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A thermoresponsive copolymer based on oligo(ethylene glycol) methacrylate, Chol-P(MEO2MA-co-OEGMA), was synthesized using Atom Transfer Radical Polymerization (ATRP) and incorporated into thermosensitive liposomes (TSLs) for controlled drug release. The copolymer exhibited a lower critical solution temperature (LCST) of 37 °C, making it suitable for biomedical applications requiring precise thermal triggers. The copolymer was incorporated into various TSL formulations alongside phospholipids such as DPPC, Lyso-PC, HSPC, and DSPC. Physicochemical characterization of the liposomes, including average size, polydispersity index, loading efficiency (LE), and encapsulation efficiency (EE), was performed using dynamic light scattering and fluorescence spectroscopy. The results showed that the incorporation of the copolymer slightly affected particle size and decreased LE and EE in most formulations. Lyso-PC-containing formulations exhibited lower LE and EE, likely due to instability during purification. Albumin encapsulation demonstrated lower LE compared to the smaller carboxyfluorescein drug model, highlighting the influence of molecular weight on loading. Although copolymer-modified liposomes showed reduced loading capacity, they enhanced thermoresponsiveness in HSPC-based formulations. These findings suggest that incorporating thermoresponsive polymers into TSLs can optimize drug delivery systems for targeted, thermally triggered release.

Narcissism and its components remain up-to-date in academic studies as a topic that has been and continues to be the focus of attention of researchers. The aim of this study is to examine the predictive effect of early maladaptive schemas on narcissism and the mediating role of self-esteem in this effect. A total of 426 university students, 229 female and 197 male, participated in the study. In addition to the demographic information form, the Narcissistic Admiration and Competition Scale, Young Schema Questionnaire-Short Form-3 and Rosenberg Self-Esteem Inventory were used to collect data. In the analysis of the data, descriptive statistics, Pearson Product of Moments Correlation analysis, mediation analysis in line with the procedures recommended by Preacher and Hayes, and Bootstrapping method were used to evaluate the mediation effect. According to the results of the research; Schema domains of impaired autonomy, unrelenting standards, disconnection, other-directedness, and impaired limits predict self-esteem. Schema domains of impaired autonomy, unrelenting standards, disconnection, impaired limits as well as self-esteem, predict narcissism, while the schema domains of other-directedness do not predict narcissism. Self-esteem acts as a mediator in the relationship between impaired autonomy, unrelenting standards, disconnection and impaired limits schema areas and narcissism.