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In quantum dots (QDs), the Auger recombination is a non-radiative scattering process in which the optical transition energy of a charged exciton (trion) is transferred to an additional electron leaving the dot. Electron tunneling from a reservoir is the competing process that replenishes the QD with an electron again. Here, we study the dependence of the tunneling and Auger recombination rate on the applied electric field using high-resolution time-resolved resonance fluorescence (RF) measurements. With the given p–i–n diode structure and a tunnel barrier between the electron reservoir and the QD of 45 nm, we measured a tunneling rate into the QD in the order of ms−1. This rate shows a strong decrease by almost an order of magnitude for decreasing electric field, while the Auger emission rate decreases by a factor of five in the same voltage range. Furthermore, we study in detail the influence of the Auger recombination and the tunneling rate from the charge reservoir into the QD on the intensity and linewidth of the trion transition. In addition to the well-known quenching of the trion transition, we observe in our time-resolved RF measurements a strong influence of the tunneling rate on the observed linewidth. The steady-state RF measurement yields a broadened trion transition of about 1.5 GHz for an Auger emission rate of the same order as the electron tunneling rate. In a non-equilibrium measurement, the Auger recombination can be suppressed, and a more than four times smaller linewidth of 340 MHz (1.4 μeV) is measured. [ABSTRACT FROM AUTHOR]

The self-consistent electromagnetic integration of tokamak plasma magnetohydrodynamic (MHD) models with external conductors is considered in this manuscript. We integrate the extended MHD code JOREK and the eddy current code CARIDDI, via a scheme based on the virtual casing principle enabling two-way coupled fully implicit simulations. The robustness of this new integrated tool is validated against JOREK-STARWALL and CarMa0NL simulations for vertical displacement events in a simplified ASDEX Upgrade-like geometry and for n = 1 tearing modes in a circular high-aspect-ratio tokamak. The impact of 3D wall structures on the plasma evolution is highlighted introducing ports at different locations of a simplified axisymmetric wall and characterizing its effect on the plasma evolution. In addition to realistically capturing the 3D interactions between plasma and wall structures, the coupled codes will allow in the future 1:1 comparisons to experiments using virtual magnetic diagnostics that capture screening effects accurately. [ABSTRACT FROM AUTHOR]

Summary: Background: Epidermal differentiation is a multilevel process in which keratinocytes need to lose their organelles, including their mitochondria, by autophagy. Disturbed autophagy leads to thickening of the epidermis as seen in pachyonychia congenita (PC), a rare skin disease caused by mutations in keratins 6, 16 and 17. Objectives: To ask if mitophagy, the selective degradation of mitochondria by autophagy, is disturbed in PC and, if so, at which stage. Methods: Immortalized keratinocytes derived from patients with PC were used in fluorescence‐based and biochemical assays to dissect the different steps of mitophagy. Results: PC keratinocytes accumulated old mitochondria and displayed disturbed clearance of mitochondria after mitochondrial uncoupling. However, early mitophagy steps and autophagosome formation were not affected. We observed that autolysosomes accumulate in PC and are not sufficiently recycled. Conclusions: We propose an influence of keratins on autolysosomal degradation and recycling. What's already known about this topic? Terminal epidermal differentiation is a multistep process that includes the elimination of cellular components by autophagy.Autophagy‐impaired keratinocytes have been shown to result in thickening of epidermal layers.Hyperkeratosis also occurs in pachyonychia congenita (PC), a rare skin disease caused by mutations in keratins 6, 16 and 17. What does this study add? Keratins contribute to mitochondrial quality control as well as maintenance of mitochondria–endoplasmic reticulum contact sites.Keratins influence autolysosomal maturation or reformation. What is the translational message? Overaged mitochondria and autolysosomes accumulate in PC.Mutations in keratin 6a lead to severely impaired mitophagy, which might contribute to PC pathogenesis. Linked Comment: Vetter and Magin. Br J Dermatol 2020; 182:529–530. Respond to this article [ABSTRACT FROM AUTHOR]

In this contribution a model for the elastic relaxation of Al0.5 Ga 0.5 As and ZnSe wire structures, respectively, is presented. The wire structures extend along 1¯1 0 and were characterized by high resolution x-ray diffraction experiments. Based on Monte Carlo simulations, the wire structures, which have been simulated at atomic resolution, were relaxed to reduce the strain caused by the lattice misfit. The x-ray diffraction patterns calculated for the final structures reproduce the observed data. The structures display a two dimensional strain gradient and curved lattice planes. Hence the introduced modeling is a powerful method in particular to resolve the atomic structure of a wet chemically etched or molecular beam epitaxial grown wire by giving a microscopic picture on an atomic scale. [ABSTRACT FROM AUTHOR]

Abstract: The potential was modelled of molecular rapid diagnostic tests (RDTs) that target agents of sexually transmitted diseases (STDs) to contribute to a reduction in the exposure risk for sexually active populations who prefer condom‐free high‐risk contacts. The biostatistical approach is exemplified by considering the use of a PCR‐based RDT for Chlamydia trachomatis and Neisseria gonorrhoeae in a population of German men having sex with men. We modelled the exposure risk as risk of sexual contact with individuals infected by a STD in spite of multiple RDTs having been conducted to identify STDs that could lead to avoidance of an infectious sexual contact. The risk for a given specific disease is influenced by the diagnostic accuracy of all diagnostic tests conducted. The simulation showed a reduction in exposure risk through conducting the selected PCR‐based RDT as a strategy to prevent infections with C. trachomatis and N. gonorrhoeae in comparison with unprotected sexual contact of >97% for C. trachomatis and ≥96% for N. gonorrhoeae. Reliable knowledge of the performance characteristics of the diagnostic tests applied is essential for a thorough risk assessment based on such diagnostic approaches. Significance and Impact of the Study: A low‐threshold use of molecular rapid diagnostic tests in settings where risky sexual activity is undertaken with deliberate non‐use of condoms is modelled. Such an approach might contribute to a considerable reduction in the exposure risk if positively tested individuals are excluded from unprotected sexual intercourse. Protective effects are influenced by the prevalence of the disease and the performance characteristics of the applied tests. Precise knowledge of the performance characteristics of the test assays employed are prerequisites of a reliable risk assessment. The modelling approach is of particular use for preventive health experts. [ABSTRACT FROM AUTHOR]