler, G. Schnell, L. Schoeffel, A. Schöning, S. Schumann, F. Sefkow, S. Shushkevich, Y. Soloviev, P. Sopicki, D. South, A. Specka, M. Steder, B. Stella, L. Stöcker, U. Straumann, C. Sun, T. Sykora, P. D. Thompson, F. Torales Acosta, D. Traynor, B. Tseepeldorj, Z. Tu, G. Tustin, A. Valkárová, C. Vallée, P. van Mechelen, D. Wegener, E. Wünsch, J. Žáček, J. Zhang, Z. Zhang, R. Žlebčík, H. Zohrabyan, and F. Zomer

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The H1 Collaboration reports the first measurement of the 1-jettiness event shape observable $$\tau _1^b$$ τ 1 b in neutral-current deep-inelastic electron-proton scattering (DIS). The observable $$\tau _1^b$$ τ 1 b is equivalent to a thrust observable defined in the Breit frame. The data sample was collected at the HERA ep collider in the years 2003–2007 with center-of-mass energy of $$\sqrt{s}=319\,\textrm{GeV} $$ s = 319 GeV , corresponding to an integrated luminosity of 351.1 $$\textrm{pb}^{-1}$$ pb - 1 . Triple differential cross sections are provided as a function of $$\tau _1^b$$ τ 1 b , event virtuality $$Q^{2}$$ Q 2 , and inelasticity y, in the kinematic region $$Q^{2} >150\,\textrm{GeV}^2 $$ Q 2 > 150 GeV 2 . Single differential cross sections are provided as a function of $$\tau _1^b$$ τ 1 b in a limited kinematic range. Double differential cross sections are measured, in contrast, integrated over $$\tau _1^b$$ τ 1 b and represent the inclusive neutral-current DIS cross section measured as a function of $$Q^{2}$$ Q 2 and y. The data are compared to a variety of predictions and include long-standing and more recent Monte Carlo event generators, predictions in fixed-order perturbative QCD where calculations up to $$\mathcal {O}(\alpha _\textrm{s} ^3)$$ O ( α s 3 ) are available for $$\tau _1^b$$ τ 1 b or inclusive DIS, and resummed predictions at next-to-leading logarithmic accuracy matched to fixed order predictions at $$\mathcal {O}(\alpha _\textrm{s} ^2)$$ O ( α s 2 ) . These comparisons reveal sensitivity of the 1-jettiness observable to QCD parton shower and resummation effects, as well as the modeling of hadronization and fragmentation. Within their range of validity, the fixed-order predictions provide a good description of the data. Monte Carlo event generators are predictive over the full measured range and hence their underlying models and parameters can be constrained by comparing to the presented data.

Published
2024
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13. Observation and differential cross section measurement of neutral current DIS events with an empty hemisphere in the Breit frame

Author

H1 Collaboration, V. Andreev, M. Arratia, A. Baghdasaryan, A. Baty, K. Begzsuren, A. Bolz, V. Boudry, G. Brandt, D. Britzger, A. Buniatyan, L. Bystritskaya, A. J. Campbell, K. B. Cantun Avila, K. Cerny, V. Chekelian, Z. Chen, J. G. Contrera, J. Cvach, J. B. Dainton, K. Daum, A. Deshpande, C. Diaconu, A. Drees, G. Eckerlin, S. Egli, E. Elsen, L. Favart, A. Fedotov, J. Feltesse, M. Fleischer, A. Fomenko, C. Gal, J. Gayler, L. Goerlich, N. Gogitidze, M. Gouzevitch, C. Grab, T. Greenshaw, G. Grindhammer, D. Haidt, R. C. W. Henderson, J. Hessler, J. Hladký, D. Hoffmann, R. Horisberger, T. Hreus, F. Huber, P. M. Jacobs, M. Jacquet, T. Janssen, A. W. Jung, J. Katzy, C. Kiesling, M. Klein, C. Kleinwort, H. T. Klest, S. Kluth, R. Kogler, P. Kostka, J. Kretzschmar, D. Krücker, K. Krüger, M. P. J. Landon, W. Lange, P. Laycock, S. H. Lee, S. Levonian, W. Li, J. Lin, K. Lipka, B. List, J. List, B. Lobodzinski, O. R. Long, E. Malinovski, H. U. Martyn, S. J. Maxfield, A. Mehta, A. B. Meyer, J. Meyer, S. Mikocki, V. M. Mikuni, M. M. Mondal, K. Müller, B. Nachman, Th. Naumann, P. R. Newman, C. Niebuhr, G. Nowak, J. E. Olsson, D. Ozerov, S. Park, C. Pascaud, G. D. Patel, E. Perez, A. Petrukhin, I. Picuric, D. Pitzl, R. Polifka, S. Preins, V. Radescu, N. Raicevic, T. Ravdandorj, D. Reichelt, P. Reimer, E. Rizvi, P. Robmann, R. Roosen, A. Rostovtsev, M. Rotaru, D. P. C. Sankey, M. Sauter, E. Sauvan, S. Schmitt, B. A. Schmookler, G. Schnell, L. Schoeffel, A. Schöning, S. Schumann, F. Sefkow, S. Shushkevich, Y. Soloviev, P. Sopicki, D. South, A. Specka, M. Steder, B. Stella, L. Stöcker, U. Straumann, C. Sun, T. Sykora, P. D. Thompson, F. Torales Acosta, D. Traynor, B. Tseepeldorj, Z. Tu, G. Tustin, A. Valkárová, C. Vallée, P. van Mechelen, D. Wegener, E. Wünsch, J. Žáček, J. Zhang, Z. Zhang, R. Žlebčík, H. Zohrabyan, and F. Zomer

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract The Breit frame provides a natural frame to analyze lepton–proton scattering events. In this reference frame, the parton model hard interactions between a quark and an exchanged boson defines the coordinate system such that the struck quark is back-scattered along the virtual photon momentum direction. In Quantum Chromodynamics (QCD), higher order perturbative or non-perturbative effects can change this picture drastically. As Bjorken-x decreases below one half, a rather peculiar event signature is predicted with increasing probability, where no radiation is present in one of the two Breit-frame hemispheres and all emissions are to be found in the other hemisphere. At higher orders in $$\alpha _{s}$$ α s or in the presence of soft QCD effects, predictions of the rate of these events are far from trivial, and that motivates measurements with real data. We report on the first observation of the empty current hemisphere events in electron–proton collisions at the HERA collider using data recorded with the H1 detector at a center-of-mass energy of 319 GeV. The fraction of inclusive neutral-current DIS events with an empty hemisphere is found to be $$0.0112 \pm 3.9\%_\text {stat} \pm 4.5\%_{\text {syst}} \pm 1.6\%_{\text {mod}}$$ 0.0112 ± 3.9 % stat ± 4.5 % syst ± 1.6 % mod in the selected kinematic region of $$150

Published
2024
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14. Cohort Profile Update: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS)

Author

Jeanine Wakim El-Khoury, Ekaterina Safroneeva, Catherine Saner, Jean-Benoit Rossel, Sven Trelle, Marcel Zwahlen, Luc Biedermann, Andrea Kreienbuehl, Thomas Greuter, Philipp Schreiner, Peter Netzer, Annett Franke, Stephan Brand, Chantal Hasler, Patrick Aepli, Emanuel Burri, Achim Weber, Christine Sempoux, Ruggero Biral, Wolfram Jochum, Joachim Diebold, Niels Willi, Alex Straumann, and Alain M. Schoepfer

Subjects
eosinophilic esophagitis, cohort, adults, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Introduction: The Swiss Eosinophilic Esophagitis Cohort Study (SEECS) is a national cohort that was established in 2015 with the aim of improving quality of care of affected adults with eosinophilic esophagitis (EoE). Between 2020 and 2022, paper questionnaires were gradually replaced by fully electronic data capture using Research Electronic Data Capture (REDCap®) software. We aim to provide an update of the SEECS 8 years after its launch. Methods: The SEECS prospectively includes adults (≥18 years of age) with EoE as well as patients with gastroesophageal reflux disease (GERD) and healthy control subjects (HC). Upon inclusion and follow-up (typically once every 12–18 months), patients and physicians complete REDCap® questionnaires, which are available in German, French, and English. Patient-reported outcomes (PROs) and biologic findings are assessed on the same day using validated instruments (EEsAI PRO for symptoms; EoE-QoL-A for QoL; EREFS for endoscopic activity; modified EoE-HSS for histologic activity). The SEECS biobank includes biosamples from patients with EoE, GERD, and HC. Results: As of July 2023, the SEECS included 778 patients (716 [92%] with EoE, 29 [3.8%] with GERD, and 33 [4.2%] HC; 559/778 [71.9%] were male). Mean age ± SD (years) at enrollment according to diagnosis was as follows: EoE 41.9 ± 12.9, GERD 53.6 ± 16.4, HC 51.7 ± 17.2. Concomitant GERD was found in 200 patients (27.9%) of the EoE cohort. Concomitant allergic disorders (asthma, rhinoconjunctivitis, eczema) were present in 500 EoE patients (74.4%). At inclusion, 686 (95.8%) of EoE patients were on ongoing treatment (orodispersible budesonide tablet [Jorveza®] in 281 patients [41%]; budesonide or fluticasone syrup or swallowed powder in 290 patients [42.3%]; proton-pump inhibitors in 162 patients [23.6%]; elimination diets in 103 patients [15%]; and esophageal dilation at last visit in 166 patients [24.2%]). A total of 8,698 biosamples were collected, of which 1,395 (16%) were used in the framework of translational research projects. Conclusion: SEECS continuously grows and is operational using fully electronic data capture. SEECS offers up-to-date epidemiologic and real-world clinical efficacy data on EoE and promotes clinical and translational research.

Published
2024
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15. Measurement of the 1-jettiness event shape observable in deep-inelastic electron-proton scattering at HERA

Author

Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contreras, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kluth, S., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H.-U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reichelt, D., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Schumann, S., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Stöcker, L., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Torales Acosta, F., Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., Mechelen, P. van, Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., and Zomer, F.

Published
2024
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16. Observation and differential cross section measurement of neutral current DIS events with an empty hemisphere in the Breit frame

Author

Andreev, V., Arratia, M., Baghdasaryan, A., Baty, A., Begzsuren, K., Bolz, A., Boudry, V., Brandt, G., Britzger, D., Buniatyan, A., Bystritskaya, L., Campbell, A. J., Avila, K. B. Cantun, Cerny, K., Chekelian, V., Chen, Z., Contrera, J. G., Cvach, J., Dainton, J. B., Daum, K., Deshpande, A., Diaconu, C., Drees, A., Eckerlin, G., Egli, S., Elsen, E., Favart, L., Fedotov, A., Feltesse, J., Fleischer, M., Fomenko, A., Gal, C., Gayler, J., Goerlich, L., Gogitidze, N., Gouzevitch, M., Grab, C., Greenshaw, T., Grindhammer, G., Haidt, D., Henderson, R. C. W., Hessler, J., Hladký, J., Hoffmann, D., Horisberger, R., Hreus, T., Huber, F., Jacobs, P. M., Jacquet, M., Janssen, T., Jung, A. W., Katzy, J., Kiesling, C., Klein, M., Kleinwort, C., Klest, H. T., Kluth, S., Kogler, R., Kostka, P., Kretzschmar, J., Krücker, D., Krüger, K., Landon, M. P. J., Lange, W., Laycock, P., Lee, S. H., Levonian, S., Li, W., Lin, J., Lipka, K., List, B., List, J., Lobodzinski, B., Long, O. R., Malinovski, E., Martyn, H. U., Maxfield, S. J., Mehta, A., Meyer, A. B., Meyer, J., Mikocki, S., Mikuni, V. M., Mondal, M. M., Müller, K., Nachman, B., Naumann, Th., Newman, P. R., Niebuhr, C., Nowak, G., Olsson, J. E., Ozerov, D., Park, S., Pascaud, C., Patel, G. D., Perez, E., Petrukhin, A., Picuric, I., Pitzl, D., Polifka, R., Preins, S., Radescu, V., Raicevic, N., Ravdandorj, T., Reichelt, D., Reimer, P., Rizvi, E., Robmann, P., Roosen, R., Rostovtsev, A., Rotaru, M., Sankey, D. P. C., Sauter, M., Sauvan, E., Schmitt, S., Schmookler, B. A., Schnell, G., Schoeffel, L., Schöning, A., Schumann, S., Sefkow, F., Shushkevich, S., Soloviev, Y., Sopicki, P., South, D., Specka, A., Steder, M., Stella, B., Stöcker, L., Straumann, U., Sun, C., Sykora, T., Thompson, P. D., Acosta, F. Torales, Traynor, D., Tseepeldorj, B., Tu, Z., Tustin, G., Valkárová, A., Vallée, C., van Mechelen, P., Wegener, D., Wünsch, E., Žáček, J., Zhang, J., Zhang, Z., Žlebčík, R., Zohrabyan, H., and Zomer, F.

Published
2024
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17. The importance of considering competing risks in recurrence analysis of intracranial meningioma

Author

Mirian, Christian, Jensen, Lasse Rehné, Juratli, Tareq A., Maier, Andrea Daniela, Torp, Sverre H., Shih, Helen A., Morshed, Ramin A., Young, Jacob S., Magill, Stephen T., Bertero, Luca, Stummer, Walter, Spille, Dorothee Cäcilia, Brokinkel, Benjamin, Oya, Soichi, Miyawaki, Satoru, Saito, Nobuhito, Proescholdt, Martin, Kuroi, Yasuhiro, Gousias, Konstantinos, Simon, Matthias, Moliterno, Jennifer, Prat-Acin, Ricardo, Goutagny, Stéphane, Prabhu, Vikram C., Tsiang, John T., Wach, Johannes, Güresir, Erdem, Yamamoto, Junkoh, Kim, Young Zoon, Lee, Joo Ho, Koshy, Matthew, Perumal, Karthikeyan, Baskaya, Mustafa K., Cannon, Donald M., Shrieve, Dennis C., Suh, Chang-Ok, Chang, Jong Hee, Kamenova, Maria, Straumann, Sven, Soleman, Jehuda, Eyüpoglu, Ilker Y., Catalan, Tony, Lui, Austin, Theodosopoulos, Philip V., McDermott, Michael W., Wang, Fang, Guo, Fuyou, Góes, Pedro, de Paiva Neto, Manoel Antonio, Jamshidi, Aria, Komotar, Ricardo, Ivan, Michael, Luther, Evan, Souhami, Luis, Guiot, Marie-Christine, Csonka, Tamás, Endo, Toshiki, Barrett, Olivia Claire, Jensen, Randy, Gupta, Tejpal, Patel, Akash J., Klisch, Tiemo J., Kim, Jun Won, Maiuri, Francesco, Barresi, Valeria, Tabernero, María Dolores, Skyrman, Simon, Broechner, Anders, Bach, Mathias Jacobsen, Law, Ian, Scheie, David, Kristensen, Bjarne Winther, Munch, Tina Nørgaard, Meling, Torstein, Fugleholm, Kåre, Blanche, Paul, and Mathiesen, Tiit

Published
2024
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27. Earth-vertical motion perception assessment using an elevator: a feasibility study

Author

Simona Schellenberg, Dominik Straumann, David Andrew Green, Philipp Schuetz, Yves Zehnder, and Jaap Swanenburg

Subjects
Medicine, Science
Abstract

Abstract A feasible, inexpensive, rapid, and easy-to-use method to measure vestibular vertical movement perception is needed to assess the sacculus-mediated low-frequency otolith function of dizzy patients. To evaluate the feasibility of reaction time assessment in response to vertical motion induced by an elevator in healthy young individuals. We recorded linear acceleration/deceleration reaction times (LA-RT/LD-RT) of 20 healthy (13 female) subjects (mean age: 22 years ± 1 SD) as a measure of vertical vestibular motion perception. LA-RT/LD-RT were defined as the time elapsed from the start of elevator acceleration or deceleration to the time at which subjects in a sitting position indicated perceiving a change in velocity by pushing a button with their thumb. The light reaction time was measured as a reference. All 20 subjects tolerated the assessment with repeated elevator rides and reported no adverse events. Over all experiments, one upward and four downward rides had to be excluded for technical reasons (2.5%). The fraction of premature button presses varied among the four conditions, possibly related to elevator vibration (upward rides: LA-RT-up 66%, LD-RT-up 0%; downward rides: LA-RT-down 12%, LD-RT-down 4%). Thus LD-RT-up yielded the most robust results. The reaction time to earth-vertical deceleration elicited by an elevator provides a consistent indicator of linear vestibular motion perception in healthy humans. The testing procedure is inexpensive and easy to use. Deceleration on upward rides yielded the most robust measurements.

Published
2023
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28. Acute effects of intravenous DMT in a randomized placebo-controlled study in healthy participants

Author

Severin B. Vogt, Laura Ley, Livio Erne, Isabelle Straumann, Anna M. Becker, Aaron Klaiber, Friederike Holze, Anja Vandersmissen, Lorenz Mueller, Urs Duthaler, Deborah Rudin, Dino Luethi, Nimmy Varghese, Anne Eckert, and Matthias E. Liechti

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract N,N-dimethyltryptamine (DMT) is distinct among classic serotonergic psychedelics because of its short-lasting effects when administered intravenously. Despite growing interest in the experimental and therapeutic use of intravenous DMT, data are lacking on its clinical pharmacology. We conducted a double-blind, randomized, placebo-controlled crossover trial in 27 healthy participants to test different intravenous DMT administration regimens: placebo, low infusion (0.6 mg/min), high infusion (1 mg/min), low bolus + low infusion (15 mg + 0.6 mg/min), and high bolus + high infusion (25 mg + 1 mg/min). Study sessions lasted for 5 h and were separated by at least 1 week. Participant’s lifetime use of psychedelics was ≤20 times. Outcome measures included subjective, autonomic, and adverse effects, pharmacokinetics of DMT, and plasma levels of brain-derived neurotropic factor (BDNF) and oxytocin. Low (15 mg) and high (25 mg) DMT bolus doses rapidly induced very intense psychedelic effects that peaked within 2 min. DMT infusions (0.6 or 1 mg/min) without a bolus induced slowly increasing and dose-dependent psychedelic effects that reached plateaus after 30 min. Both bolus doses produced more negative subjective effects and anxiety than infusions. After stopping the infusion, all drug effects rapidly decreased and completely subsided within 15 min, consistent with a short early plasma elimination half-life (t1/2α) of 5.0–5.8 min, followed by longer late elimination (t1/2β = 14–16 min) after 15–20 min. Subjective effects of DMT were stable from 30 to 90 min, despite further increasing plasma concentrations, thus indicating acute tolerance to continuous DMT administration. Intravenous DMT, particularly when administered as an infusion, is a promising tool for the controlled induction of a psychedelic state that can be tailored to the specific needs of patients and therapeutic sessions. Trial registration: ClinicalTrials.gov identifier: NCT04353024

Published
2023
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29. Monitoring Patients With Eosinophilic Esophagitis in Routine Clinical Practice - International Expert Recommendations

Author

Arnim, Ulrike von, Biedermann, Luc, Aceves, Seema S., Bonis, Peter A., Collins, Margaret H., Dellon, Evan S., Furuta, Glenn T., Gonsalves, Nirmala, Gupta, Sandeep, Hirano, Ikuo, Lucendo, Alfredo J., Miehlke, Stephan, Oliva, Salvatore, Schlag, Christoph, Schoepfer, Alain, Straumann, Alex, Vieth, Michael, and Bredenoord, Albert J.

Published
2023
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32. Measurement of the $CP$-violating phase $\phi_s$ from $B_{s}^{0}\to J/\psi\pi^+\pi^-$ decays in 13 TeV $pp$ collisions

Author

LHCb Collaboration, Aaij, R., Beteta, C. Abellán, Adeva, B., Adinolfi, M., Aidala, C. A., Ajaltouni, Z., Akar, S., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Albero, A. Alfonso, Alkhazov, G., Cartelle, P. Alvarez, Alves Jr, A. A., Amato, S., Amhis, Y., An, L., Anderlini, L., Andreassi, G., Andreotti, M., Andrews, J. E., Archilli, F., Romeu, J. Arnau, Artamonov, A., Artuso, M., Arzymatov, K., Aslanides, E., Atzeni, M., Audurier, B., Bachmann, S., Back, J. J., Baker, S., Balagura, V., Baldini, W., Baranov, A., Barlow, R. J., Barrand, G. C., Barsuk, S., Barter, W., Bartolini, M., Baryshnikov, F., Batozskaya, V., Batsukh, B., Battig, A., Battista, V., Bay, A., Bedeschi, F., Bediaga, I., Beiter, A., Bel, L. J., Belin, S., Beliy, N., Bellee, V., Belloli, N., Belous, K., Belyaev, I., Bencivenni, G., Ben-Haim, E., Benson, S., Beranek, S., Berezhnoy, A., Bernet, R., Berninghoff, D., Bertholet, E., Bertolin, A., Betancourt, C., Betti, F., Bettler, M. O., Bezshyiko, Ia., Bhasin, S., Bhom, J., Bieker, M. S., Bifani, S., Billoir, P., Birnkraut, A., Bizzeti, A., Bjørn, M., Blago, M. P., Blake, T., Blanc, F., Blusk, S., Bobulska, D., Bocci, V., Garcia, O. Boente, Boettcher, T., Bondar, A., Bondar, N., Borghi, S., Borisyak, M., Borsato, M., Boubdir, M., Bowcock, T. J. V., Bozzi, C., Braun, S., Brodski, M., Brodzicka, J., Gonzalo, A. Brossa, Brundu, D., Buchanan, E., Buonaura, A., Burr, C., Bursche, A., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Calladine, R., Calvi, M., Gomez, M. Calvo, Camboni, A., Campana, P., Perez, D. H. Campora, Capriotti, L., Carbone, A., Carboni, G., Cardinale, R., Cardini, A., Carniti, P., Akiba, K. Carvalho, Casse, G., Cattaneo, M., Cavallero, G., Cenci, R., Chamont, D., Chapman, M. G., Charles, M., Charpentier, Ph., Chatzikonstantinidis, G., Chefdeville, M., Chekalina, V., Chen, C., Chen, S., Chitic, S. -G., Chobanova, V., Chrzaszcz, M., Chubykin, A., Ciambrone, P., Vidal, X. Cid, Ciezarek, G., Cindolo, F., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Coco, V., Coelho, J. A. B., Cogan, J., Cogneras, E., Cojocariu, L., Collins, P., Colombo, T., Comerma-Montells, A., Contu, A., Coombs, G., Coquereau, S., Corti, G., Sobral, C. M. Costa, Couturier, B., Cowan, G. A., Craik, D. C., Crocombe, A., Torres, M. Cruz, Currie, R., Da Silva, C. L., Dall'Occo, E., Dalseno, J., D'Ambrosio, C., Danilina, A., d'Argent, P., Davis, A., Francisco, O. De Aguiar, De Bruyn, K., De Capua, S., De Cian, M., De Miranda, J. M., De Paula, L., De Serio, M., De Simone, P., de Vries, J. A., Dean, C. T., Dean, W., Decamp, D., Del Buono, L., Delaney, B., Dembinski, H. -P., Demmer, M., Dendek, A., Derkach, D., Deschamps, O., Desse, F., Dettori, F., Dey, B., Di Canto, A., Di Nezza, P., Didenko, S., Dijkstra, H., Dordei, F., Dorigo, M., Reis, A. C. dos, Suárez, A. Dosil, Douglas, L., Dovbnya, A., Dreimanis, K., Dufour, L., Dujany, G., Durante, P., Durham, J. M., Dutta, D., Dzhelyadin, R., Dziewiecki, M., Dziurda, A., Dzyuba, A., Easo, S., Egede, U., Egorychev, V., Eidelman, S., Eisenhardt, S., Eitschberger, U., Ekelhof, R., Eklund, L., Ely, S., Ene, A., Escher, S., Esen, S., Evans, T., Falabella, A., Färber, C., Farley, N., Farry, S., Fazzini, D., Féo, M., Declara, P. Fernandez, Prieto, A. Fernandez, Ferrari, F., Lopes, L. Ferreira, Rodrigues, F. Ferreira, Sole, S. Ferreres, Ferro-Luzzi, M., Filippov, S., Fini, R. A., Fiorini, M., Firlej, M., Fitzpatrick, C., Fiutowski, T., Fleuret, F., Fontana, M., Fontanelli, F., Forty, R., Lima, V. Franco, Frank, M., Frei, C., Fu, J., Funk, W., Gabriel, E., Torreira, A. Gallas, Galli, D., Gallorini, S., Gambetta, S., Gan, Y., Gandelman, M., Gandini, P., Gao, Y., Martin, L. M. Garcia, Pardiñas, J. García, Plana, B. Garcia, Tico, J. Garra, Garrido, L., Gascon, D., Gaspar, C., Gazzoni, G., Gerick, D., Gersabeck, E., Gersabeck, M., Gershon, T., Gerstel, D., Ghez, Ph., Gibson, V., Girard, O. G., Gironell, P. Gironella, Giubega, L., Gizdov, K., Gligorov, V. V., Göbel, C., Golubkov, D., Golutvin, A., Gomes, A., Gorelov, I. V., Gotti, C., Govorkova, E., Grabowski, J. P., Diaz, R. Graciani, Cardoso, L. A. Granado, Graugés, E., Graverini, E., Graziani, G., Grecu, A., Greim, R., Griffith, P., Grillo, L., Gruber, L., Cazon, B. R. Gruberg, Gu, C., Gushchin, E., Guth, A., Guz, Yu., Gys, T., Hadavizadeh, T., Hadjivasiliou, C., Haefeli, G., Haen, C., Haines, S. C., Hamilton, B., Han, X., Hancock, T. H., Hansmann-Menzemer, S., Harnew, N., Harrison, T., Hasse, C., Hatch, M., He, J., Hecker, M., Heinicke, K., Heister, A., Hennessy, K., Henry, L., Heß, M., Heuel, J., Hicheur, A., Charman, R. Hidalgo, Hill, D., Hilton, M., Hopchev, P. H., Hu, J., Hu, W., Huang, W., Huard, Z. C., Hulsbergen, W., Humair, T., Hushchyn, M., Hutchcroft, D., Hynds, D., Ibis, P., Idzik, M., Ilten, P., Inglessi, A., Inyakin, A., Ivshin, K., Jacobsson, R., Jakobsen, S., Jalocha, J., Jans, E., Jashal, B. K., Jawahery, A., Jiang, F., John, M., Johnson, D., Jones, C. R., Joram, C., Jost, B., Jurik, N., Kandybei, S., Karacson, M., Kariuki, J. M., Karodia, S., Kazeev, N., Kecke, M., Keizer, F., Kelsey, M., Kenzie, M., Ketel, T., Khanji, B., Kharisova, A., Khurewathanakul, C., Kim, K. E., Kirn, T., Kirsebom, V. S., Klaver, S., Klimaszewski, K., Koliiev, S., Kolpin, M., Kopecna, R., Koppenburg, P., Kostiuk, I., Kotriakhova, S., Kozeiha, M., Kravchuk, L., Kreps, M., Kress, F., Kretzschmar, S., Krokovny, P., Krupa, W., Krzemien, W., Kucewicz, W., Kucharczyk, M., Kudryavtsev, V., Kunde, G. J., Kuonen, A. K., Kvaratskheliya, T., Lacarrere, D., Lafferty, G., Lai, A., Lancierini, D., Lanfranchi, G., Langenbruch, C., Latham, T., Lazzeroni, C., Gac, R. Le, Lefèvre, R., Leflat, A., Lemaitre, F., Leroy, O., Lesiak, T., Leverington, B., Li, H., Li, P. -R., Li, Y., Li, Z., Liang, X., Likhomanenko, T., Lindner, R., Lionetto, F., Lisovskyi, V., Liu, G., Liu, X., Loh, D., Loi, A., Longstaff, I., Lopes, J. H., Loustau, G., Lovell, G. H., Lucchesi, D., Martinez, M. Lucio, Luo, Y., Lupato, A., Luppi, E., Lupton, O., Lusiani, A., Lyu, X., Machefert, F., Maciuc, F., Macko, V., Mackowiak, P., Maddrell-Mander, S., Maev, O., Maguire, K., Maisuzenko, D., Majewski, M. W., Malde, S., Malecki, B., Malinin, A., Maltsev, T., Malygina, H., Manca, G., Mancinelli, G., Marangotto, D., Maratas, J., Marchand, J. F., Marconi, U., Benito, C. Marin, Marinangeli, M., Marino, P., Marks, J., Marshall, P. J., Martellotti, G., Martinelli, M., Santos, D. Martinez, Vidal, F. Martinez, Massafferri, A., Materok, M., Matev, R., Mathad, A., Mathe, Z., Matiunin, V., Matteuzzi, C., Mattioli, K. R., Mauri, A., Maurice, E., Maurin, B., McCann, M., McNab, A., McNulty, R., Mead, J. V., Meadows, B., Meaux, C., Meinert, N., Melnychuk, D., Merk, M., Merli, A., Michielin, E., Milanes, D. A., Millard, E., Minard, M. -N., Minzoni, L., Mitzel, D. S., Mödden, A., Mogini, A., Moise, R. D., Mombächer, T., Monroy, I. A., Monteil, S., Morandin, M., Morello, G., Morello, M. J., Moron, J., Morris, A. B., Mountain, R., Muheim, F., Mukherjee, M., Mulder, M., Müller, D., Müller, J., Müller, K., Müller, V., Murphy, C. H., Murray, D., Naik, P., Nakada, T., Nandakumar, R., Nandi, A., Nanut, T., Nasteva, I., Needham, M., Neri, N., Neubert, S., Neufeld, N., Newcombe, R., Nguyen, T. D., Nguyen-Mau, C., Nieswand, S., Niet, R., Nikitin, N., Nolte, N. S., Oblakowska-Mucha, A., Obraztsov, V., Ogilvy, S., O'Hanlon, D. P., Oldeman, R., Onderwater, C. J. G., Osborn, J. D., Ossowska, A., Goicochea, J. M. Otalora, Ovsiannikova, T., Owen, P., Oyanguren, A., Pais, P. R., Pajero, T., Palano, A., Palutan, M., Panshin, G., Papanestis, A., Pappagallo, M., Pappalardo, L. L., Parker, W., Parkes, C., Passaleva, G., Pastore, A., Patel, M., Patrignani, C., Pearce, A., Pellegrino, A., Penso, G., Altarelli, M. Pepe, Perazzini, S., Pereima, D., Perret, P., Pescatore, L., Petridis, K., Petrolini, A., Petrov, A., Petrucci, S., Petruzzo, M., Pietrzyk, B., Pietrzyk, G., Pikies, M., Pili, M., Pinci, D., Pinzino, J., Pisani, F., Piucci, A., Placinta, V., Playfer, S., Plews, J., Casasus, M. Plo, Polci, F., Lener, M. Poli, Poliakova, M., Poluektov, A., Polukhina, N., Polyakov, I., Polycarpo, E., Pomery, G. J., Ponce, S., Popov, A., Popov, D., Poslavskii, S., Price, E., Prouve, C., Pugatch, V., Navarro, A. Puig, Pullen, H., Punzi, G., Qian, W., Qin, J., Quagliani, R., Quintana, B., Raab, N. V., Rachwal, B., Rademacker, J. H., Rama, M., Pernas, M. Ramos, Rangel, M. S., Ratnikov, F., Raven, G., Salzgeber, M. Ravonel, Reboud, M., Redi, F., Reichert, S., Reiss, F., Alepuz, C. Remon, Ren, Z., Renaudin, V., Ricciardi, S., Richards, S., Rinnert, K., Robbe, P., Robert, A., Rodrigues, A. B., Rodrigues, E., Lopez, J. A. Rodriguez, Roehrken, M., Roiser, S., Rollings, A., Romanovskiy, V., Vidal, A. Romero, Roth, J. D., Rotondo, M., Rudolph, M. S., Ruf, T., Vidal, J. Ruiz, Silva, J. J. Saborido, Sagidova, N., Saitta, B., Guimaraes, V. Salustino, Gras, C. Sanchez, Mayordomo, C. Sanchez, Sedes, B. Sanmartin, Santacesaria, R., Rios, C. Santamarina, Santimaria, M., Santovetti, E., Sarpis, G., Sarti, A., Satriano, C., Satta, A., Saur, M., Savrina, D., Schael, S., Schellenberg, M., Schiller, M., Schindler, H., Schmelling, M., Schmelzer, T., Schmidt, B., Schneider, O., Schopper, A., Schreiner, H. F., Schubiger, M., Schulte, S., Schune, M. H., Schwemmer, R., Sciascia, B., Sciubba, A., Semennikov, A., Sepulveda, E. S., Sergi, A., Serra, N., Serrano, J., Sestini, L., Seuthe, A., Seyfert, P., Shapkin, M., Shears, T., Shekhtman, L., Shevchenko, V., Shmanin, E., Siddi, B. G., Coutinho, R. Silva, de Oliveira, L. Silva, Simi, G., Simone, S., Skiba, I., Skidmore, N., Skwarnicki, T., Slater, M. W., Smeaton, J. G., Smith, E., Smith, I. T., Smith, M., Soares, M., Lavra, l. Soares, Sokoloff, M. D., Soler, F. J. P., De Paula, B. Souza, Spaan, B., Norella, E. Spadaro, Spradlin, P., Stagni, F., Stahl, M., Stahl, S., Stefko, P., Stefkova, S., Steinkamp, O., Stemmle, S., Stenyakin, O., Stepanova, M., Stevens, H., Stocchi, A., Stone, S., Stracka, S., Stramaglia, M. E., Straticiuc, M., Straumann, U., Strokov, S., Sun, J., Sun, L., Sun, Y., Swientek, K., Szabelski, A., Szumlak, T., Szymanski, M., Tang, Z., Tekampe, T., Tellarini, G., Teubert, F., Thomas, E., Tilley, M. J., Tisserand, V., T'Jampens, S., Tobin, M., Tolk, S., Tomassetti, L., Tonelli, D., Tou, D. Y., Aoude, R. Tourinho Jadallah, Tournefier, E., Traill, M., Tran, M. T., Trisovic, A., Tsaregorodtsev, A., Tuci, G., Tully, A., Tuning, N., Ukleja, A., Usachov, A., Ustyuzhanin, A., Uwer, U., Vagner, A., Vagnoni, V., Valassi, A., Valat, S., Valenti, G., van Beuzekom, M., Van Hecke, H., van Herwijnen, E., Van Hulse, C. B., van Tilburg, J., van Veghel, M., Gomez, R. Vazquez, Regueiro, P. Vazquez, Sierra, C. Vázquez, Vecchi, S., Velthuis, J. J., Veltri, M., Venkateswaran, A., Vernet, M., Veronesi, M., Vesterinen, M., Barbosa, J. V. Viana, Vieira, D., Diaz, M. Vieites, Viemann, H., Vilasis-Cardona, X., Vitkovskiy, A., Vitti, M., Volkov, V., Vollhardt, A., Bruch, D. Vom, Voneki, B., Vorobyev, A., Vorobyev, V., Voropaev, N., Waldi, R., Walsh, J., Wang, J., Wang, M., Wang, Y., Wang, Z., Ward, D. R., Wark, H. M., Watson, N. K., Websdale, D., Weiden, A., Weisser, C., Whitehead, M., Wilkinson, G., Wilkinson, M., Williams, I., Williams, M., Williams, M. R. J., Williams, T., Wilson, F. F., Winn, M., Wislicki, W., Witek, M., Wormser, G., Wotton, S. A., Wyllie, K., Xiao, D., Xie, Y., Xing, H., Xu, A., Xu, M., Xu, Q., Xu, Z., Yang, Z., Yao, Y., Yeomans, L. E., Yin, H., Yu, J., Yuan, X., Yushchenko, O., Zarebski, K. A., Zavertyaev, M., Zeng, M., Zhang, D., Zhang, L., Zhang, W. C., Zhang, Y., Zhelezov, A., Zheng, Y., Zhu, X., Zhukov, V., Zonneveld, J. B., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

Decays of $B_{s}^{0}$ and $\overline{B}{}_{s}^{0}$ mesons into $J/\psi\pi^+\pi^-$ final states are studied in a data sample corresponding to 1.9 fb$^{-1}$ of integrated luminosity collected with the LHCb detector in 13 TeV $pp$ collisions. A time-dependent amplitude analysis is used to determine the final-state resonance contributions, the $CP$-violating phase $\phi_s=-0.057\pm 0.060\pm 0.011$ rad, the decay-width difference between the heavier mass $B_{s}^{0}$ eigenstate and the $B^{0}$ meson of $-0.050\pm 0.004\pm 0.004$ ps$^{-1}$, and the $CP$-violating parameter $|\lambda|=1.01_{-0.06}^{+0.08}\pm0.03$, where the first uncertainty is statistical and the second systematic. These results are combined with previous LHCb measurements in the same decay channel using 7 TeV and 8 TeV $pp$ collisions obtaining $\phi_s =0.002\pm0.044\pm0.012$ rad, and $|\lambda| =0.949\pm0.036\pm0.019$., Comment: All figures and tables, along with any supplementary material and additional information, are available at https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2019-003.html

Published
2019
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33. The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants

Author

Rothenberger, Sylvia, Hurdiss, Daniel L., Walser, Marcel, Malvezzi, Francesca, Mayor, Jennifer, Ryter, Sarah, Moreno, Hector, Liechti, Nicole, Bosshart, Andreas, Iss, Chloé, Calabro, Valérie, Cornelius, Andreas, Hospodarsch, Tanja, Neculcea, Alexandra, Looser, Thamar, Schlegel, Anja, Fontaine, Simon, Villemagne, Denis, Paladino, Maria, Schiegg, Dieter, Mangold, Susanne, Reichen, Christian, Radom, Filip, Kaufmann, Yvonne, Schaible, Doris, Schlegel, Iris, Zitt, Christof, Sigrist, Gabriel, Straumann, Marcel, Wolter, Julia, Comby, Marco, Sacarcelik, Feyza, Drulyte, Ieva, Lyoo, Heyrhyoung, Wang, Chunyan, Li, Wentao, Du, Wenjuan, Binz, H. Kaspar, Herrup, Rachel, Lusvarghi, Sabrina, Neerukonda, Sabari Nath, Vassell, Russell, Wang, Wei, Adler, Julia M., Eschke, Kathrin, Nascimento, Mariana, Abdelgawad, Azza, Gruber, Achim D., Bushe, Judith, Kershaw, Olivia, Knutson, Charles G., Balavenkatraman, Kamal K., Ramanathan, Krishnan, Wyler, Emanuel, Teixeira Alves, Luiz Gustavo, Lewis, Seth, Watson, Randall, Haeuptle, Micha A., Zürcher, Alexander, Dawson, Keith M., Steiner, Daniel, Weiss, Carol D., Amstutz, Patrick, van Kuppeveld, Frank J. M., Stumpp, Michael T., Bosch, Berend-Jan, Engler, Olivier, and Trimpert, Jakob

Published
2022
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34. The limits of internal devaluation: Switzerland during the great depression

Author

Peter Rosenkranz, Tobias Straumann, and Ulrich Woitek

Subjects
Great Depression, Switzerland, New Keynesian business cycle model, Statistics, HA1-4737, Economics as a science, HB71-74
Abstract

Abstract During the Great Depression, countries endowed with abundant gold reserves were not able to leave the gold standard and devalue their currencies until the mid-1930s. Instead, they were forced to go down the road of internal devaluation. We analyze the policies of the Swiss authorities by estimating a New Keynesian small open economy model. Our results show that the long adherence to the gold standard and the failure of internal devaluation imposed considerable costs on the Swiss economy. Moreover, counterfactual exercises suggest that a timely devaluation would have led to an early recovery from the Great Depression.

Published
2022
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35. Unbinned deep learning jet substructure measurement in high Q2 ep collisions at HERA

Author

V. Andreev, M. Arratia, A. Baghdasaryan, A. Baty, K. Begzsuren, A. Bolz, V. Boudry, G. Brandt, D. Britzger, A. Buniatyan, L. Bystritskaya, A.J. Campbell, K.B. Cantun Avila, K. Cerny, V. Chekelian, Z. Chen, J.G. Contreras, J. Cvach, J.B. Dainton, K. Daum, A. Deshpande, C. Diaconu, A. Drees, G. Eckerlin, S. Egli, E. Elsen, L. Favart, A. Fedotov, J. Feltesse, M. Fleischer, A. Fomenko, C. Gal, J. Gayler, L. Goerlich, N. Gogitidze, M. Gouzevitch, C. Grab, T. Greenshaw, G. Grindhammer, D. Haidt, R.C.W. Henderson, J. Hessler, J. Hladký, D. Hoffmann, R. Horisberger, T. Hreus, F. Huber, P.M. Jacobs, M. Jacquet, T. Janssen, A.W. Jung, J. Katzy, C. Kiesling, M. Klein, C. Kleinwort, H.T. Klest, R. Kogler, P. Kostka, J. Kretzschmar, D. Krücker, K. Krüger, M.P.J. Landon, W. Lange, P. Laycock, S.H. Lee, S. Levonian, W. Li, J. Lin, K. Lipka, B. List, J. List, B. Lobodzinski, O.R. Long, E. Malinovski, H.-U. Martyn, S.J. Maxfield, A. Mehta, A.B. Meyer, J. Meyer, S. Mikocki, V.M. Mikuni, M.M. Mondal, K. Müller, B. Nachman, Th. Naumann, P.R. Newman, C. Niebuhr, G. Nowak, J.E. Olsson, D. Ozerov, S. Park, C. Pascaud, G.D. Patel, E. Perez, A. Petrukhin, I. Picuric, D. Pitzl, R. Polifka, S. Preins, V. Radescu, N. Raicevic, T. Ravdandorj, P. Reimer, E. Rizvi, P. Robmann, R. Roosen, A. Rostovtsev, M. Rotaru, D.P.C. Sankey, M. Sauter, E. Sauvan, S. Schmitt, B.A. Schmookler, G. Schnell, L. Schoeffel, A. Schöning, F. Sefkow, S. Shushkevich, Y. Soloviev, P. Sopicki, D. South, A. Specka, M. Steder, B. Stella, U. Straumann, C. Sun, T. Sykora, P.D. Thompson, F. Torales Acosta, D. Traynor, B. Tseepeldorj, Z. Tu, G. Tustin, A. Valkárová, C. Vallée, P. Van Mechelen, D. Wegener, E. Wünsch, J. Žáček, J. Zhang, Z. Zhang, R. Žlebčík, H. Zohrabyan, and F. Zomer

Subjects
Physics, QC1-999
Abstract

The radiation pattern within high energy quark- and gluon-initiated jets (jet substructure) is used extensively as a precision probe of the strong force as well as an environment for optimizing event generators with numerous applications in high energy particle and nuclear physics. Looking at electron-proton collisions is of particular interest as many of the complications present at hadron colliders are absent. A detailed study of modern jet substructure observables, jet angularities, in electron-proton collisions is presented using data recorded using the H1 detector at HERA. The measurement is unbinned and multi-dimensional, using machine learning to correct for detector effects. All of the available reconstructed object information of the respective jets is interpreted by a graph neural network, achieving superior precision on a selected set of jet angularities. Training these networks was enabled by the use of a large number of GPUs in the Perlmutter supercomputer at Berkeley Lab. The particle jets are reconstructed in the laboratory frame, using the kT jet clustering algorithm. Results are reported at high transverse momentum transfer Q2>150GeV2, and inelasticity 0.2

Published
2023
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36. Imaging increased metabolism in the spinal cord in mice after middle cerebral artery occlusion

Author

Ruiqing Ni, Nadja Straumann, Serana Fazio, Xose Luis Dean-Ben, Georgios Louloudis, Claudia Keller, Daniel Razansky, Simon Ametamey, Linjing Mu, César Nombela-Arrieta, and Jan Klohs

Subjects
fluorodeoxyglucose (FDG), Ischemic stroke, Metabolism, MSOT, Optoacoustic tomography, Oxygenation, Physics, QC1-999, Acoustics. Sound, QC221-246, Optics. Light, QC350-467
Abstract

Emerging evidence indicates crosstalk between the brain and hematopoietic system following cerebral ischemia. Here, we investigated metabolism and oxygenation in the spleen and spinal cord in a transient middle cerebral artery occlusion (tMCAO) model. Sham-operated and tMCAO mice underwent [18F]fluorodeoxyglucose (FDG)-positron emission tomography (PET) to assess glucose metabolism. Naïve, sham-operated and tMCAO mice underwent multispectral optoacoustic tomography (MSOT) assisted by quantitative model-based reconstruction and unmixing algorithms for accurate mapping of oxygenation patterns in peripheral tissues at 24 h after reperfusion. We found increased [18F]FDG uptake and reduced MSOT oxygen saturation, indicating hypoxia in the thoracic spinal cord of tMCAO mice compared with sham-operated mice but not in the spleen. Reduced spleen size was observed in tMCAO mice compared with sham-operated mice ex vivo. tMCAO led to an increase in the numbers of mature T cells in femoral bone marrow tissues, concomitant with a stark reduction in these cell subsets in the spleen and peripheral blood. The combination of quantitative PET and MSOT thus enabled observation of hypoxia and increased metabolic activity in the spinal cord of tMCAO mice at 24 h after occlusion compared to sham-operated mice.

Published
2023
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37. Editorial: Impacts of VEMP and VHIT on the diagnosis of vestibular diseases

Author

Alexander Andrea Tarnutzer, Toru Seo, Chisato Fujimoto, Dominik Straumann, and Toshihisa Murofushi

Subjects
vestibular, vestibular-evoked myogenic-potentials (VEMPs), video head impulse test, acute vestibular syndrome (AVS), acute peripheral vestibulopathy, state-of-the-art research, Neurology. Diseases of the nervous system, RC346-429
Published
2023
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40. Measurement of $CP$ violation in $B^{0}\rightarrow D^{\mp}\pi^{\pm}$ decays

Author

LHCb collaboration, Aaij, R., Adeva, B., Adinolfi, M., Ajaltouni, Z., Akar, S., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Albero, A. Alfonso, Ali, S., Alkhazov, G., Cartelle, P. Alvarez, Alves Jr, A. A., Amato, S., Amerio, S., Amhis, Y., An, L., Anderlini, L., Andreassi, G., Andreotti, M., Andrews, J. E., Appleby, R. B., Archilli, F., d'Argent, P., Romeu, J. Arnau, Artamonov, A., Artuso, M., Aslanides, E., Atzeni, M., Auriemma, G., Bachmann, S., Back, J. J., Baker, S., Balagura, V., Baldini, W., Baranov, A., Barlow, R. J., Barsuk, S., Barter, W., Baryshnikov, F., Batozskaya, V., Battista, V., Bay, A., Beddow, J., Bedeschi, F., Bediaga, I., Beiter, A., Bel, L. J., Beliy, N., Bellee, V., Belloli, N., Belous, K., Belyaev, I., Ben-Haim, E., Bencivenni, G., Benson, S., Beranek, S., Berezhnoy, A., Bernet, R., Berninghoff, D., Bertholet, E., Bertolin, A., Betancourt, C., Betti, F., Bettler, M. O., van Beuzekom, M., Bezshyiko, Ia., Bifani, S., Billoir, P., Birnkraut, A., Bizzeti, A., Bjørn, M., Blake, T., Blanc, F., Blusk, S., Bocci, V., Garcia, O. Boente, Boettcher, T., Bondar, A., Bondar, N., Borghi, S., Borisyak, M., Borsato, M., Bossu, F., Boubdir, M., Bowcock, T. J. V., Bowen, E., Bozzi, C., Braun, S., Brodski, M., Brodzicka, J., Brundu, D., Buchanan, E., Burr, C., Bursche, A., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Calladine, R., Calvi, M., Gomez, M. Calvo, Camboni, A., Campana, P., Perez, D. H. Campora, Capriotti, L., Carbone, A., Carboni, G., Cardinale, R., Cardini, A., Carniti, P., Carson, L., Akiba, K. Carvalho, Casse, G., Cassina, L., Cattaneo, M., Cavallero, G., Cenci, R., Chamont, D., Chapman, M. G., Charles, M., Charpentier, Ph., Chatzikonstantinidis, G., Chefdeville, M., Chen, S., Chitic, S. -G., Chobanova, V., Chrzaszcz, M., Chubykin, A., Ciambrone, P., Vidal, X. Cid, Ciezarek, G., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Coco, V., Cogan, J., Cogneras, E., Cogoni, V., Cojocariu, L., Collins, P., Colombo, T., Comerma-Montells, A., Contu, A., Coombs, G., Coquereau, S., Corti, G., Corvo, M., Sobral, C. M. Costa, Couturier, B., Cowan, G. A., Craik, D. C., Crocombe, A., Torres, M. Cruz, Currie, R., D'Ambrosio, C., Marinho, F. Da Cunha, Da Silva, C. L., Dall'Occo, E., Dalseno, J., Danilina, A., Davis, A., Francisco, O. De Aguiar, De Bruyn, K., De Capua, S., De Cian, M., De Miranda, J. M., De Paula, L., De Serio, M., De Simone, P., Dean, C. T., Decamp, D., Del Buono, L., Delaney, B., Dembinski, H. -P., Demmer, M., Dendek, A., Derkach, D., Deschamps, O., Dettori, F., Dey, B., Di Canto, A., Di Nezza, P., Didenko, S., Dijkstra, H., Dordei, F., Dorigo, M., Suárez, A. Dosil, Douglas, L., Dovbnya, A., Dreimanis, K., Dufour, L., Dujany, G., Durante, P., Durham, J. M., Dutta, D., Dzhelyadin, R., Dziewiecki, M., Dziurda, A., Dzyuba, A., Easo, S., Egede, U., Egorychev, V., Eidelman, S., Eisenhardt, S., Eitschberger, U., Ekelhof, R., Eklund, L., Ely, S., Ene, A., Escher, S., Esen, S., Evans, H. M., Evans, T., Falabella, A., Farley, N., Farry, S., Fazzini, D., Federici, L., Fernandez, G., Declara, P. Fernandez, Prieto, A. Fernandez, Ferrari, F., Lopes, L. Ferreira, Rodrigues, F. Ferreira, Ferro-Luzzi, M., Filippov, S., Fini, R. A., Fiorini, M., Firlej, M., Fitzpatrick, C., Fiutowski, T., Fleuret, F., Fontana, M., Fontanelli, F., Forty, R., Lima, V. Franco, Frank, M., Frei, C., Fu, J., Funk, W., Färber, C., Gabriel, E., Torreira, A. Gallas, Galli, D., Gallorini, S., Gambetta, S., Gandelman, M., Gandini, P., Gao, Y., Martin, L. M. Garcia, Plana, B. Garcia, Pardiñas, J. García, Tico, J. Garra, Garrido, L., Gascon, D., Gaspar, C., Gavardi, L., Gazzoni, G., Gerick, D., Gersabeck, E., Gersabeck, M., Gershon, T., Ghez, Ph., Gianì, S., Gibson, V., Girard, O. G., Giubega, L., Gizdov, K., Gligorov, V. V., Golubkov, D., Golutvin, A., Gomes, A., Gorelov, I. V., Gotti, C., Govorkova, E., Grabowski, J. P., Diaz, R. Graciani, Cardoso, L. A. Granado, Graugés, E., Graverini, E., Graziani, G., Grecu, A., Greim, R., Griffith, P., Grillo, L., Gruber, L., Cazon, B. R. Gruberg, Grünberg, O., Gushchin, E., Guz, Yu., Gys, T., Göbel, C., Hadavizadeh, T., Hadjivasiliou, C., Haefeli, G., Haen, C., Haines, S. C., Hamilton, B., Han, X., Hancock, T. H., Hansmann-Menzemer, S., Harnew, N., Harnew, S. T., Hasse, C., Hatch, M., He, J., Hecker, M., Heinicke, K., Heister, A., Hennessy, K., Henry, L., van Herwijnen, E., Heß, M., Hicheur, A., Hill, D., Hopchev, P. H., Hu, W., Huang, W., Huard, Z. C., Hulsbergen, W., Humair, T., Hushchyn, M., Hutchcroft, D., Ibis, P., Idzik, M., Ilten, P., Ivshin, K., Jacobsson, R., Jalocha, J., Jans, E., Jawahery, A., Jiang, F., John, M., Johnson, D., Jones, C. R., Joram, C., Jost, B., Jurik, N., Kandybei, S., Karacson, M., Kariuki, J. M., Karodia, S., Kazeev, N., Kecke, M., Keizer, F., Kelsey, M., Kenzie, M., Ketel, T., Khairullin, E., Khanji, B., Khurewathanakul, C., Kim, K. E., Kirn, T., Klaver, S., Klimaszewski, K., Klimkovich, T., Koliiev, S., Kolpin, M., Kopecna, R., Koppenburg, P., Kotriakhova, S., Kozeiha, M., Kravchuk, L., Kreps, M., Kress, F., Krokovny, P., Krupa, W., Krzemien, W., Kucewicz, W., Kucharczyk, M., Kudryavtsev, V., Kuonen, A. K., Kvaratskheliya, T., Lacarrere, D., Lafferty, G., Lai, A., Lanfranchi, G., Langenbruch, C., Latham, T., Lazzeroni, C., Gac, R. Le, Leflat, A., Lefrançois, J., Lefèvre, R., Lemaitre, F., Leroy, O., Lesiak, T., Leverington, B., Li, P. -R., Li, T., Li, Z., Liang, X., Likhomanenko, T., Lindner, R., Lionetto, F., Lisovskyi, V., Liu, X., Loh, D., Loi, A., Longstaff, I., Lopes, J. H., Lucchesi, D., Martinez, M. Lucio, Lupato, A., Luppi, E., Lupton, O., Lusiani, A., Lyu, X., Machefert, F., Maciuc, F., Macko, V., Mackowiak, P., Maddrell-Mander, S., Maev, O., Maguire, K., Maisuzenko, D., Majewski, M. W., Malde, S., Malecki, B., Malinin, A., Maltsev, T., Manca, G., Mancinelli, G., Marangotto, D., Maratas, J., Marchand, J. F., Marconi, U., Benito, C. Marin, Marinangeli, M., Marino, P., Marks, J., Martellotti, G., Martin, M., Martinelli, M., Santos, D. Martinez, Vidal, F. Martinez, Massafferri, A., Matev, R., Mathad, A., Mathe, Z., Matteuzzi, C., Mauri, A., Maurice, E., Maurin, B., Mazurov, A., McCann, M., McNab, A., McNulty, R., Mead, J. V., Meadows, B., Meaux, C., Meier, F., Meinert, N., Melnychuk, D., Merk, M., Merli, A., Michielin, E., Milanes, D. A., Millard, E., Minard, M. -N., Minzoni, L., Mitzel, D. S., Mogini, A., Rodriguez, J. Molina, Mombächer, T., Monroy, I. A., Monteil, S., Morandin, M., Morello, G., Morello, M. J., Morgunova, O., Moron, J., Morris, A. B., Mountain, R., Muheim, F., Mulder, M., Müller, D., Müller, J., Müller, K., Müller, V., Naik, P., Nakada, T., Nandakumar, R., Nandi, A., Nasteva, I., Needham, M., Neri, N., Neubert, S., Neufeld, N., Neuner, M., Nguyen, T. D., Nguyen-Mau, C., Nieswand, S., Niet, R., Nikitin, N., Nogay, A., O'Hanlon, D. P., Oblakowska-Mucha, A., Obraztsov, V., Ogilvy, S., Oldeman, R., Onderwater, C. J. G., Ossowska, A., Goicochea, J. M. Otalora, Owen, P., Oyanguren, A., Pais, P. R., Palano, A., Palutan, M., Panshin, G., Papanestis, A., Pappagallo, M., Pappalardo, L. L., Parker, W., Parkes, C., Passaleva, G., Pastore, A., Patel, M., Patrignani, C., Pearce, A., Pellegrino, A., Penso, G., Altarelli, M. Pepe, Perazzini, S., Pereima, D., Perret, P., Pescatore, L., Petridis, K., Petrolini, A., Petrov, A., Petruzzo, M., Pietrzyk, B., Pietrzyk, G., Pikies, M., Pinci, D., Pisani, F., Pistone, A., Piucci, A., Placinta, V., Playfer, S., Casasus, M. Plo, Polci, F., Lener, M. Poli, Poluektov, A., Polukhina, N., Polyakov, I., Polycarpo, E., Pomery, G. J., Ponce, S., Popov, A., Popov, D., Poslavskii, S., Potterat, C., Price, E., Prisciandaro, J., Prouve, C., Pugatch, V., Navarro, A. Puig, Pullen, H., Punzi, G., Qian, W., Qin, J., Quagliani, R., Quintana, B., Rachwal, B., Rademacker, J. H., Rama, M., Pernas, M. Ramos, Rangel, M. S., Ratnikov, F., Raven, G., Salzgeber, M. Ravonel, Reboud, M., Redi, F., Reichert, S., Reis, A. C. dos, Alepuz, C. Remon, Renaudin, V., Ricciardi, S., Richards, S., Rinnert, K., Robbe, P., Robert, A., Rodrigues, A. B., Rodrigues, E., Lopez, J. A. Rodriguez, Rogozhnikov, A., Roiser, S., Rollings, A., Romanovskiy, V., Vidal, A. Romero, Rotondo, M., Ruf, T., Vidal, J. Ruiz, Silva, J. J. Saborido, Sagidova, N., Saitta, B., Guimaraes, V. Salustino, Mayordomo, C. Sanchez, Sedes, B. Sanmartin, Santacesaria, R., Rios, C. Santamarina, Santimaria, M., Santovetti, E., Sarpis, G., Sarti, A., Satriano, C., Satta, A., Savrina, D., Schael, S., Schellenberg, M., Schiller, M., Schindler, H., Schmelling, M., Schmelzer, T., Schmidt, B., Schneider, O., Schopper, A., Schreiner, H. F., Schubiger, M., Schune, M. H., Schwemmer, R., Sciascia, B., Sciubba, A., Semennikov, A., Sepulveda, E. S., Sergi, A., Serra, N., Serrano, J., Sestini, L., Seyfert, P., Shapkin, M., Shcheglov, Y., Shears, T., Shekhtman, L., Shevchenko, V., Siddi, B. G., Coutinho, R. Silva, de Oliveira, L. Silva, Simi, G., Simone, S., Skidmore, N., Skwarnicki, T., Smith, I. T., Smith, M., Lavra, l. Soares, Sokoloff, M. D., Soler, F. J. P., De Paula, B. Souza, Spaan, B., Spradlin, P., Stagni, F., Stahl, M., Stahl, S., Stefko, P., Stefkova, S., Steinkamp, O., Stemmle, S., Stenyakin, O., Stepanova, M., Stevens, H., Stone, S., Storaci, B., Stracka, S., Stramaglia, M. E., Straticiuc, M., Straumann, U., Strokov, S., Sun, J., Sun, L., Swientek, K., Syropoulos, V., Szumlak, T., Szymanski, M., T'Jampens, S., Tang, Z., Tayduganov, A., Tekampe, T., Tellarini, G., Teubert, F., Thomas, E., van Tilburg, J., Tilley, M. J., Tisserand, V., Tobin, M., Tolk, S., Tomassetti, L., Tonelli, D., Aoude, R. Tourinho Jadallah, Tournefier, E., Traill, M., Tran, M. T., Tresch, M., Trisovic, A., Tsaregorodtsev, A., Tully, A., Tuning, N., Ukleja, A., Usachov, A., Ustyuzhanin, A., Uwer, U., Vacca, C., Vagner, A., Vagnoni, V., Valassi, A., Valat, S., Valenti, G., Gomez, R. Vazquez, Regueiro, P. Vazquez, Vecchi, S., van Veghel, M., Velthuis, J. J., Veltri, M., Veneziano, G., Venkateswaran, A., Verlage, T. A., Vernet, M., Vesterinen, M., Barbosa, J. V. Viana, Vieira, D., Diaz, M. Vieites, Viemann, H., Vilasis-Cardona, X., Vitkovskiy, A., Vitti, M., Volkov, V., Vollhardt, A., Voneki, B., Vorobyev, A., Vorobyev, V., Voß, C., de Vries, J. A., Sierra, C. Vázquez, Waldi, R., Walsh, J., Wang, J., Wang, M., Wang, Y., Wang, Z., Ward, D. R., Wark, H. M., Watson, N. K., Websdale, D., Weiden, A., Weisser, C., Whitehead, M., Wicht, J., Wilkinson, G., Wilkinson, M., Williams, M. R. J., Williams, M., Williams, T., Wilson, F. F., Wimberley, J., Winn, M., Wishahi, J., Wislicki, W., Witek, M., Wormser, G., Wotton, S. A., Wyllie, K., Xiao, D., Xie, Y., Xu, A., Xu, M., Xu, Q., Xu, Z., Yang, Z., Yao, Y., Yin, H., Yu, J., Yuan, X., Yushchenko, O., Zarebski, K. A., Zavertyaev, M., Zhang, L., Zhang, W. C., Zhang, Y., Zhelezov, A., Zheng, Y., Zhu, X., Zhukov, V., Zonneveld, J. B., and Zucchelli, S.

Subjects
High Energy Physics - Experiment
Abstract

A measurement of the $CP$ asymmetries $S_{f}$ and $S_{\bar{f}}$ in $B^0\to D^{\mp}\pi^{\pm}$ decays is reported. The decays are reconstructed in a dataset collected with the LHCb experiment in proton-proton collisions at centre-of-mass energies of 7 and 8 TeV and corresponding to an integrated luminosity of $3.0 \rm{ fb}^{-1}$. The $CP$ asymmetries are measured to be $S_{f} = 0.058 \pm 0.020 (\rm{stat}) \pm 0.011(\rm{syst})$ and $S_{\bar{f}} = 0.038\pm 0.020 (\text{stat})\pm 0.007 (\text{syst})$. These results are in agreement with, and more precise than, previous determinations. They are used to constrain $|\sin\left(2\beta+\gamma\right)|$ and $\gamma$ to intervals that are consistent with the current world-average values., Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2018-009.html

Published
2018
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41. International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature

Author

Dellon, Evan S., Gonsalves, Nirmala, Abonia, J. Pablo, Alexander, Jeffrey A., Arva, Nicoleta C., Atkins, Dan, Attwood, Stephen E., Auth, Marcus K.H., Bailey, Dominique D., Biederman, Luc, Blanchard, Carine, Bonis, Peter A., Bose, Paroma, Bredenoord, Albert J., Chang, Joy W., Chehade, Mirna, Collins, Margaret H., Di Lorenzo, Carlo, Dias, Jorge Amil, Dohil, Ranjan, Dupont, Christophe, Falk, Gary W., Ferreira, Cristina T., Fox, Adam T., Genta, Robert M., Greuter, Thomas, Gupta, Sandeep K., Hirano, Ikuo, Hiremath, Girish S., Horsley-Silva, Jennifer L., Ishihara, Shunji, Ishimura, Norihisa, Jensen, Elizabeth T., Gutiérrez-Junquera, Carolina, Katzka, David A., Khoury, Paneez, Kinoshita, Yoshikazu, Kliewer, Kara L., Koletzko, Sibylle, Leung, John, Liacouras, Chris A., Lucendo, Alfredo J., Martin, Lisa J., McGowan, Emily C., Menard-Katcher, Calies, Metz, David C., Miller, Talya L., Moawad, Fouad J., Muir, Amanda B., Mukkada, Vincent A., Murch, Simon, Nhu, Quan M., Nomura, Ichiro, Nurko, Samuel, Ohtsuka, Yoshikazu, Oliva, Salvatore, Orel, Rok, Papadopoulou, Alexandra, Patel, Dhyanesh A., Pesek, Robert D., Peterson, Kathryn A., Philpott, Hamish, Putnam, Philip E., Richter, Joel E., Rosen, Rachel, Ruffner, Melanie A., Safroneeva, Ekaterina, Schreiner, Philipp, Schoepfer, Alain, Schroeder, Shauna R., Shah, Neil, Souza, Rhonda F., Spechler, Stuart J., Spergel, Jonathan M., Straumann, Alex, Talley, Nicholas J., Thapar, Nikhil, Vandenplas, Yvan, Venkatesh, Rajitha D., Vieira, Mario C., von Arnim, Ulrike, Walker, Marjorie M., Wechsler, Joshua B., Wershil, Barry K., Wright, Benjamin L., Yamada, Yoshiyuki, Yang, Guang-Yu, Zevit, Noam, Rothenberg, Marc E., Furuta, Glenn T., and Aceves, Seema S.

Published
2022
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42. Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial): a randomised, single-blind, adaptive non-inferiority trial

Author

Bloemen-Carlier, Eltje M., Cibulková, Veronika, de Munnink, Renee, van der Salm, Sandra, Eijkemans, Martinus J.C., Ophorst-van Eck, Janine M., Velders, Anouk, van Asch, Charlotte J.J., Zwemmer, Jack, van Regteren-van Griethuysen, Renate, Smeding, Henriette, van der Berg, Lydia, de Bresser, Jeroen, de Kort, Gérard A.P., Dankbaar, Jan-Willem, Zweiphenning, Willemiek, Klooster, Maryse A van 't, van Klink, Nicole E C, Leijten, Frans S S, Ferrier, Cyrille H, Gebbink, Tineke, Huiskamp, Geertjan, van Zandvoort, Martine J E, van Schooneveld, Monique M J, Bourez, M, Goemans, Sophie, Straumann, Sven, van Rijen, Peter C, Gosselaar, Peter H, van Eijsden, Pieter, Otte, Willem M, van Diessen, Eric, Braun, Kees P J, and Zijlmans, Maeike

Published
2022
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43. Endoscopic approach to eosinophilic esophagitis: American Society for Gastrointestinal Endoscopy Consensus Conference

Author

Aceves, Seema S., Alexander, Jeffrey A., Baron, Todd H., Bredenoord, Arjan J., Day, Lukejohn, Dellon, Evan S., Falk, Gary W., Furuta, Glenn T., Gonsalves, Nirmala, Hirano, Ikuo, Konda, Vani J.A., Lucendo, Alfredo J., Moawad, Fouad, Peterson, Kathryn A., Putnam, Philip E., Richter, Joel, Schoepfer, Alain M., Straumann, Alex, McBride, Deborah L., Sharma, Prateek, and Katzka, David A.

Published
2022
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46. A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions

Author

Dellon, Evan S., Khoury, Paneez, Muir, Amanda B., Liacouras, Chris A., Safroneeva, Ekaterina, Atkins, Dan, Collins, Margaret H., Gonsalves, Nirmala, Falk, Gary W., Spergel, Jonathan M., Hirano, Ikuo, Chehade, Mirna, Schoepfer, Alain M., Menard-Katcher, Calies, Katzka, David A., Bonis, Peter A., Bredenoord, Albert J., Geng, Bob, Jensen, Elizabeth T., Pesek, Robert D., Feuerstadt, Paul, Gupta, Sandeep K., Lucendo, Alfredo J., Genta, Robert M., Hiremath, Girish, McGowan, Emily C., Moawad, Fouad J., Peterson, Kathryn A., Rothenberg, Marc E., Straumann, Alex, Furuta, Glenn T., and Aceves, Seema S.

Published
2022
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48. Reliability and responsiveness of endoscopic disease activity assessment in eosinophilic esophagitis

Author

Ma, Christopher, Bredenoord, Albert J., Dellon, Evan S., Alexander, Jeffrey A., Biedermann, Luc, Hogan, Malcolm, Guizzetti, Leonardo, Zou, Guangyong, Katzka, David A., Chehade, Mirna, Falk, Gary W., Furuta, Glenn T., Gupta, Sandeep K., Kagalwalla, Amir F., Schoepfer, Alain M., Miehlke, Stephan, Moawad, Fouad J., Peterson, Kathryn, Gonsalves, Nirmala P., Straumann, Alex, Wechsler, Joshua B., Rémillard, Julie, Shackelton, Lisa M., Almonte, Hector S., Feagan, Brian G., Jairath, Vipul, and Hirano, Ikuo

Published
2022
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49. Eosinophile Ösophagitis – aktuelles und zukünftiges Management.

Author

Kreienbühl, Andrea and Straumann, Alex

Abstract

Copyright of Die Gastroenterologie is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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50. Visualizing alpha‐synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo.

Author

Straumann, Nadja, Combes, Benjamin F., Dean Ben, Xose Luis, Sternke‐Hoffmann, Rebecca, Gerez, Juan A., Dias, Ines, Chen, Zhenyue, Watts, Benjamin, Rostami, Iman, Shi, Kuangyu, Rominger, Axel, Baumann, Christian R., Luo, Jinghui, Noain, Daniela, Nitsch, Roger M., Okamura, Nobuyuki, Razansky, Daniel, and Ni, Ruiqing

Subjects
*IRON ores, *MAGNETIC resonance imaging, *PARKINSON'S disease, *PRUSSIAN blue, *LABORATORY mice, *IMMUNOFLUORESCENCE
Abstract

Abnormal alpha‐synuclein (αSyn) and iron accumulation in the brain play an important role in Parkinson's disease (PD). Herein, we aim to visualize αSyn inclusions and iron deposition in the brains of M83 (A53T) mouse models of PD in vivo. The fluorescent pyrimidoindole derivative THK‐565 probe was characterized by means of recombinant fibrils and brains from 10‐ to 11‐month‐old M83 mice. Concurrent wide‐field fluorescence and volumetric multispectral optoacoustic tomography (vMSOT) imaging were subsequently performed in vivo. Structural and susceptibility weighted imaging (SWI) magnetic resonance imaging (MRI) at 9.4 T as well as scanning transmission x‐ray microscopy (STXM) were performed to characterize the iron deposits in the perfused brains. Immunofluorescence and Prussian blue staining were further performed on brain slices to validate the detection of αSyn inclusions and iron deposition. THK‐565 showed increased fluorescence upon binding to recombinant αSyn fibrils and αSyn inclusions in post‐mortem brain slices from patients with PD and M83 mice. Administration of THK‐565 in M83 mice showed higher cerebral retention at 20 and 40 min post‐intravenous injection by wide‐field fluorescence compared to nontransgenic littermate mice, in congruence with the vMSOT findings. SWI/phase images and Prussian blue indicated the accumulation of iron deposits in the brains of M83 mice, presumably in the Fe3+ form, as evinced by the STXM results. In conclusion, we demonstrated in vivo mapping of αSyn by means of noninvasive epifluorescence and vMSOT imaging and validated the results by targeting the THK‐565 label and SWI/STXM identification of iron deposits in M83 mouse brains ex vivo. [ABSTRACT FROM AUTHOR]

Published
2024
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