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13. Combination of low body mass index and serum albumin level is associated with chronic kidney disease progression: the chronic kidney disease-research of outcomes in treatment and epidemiology (CKD-ROUTE) study

Author

Kikuchi, Hiroaki, Kanda, Eiichiro, Mandai, Shintaro, Akazawa, Masanobu, Iimori, Soichiro, Oi, Katsuyuki, Naito, Shotaro, Noda, Yumi, Toda, Takayuki, Tamura, Teiichi, Sasaki, Sei, Sohara, Eisei, Okado, Tomokazu, Rai, Tatemitsu, and Uchida, Shinichi

Published
2017
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16. Properties of Renshaw-like cells excited by recurrent collaterals of pudendal motoneurons in the cat

Author

Muramatsu, Ken, Niwa, Masatoshi, and Sasaki, Sei-Ichi

Subjects
Diseases -- Relapse, Employee dismissals -- Analysis, Psychology and mental health
Abstract

Although anatomical studies have indicated pudendal motoneurons to give off recurrent collaterals, they are not considered to make synapses onto interneurons, such as Renshaw cells, and rather terminate their own signals. No study till date has examined interneurons being driven by recurrent collaterals of pudendal motoneurons. Here, we aimed to investigate the existence of Renshaw cells driven by pudendal motoneurons along with the recurrent inhibition of the latter. Extracellular recordings were obtained from the ventral horn of the sacral spinal cord of anesthetized cats. Dorsal roots were sectioned, and motor axons were electrically stimulated. Renshaw-like cells driven by recurrent collaterals, with high-frequency firings at short latency discharge, were observed around Onuf's nucleus. However, the recurrent inhibitory post-synaptic potentials were not recorded by intracellular recordings from the pudendal motoneurons. In summary, we found Renshaw-like cells driven by pudendal motoneurons, but we could not identify the synaptic connection of these neurons. Keywords: Pudendal motoneurons, Recurrent collateral, Renshaw cell, Interneuron, Recurrent inhibition, Author(s): Ken Muramatsu[sup.1], Masatoshi Niwa[sup.2] and Sei-Ichi Sasaki[sup.3,4] Background The pudendal motoneurons (PMNs) are located in Onuf's nucleus, innervating perineal striated muscles, such as external anal and urethral sphincters, and [...]

Published
2020
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18. Urinary excretion of the water channel aquaporin 2 correlated with the pharmacological effect of tolvaptan in cirrhotic patients with ascites

Author

Nakanishi, Hiroyuki, Kurosaki, Masayuki, Hosokawa, Takanori, Takahashi, Yuka, Itakura, Jun, Suzuki, Shoko, Yasui, Yutaka, Tamaki, Nobuharu, Nakakuki, Natsuko, Takada, Hitomi, Higuchi, Mayu, Komiyama, Yasuyuki, Yoshida, Tsubasa, Takaura, Kenta, Hayashi, Tsuguru, Kuwabara, Konomi, Sasaki, Sei, and Izumi, Namiki

Published
2016
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19. Aquaporins and Ion Conductance

Author

Agre, Peter, Lee, M. Douglas, Devidas, Sreenivas, Guggino, William B., Sasaki, Sei, Uchida, Shinichi, Kuwahara, Michio, Fushimi, Kiyohide, Marumo, Fumiaki, Verkman, A. S., Yang, Baoxue, Deen, P. M. T., Mulders, S. M., Kansen, S. M., van Os, C. H., Fischbarg, Jorge, Kuang, Kunyan, Li, Jun, Iserovich, Pavel, Wen, Qian, Patil, Rajkumar V., Han, Zhiquang, Wax, Martin B., Regan, John W., Stamer, W. Daniel, and Yool, Andrea J.

Published
1997

26. Electrophysiological properties of Ia excitation and recurrent inhibition in cat abdominal motoneurons

Author

Niwa, Masatoshi, Muramatsu, Ken, Nakayama, Kiyomi, and Sasaki, Sei-Ichi

Subjects
Psychology and mental health
Abstract

Ia excitation and recurrent inhibition are basic neuronal circuits in motor control in hind limb. Renshaw cells receive synaptic inputs from axon collaterals of motoneurons and inhibit motoneurons and Ia inhibitory interneurons. It is important to know properties of Ia excitation and recurrent inhibition of trunk muscle such as abdominal muscles. The abdominal muscles have many roles and change those roles for different kind of functions. Intracellular recordings were obtained from the abdominal motoneurons of the upper lumbar segments in cats anesthetized. First, dorsal roots were left intact, and sensory and motor axons were electrically stimulated. Ia excitatory post-synaptic potentials were elicited in five of eight motoneurons at same segment stimulated. Second, dorsal roots were sectioned, and motor axons were electrically stimulated. Recurrent inhibitory post-synaptic potentials were elicited in one of 11 abdominal motoneurons. Renshaw cells extracellularly fired high-frequency bursts at short latency and at same segment stimulated. Keywords: Abdominal motoneuron, Ia-EPSP, Recurrent IPSP, Spinal cord, Inhibition, Author(s): Masatoshi Niwa[sup.1], Ken Muramatsu[sup.2], Kiyomi Nakayama[sup.3] and Sei-Ichi Sasaki[sup.4,5] Introduction Recently, we reported that the patterns of neural discharge in the abdominal muscles are critical for increasing intra-abdominal pressure [...]

Published
2018
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50. FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells

Author

Yui, Naofumi, Okutsu, Rie, Sohara, Eisei, Rai, Tatemitsu, Ohta, Akihito, Noda, Yumi, Sasaki, Sei, and Uchida, Shinichi

Subjects
Aquaporins -- Physiological aspects, Aquaporins -- Genetic aspects, Aquaporins -- Research, Golgi apparatus -- Physiological aspects, Golgi apparatus -- Research, Phosphatidylinositol -- Physiological aspects, Phosphatidylinositol -- Research, Phosphorylation -- Physiological aspects, Phosphorylation -- Research, Biological sciences
Abstract

Yui N, Okutsu R, Sohara E, Rai T, Ohta A, Noda Y, Sasaki S, Uchida S. FAPP2 is required for aquaporin-2 apical sorting at Trans-Golgi network in polarized MDCK cells. Am J Physiol Cell Physiol 297: C1389-C1396, 2009. First published September 30, 2009; doi: 10.1152/ajpcell.00098.2009.--FAPP2 is an adaptor protein of phosphatidylinositol-4-phosphate and is involved in the transport of some apical cargos from the trans-Golgi network (TGN). To investigate whether the regulated apical transport of aquaporin-2 (AQP2) is involved in the FAPP2-dependent apical protein-sorting machinery, we measured apical sorting of AQP2 in Madin-Darby canine kidney (MDCK) cells with or without FAPP2 knockdown. We established MDCK cell lines that stably express rat AQP2 without any tag sequence. Then, FAPP2-deficient stable cell lines were established from the AQP2-expressing cell lines by a retrovirus-mediated RNA interference system. In the established cell lines, AQP2 was detected in both apical and basolateral membranes. Forskolin increased only the apical localization of AQP2, which was not affected by basolateral treatment with 0.5% tannic acid, indicating that the forskolin-induced apical transport of AQP2 did not include the transcytotic pathway from basolateral to apical membranes but is a direct transport from TGN to the apical membranes. Using these cell lines, we tested the effect of FAPP2 knockdown on the polarized AQP2 transport to plasma membranes and found that the forskolin-induced apical transport of AQP2 was completely abolished by FAPP2 knockdown. By contrast, the basolateral localization of AQP2 was not affected by FAPP2 knockdown. AQP2 phosphorylation by forskolin was also impaired in FAPP2 knockdown MDCK cells. These results suggest that FAPP2 is necessary to generate AQP2-bearing vesicles at trans-Golgi that will undergo phosphorylation by PKA in subapical regions. phosphatidylinositol; forskolin; short hairpin RNA; biotinylation assay doi: 10.1152/ajpcell.00098.2009

Published
2009

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