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Copyright of HNO is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Monatsschrift Kinderheilkunde is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Der Radiologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Der Radiologe is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of HNO is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Monatsschrift Kinderheilkunde is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Background.Patients with end-stage renal failure undergoing haemodialysis (HD) are exposed to oxidative stress. Increased levels of malondialdehyde (MDA) were demonstrated in plasma of uraemic patients, indicating accelerated lipid peroxidation (LPO) as a consequence of multiple pathogenetic factors. The aim of our investigation was to examine the role of renal anaemia in oxidative stress in HD patients. [ABSTRACT FROM PUBLISHER]

Objectives Chronic rhinosinusitis significantly impairs CF patients’ quality of life. The PariSinus™ device effectively delivers vibrating aerosols to paranasal sinuses. Previously, we demonstrated a significant reduction of sinonasal symptoms by inhalation of dornase alfa with the device (JCF 2014). Bronchially inhaled hypertonic saline (3–7%) was shown to reduce pulmonary symptoms and exacerbations in CF. Aims of this multicentre, double-blind, controlled, crossover trial were to assess effects of hypertonic (6%) and isotonic saline on sinonasal outcome measures. Methods 69 CF patients were randomised to inhale either hypertonic or isotonic saline for 28 days with the PariSinus™. After 28 days of wash-out patients crossed over to the alternative treatment. The primary outcome parameter was upper airway symptoms / disease-specific QoL (Sino-Nasal Outcome Test-20 – SNOT-20). Results Sinonasal inhalation of isotonic and hypertonic saline was well tolerated. Both arms showed slight but not significant reductions of SNOT-20 scores (6% –3.1±6.5pts/0.9% –5.1±8.3pts). Interestingly, a post-hoc analysis of the single therapeutic periods revealed a significant improvement, especially for isotonic saline. We additionally present changes in rhinoscopy, rhinomanometry, and cytokines in nasal lavage. Conclusion Compared to sinonasal inhalation with dornase alfa, effects of isotonic and hypertonic saline on sinonasal symptoms did not reach significance. Possibly, SNOT-20 is not the best outcome parameter for therapy with hypertonic saline due to irritating properties, even if patients reported effective mobilization of mucus, which is difficult to quantify in both airway levels. [ABSTRACT FROM AUTHOR]

Objectives MBW and MRI have both been shown to be sensitive outcome measures for CF lung disease. Therefore, we wanted to determine the correlation of the LCI with alterations in the MRI chest score as markers of CF lung disease under stable conditions and at exacerbation. Methods 57 stable children with CF (mean age, 9.5±6.2 years) had chest MRI scans performed. All children with CF and 106 healthy children (mean age, 8.9±4.8 years) underwent age-adapted MBW testing to assess LCI and to calculate LCI z-scores. 36 children (mean age, 13.9±4.4 years) were investigated at time of pulmonary exacerbation either via MRI (n = 10) or MBW (n = 26). Results Mean LCI z-score in healthy children was 0.1±1.2). LCI z-score was significantly higher in stable children with CF (5.4±5.5, P<0.001). Morphological, perfusion and global MRI chest score were elevated in stable children with CF and were positively correlated with a higher LCI z-score (R 0.682; 0.669; 0.711). Concordance between abnormal findings in MBW and MRI was above 70%. At exacerbation, LCI increased in children with CF from baseline (P<0.001) and decreased after antibiotic therapy (P<0.001). The MRI chest scores also decreased after iv antibiotic treatment (P<0.05). Conclusion LCI z-score and MRI chest score are elevated in CF and show a high correlation. Both methods are feasible and sensitive non-invasive markers of CF lung disease in children with CF under stable conditions and at time of exacerbation. [ABSTRACT FROM AUTHOR]