This paper investigates Automatic Repeat request (ARQ) designs for Physical-layer Network Coding (PNC) systems. Most prior work related to PNC explores its use in Two-Way Relay Channel (TWRC). We have previously found that, besides TWRC, there are many other PNC building blocks—building blocks are simple small network structures that can be used to construct a large network. In some of these PNC building blocks, the receivers can obtain side information through overhearing. Although such overheard information is not the target information that the receivers desire, the receivers can exploit the overheard information together with a network-coded packet received to obtain a desired native packet. This can yield substantial throughput gain. Our previous study, however, assumed what is sent always gets received. In practice, that is not the case. Error control is needed to ensure reliable communication. This paper focuses on ARQ designs for ensuring reliable PNC communication. The availability of overheard Information and its potential exploitation make the ARQ design of a network-coded system different from that of a non-network-coded system. In this paper, we lay out the fundamental considerations for such ARQ designs: 1) we put forth a framework to track the stored coded packets and overheard packets to increase the chance of packet extraction, and derive the throughput gain achieved therefore; 2) we investigate two variations of PNC ARQ, coupled and non-coupled ARQs, and prove that non-coupled ARQ is more efficient; 3) we show how to optimize parameters in PNC ARQ—specifically the window size and the ACK frequency—to minimize the throughput degradation caused by ACK feedback overhead and wasteful retransmissions due to lost ACK. [ABSTRACT FROM PUBLISHER]