82 results on '"Sheridan H"'
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2. A comparison of grassland vegetation from three agri-environment conservation measures
- Author
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Ó hUallacháin D., Finn J.A., Keogh B., Fritch R., and Sheridan H.
- Subjects
agri-environment scheme ,grassland botanical diversity ,grassland conservation ,high nature value farmland ,semi-natural grassland ,Agriculture (General) ,S1-972 ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Semi-natural grassland habitats have declined significantly throughout Europe. To halt the decline, grassland conservation measures have been included in most European agri-environment schemes. This is the first study to compare the botanical composition of grassland habitats managed under the Irish Agri-Environment Options Scheme (AEOS). Sixty fields on drystock pastoral farms in receipt of agri-environment payments for grassland conservation were surveyed, with 20 fields being enrolled in each of the following AEOS options: Traditional Hay Meadow (THM), Species-Rich Grassland (SRG) and Natura 2000 species-rich grassland (Natura). The vegetation quality of sites enrolled in the Natura measure was higher than the quality of those enrolled in the THM and SRG measures. Natura sites had the greatest species richness, with a mean >40 species per site, which included approximately 17 species indicative of high botanical quality. Traditional Hay Meadows sites had the lowest species richness (mean: 29 species per site) and were dominated by species associated with improved grassland. Some THM sites had good levels of botanical richness and were similar in composition to Natura sites, with some Natura sites having lower vegetation quality, more similar to that of THM sites. Species-Rich Grassland had botanical richness that was intermediate between THM and Natura sites. A thorough assessment of the effectiveness of these measures was confounded by a lack of quantitative objectives for the target community composition to be attained. We discuss limitations and potential opportunities regarding the design, targeting, implementation and cost-effectiveness of these agri-environment measures.
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- 2016
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3. Prevalence and distribution of paratuberculosis (johne's disease) in cattle herds in ireland
- Author
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Good M, Clegg T, Sheridan H, Yearsely D, O'Brien T, Egan J, and Mullowney P
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herd ELISA-prevalence ,Ireland ,Johne's disease ,Mycobacterium avium subspecies paratuberculosis ,Paratuberculosis ,Veterinary medicine ,SF600-1100 - Abstract
Abstract A simple random survey was conducted in Ireland during 2005 to estimate the ELISA-prevalence of paratuberculosis, commonly called Johne's disease (JD), in the cattle population. Serum samples were collected from all 20,322 females/breeding bulls over 12 months-of-age in 639 herds. All samples were tested using a commercially available absorbed ELISA. The overall prevalence of infected herds, based on the presence of at least one ELISA-positive animal, was 21.4% (95% CI 18.4%-24.9%). Herd prevalence levels amongst dairy herds (mean 31.5%; 95% CI: 24.6%, 39.3%) was higher than among beef herds (mean 17.9%; 95% CI: 14.6%-21.8%). However, the animal level prevalence was similar. The true prevalence among all animals tested, was calculated to be 2.86% (95%CI: 2.76, 2.97) and for animals >= 2 yrs, it was 3.30% (95%CI: 3.17, 3.43). For animals in beef herds, true prevalence was 3.09% (95%CI: 2.93, 3.24), and for those in dairy herds, 2.74% (95%CI: 2.59, 2.90). The majority of herds had only one ELISA-positive infected animal. Only 6.4% (95% CI 4.7%-8.7%) of all herds had more than one ELISA-positive infected animal; 13.3% (CI 8.7%-19.7%) of dairy herds ranging from two to eight ELISA-positive infected animals; and, 3.9% beef herds (CI 2.4%-6.2%) ranging from two to five ELISA-positive infected animals. The true prevalence of herds infected and shedding Mycobacterium avium subspecies paratuberculosis is estimated to be 9.5% for all herd types; 20.6% for dairy herds; and 7.6% for beef herds. If ELISA positive animals
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- 2009
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4. Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3′ UTR of FAIM2
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Littleton, Sheridan H., Trang, Khanh B., Volpe, Christina M., Cook, Kieona, DeBruyne, Nicole, Maguire, Jean Ann, Weidekamp, Mary Ann, Hodge, Kenyaita M., Boehm, Keith, Lu, Sumei, Chesi, Alessandra, Bradfield, Jonathan P., Pippin, James A., Anderson, Stewart A., Wells, Andrew D., Pahl, Matthew C., and Grant, Struan F.A.
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- 2024
- Full Text
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5. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Huyen, T, Jagne, A, Karkey, A, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, Skinner, T, Slade, H, Sutu, M, Taylor, J, Thomas, E, Tinkler, H, Unsworth, A, Usher, R, van't Hoff, W, Walker, S, Walters, J, Walton, E, Warmington, J, Wayman, E, Williams, P, Williamson, J, Williamson, D, Yelnoorkar, F, Knight, M, Hodson, K, Pavord, S, Williamson, C, Bowman, L, Chen, F, Clarke, R, Goonasekara, M, Herrington, W, Judge, P, Ng, S, Preiss, D, Sammons, E, Zhu, D, Arkley, C, Bowker, P, Bruce, J, Byrne-Watts, V, Chapman, G, Coleman, G, Denwood, T, Gray, J, Harrison, D, Mather, N, Pinches, H, Rees, A, Rees, S, Turner, G, Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Aboaba, A, Aboagye-Odei, A, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, H, Abu-Arafeh, A, Abubacker, S, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, S, Acheampong, P, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adati, K, Adcock, K, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, F, Adesemoye, O, Adewunmi, E, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikary, R, Aditya, A, Adkins, G, Adnan, A, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Aftab, Z, Agarwal, M, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Ahamed Sadiq, S, Ahammed Nazeer, M, Ahmed, A, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmad, M, Ahmed, N, Ahmed, O, Ahmed, R, Ahmad, S, Ahmed, S H, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, Akinpelu, I, Akram, M, Aktinade, O, Akudi, U, Al Aaraj, A, Al Balushi, A, Al Dakhola, M, Al Swaifi, A, Al-Abadi, E, Alabi, A, Aladangady, N, Alafifi, M, Alam, A, Alam, S, Al-Asadi, A, Alatzoglou, K, Albert, P, Albon, L, Alcala, A, Alcorn, G, Alcorn, S, Aldana, A, Alderdice, D, Aldesouki, A, Aldouri, R, Aldridge, J, Aldridge, N, Alegria, A, Alexander, C, Alexander, J, Alexander, P, Al-Fori, J, Alghazawi, L, Alhabsha, O, Al-Hakim, B, Alhameed, R, Al-Hayali, M, Al-Hity, S, Ali, A, Ali, F, Ali, J, Ali, M, Ali, N, Ali, O, Ali, R, Ali, S, Aliberti, E, Alin, J, Alina, A, Alipustain, A, Aliyuda, F, Alizaedeh, K, Al-Jibury, M, Al-Juboori, S, Al-Khalil, M, Alkhudhayri, A, Alkhusheh, M, Allan, F, Allan, N, Allanson, A, Allcock, R, Allen, E, Allen, J, Allen, K, Allen, L, Allen, P, Allen, R, Allen, S, Allen, T, Alli, A, Allison, K, Allman, B, Allsup, D, Allsop, H, Allsop, L, Almahroos, A, Al-Moasseb, H, Al-Obaidi, M, Alomari, L, Al-Rabahi, A, Al-Ramadhani, B, Al-Saadi, Z, Al-Sammarraie, R, Alshaer, I, Al-Shahi Salman, R, Al-Shamkhani, W, Alsheikh, F, Al-Sheklly, B, Altaf, S, Alty, A, Alvarez, M, Alvarez Corral, M, Alveyn, E, Alzetani, M, Amamou, S, Amar, N, Ambalavanan, S, Ambrogetti, R, Ambrose, C, Ameen, A, Ames, K, Amin, A, Amin, K, Amin, S, Amin, T, Amit, B, Amjad, A, Amjad, N, Amosun, V, Amsal, M, Amsha, K, Amutio Martin, N, Amy, P, Anada, A, Anand, A, Anandappa, S, Anantapatnaikuni, S, Anderson, E, Anderson, J, Anderson, L, Anderson, M, Anderson, N, Anderson, R, Anderson, S, Anderson, W, Andreou, P, Andrews, A, Andrews, J, Aneke, K, Ang, A, Ang, W, Angel, T, Angela, A, Angelini, P, Anguvaa, L, Anichtchik, O, Anim-Somuah, M, Aniruddhan, K, Annett, J, Anning, L, Anstey, P, Anstey, R, Anthony, A, Anthony-Pillai, A, Antill, P, Antonnia, Z, Anu, V, Anwar, M, Apetri, E, Apostolopoulos, A, Appleby, S, Appleyard, D, Aquino, M, Araba, B, Aransiola, S, Araujo, M, Archer, A, Archer, D, Archer, S, Arcoria, D, Ardley, C, Arias, A, Aribike, O, Arimoto, R, Armata, I, Armistead, J, Armitage, A, Armstrong, C, Armstrong, M, Armstrong, S, Armstrong, W, Armtrong, P, Arndt, H, Arnison-Newgass, C, Arnold, D, Arnold, R, Arnott, A, Arora, D, Arora, R, Arora, K, Arora, P, Arter, A, Arumaithurai, A, Arya, A, Arya, R, Asandei, D, Asghar, M, Ashab, M, Ashbrook-Raby, C, Ashby, H, Ashcroft, J, Ashcroft, S, Asher, G, Ashfak, Z, Ashfaq, A, Ashish, A, Ashley, D, Ashman-Flavell, S, Ashok, S, Ashour, A, Ashraf, S, Ashraf, M, Ashraq, M, Ashton, D, Ashton, S, Ashworth, A, Ashworth, F, Ashworth, R, Aslam, A, Aslam, I, Aslam, S, Aslett, L, Asogan, H, Asrar, A, Assaf, O, Astin-Chamberlain, R, Athorne, D, Atkins, B, Atkins, C, Atkins, S, Atkinson, J, Atkinson, V, Atomode, A, Atraskiewicz, B, Attia, A, Attubato, E, Attwood, M, Auer, Z, Aujayeb, A, Aung, A, Aung, H, Aung, K, Aung, N, Aung, Y, Aung, Z, Austin, E, Austin, K, Auwal, A, Avari, M, Avery, M, Aveyard, N, Avis, J, Aviss, G, Avram, C, Avram, P, Awadelkareem, A, Awadzi, G, Awaly, M, Awan, A, Awoseyila, A, Aya, A, Ayaz, E, Ayers, A, Azam, J, Azeem, A, Azharuddin, M, Aziz, A, Aziz, G, Aziz, I, Aziz, N, Azkoul, A, Azman Shah, A, Azzopardi, G, Azzoug, H, Babatunde, F, Babi, M, Babiker, B, Babington, G, Babirecki, M, Babores, M, Babs-Osibodu, A, Bacciarelli, S, Bachar, R, Bachour, M, Bacon, G, Bacon, J, Badal, B, Bader, M, Badhan, G, Badhrinarayanan, S, Bae, J, Baggaley, A, Baggott, A, Bagmane, D, Bagshaw, L, Bahadori, K, Bailey, A, Bailey, J, Bailey, K, Bailey, L, Bailey, M, Bailey, P, Bailey, S, Baillie, H, Baillie, J, Bain, J, Bains, V, Baird, D, Baird, E, Baird, S, Baird, T, Baird, Y, Bajandouh, A, Baker, D, Baker, E, Baker, J, Baker, K, Baker, M, Baker, R, Baker, T, Baker, V, Bakere, H, Bakerly, N, Baker-Moffatt, M, Bakhai, A, Bakhtiar, N, Bakoulas, P, Bakthavatsalam, D, Balachandran, N, Balan, A, Balasingam, P, Balaskas, T, Balasubramania, M, Balatoni, N, Balcombe, A, Baldwin, A, Baldwin, C, Baldwin, D, Baldwin, F, Baldwin-Jones, R, Bale, N, Balfour, J, Ball, R, Ball, M, Ballard, K, Balluz, I, Balmforth, C, Balogh, E, Baltmr, A, Baluwala, A, Bambridge, G, Bamford, P, Bamford, A, Bamgboye, A, Bancroft, H, Bancroft, E, Banda, J, Bandaru, K, Bandla, N, Bandyopadhyam, S, Banerjee, A, Banerjee, R, Bani-Saad, O, Banks, H, Banks, L, Banks, P, Bann, C, Bannister, H, Bannister, O, Banton, L, Baptist, M, Baqai, T, Baral, A, Baramova, D, Barbe, R, Barbon, E, Barbosa, M, Barbour, J, Barclay, A, Barclay, C, Bardsley, G, Bareford, S, Bari, S, Barker, A, Barker, D, Barker, E, Barker, H, Barker, J, Barker, L, Barker, O, Barkha, S, Barla, J, Barlow, G, Barlow, R, Barlow, V, Barnacle, J, Barnes, D, Barnes, N, Barnes, R, Barnes, T, Barnetson, C, Barnett, A, Barnett-Vanes, A, Barnsley, W, Barr, A, Barr, C, Barr, D, Barr, J, Barratt, N, Barratt, S, Barrera, M, Barrett, A, Barrett, F, Barrett, J, Barrett, S, Barrow, E, Bartlett, C, Bartlett, G, Bartlett, J, Bartlett, L, Bartley, S, Bartolmeu-Pires, S, Barton, A, Barton, G, Barton, L, Barton, R, Baruah, R, Baryschpolec, S, Bashir, H, Bashyal, A, Basker, B, Basran, A, Bassett, G, Bassett, J, Bassford, C, Bassoy, B, Bastion, V, Basumatary, A, Basvi, P, Bataduwaarachchi, V, Bate, T, Bateman, H, Bateman, K, Bateman, V, Bates, E, Bates, H, Bates, M, Bates, S, Batham, S, Batista, A, Batla, A, Batra, D, Batty, A, Batty, H, Batty, T, Baum, M, Baumbe, R, Bautista, C, Bawa, T, Bawa, F, Bawani, F, Bax, S, Baxter, M, Baxter, N, Baxter, Z, Bayes, H, Bayo, L-A, Bazari, F, Bazaz, R, Bazli, A, Beacham, L, Beadles, W, Beadon, K, Beak, P, Beale, A, Beard, K, Beardsal, K, Bearpark, J, Beasley, A, Beattie, S, Beaumont, K, Beaver, T, Beavis, S, Beazley, C, Beck, S, Beckett, V, Beckitt, R, Beckley, S, Beddall, H, Beeby, D, Beeby, S, Beech, G, Beecroft, M, Beer, S, Beer, N, Bega, G, Begg, A, Begg, S, Beghini, S, Begum, A, Begum, S, Behan, T, Behrouzi, R, Beishon, J, Beith, C, Belcher, J, Belfield, H, Belfield, K, Belgaumkar, A, Bell, D, Bell, G, Bell, J, Bell, L, Bell, N, Bell, P, Bell, S, Bellamu, J, Bellamy, M, Bellamy, T, Bellini, A, Bellis, A, Bellis, F, Bendall, L, Benesh, N, Benetti, N, Benham, L, Benison-Horner, G, Benkenstein, S, Benn, T, Bennett, A, Bennett, C, Bennett, D, Bennett, G, Bennett, K, Bennett, L, Bennett, M, Bennett, S, Bennion, K, Benoy, G, Benson, V, Bentley, A, Bentley, J, Benton, I, Beranova, E, Beresford, M, Bergin, C, Bergstrom, M, Berriman, T, Berry, Z, Best, K, Best, F, Bester, A, Beuvink, Y, Bevan, E, Bevins, S, Bewick, T, Bexley, A, Beyatli, S, Beynon, F, Bhadi, A, Bhagani, S, Bhakta, S, Bhalla, R, Bhandal, K, Bhandari, A, Bhandari, S, Bhanich Supapol, J, Bhanot, A, Bhanot, R, Bhasin, S, Bhat, A, Bhat, P, Bhatnagar, R, Bhatt, K, Bhayani, J, Bhojwani, D, Bhuie, P, Bhuiyan, S, Bibby, A, Bibi, F, Bibi, N, Bibi, S, Bicanic, T, Bidgood, S, Bigg, J, Biggs, S, Biju, A, Bikov, A, Billingham, S, Billings, J, Binns, A, BinRofaie, M, Bintcliffe, O, Birch, J, Birchall, K, Bird, S, Birt, M, Bishop, C, Bishop, K, Bishop, L, Bisnauthsing, K, Biswas, N, Biuk, S, Blachford, K, Black, E, Black, H, Black, K, Black, M, Black, P, Black, S, Blackgrove, H, Blackledge, B, Blackler, J, Blackley, S, Blackman, H, Blackstock, C, Blair, C, Blakemore, F, Blamey, H, Bland, A, Blane, S, Blankley, S, Blaxill, P, Blaylock, K, Blazeby, J, Blencowe, N, Bloom, B, Bloomfield, J, Bloss, A, Blowers, A, Blows, S, Bloxham, H, Blundell, L, Blunsum, A, Blunt, M, Blunt, T, Blyth, I, Blyth, K, Blythe, A, Blythe, K, Boampoaa, M, Board, S, Bobie, B, Bobruk, K, Bodalia, P, Bodasing, N, Boden, M, Bodenham, T, Boehmer, G, Boffito, M, Bohanan, K, Bohmov, K, Bohnacker, N, Bokhandi, S, Bokhar, M, Bokhari, S, Bokobza, I, Boles, A, Bolger, C, Bond, C, Bond, H, Bond, S, Bond, T, Bone, A, Boniface, G, Bonney, L, Booker, L, Boot, S, Boothroyd, M, Borbone, J, Borman, N, Bosence, S, Bostock, K, Botting, N, Bottrill, F, 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Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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6. Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Abidin, A, Aboaba, A, Aboagye-Odei, A, Aboah, C, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, HJ, Abu-Arafeh, A, Abubacker, SM, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, F, Acheampong, P, Acheampong, S, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, AS, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adatia, K, 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Western, L, Westhead, R, Weston, H, Westwood, A, Westwood, K, Westwood, S, Wetherill, B, Wheaver, S, Wheeler, H, Whelan, B, Whelband, M, Whileman, A, Whitcher, A, White, A, White, B, White, C, White, D, White, J, White, K, White, M, White, N, White, S, White, T, Whitehead, C, Whitehorn, K, Whitehouse, A, Whitehouse, C, Whitehouse, T, Whiteley, J, Whiteley, L, Whiteley, S, Whitham, R, Whitlingum, G, Whitmore, D, Whittaker, E, Whittam, L, Whittington, A, Whittle, H, Whittle, R, Wiafe, E, Wiblin, L, Wickens, O, Widdrington, J, Wieboldt, J, Wieringa, H, Wiesender, C, Wiffen, L, Wight, A, Wignall, A, Wignall, C, Wilce, A, Wilcock, D, Wilcock, E, Wilcox, L, Wild, B, Wild, L, Wild, S, Wilde, M, Wilding, L, Wilding, P, Wildsmith, T, Wileman, J, Wiles, J, Wiles, K, Wilhelmsen, E, Wiliams, T, Wilkie, J, Wilkin, D, Wilkins, H, Wilkins, J, Wilkins, S, Wilkinson, I, Wilkinson, L, Wilkinson, N, Wilkinson, S, Wilkinson, T, Willetts, S, Williams, A, Williams, C, Williams, CV, Williams, D, Williams, E, Williams, G, Williams, H, Williams, J, Williams, K, Williams, M, Williams, P, Williams, R, Williams, S, Williams, T, Williamson, A, Williamson, C, Williamson, D, Williamson, J, Williamson, JD, Williamson, R, Williamson, H, Willis, E, Willis, H, Willis, J, Wills, L, Willsher, L, Willshire, C, Willson, F, Willson, J, Wilson, A, Wilson, B, Wilson, D, Wilson, I, Wilson, J, Wilson, K, Wilson, K-A, Wilson, L, Wilson, M, Wilson, S, Wilson, T, Win, KLY, Win, M, Win, T, Win, TT, Win, WYW, Winckworth, L, Winder, L, Winder, P, Winearl, S, Winmill, H, Winn, S, Winpenny, C, Winslow, H, Winter, H, Winter, J, Winter-Goodwin, B, Winterton, J, Winwood, H, Wischhusen, J, Wisdom, S, Wise, M, Wiselka, M, Wiseman, R, Wiseman, S, Wishart, S, WIshlade, T, Witele, E, Withers, N, Wittes, J, Wixted, D, Wodehouse, T, Wolf, W, Wolff, N, Wolffsohn, K, Wolf-Roberts, R, Wolodimeroff, E, Wolstencroft, A, Wong, A, Wong, C, Wong, C-H, Wong, C-M, Wong, E, Wong, JSY, Wong, KY, Wong, MY, Wong, N, Wong, S, Wong, T, Wongkyezeng, AA, Wood, A, Wood, C, Wood, D, Wood, F, Wood, G, Wood, H, Wood, J, Wood, L, Wood, M, Wood, S, Wood, T, Woodall, K, Woodfield, R, Woodford, C, Woodford, E, Woodford, J, Woodhead, L, Woodhead, T, Woodland, P, Woodman, M, Woodmansey, S, Woods, C, Woods, J, Woods, K, Woods, S, Woodward, Z, Woolcock, M, Wooldridge, G, Woolf, R, Woollard, C, Woollen, L, Woolley, E, Woolley, J, Woosey, D, Wootton, D, Wootton, J, Worley, D, Worton, S, Wraight, J, Wray, M, Wren, K, Wren, L, Wrey Brown, C, Wright, C, Wright, D, Wright, F, Wright, H, Wright, I, Wright, L, Wright, R, Wright, S, Wright, T, Wroe, C, Wroe, H, Wu, H, Wu, P, Wubetu, J, Wulandari, F, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, BE, Xia, Z, Yacoba, E, Yadav, S, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, WL, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, T, Yates, M, Ye, J, Yearwood Martin, C, Yein, K, Yelnoorkar, F, Yen, LM, Yeoh, A, Yeung, CY, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yovita, H, Yu, C, Yuan, JSJ, Yufaniaputri, N, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-S, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zayed, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zhu, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, ET, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2023
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7. Benefit of inhalation aromatherapy as a complementary treatment for stress and anxiety in a clinical setting – A systematic review
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Hedigan, F., Sheridan, H., and Sasse, A.
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- 2023
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8. Field margin botanical diversity, composition and quality on intensively managed farming systems
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Larkin, J., hUallacháin, D. Ó, Finn, J.A., and Sheridan, H.
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- 2022
9. BOTANICAL REJUVENATION OF FIELD MARGINS AND BENEFITS FOR INVERTEBRATE FAUNA ON A DRYSTOCK FARM IN COUNTY LONGFORD
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Sheridan, H., Finn, J.A., and O'Donovan, G.
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- 2022
10. Quality control of herbal drugs and preparations: The methods of analysis, their relevance and applications
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Muyumba, N.W., Mutombo, S.C., Sheridan, H, Nachtergael, A., and Duez, P.
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- 2021
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11. Yield of binary- and multi-species swards relative to single-species swards in intensive silage systems
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Moloney, T., Sheridan, H., Grant, J., O’Riordan, E.G., and O’Kiely, P.
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- 2020
12. Herbage nutritive value of binary- and multi-species swards relative to single-species swards in intensive silage systems
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Moloney, T., Sheridan, H., Grant, J., O’Riordan, E.G., and O’Kiely, P.
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- 2020
13. Conservation efficiency and nutritive value of silages made from grass-red clover and multi-species swards compared with grass monocultures
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Moloney, T., Sheridan, H., Grant, J., O’Riordan, E.G., and O’Kiely, P.
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- 2020
14. Perturbation of the insomnia WDR90 genome-wide association studies locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.
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Sonti, Shilpa, Littleton, Sheridan H, Pahl, Matthew C, Zimmerman, Amber J, Chesi, Alessandra, Palermo, Justin, Lasconi, Chiara, Brown, Elizabeth B, Pippin, James A, Wells, Andrew D, Doldur-Balli, Fusun, Pack, Allan I, Gehrman, Phillip R, Keene, Alex C, and Grant, Struan F A
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- 2024
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15. Analysis of international, European and Scot's law governing marine litter and integration of policy within regional marine plans
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Sheridan, H., Johnson, K., and Capper, A.
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- 2020
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16. Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
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Pahl, Matthew C., Doege, Claudia A., Hodge, Kenyaita M., Littleton, Sheridan H., Leonard, Michelle E., Lu, Sumei, Rausch, Rick, Pippin, James A., De Rosa, Maria Caterina, Basak, Alisha, Bradfield, Jonathan P., Hammond, Reza K., Boehm, Keith, Berkowitz, Robert I., Lasconi, Chiara, Su, Chun, Chesi, Alessandra, Johnson, Matthew E., Wells, Andrew D., Voight, Benjamin F., Leibel, Rudolph L., Cousminer, Diana L., and Grant, Struan F. A.
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- 2021
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17. Including clover and herb species in grazing forages – effects on milk production, milk processability and milk fatty acid profile of late lactation dairy cows supplemented with grass silage and concentrate.
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McCarthy, K. M., Walsh, N., Serra, E., Fahey, A. G., Lynch, M. B., Pierce, K. M., Boland, T. M., Sheridan, H., Markiewicz-Keszycka, M., and Mulligan, F. J.
- Abstract
Milk production declines as dairy cows enter late lactation, resulting in reduced milk quality and negatively impacting milk processability, such as rennet coagulation time (RCT), milk pH and ethanol stability (ES), leading to seasonality issues for milk processors. Multispecies forages, containing grass, legume and herb species, require lower N inputs and are of interest to dairy farmers. However, little is known about the effect of grazing multispecies forages on milk processability characteristics in late lactation dairy cows. Forty-five autumn-calving dairy cows in late lactation were allocated to 1 of 3 grazing forages; perennial ryegrass (PRG; Lolium perenne), perennial ryegrass and white clover (Trifolium pratense) (PRGWC), and a 6 – species multispecies forage (MULTI) containing perennial ryegrass, timothy (Phleum pratense), white clover, red clover (Trifolium repens), chicory (Cichorium intybus) and plantain (Plantago lanceolata). Cows were allocated 12 kg DM grazed forage and supplemented with a grass – silage TMR and concentrate. Forage DMI was significantly lower for cows grazing PRG. Milk yield increased when cows grazed PRGWC (18.07 kg/d) and MULTI (17.84 kg/d) compared to PRG (16.08 kg/d). Milk RCT (mins) and ES (%) were unaffected by treatment. However, offering cows PRGWC and MULTI increased the concentration of C18:2 cis – 9, 12 and C18:3 cis – 9, 12, 15 in milk compared to PRG. Compared to PRG, grazing forages containing clover and herb species improved milk yield and beneficially altered milk fatty acid profile in late lactation dairy cows without negatively impacting milk processability. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Farmland habitat diversity in Ireland
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Sheridan, H., Keogh, B., Anderson, A., Carnus, T., McMahon, B.J., Green, S., and Purvis, G.
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- 2017
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19. BOTANICAL REJUVENATION OF FIELD MARGINS AND BENEFITS FOR INVERTEBRATE FAUNA ON A DRYSTOCK FARM IN COUNTY LONGFORD
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Sheridan, H., Finn, J.A., and O'Donovan, G.
- Published
- 2009
20. Strategies to identify causal common genetic variants and corresponding effector genes for paediatric obesity.
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Littleton, Sheridan H. and Grant, Struan F. A.
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IN vitro studies , *CHILDHOOD obesity , *SINGLE nucleotide polymorphisms , *GENETIC variation , *GENETIC testing , *RISK assessment , *TREATMENT effectiveness , *GENES , *SEX chromatin - Abstract
Summary: Background: Childhood obesity rates are on the rise, but there are currently no effective therapies available to slow or halt their progression. Although environmental and lifestyle factors have been implicated in its pathogenesis, childhood obesity is considered a complex disorder with a clear genetic component. Intense genome‐wide association study (GWAS) efforts through large‐scale collaborations have enabled the discovery of genetic loci robustly associated with childhood obesity beyond the classic FTO locus. That said, GWAS itself does not pinpoint the actual underlying causal effector genes, but rather just yields association signals in the genome. Objective: This review aims to outline what has been elucidated thus far on the genetic aetiology of commong childhood obesity and to describe strategies to identify and validate both causal common genetic variants and their corresponding effector genes. Results: Relevant cell types for molecular studies can be identified by gene set enrichment analysis and considering known biology of obesity‐related physiological processes. Putatively causal single nucleotide polymorphisms (SNPs) can be identified by several methods including statistical fine mapping and 'assay for transposase accessible chromatin sequencing' (ATAC‐seq). Variant to gene mapping can then nominate effector genes likely regulated by cis‐regulatory elements harbouring putatively causal SNPs. A SNP's cis‐regulatory activity can be functionally validated by several in vitro methods including luciferase assay and CRISPR approaches. These CRISPR approaches can also be used to investigate how dysregulatn of effector genes may confer obesity risk. Conclusion: Uncovering the causative genes related to GWAS signals and elucidating their functional contributions to paediatric obesity with these strategies will deepen our understanding of this disease and serve better treatment outcomes. [ABSTRACT FROM AUTHOR]
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- 2022
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21. A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties
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Sheridan, H., Walsh, J.J., Jordan, M., Cogan, C., and Frankish, N.
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- 2009
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22. The Mode of Egg Dispersal in Physaloptera phrynosoma Ortlepp (Nematoda: Spiruroidea), a Gastric Nematode of Texas Horned Toads, Phrynosoma cornutum
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Lee, Sheridan H.
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- 1955
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23. The Life Cycle of Skrjabinoptera phrynosoma (Ortlepp) Schulz, 1927 (Nematoda: Spiruroidea), a Gastric Nematode of Texas Horned Toads, Phrynosoma cornutum
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Lee, Sheridan H.
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- 1957
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24. Synthesis and pharmacological activity of aminoindanone dimers and related compounds
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Sheridan, H., Butterly, S., Walsh, J.J., Cogan, C., Jordan, M., Nolan, O., and Frankish, N.
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- 2008
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25. Plant and invertebrate diversity in grassland field margins
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Sheridan, H., Finn, J.A., Culleton, N., and O’Donovan, G.
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- 2008
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26. S22 Lung clearance index, FEV1 and CT findings in cystic fibrosis: data from the UK CF Gene Therapy Consortium run-in study
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Sheridan, H S, Bell, N J, Macleod, K A, Reid, P A, Horsley, A R, Davies, G, Saunders, C, Cunningham, S, Innes, J A, Davies, J C, and Alton, E W
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- 2010
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27. Toll-like Receptors and RBL-2H3 Mast Cells
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Passante, E., Ehrhardt, C., Sheridan, H., and Frankish, N.
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- 2009
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28. Purification and characterization of a fix ABCX-linked 2[4Fe-4S] ferredoxin from Azotobacter vinelandii
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Reyntjens, Bruno, Jollie, David R., Stephens, Philip J., Gao-Sheridan, H. Samantha, and Burgess, B. K.
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- 1997
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29. In vitro inhibition of rat basophilic leukaemia mast cell (RBL-2H3) degranulation by novel indane compounds
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Passante, E., Ehrhardt, C., Sheridan, H., and Frankish, N.
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- 2008
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30. Delta-T14/Delta-D15 Azotobacter vinelandii ferredoxin I: creation of a new CysXXCysXXCys motif that ligates a (4Fe-4S) cluster
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Kemper, Mary A., Gao-Sheridan, H. Samantha, Shen, Binghui, Duff, Jillian L.C., Tilley, Gareth J., Armstrong, Fraser A., and Burgess, Barbara K.
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Proteins -- Research ,Anaerobic bacteria -- Research ,Biological sciences ,Chemistry - Abstract
A study was conducted to characterize a stable 8Fe Azotobacter vinelandii ferrodoxin I (AvFdI), a member of a class of proteins associated with aerobic organisms supporting one (3Fe-4S)(super +/0) cluster and one (4Fe-4S)(super 2+/+) cluster. Protein samples were anaerobically determined under Ar in a Vacuum Atmospheres glovebox. Results indicated that AvFDI supported 3Fe and 4Fe clusters with similar reduction potentials.
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- 1998
31. Genetic Determinants of Childhood Obesity.
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Littleton, Sheridan H., Berkowitz, Robert I., and Grant, Struan F. A.
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- *
TYPE 2 diabetes , *HIGH-calorie diet , *CHILDHOOD obesity , *LAURENCE-Moon-Biedl syndrome , *PRADER-Willi syndrome , *GENE targeting , *NUCLEOTIDE sequencing - Abstract
Obesity represents a major health burden to both developed and developing countries. Furthermore, the incidence of obesity is increasing in children. Obesity contributes substantially to mortality in the United States by increasing the risk for type 2 diabetes, cardiovascular-related diseases, and other comorbidities. Despite environmental changes over past decades, including increases in high-calorie foods and sedentary lifestyles, there is very clear evidence of a genetic predisposition to obesity risk. Childhood obesity cases can be categorized in one of two ways: syndromic or non-syndromic. Syndromic obesity includes disorders such as Prader-Willi syndrome, Bardet-Biedl syndrome, and Alström syndrome. Non-syndromic cases of obesity can be further separated into rarer instances of monogenic obesity and much more common forms of polygenic obesity. The advent of genome-wide association studies (GWAS) and next-generation sequencing has driven significant advances in our understanding of the genetic contribution to childhood obesity. Many rare and common genetic variants have been shown to contribute to the heritability in obesity, although the molecular mechanisms underlying most of these variants remain unclear. An important caveat of GWAS efforts is that they do not strictly represent gene target discoveries, rather simply the uncovering of robust genetic signals. One clear example of this is with progress in understanding the key obesity signal harbored within an intronic region of the FTO gene. It has been shown that the non-coding region in which the variant actually resides in fact influences the expression of genes distal to FTO instead, specifically IRX3 and IRX5. Such discoveries suggest that associated non-coding variants can be embedded within or next to one gene, but commonly influence the expression of other, more distal effector genes. Advances in genetics and genomics are therefore contributing to a deeper understanding of childhood obesity, allowing for development of clinical tools and therapeutic agents. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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32. Effects of (±)-dunnione and quinone-containing extracts from in vitro-cultured plantlets of Streptocarpus dunnii Hook. f. and a hybrid 'Ruby' on seed germination.
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Hook, I. and Sheridan, H.
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- *
GERMINATION , *RADISHES , *ANALYTICAL chemistry , *ANTHRAQUINONES , *OXIDATIVE stress , *EXTRACTS , *BOTANICAL chemistry - Abstract
• In vitro Streptocarpus plantlets excreted quinones into their growth medium from leaflet bases, petiolodes and roots. • Extracts of growth medium inhibited radish seed germination in a concentration-dependent manner. • (±)-Dunnione is considered to affect germination through redox-cycling and ROS production. • Actions of (±)-dunnione appeared bi-phasic: low concentrations (<25 g) being anti-oxidant and high concentrations (>>125 g) pro-oxidant. Mature plants of S. dunnii Hook. f. produce naphthoquinones in aerial structures and anthraquinones in roots. Immature in vitro -cultured plantlets of Streptocarpus dunnii and S. × hybridus 'Ruby' (Gesneriaceae) excrete orange-red metabolites into their growth media ('artificial' rhizosphere). Our objectives were to: (i) extract and identify excreted compounds; (ii) determine the phytochemical effects of prolonged micropropagation and (iii) examine if excreted compounds affected seed germination. Results demonstrated that both Streptocarpus plantlets excreted complex mixtures of naphtho- and anthraquinones from around leaflet bases, petiolodes and fibrous roots. Chemical analyses showed (±)-dunnione as the main naphthoquinone, even after prolonged micropropagation. A TLC-based bioassay and a replicated, multifactorial, concentration-dependent experiment, found radish seed germination was inhibited in a concentration-dependent manner. 'Low' (±)-dunnione (25 μg) concentrations delayed germination for 2 days, with higher (125 μg) concentrations producing longer, but still transient, delays, i.e. not high enough to inhibit germination. (±)-Dunnione exerts its effects through redox cycling and ROS production. Since ROS production is essential for triggering germination, low concentrations were considered antioxidant reducing ROS production in seed coats and embryos thereby delaying germination, while higher concentrations were pro-oxidant, creating oxidative stress and poor seedling growth. Our results suggest that effects on seeds are biphasic and concentration-dependent. The significantly greater inhibitions in germination produced with whole medium extracts were attributed to higher (±)-dunnione levels in combination with other bioactive quinones. Since (±)-dunnione is also fungitoxic, we conclude that it acts an allelochemical protecting developing Streptocarpus plantlets from fungal attack and together with other excreted quinones can inhibit germination of seeds from competitor plants. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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33. Grazing multispecies swards improves ewe and lamb performance.
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Grace, C., Lynch, M. B., Sheridan, H., Lott, S., Fritch, R., and Boland, T. M.
- Abstract
A two-year (2015 and 2016) grazing study was established to compare ewe and lamb performance when grazed on a perennial ryegrass only sward compared to more diverse sward types. In that study four sward types were investigated: a perennial ryegrass (Lolium perenne) only sward receiving 163 kg nitrogen per hectare per year (N/ha/yr) (PRG); a perennial ryegrass and white clover (Trifolium repens) sward receiving 90 kg N/ha/yr (PRGWC); a six species sward (two grasses (perennial ryegrass and timothy (Phleum pratense)), two legumes (white and red clover (Trifolium pratense)) and two herbs (ribwort plantain (Plantago lanceolata) and chicory (Cichorium intybus)) receiving 90 kg N/ha/yr (6S); and a nine species sward containing cocksfoot (Dactylis glomerata), greater birdsfoot trefoil (Lotus pedunculatus) and yarrow (Achillea millefolium) in addition to the six species listed above, receiving 90 kg N/ha/yr (9S). Each sward type was managed as a separate farmlet and stocked with 30 twin-rearing ewes at a stocking rate of 12.5 ewes/ha under rotational grazing management from turnout post-lambing until housing. Lamb live weight was recorded fortnightly and lambs were drafted for slaughter at 45 kg. Ewe live weight and body condition score (BCS) were recorded on five occasions annually. Lamb faecal egg count (FEC) was recorded fortnightly and lambs were treated with anthelmintics when mean lamb FEC per sward type was above 400 eggs per gram. Ewes grazing the 6S and 9S swards had heavier (P < 0.01) live weights and BCS throughout the study than the ewes grazing the PRG sward. Lambs grazing the 6S sward were heavier than lambs grazing all other sward types of 14 weeks old (P < 0.05). Lambs grazing the PRG sward required more days to reach slaughter weight than lambs grazing all other sward types (P < 0.001). Lambs grazing the 6S and 9S swards required fewer anthelmintic treatments than lambs grazing the PRG or PRGWC swards. In conclusion, grazing multispecies swards improved ewe and lamb performance and reduced the requirement for chemical anthelmintics. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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34. Trichomes and naphthoquinones protect Streptocarpus dunnii Hook.f. against environmental stresses.
- Author
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Hook, I., Sheridan, H., and Reid, C.
- Subjects
- *
TRICHOMES , *NAPHTHOQUINONE , *STREPTOCARPUS , *EPIDERMIS , *MEDICINAL plants - Abstract
Abstract Streptocarpus dunnii Hook.f. (Gesneriaceae) grows wild in South Africa in rocky terrain and at high altitude. It possesses unique patterns of growth, is acaulescent, unifoliate and monocarpic and produces unique naphthoquinones. Morphological examinations of Streptocarpus species have tended to concentrate on germination, cotyledon anatomy and development of the primary leaf (phyllomorph) while mature phyllomorphs are rarely examined. This study sought to examine the morphology of the mature phyllomorph and to more accurately determine the type and site of naphthoquinone(s)excretion. Plants were developed from invitro plantlets originating from authenticated seeds and allowed to grow in a peat-based potting compost for a year, under ambient room conditions. Mature lamina samples were examined morphologically by light, stereo and scanning electron microscopy. Results showed anisocytic stomata only on the abaxial epidermis, with numerous non-glandular and glandular trichomes on both epidermises, especially at the proximal end of the phyllomorph. Energy-dispersiveX-ray analysis indicated both trichome types to be rich in potassium. Glandular trichomes were more abundant on the abaxial surface, especially at non-glandular trichome bases over veins and adjacent to stomata in lamina areas between veins. These trichomes were shown for the first time to be the source of the naphthoquinones in S.dunnii. Chromatographic and FT-IR analyses confirmed the glandular secretions as being mainly (±)-dunnione. Results suggest that mature phyllomorphs with densely packed epidermal trichomes and a restricted distribution of stomata are adaptations by this plant to dehydration stress, while dunnione-type naphthoquinones may function in the amelioration of oxidative stress whether of biotic or abiotic origin. Highlights • Streptocarpus dunnii shows unique patterns of growth and rare naphthoquinones. • Glandular trichomes were site of naphthoquinone synthesis, mainly (±)-dunnione. • Phyllomorph microscopy including SEM, found abundant covering and glandular trichomes. • Trichomes mainly at proximal end, along veins; stomata only on abaxial epidermis. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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35. Palmitoylation and Membrane Binding of Arc/Arg3.1: A Potential Role in Synaptic Depression.
- Author
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Barylko, Barbara, Wilkerson, Julia R., Cavalier, Sheridan H., Binns, Derk D., James, Nicholas G., Jameson, David M., Huber, Kimberly M., and Albanesi, Joseph P.
- Published
- 2018
- Full Text
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36. The effects of defoliating grass in winter or spring on herbage yields and ensilage characteristics.
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Moloney, T., O'Riordan, E. G., Sheridan, H., and O'Kiely, P.
- Subjects
GRASS yields ,DEFOLIATION ,SILAGE ,CLIMATE change ,WINTER - Abstract
Under Irish conditions, the digestibility in May of grass managed for silage production is sometimes lower than expected. In each of two successive years, replicate field plots were established to examine the effects of three defoliation heights (uncut or cut to a stubble height of 10 or 5 cm) applied in winter and/or spring on herbage yields harvested in May and again in July, and on chemical composition and conservation characteristics associated with first-cut silage. Swards that were not defoliated in December or March had a dry-matter (DM) yield and in vitro DM digestibility (DMD) in mid-May of 6597 kg ha
−1 and 736 g kg−1 , respectively, in Year 1, and corresponding values of 7338 kg ha−1 and 771 g kg−1 in Year 2. Defoliating swards to 5 cm in December reduced ( P < 0·001) May DM yields compared to swards that were not defoliated in both December and March, while herbage DMD in May increased ( P < 0·001) when defoliated in December or March. There were no clear effects of defoliation height or its timing on herbage ensilability or resultant conservation efficiency characteristics. The effects of defoliation on July yield were the reverse of those observed for May, while the total yield of the December and March defoliations plus the two silage harvests increased as defoliation height was lowered in Year 2 only. It is concluded that defoliation in winter and/or spring can increase herbage digestibility but will likely reduce DM yields in May. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
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37. Sex Ratio and Distribution of Angiostrongylus cantonensis in Laboratory-Infected White Rats
- Author
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Lee, Sheridan H.
- Published
- 1967
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38. Absence of Angiostrongylus cantonensis (Cheng, 1935) among Rodents Trapped on Tokelau Islands
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Lee, Sheridan H.
- Published
- 1967
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39. A Response to Managerial Education. Peter Hilton J. Myron Atkin Ernest R. House Robert M. Exner Robert B. Davis Leo Ruth Peter Braunfeld Burt A. Kaufman Vincent Haag Gail S. Young Gerald R. Rising
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Sheridan, H. W. and Jorgensen, P. S.
- Published
- 1974
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40. The limits of utilitarianism as a professional ethic in public sector leisure policy and provision.
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McNamee, M. J., Sheridan, H., and Buswell, J.
- Subjects
- *
UTILITARIANISM , *PROFESSIONAL ethics , *LEISURE industry - Abstract
In a previous issue of this journal we developed a moral philosophical account of the relations between the paradigmatic leisure profession, leisure management, and it's clientele. Professional status was characterized as a set of relations necessarily involving moral authority and not merely technical expertise as is commonly supposed. In that account, professional paternalism was interpreted and justified differently in relation to the specific roles and relations incorporated in leisure management ranging from national policy planning to operational delivery. That position is developed and contextualized here by setting out an account of the nature of utilitarianism which is commonly thought to underwrite state paternalism in policy issues. The account charts the development within utilitarian thinking from its classical hedonistic beginnings in the thinking of Jeremy Bentham and John Stuart Mill into more sophisticated versions of welfarism in Amartya Sen. The essay sets out some critical difficulties in the application of a moral theory to leisure practice. It explores the limits to which utilitarian theories may specifically underwrite the leisure professional working in the public sector in a manner which, though paternalistic, is not disrespectful of the autonomy of its clients: citizens and consumers. [ABSTRACT FROM AUTHOR]
- Published
- 2001
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41. Paternalism, professionalism and public sector leisure provision: the boundaries of a leisure profession.
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McNamee, M. J., Sheridan, H., and Buswell, J.
- Subjects
- *
LEISURE industry , *PROFESSIONAL employees , *PATERNALISM - Abstract
A significant body of research has emerged concerning issues of the professionalization of, and professionalism in, leisure. Much of this literature has focused on the political and/or technical dimensions of the leisure professional and the customers or citizens they purport to serve. In this paper we offer a moral philosophical account of the relations between the paradigmatic leisure profession, leisure management, and its clientele. An account of the varieties of paternalism is developed and a more specific picture of professional paternalism in the context of leisure professions is articulated, while stopping short of providing a justification for the autonomy – respectful and disrespectful forms that they can take. We characterize the relations as necessarily involving moral authority, and not merely technical expertise, as is commonly supposed. [ABSTRACT FROM AUTHOR]
- Published
- 2000
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42. Noise levels during cesarean delivery: a prospective observational study.
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Sheridan, H., Plaza, E., Hendren, G., Hu, J., and Ortman, A.J.
- Abstract
Background: Excessive noise has negative implications for both clinicians and patients. Emergency cesarean deliveries require rapid co-ordination and communication, possibly increasing noise pollution. We aimed to determine if noise levels in the Labor and Delivery operating room were higher during emergency cesarean deliveries than during non-emergency cesarean deliveries.Methods: We conducted a prospective observational study measuring noise levels in Labor and Delivery operating rooms at a single academic medical center. Sound meters placed on anesthesia machines and events charted in the electronic medical record were used to correlate noise levels to clinical activity. Noise levels in all cesarean deliveries were recorded for one year. Deliveries were classified into two groups: non-emergency (routine or urgent) and emergency. We compared noise levels of the groups at eight time points of interest: anesthesia provider enters operating room (T1), induction (T2), five minutes before incision (T3), three minutes before incision (T4), one minute before incision (T5), time of incision (T6), delivery (T7), and five minutes before initiating emergence (T8).Results: Noise levels were measured for 440 cesarean deliveries. Forty were classified emergency and 400 non-emergency (304 routine, 96 urgent) procedures. Emergency cesarean deliveries were noisier at all eight time points, although the absolute difference in decibels between the two groups was modest. The difference in noise level reached statistical significance at five time points (T1, T2, T5, T6, and T7).Conclusion: Noise levels were higher during emergency than during non-emergency cesarean deliveries. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
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43. ...T14/...D15 Azotobacter vinelandii ferredoxin I: Creation of a new cysXXCysXXCys motif that...
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Kemper, Mary A. and Gao-Sheridan, H. Samantha
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- *
BIOCHEMISTRY - Abstract
Looks at Azotobacter vinelanidii ferredoxin I (AvFdI), with emphasis on biochemistry. Evolution of the 7Fe azobacter-type ferredoxins from the 8Fe clostridial-type ferredoxins; Details on the oxygen 4Fe cluster.
- Published
- 1998
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44. Interstitial deletion of the long arm of chromosome 18, del(18)(q12.2q21.1): a report of three cases of an autosomal deletion with a mild phenotype.
- Author
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Schinzel, A, Binkert, F, Lillington, D M, Sands, M, Stocks, R J, Lindenbaum, R H, Matthews, H, and Sheridan, H
- Abstract
We describe three unrelated patients with apparently identical interstitial deletions of the segment (18) (q12.2q21.1). They were a short and markedly mentally retarded 5 year old girl, a macrocephalic and obese 2 1/2 year old boy with moderate mental retardation, and a macrocephalic, severely mentally retarded 5 year old boy. Findings common to all five liveborn patients so far identified as carrying this deletion include a pattern of minor dysmorphic features (prominent forehead, ptosis of the upper eyelids, full periorbital tissue, epicanthic folds, strabismus), muscular hypotonia, seizures, behavioural disorders, and lack of major malformations. [ABSTRACT FROM PUBLISHER]
- Published
- 1991
45. The Core Curriculum: Changing Times and Changing Institutions
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Sheridan, H. W.
- Published
- 1983
46. Southwest Travel in the Seventies.
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Garth, Sheridan H.
- Published
- 1970
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47. 245-OR: CIS-Regulatory Architecture of Human ESC-Derived Hypothalamic Neuron Differentiation Aids in Variant-to-Gene Mapping of Type 2 Diabetes Related Traits.
- Author
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PAHL, MATTHEW C., LITTLETON, SHERIDAN H., DOEGE, CLAUDIA, HODGE, KENYAITA M., LEONARD, MICHELLE, LU, SUMEI, HAMMOND, REZA, BOEHM, KEITH, LASCONI, CHIARA, SU, CHUN, CHESI, ALESSANDRA, PIPPIN, JAMES A., JOHNSON, MATTHEW, WELLS, ANDREW D., VOIGHT, BENJAMIN F., LEIBEL, RUDOLPH, GRANT, STRUAN F., and COUSMINER, DIANA L.
- Abstract
Dysregulation of hypothalamus-mediated metabolic homeostasis influences risk factors for T2D, such as BMI, pubertal timing and sleep. However, the gene regulatory landscape of the hypothalamus remains unclear. We characterized the physical relationships among gene promoters and their corresponding cis-regulatory elements in human embryonic stem cell (ESC)-derived hypothalamic cells by integrating RNA-seq, ATAC-seq and promoter-focused Capture C profiles. We conducted this effort in an in vitro model of hypothalamic neurons using human ESCs at 3 stages of differentiation: ESCs, hypothalamic progenitors (HPs) and hypothalamic-like neurons (HNs). We identified 87,170 open chromatin regions (OCRs) contacting promoters in at least 1 stage of HN differentiation. Interestingly, we observed that regardless of gene expression pattern during differentiation, overall accessibility of interacting OCRs first increased during the transition to HP, then decreased following differentiation to HN. In order to relate these findings to GWAS data, we tested for enrichment of SNPs within promoter-interacting OCRs. We found significant associations with BMI, sleep traits, age at menarche (AAM) and major depressive disorder (MDD). We mapped these trait-associated variants to their physically interacting genes. We identified 2 putative effector genes for AAM (RPS26 and SUOX at chr12q13.2) and 1 for BMI (DHRS11), which were also supported by colocalized hypothalamus eQTLs in GTEx. Additionally, HyPrColoc analyses revealed several putative effector genes associated with >1 trait, including ZRANB2 for AAM, BMI and MDD, and FEZF1 for AAM and BMI, the latter being known to harbor Mendelian mutations that impair puberty. Taken together, our analyses provide insight into cis-regulatory architecture during hypothalamic development and how it may contribute to phenotypes associated with T2D risk. Disclosure: M.C. Pahl: None. S.H. Littleton: None. C. Doege: None. K.M. Hodge: None. M. Leonard: None. S. Lu: None. R. Hammond: None. K. Boehm: None. C. Lasconi: None. C. Su: None. A. Chesi: None. J.A. Pippin: None. M. Johnson: None. A.D. Wells: None. B.F. Voight: None. R. Leibel: None. S.F. Grant: None. D.L. Cousminer: None. Funding: American Diabetes Association (1-17-PDF-077 to D.L.C.); National Institutes of Health (K99HD099330-01); National Center for Research Resources (UL1RR024134); National Center for Advancing Translational Sciences (UL1TR000003); Institute for Translational Medicine and Therapeutics; Children's Hospital of Philadelphia [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
48. Practical experience using transabdominal chorionic villus biopsies taken after 16 weeks' gestation for rapid prenatal diagnosis of chromosomal abnormalities.
- Author
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Wolstenholme, J., Hoogwerf, A. M., Sheridan, H., Maher, E. J., and Little, D. J.
- Published
- 1989
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49. LUNG CLEARANCE INDEX IN CHILDREN WITH ACUTE EXACERBATION OF ASTHMA.
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Sheridan, H. S. and Cunningham, S.
- Subjects
- *
ASTHMA in children , *DISEASE exacerbation , *OBSTRUCTIVE lung disease diagnosis , *PULMONARY function tests , *ADRENOCORTICAL hormones , *HOSPITAL admission & discharge , *ASTHMATICS - Abstract
Introduction Lung clearance index (LCI) can detect small airways disease in asthma; however there is no published LCI data collected during acute exacerbation. We aimed to investigate LCI in asthmatic children requiring oral corticosteroids and admission to hospital. Methods Children were recruited from acute medical wards. We tested children once they did not require oxygen or >2 hourly salbutamol. Admission details were extracted from medical notes. Multiple breath washout (MBW) was performed with sulphur hexafluoride and the Innocor photoacoustic gas analyser. Spirometry complied with ATS/ERS standards and was performed using the Easyone spirometer. MBW and spirometry were performed shortly before and 15 min after children's clinically prescribed salbutamol. Paired t tests and Pearson correlation coefficients were used in the analysis. Results Nine children aged 6.4-13.6 years were recruited. Testing began on average 201 min after each child's last salbutamol. LCI was calculated for eight children, the ninth was excluded due to variable FRC. Pre bronchodilator mean (SD) LCI was 8.6 (1.8), but was only abnormal (=7.4) in 5/8 children; following bronchodilator mean (SD) LCI was 8.1 (1.2). Mean (SD) FEV1 z-score was -3.5 (1.6) and was abnormal (<-1.96) in 6/8 children; post bronchodilator FEV1 z-score was -2.9 (1.4). Mean LCI correlated with FEV1 z-score before and after bronchodilator (r=-0.80, p=0.017 and r=-0.76, p=0.030). In patients with abnormal LCI there was a significant improvement after salbutamol; with a mean difference of -0.918, p=0.018. In this group FEV1 z-score improved by a mean of 0.802, p=0.051. Although overall both measures improved, the degrees of improvement in LCI and FEV1 did not correlate (r=-0.361, p=0.550). Two patients who both had abnormal pre bronchodilator LCI (mean 11.1) returned 8-10 weeks later, both had normal LCI (mean 6.9). Conclusions LCI is abnormal in children during exacerbation of asthma. Abnormal LCI improves following bronchodilator, but changes do not correlate with changes in FEV1. This suggests variable bronchodilator response throughout the airway. Recruitment for this study is ongoing. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
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50. The Race Between People and Nature.
- Author
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Garth, Sheridan H.
- Published
- 1969
- Full Text
- View/download PDF
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