1. Fungi.guru: Comparative genomic and transcriptomic resource for the fungi kingdom
- Author
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Jolyn Jia Jia Lim, Jace Koh, Jia Rong Moo, Erielle Marie Fajardo Villanueva, Dhira Anindya Putri, Yuen Shan Lim, Wei Song Seetoh, Sriya Mulupuri, Janice Wan Zhen Ng, Nhi Le Uyen Nguyen, Rinta Reji, Herman Foo, Margaret Xuan Zhao, Tong Ling Chan, Edbert Edric Rodrigues, Ryanjit Singh Kairon, Ker Min Hee, Natasha Cassandra Chee, Ann Don Low, Zoe Hui Xin Chen, Shan Chun Lim, Vanessa Lunardi, Tuck Choy Fong, Cherlyn Xin'Er Chua, Kenny Ting Sween Koh, Irene Julca, Riccardo Delli-Ponti, Jonathan Wei Xiong Ng, and Marek Mutwil
- Subjects
Fungi ,Co-expression ,Expression ,Metabolism ,Gene function ,Database ,Biotechnology ,TP248.13-248.65 - Abstract
The fungi kingdom is composed of eukaryotic heterotrophs, which are responsible for balancing the ecosystem and play a major role as decomposers. They also produce a vast diversity of secondary metabolites, which have antibiotic or pharmacological properties. However, our lack of knowledge of gene function in fungi precludes us from tailoring them to our needs and tapping into their metabolic diversity. To help remedy this, we gathered genomic and gene expression data of 19 most widely-researched fungi to build an online tool, fungi.guru, which contains tools for cross-species identification of conserved pathways, functional gene modules, and gene families. We exemplify how our tool can elucidate the molecular function, biological process and cellular component of genes involved in various biological processes, by identifying a secondary metabolite pathway producing gliotoxin in Aspergillus fumigatus, the catabolic pathway of cellulose in Coprinopsis cinerea and the conserved DNA replication pathway in Fusarium graminearum and Pyricularia oryzae. The tool is available at www.fungi.guru.
- Published
- 2020
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