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Grassland net primary productivity, carbon (C) allocation to roots, root production and subsequent turnover time in grazed pastures have significant implications for modelling landuse effects on global carbon dynamics. The objective of this work, using the decline of assimilated 13C, was to quantify C allocation to roots, root production and turnover time in response to long-term fertiliser and irrigation treatments. The treatments on the pastures on a long-term research site at Winchmore, Canterbury, New Zealand were 0 or 375 kg ha−1 y−1 superphosphate under irrigation and, on a nearby irrigation experiment, unirrigated or irrigated (with fertilisation of 250 kg ha−1 y−1 superphosphate) when the soil water content fell to 20% w/w (50% available moisture). The pasture treatments were pulse-labelled using 13CO2 within portable gas-tight enclosures. Separate micro-plots were 13CO2 pulse-labelled in late spring, summer and autumn. Below ground net primary production (206 g C m−2 y−1) was similar in unfertilised, unirrigated, fertilised and irrigated pastures, despite marked differences in above ground production. Unfertilised/irrigated and unirrigated/fertilised treatments had greater root biomass, root C allocation and longer root turnover time (1.9 y and 2.0 y, respectively) than fertilised and irrigated treatments (1.3 y). These root turnover times appeared to be consistent with the improved substrate quality attributed to the species found in the irrigated and fertilised treatments. [ABSTRACT FROM AUTHOR]

We systematically reviewed studies examining information needs of post-myocardial infarction patients and their families. Electronic databases and bibliographies of relevant papers were searched and experts in the field contacted to find relevant studies. A standardised data form was used to extract data on study populations, instruments and results. Of 14 published studies, 6 used the same instrument. Information about risk factors ranked as the most important category overall, followed by information on cardiac anatomy and physiology, medications, and physical activity. Information about miscellaneous items, diet, psychological factors, and the CCU, although ranked lower, were still rated important. Some variation between settings was evident. Patients preferred physicians over nurses as information givers. Differences were found between patient and nurse ratings of information categories. Differences were found in the self-perceived information needs of patients responding to different instruments, indicating a priming effect. Changes in ranking of information categories between CCU, PCCU and PD are congruent with decreasing levels of patient dependency. The information needs of women and other post-MI subgroups, including the elderly, minority ethnic groups, patients with severe coronary disease, and deprived patients, have not been assessed. Patients have not been involved in the design of information needs assessment instruments. [ABSTRACT FROM AUTHOR]

Azapropazone is an anti-inflammatory agent with reported uricosuric properties. The aim of the present study was to extend these observations, by examining the dose-response and to compare the uricosuric effect of azapropazone with that of probenecid. Patients were given varying doses of azapropazone from 900-2400 mg daily for 4- day periods at separated intervals. Plasma uric acid levels were measured before and at the end of each treatment period. Three other patients maintained on low purine diets were given a 4-day course of 1200 mg azapropazone daily followed at an interval by a 4-day period of probenecid 1 g daily. Plasma uric acid levels and 24 h urinary uric acid excretion were compared. The mean fall in plasma uric acid level after four days of 900 mg azapropazone daily was 31.4% (n = 9) compared with 33.9% (n = 12) on 1200 mg daily; 42.3% (n = 10) on 1800 mg daily; and 46% (n = 6) on 2400 mg daily, indicating a graded dosage response. In the three patients on low purine diets the falls in plasma uric acid levels on probenecid 1 g daily were 50.5%, 46% and 29% compared with 33.5%, 32% and 20% respectively on azapropazone 1200 mg daily. Similarly the total amount of uric acid excreted in the urine by each patient during the 4-day period on probenecid 1 g daily was 14.01; 13.03 and 8.97 mmol compared with 23.53, 10.9 and 7.69 mmol on azapropazone 1200 mg daily.(ABSTRACT TRUNCATED AT 250 WORDS) [ABSTRACT FROM AUTHOR]

Flurbiprofen has been compared with phenylbutazone in a double-blind study involving 33 patients with acute gout. Patients received either flurbiprofen 400 mg daily for 48 h followed by 200 mg daily, or phenylbutazone 800 mg daily for 48 h followed by 400 mg daily. The drugs were of comparable efficacy, while side-effects were uncommon and relatively mild. Flurbiprofen appears to be a satisfactory alternative to phenylbutazone in the management of acute gouty arthritis. [ABSTRACT FROM AUTHOR]