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22 results on '"Sanz, X"'

3. Could pulmonary low-dose radiation therapy be an alternative treatment for patients with COVID-19 pneumonia? Preliminary results of a multicenter SEOR-GICOR nonrandomized prospective trial (IPACOVID trial)

Author

Arenas, M., Algara, M., De Febrer, G., Rubio, C., Sanz, X., de la Casa, M. A., Vasco, C., Marín, J., Fernández-Letón, P., Villar, J., Torres-Royo, L., Villares, P., Membrive, I., Acosta, J., López-Cano, M., Araguas, P., Quera, J., Rodríguez-Tomás, F., and Montero, A.

Published
2021
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11. Accelerated hypofractionated radiation therapy (AHRT) for non-small-cell lung cancer: can we leave standard fractionation?

Author

Dios, N., Sanz, X., Foro, P., Membrive, I., Reig, A., Ortiz, A., Jiménez, R., and Algara, M.

Abstract

Purpose: To report interim results from a single-institution study conducted to assess accelerated hypofractionated radiotherapy (AHRT) delivered with 3D conformal radiotherapy in two groups of patients with non-small cell lung cancer: (1) patients with early stage disease unable to tolerate surgery and ineligible for stereotactic body radiation therapy, and (2) patients with locally advanced disease unsuitable for concurrent chemoradiotherapy. Methods/patients: A total of 83 patients (51 stage I-II, 32 stage III) were included. Radiotherapy targets included the primary tumor and positive mediastinal areas identified on the pre-treatment PET-CT. Mean age was 77.8 ± 7.8 years. ECOG performance status (PS) was ≥2 in 50.6 % of cases. Radiotherapy was delivered in daily fractions of 2.75 Gy to a total dose of 66 Gy (BED 84 Gy). Acute and late toxicities were evaluated according to NCI CTC criteria. Results: At a median follow-up of 42 months, median overall survival (OS) and cause-specific survival (CSS) were 23 and 36 months, respectively. On the multivariate analysis, PS [HR 4.14, p = 0.0001)], stage [HR 2.51, p = 0.005)], and maximum standardized uptake values (SUVmax) [HR 1.04, p = 0.04)] were independent risk factors for OS. PS [HR 5.2, p = 0.0001)] and stage [HR 6.3, p = 0.0001)] were also associated with CSS. No cases of severe acute or late treatment-related toxicities were observed. Conclusions: OS and CSS rates in patients treated with AHRT for stage I-II and stage III NSCLC were good. Treatment was well tolerated with no grade three or higher treatment-related toxicity. PS, stage, and SUV max were predictive for OS and CSS. [ABSTRACT FROM AUTHOR]

Published
2017
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12. 18F-FDG PET definition of gross tumor volume for radiotherapy of lung cancer: is the tumor uptake value-based approach appropriate for lymph node delineation?

Author

Rodríguez N, Sanz X, Trampal C, Foro P, Reig A, Lacruz M, Membrive I, Lozano J, Quera J, Algara M, Rodríguez, Núria, Sanz, Xavier, Trampal, Carlos, Foro, Palmira, Reig, Anna, Lacruz, Martí, Membrive, Ismael, Lozano, Joan, Quera, Jaime, and Algara, Manuel

Abstract

Purpose: Positron emission tomography (PET) with the glucose analogue [18F] fluoro-2-deoxy-D-glucose ((18)F-FDG-PET) has been used in radiation treatment planning for non-small-cell carcinoma. To date, lymph nodes have been contoured according to the uptake of the tumor. This prospective study was performed to evaluate if nodal volume delineates according to FDG uptake within the primary tumor (PET-GTVnt) is suitable for nodal target volume delineation or if individualized nodal FDG uptake measure (PET-GTVnn) is necessary to better nodal target definition. Methods and Materials: Forty cases, who underwent a diagnostic (18)F-FDG PET/computed tomography (CT) scan, were included. Two PET-based GTVs for each lymph node were contoured and compared. First, we used an isocontour of 40% of the maximum tumor uptake (PET-GTVnt). Second, an isocontour of 40% of the maximum uptake of each node (PET-GTVnn) was employed. To avoid interobserver variability, this was carried out by the same radiation oncologist. Afterwards, the difference between both lymph node volumes was plotted against the ratio of the maximum uptakes (I(n)/I(t)) in a linear regression analysis. Results: Compared with CT-based lymph node volume (CT-GTVn), the intraclass correlation coefficient of PET-GTVnn was higher than the coefficient of PET-GTVnt (p < 0.001). All cases could be divided into four groups: undetected (17.5%), detected but overestimated (10%), detected but underestimated (35%), and correctly detected (37.5%). Conclusions: If a method of automatic delineation shall be applied, this method must be applied to every lesion separately. However, to facilitate the delineation in daily practice, when I(n)/I(t) is ≤25%, lymph nodes could be delineated in accordance with tumor uptake, keeping an absolute difference in radii <5 mm. [ABSTRACT FROM AUTHOR]

Published
2010
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21. 157 Poster - P53 and axillary tumor burden in breast cancer.

Author

Nicolau, P., Argudo, N., Jimenez, M., Segura, M., Maso, P., Vazquez, I., Comerma, L., Servitja, S., Martinez, M., Martos, T., Casadevall, D., Alcantara, R., Plancarte, F., Pitarch, M., Arenas, N., Sanz, X., Rodriguez, N., Algara, M., and Vernet-Tomás, M.

Subjects
*BREAST tumors, *CANCER patients, *CONFERENCES & conventions, *GENE expression, *LYMPH nodes
Published
2020
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22. A New Dietary and Laxative Protocol Reduces Rectal Distension and Acute Rectal Toxicity in Prostate Cancer Patients Treated by Radiation Therapy.

Author

Lozano, J., Pera, O., Foro, P., Lio, J., Membrive, I., Reig, A., Sanz, X., Rodríguez, N., Fernández-Velilla, E., and Algara, M.

Subjects
*PROSTATE cancer patients, *CANCER radiotherapy, *DIET therapy for cancer patients, *MAGNESIUM hydroxide, *ACUTE toxicity testing, *INTENSITY modulated radiotherapy, *CONTROL groups, *SCIENTIFIC observation
Published
2013
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