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4. Role of individual genes of the A/Leningrad/134/17/57 (H2N2) cold-adapted donor strain in manifestation of the temperature-sensitive phenotype of reassortant influenza A viruses

Author

Kiseleva, I., Klimov, A., Su, Q., Szymkowiak, C., Toner, T.J., Kwan, W.-S., Rudenko, L., Shaw, A.R., and Youil, R.

Subjects
*INFLUENZA viruses, *PHENOTYPES, *GENETICS, *RESPIRATORY infections
Abstract

The main focus of this study was to explore the role of the gene segments of the cold-adapted (ca) A/Leningrad/134/17/57 (Len/17) influenza virus in the context of heterologous wild-type (wt) viruses. In this study, 34 MDCK-derived reassortants between Len/17 and the A/New Caledonia/20/99 (H1N1) wt virus (A/NC) and 141 egg-derived reassortants of Len/17 and current influenza A viruses were evaluated to identify the gene(s) responsible for the ts phenotype. Data obtained from these studies showed PB2 to be the critical mutant gene in conferring ts in the Len/17 strain. However, the other polymerase genes (PB1 and PA) were found to be essential in maintaining ts in the background of heterologous gene constellations. [Copyright &y& Elsevier]

Published
2004
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