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2. An activatable red emitting fluorescent probe for monitoring vicinal dithiol protein fluctuations in a stroke model.

Author

Shen, Ruipeng, Chen, Ya-xiong, Chen, Yating, Sayed, Zahid Nasim, Yi, Meirong, Sun, Chunlin, Zhang, Baoxin, and Fang, Jianguo

Subjects
FLUORESCENT probes, PROTEIN synthesis, LABORATORY mice, ANIMAL disease models, OXIDATION-reduction reaction
Abstract

Vicinal dithiol proteins (VDPs) facilitate cellular redox homeostasis, modulate protein synthesis and participate in post-translational modifications through the dynamic equilibrium of dithiol and disulfide bonds. Herein, an activatable red emitting fluorescent probe, VDP-red, is developed for detecting VDPs. With the aid of this probe, we have discovered for the first time a reduction in the levels of reduced VDPs in a stroke mouse model. This work provides a fresh viewpoint for understanding stroke mechanisms. [ABSTRACT FROM AUTHOR]

Published
2024
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