85 results on '"Sang Beom Kim"'
Search Results
2. Compound Heterozygous Mutations of SACS in a Korean Cohort Study of Charcot-Marie-Tooth Disease Concurrent Cerebellar Ataxia and Spasticity
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Byung Kwon Pi, Yeon Hak Chung, Hyun Su Kim, Soo Hyun Nam, Ah Jin Lee, Da Eun Nam, Hyung Jun Park, Sang Beom Kim, Ki Wha Chung, and Byung-Ok Choi
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autosomal recessive spastic ataxia of Charlevoix-Saguenay disease (ARSACS) ,cerebellar ataxia ,Charcot-Marie-Tooth disease (CMT) ,Korean ,SACS ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Mutations in the SACS gene are associated with autosomal recessive spastic ataxia of Charlevoix-Saguenay disease (ARSACS) or complex clinical phenotypes of Charcot-Marie-Tooth disease (CMT). This study aimed to identify SACS mutations in a Korean CMT cohort with cerebellar ataxia and spasticity by whole exome sequencing (WES). As a result, eight pathogenic SACS mutations in four families were identified as the underlying causes of these complex phenotypes. The prevalence of CMT families with SACS mutations was determined to be 0.3%. All the patients showed sensory, motor, and gait disturbances with increased deep tendon reflexes. Lower limb magnetic resonance imaging (MRI) was performed in four patients and all had fatty replacements. Of note, they all had similar fatty infiltrations between the proximal and distal lower limb muscles, different from the neuromuscular imaging feature in most CMT patients without SACS mutations who had distal dominant fatty involvement. Therefore, these findings were considered a characteristic feature in CMT patients with SACS mutations. Although further studies with more cases are needed, our results highlight lower extremity MRI findings in CMT patients with SACS mutations and broaden the clinical spectrum. We suggest screening for SACS in recessive CMT patients with complex phenotypes of ataxia and spasticity.
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- 2024
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3. Multi-millijoule terahertz emission from laser-wakefield-accelerated electrons
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Taegyu Pak, Mohammad Rezaei-Pandari, Sang Beom Kim, Geonwoo Lee, Dae Hee Wi, Calin Ioan Hojbota, Mohammad Mirzaie, Hyeongmun Kim, Jae Hee Sung, Seong Ku Lee, Chul Kang, and Ki-Yong Kim
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Applied optics. Photonics ,TA1501-1820 ,Optics. Light ,QC350-467 - Abstract
The electrons, accelerated by the laser ponderomotive force and subsequent plasma wakefields, radiate broadband emission continuously along the laser propagation direction, resulting in multi-mJ THz radiation in the far field.
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- 2023
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4. Stimulated triplet–triplet fusion by carrier trap-detrap mechanism in organic light-emitting diodes
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Kyung Hyung Lee, Jae Min Kim, Sook-Hee Jeong, Ji Ho Baek, Jeong Dae Seo, Inbum Song, Sang Beom Kim, Hyun Chul Choi, and Jun Yeob Lee
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Triplet-triplet fusion·external quantum efficiency· fluorescent OLEDs ,Computer engineering. Computer hardware ,TK7885-7895 - Abstract
Triplet–triplet fusion (TTF) has been an efficiency-enhancing mechanism in fluorescent organic light-emitting diodes (OLEDs) caused by the collision of two triplet excitons. However, achieving a high TTF ratio in fluorescent OLEDs has been difficult despite device strategies to maximize the triplet exciton density within a narrow recombination zone near the electron blocking layer (EBL) due to charge imbalance and hole accumulation between the TTF type emitter and EBL. Based on a trap-detrap mechanism, we were able to realize an improved TTF ratio and reduce hole accumulation by adding a TTF-assisting material (TTF-AM) in the TTF emitter. The TTF-AM served as the hole transport channel, triggering hole trap and detrap while improving the hole transport character of the emitting layer. Through the process of hole detrapping, the improved hole transport properties balanced carriers and generated more triplet excitons in order to activate the TTF mechanism from low to high current density ranges. By adjusting the TTF-AM, the TTF ratio of the anthracene-based emitter was increased from 5.5/20.1% to 13.4/25.5% (low/high current density), thereby resulting in more than doubled external quantum efficiency at low current density.
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- 2022
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5. Editorial: Application of ultrasound on peripheral neuromuscular disorders: From anatomy to clinic
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Ke-Vin Chang, Alexander Grimm, and Sang Beom Kim
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ultrasound ,sonography ,nerve ,muscle ,pain ,Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2023
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6. Phenotypic heterogeneity in patients with NEFL‐related Charcot–Marie–Tooth disease
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Hye Jin Kim, Sang Beom Kim, Hyun Su Kim, Hye Mi Kwon, Jae Hong Park, Ah Jin Lee, Si On Lim, Soo Hyun Nam, Young Bin Hong, Ki Wha Chung, and Byung‐Ok Choi
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Charcot–Marie–Tooth disease ,heterogeneity ,NEFL ,phenotype ,Genetics ,QH426-470 - Abstract
Abstract Charcot–Marie–Tooth disease (CMT) is the most common hereditary peripheral neuropathy. Mutations in the neurofilament light polypeptide (NEFL) gene produce diverse clinical phenotypes, including demyelinating (CMT1F), axonal (CMT2E), and intermediate (CMTDIG) neuropathies. From 2005 to 2020, 1,143 Korean CMT families underwent gene sequencing, and we investigated the clinical, genetic, and neuroimaging spectra of NEFL‐related CMT patients. Ten NEFL mutations in 17 families (1.49%) were identified, of which three (p.L312P, p.Y443N, and p.K467N) were novel. Eight de novo cases were identified at a rate of 0.47 based on a cosegregation analysis. The age of onset was ≤3 years in five cases (13.5%). The patients revealed additional features including delayed walking, ataxia, dysphagia, dysarthria, dementia, ptosis, waddling gait, tremor, hearing loss, and abnormal visual evoked potential. Signs of ataxia were found in 26 patients (70.3%). In leg MRI analyses, various degrees of intramuscular fat infiltration were found. All compartments were evenly affected in CMT1F patients. The anterior and anterolateral compartments were affected in CMT2E, and the posterior compartment was affected in CMTDIG. Thus, NEFL‐related CMT patients showed phenotypic heterogeneities. This study's clinical, genetic, and neuroimaging results could be helpful in the evaluation of novel NEFL variants and differential diagnosis against other CMT subtypes.
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- 2022
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7. Effects of Extracorporeal Shockwave Therapy on Improvements in Lymphedema, Quality of Life, and Fibrous Tissue in Breast Cancer-Related Lymphedema
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Kyeong Woo Lee, Sang Beom Kim, Jong Hwa Lee, and Young Sam Kim
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extracorporeal shockwave therapy ,breast cancer lymphedema ,fibrosis ,electric impedance ,Medicine - Abstract
Objective To evaluate the effects of extracorporeal shockwave therapy (ESWT) on improving lymphedema, quality of life, and fibrous tissue in patients with stage 2 lymphedema. Methods Breast cancer-related lymphedema patients referred to the rehabilitation center were recruited. We enrolled stage 2 lymphedema patients who had firmness of the skin at their forearm, a circumference difference of more than 2 cm between each arm, or a volume difference between upper extremities greater than 200 mL, confirmed by lymphoscintigraphy. The patients were randomly divided into the ESWT group and the control group. ESWT was performed for 3 weeks (two sessions per week); both groups received complex decongestive physical therapy. All patients were evaluated at baseline and at 3 weeks after treatment. The measurements performed included visual analog scale score, volume, circumference, QuickDASH (Quick Disabilities of the Arm, Shoulder and Hand) score, bioelectrical impedance, and skin thickness. Results The patients in both groups (n=15 in each group) completed the 3-week therapy experiment. No significant differences were observed in demographic characteristics between groups. After the 3-week treatment period, improvement was noted in the circumference difference below the elbow, volume, ratio of extracellular water to total body water, and skin thickness in the ESWT group. A significant difference was found in all the above-mentioned areas except in circumference below the elbow in the ESWT group. Conclusion ESWT reduced edema and skin fibrosis without significant complications. Therefore, ESWT can be used together with complex decongestive physical therapy for treating lymphedema.
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- 2020
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8. Genetic and clinical spectrums in Korean Charcot‐Marie‐Tooth disease patients with myelin protein zero mutations
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Hye Jin Kim, Soo Hyun Nam, Hye Mi Kwon, Si On Lim, Jae Hong Park, Hyun Su Kim, Sang Beom Kim, Kyung Suk Lee, Ji Eun Lee, Byung‐Ok Choi, and Ki Wha Chung
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Charcot‐Marie‐Tooth disease ,Korea ,MPZ ,phenotypic heterogeneity ,Genetics ,QH426-470 - Abstract
Abstract Background Charcot‐Marie‐Tooth disease (CMT) is the most common disorder of inherited peripheral neuropathies characterized by distal muscle weakness and sensory loss. CMT is usually classified into three types, demyelinating, axonal, and intermediate neuropathies. Mutations in myelin protein zero (MPZ) gene which encodes a transmembrane protein of the Schwann cells as a major component of peripheral myelin have been reported to cause various type of CMT. Methods This study screened MPZ mutations in Korean CMT patients (1,121 families) by whole exome sequencing and targeted sequencing. Results We identified 22 pathogenic or likely pathogenic MPZ mutations in 36 families as the underlying cause of the CMT1B, CMTDID, or CMT2I subtypes. Among them, five mutations were novel. The frequency of CMT patients with the MPZ mutations was similar or slightly lower compared to other ethnic groups. Conclusions We showed that the median onset ages and clinical phenotypes varied by subtypes: the most severe in the CMT1B group, and the mildest in the CMT2I group. This study also observed a clear correlation that earlier onsets cause more severe symptoms. We believe that this study will provide useful reference data for genetic and clinical information on CMT patients with MPZ mutations in Korea.
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- 2021
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9. Effect of Decreased Skeletal Muscle Index and Hand Grip Strength on Functional Recovery in Subacute Ambulatory Stroke Patients
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Jin Gee Park, Kyeong Woo Lee, Sang Beom Kim, Jong Hwa Lee, and Young Hwan Kim
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stroke ,subacute ,skeletal muscle index ,hand grip strength ,function ,Medicine - Abstract
Objective To investigate the effect of decreased Skeletal Muscle Index (SMI) and hand grip strength on functional recovery in subacute ambulatory stroke patients. Methods Subacute stroke patients who were referred to the rehabilitation center were recruited. Decreased SMI and hand grip strength were diagnosed according to the Asian Working Group on Sarcopenia. Diagnostic criteria were decreased SMI and decreased unaffected hand grip strength. SMI was measured by bioelectrical impedance analysis. Unaffected hand grip strength was measured with a hand dynamometer. Patients were divided into two groups, decreased group (DG) and not-decreased group (NDG), according to the presence of decreased SMI and hand grip strength. Both groups received conventional stroke rehabilitation for 3 weeks. All patients were evaluated at the baseline and at 3 weeks after treatment. Functional status was evaluated with 4-meter walk test (4MWT), 6-minute walk test (6MWT), Timed Up and Go test (TUG), and Modified Barthel Index (MBI). Results Both groups showed improvement in 4MWT, TUG, and MBI. NDG showed improvement in 6MWT. Comparing improvements between the two groups, NDG showed more improvement in 6MWT and TUG than DG. Conclusion The presence of decreased SMI and hand grip strength had negative effects on functional recovery in subacute ambulatory stroke patients.
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- 2019
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10. Effects of Neuromuscular Electrical Stimulation for Masseter Muscle on Oral Dysfunction After Stroke
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Kyeong Woo Lee, Sang Beom Kim, Jong Hwa Lee, Sook Joung Lee, Jin Gee Park, and Kyung Won Jang
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Stroke ,Post-stroke dysphagia ,Oral phase dysfunction ,Videofluoroscopy swallowing study ,Neuromuscular electrical stimulation ,NMES ,Masseter muscle ,Medicine - Abstract
Objective To determine positive effect of neuromuscular electrical stimulation (NMES) in conventional dysphagia therapy on masseter muscle oral dysfunction of patients after subacute stroke. Methods Among subacute stroke patients who were diagnosed as oropharyngeal dysphagia by videofluoroscopy swallowing study (VFSS), those with oral dysfunction were enrolled. They were randomly assigned to a study group or a control group. The study group received NMES on masseter muscle and suprahyoid muscle simultaneously, while the control group received NMES only on suprahyoid muscle. NMES therapy session as applied 30 minutes each time, two times per day for a total of 20 sessions. Both groups received conventional dysphagia therapy for 2 weeks. All enrolled patients were evaluated by VFSS after 2 weeks. Oropharyngeal swallowing function was evaluated by Penetration-Aspiration Scale, Functional Dysphagia Scale (FDS), and American Speech-Language-Hearing Association National Outcome Measurement System swallowing scale based on results of VFSS. Results Patients were randomly assigned to the study group (n=20) or the control group (n=20). There were no significant differences in baseline characteristics or initial values between the two groups. After 2 weeks of NMES, both groups showed improvement in scores of total FDS and pharyngeal phase FDS. Additionally, the study group showed improvement in oral phase FDS. Changes in all measurements were similar between the two groups. Conclusion In this preliminary study, NMES for masseter muscle has a therapeutic effect on oral dysfunction of patients after subacute stroke.
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- 2019
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11. Combined Therapy With Functional Electrical Stimulation and Standing Frame in Stroke Patients
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Joung Bok Lee, Sang Beom Kim, Kyeong Woo Lee, Jong Hwa Lee, Jin Gee Park, and Sook Joung Lee
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Stroke ,Standing frame ,Functional electrical stimulation ,Standing balance ,Rehabilitation ,Medicine - Abstract
Objective To investigate the effects of combination functional electrical stimulation (FES) and standing frame training on standing balance in stroke patients. Methods Patients who had hemiparesis and postural instability after stroke were randomly assigned to one of the two groups; study group underwent FES on the quadriceps and tibialis anterior muscle simultaneously with standing balance training. The control group received standing frame training and FES separately. Both the groups received their respective therapies for 3 weeks. Stability index in Biodex Balance master system, Berg Balance Scale (BBS), manual muscle test, the Korean version of Modified Barthel Index, and Korean version of Mini-Mental State Examination were used to evaluate the effects of the treatment. Results In total, 30 patients were recruited to the study group and 30 to the control group. Three weeks after treatment, both the groups showed improvement in postural stability scores and physical and cognitive functions. When changes in postural stability were compared between the groups, the study group showed more significant improvement than the control group with regards to the scores of BBS and the stability indices. Conclusion In this study, we found the therapeutic effectiveness of combined therapy of FES and standing frame in subacute stroke patients. The presented protocol is proposed as time-saving and can be applied easily in the clinical setting. Thus, the proposed combined therapy could be a useful method for improving standing balance in subacute stroke patients.
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- 2019
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12. Peripheral Myelin Protein 22 Gene Mutations in Charcot-Marie-Tooth Disease Type 1E Patients
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Na Young Jung, Hye Mi Kwon, Da Eun Nam, Nasrin Tamanna, Ah Jin Lee, Sang Beom Kim, Byung-Ok Choi, and Ki Wha Chung
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Charcot-Marie-Tooth disease type 1E (CMT1E) ,Korean ,PMP22 ,point mutation ,whole-exome sequencing ,Genetics ,QH426-470 - Abstract
Duplication and deletion of the peripheral myelin protein 22 (PMP22) gene cause Charcot-Marie-Tooth disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP), respectively, while point mutations or small insertions and deletions (indels) usually cause CMT type 1E (CMT1E) or HNPP. This study was performed to identify PMP22 mutations and to analyze the genotype–phenotype correlation in Korean CMT families. By the application of whole-exome sequencing (WES) and targeted gene panel sequencing (TS), we identified 14 pathogenic or likely pathogenic PMP22 mutations in 21 families out of 850 CMT families who were negative for 17p12 (PMP22) duplication. Most mutations were located in the well-conserved transmembrane domains. Of these, eight mutations were not reported in other populations. High frequencies of de novo mutations were observed, and the mutation sites of c.68C>G and c.215C>T were suggested as the mutational hotspots. Affected individuals showed an early onset-severe phenotype and late onset-mild phenotype, and more than 40% of the CMT1E patients showed hearing loss. Physical and electrophysiological symptoms of the CMT1E patients were more severely damaged than those of CMT1A while similar to CMT1B caused by MPZ mutations. Our results will be useful for the reference data of Korean CMT1E and the molecular diagnosis of CMT1 with or without hearing loss.
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- 2022
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13. Effect of Combined Therapy of Robot and Low-Frequency Repetitive Transcranial Magnetic Stimulation on Hemispatial Neglect in Stroke Patients
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Sang Beom Kim, Kyeong Woo Lee, Jong Hwa Lee, Sook Joung Lee, Jin Gee Park, and Joung Bok Lee
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Stroke ,Perceptual disorders ,Rehabilitation ,Robotics ,Transcranial magnetic stimulation ,Medicine - Abstract
Objective To investigate the effect of upper limb rehabilitation combining robot with low-frequency repetitive transcranial magnetic stimulation (rTMS) on unilateral spatial neglect in stroke patients. Methods Patients who had hemispatial neglect after right hemisphere stroke were randomly divided into rTMS only group, robot only group, and combined group. All groups received conventional neglect therapy and additional treatment for each group. rTMS group received rTMS therapy. Robot group received robot therapy, while combined group received both therapies. The effect of therapy was assessed with Motor-Free Visual Perception Test-3 (MVPT-3), line bisection test, star cancellation test, Catherine Bergego Scale (CBS), Mini-Mental State Examination (MMSE), and the Korean version of Modified Barthel Index (K-MBI). These measurements were evaluated before and after treatment. Results For each group, 10 patients were recruited. There were no significant differences in baseline characteristics or initial values among the three groups. Two weeks after the therapy, all groups showed significant improvement in MVPT-3, line bisection test, star cancellation test, CBS, MMSE, and K-MBI. However, changes in measurements showed no significant differences among groups. Conclusion Treatment effect of the combined therapy of robotic therapy and low-frequency rTMS therapy for hemispatial neglect was not statistically different from that of each single treatment. Results of this study did not prove the superiority of any of the three treatments. Further study with large number of patients is needed to evaluate the superiority of these treatments.
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- 2018
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14. Effects of mechanical inspiration and expiration exercise on velopharyngeal incompetence in subacute stroke patients
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Kyung Won Jang, Sook Joung Lee, Sang Beom Kim, Kyeong Woo Lee, Jong Hwa Lee, and Jin Gee Park
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stroke ,velopharyngeal incompetence ,mechanical inspiration and expiration exercise ,videofluoroscopic swallowing study ,deglutition disorders. ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Objective: To investigate the therapeutic effects of mechanical inspiration and expiration exercise using mechanical cough assist on velopharyngeal incompetence in patients with subacute stroke. Design: Pilot, randomized controlled study. Setting: University-based rehabilitation centre. Subjects: Thirty-six patients with subacute stroke diagnosed with velopharyngeal incompetence by videofluoroscopic swallowing study. Methods: Subjects were randomly assigned to 2 groups. The study group received conventional dysphagia therapy and additional mechanical inspiration and expiration exercise. The control group received conventional dysphagia therapy only. Swallowing function was evaluated according to the American Speech-Language-Hearing association scale, functional dysphagia score, and the penetration aspiration scale, based on the videofluoroscopic swallowing study. Coughing function was measured using peak cough flow. Results: Eighteen patients in each group completed the protocol and were analysed. After treatment, the study group showed significant improvement in functional dysphagia score with regard to nasal penetration degree. Comparing the treatment effect between the 2 groups, nasal penetration degree and peak cough flow showed greater improvement in the study group. Conclusion: Mechanical inspiration and expiration exercise had a therapeutic effect on velopharyngeal incompetence in subacute stroke patients with dysphagia. This therapy is easy to provide clinically and could be a useful therapeutic strategy for velo-pharyngeal incompetence with dysphagia in patients with stroke.
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- 2018
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15. Editorial: Use of Ultrasound in Diagnosis and Treatment of Peripheral Nerve Entrapment Syndrome
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Ke-Vin Chang and Sang Beom Kim
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ultrasound ,peripheral nerve ,entrapment syndrome ,neuropathic pain syndromes ,diagnosis and treatment ,Neurology. Diseases of the nervous system ,RC346-429 - Published
- 2020
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16. Effects of Hand Training During the Aftereffect Period of Low-Frequency rTMS in Subacute Stroke Patients
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Joo Won Park, Sang Beom Kim, Kyeong Woo Lee, Jong Hwa Lee, Jin Gee Park, and Sook Joung Lee
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Transcranial magnetic stimulation ,Stroke ,Functional recovery ,Aftereffect ,Medicine - Abstract
Objective To investigate the effects of hand training using low-frequency repetitive transcranial magnetic stimulation (rTMS) within the aftereffect period on hand function in patients with subacute stroke. Methods The subacute stroke patients with hand weaknesses were divided randomly into two groups. Patients in the intervention group underwent hand training within the aftereffect period, that is, immediately after receiving low-frequency rTMS treatment. Patients in the control group underwent hand training 2 hours after the low-frequency rTMS treatment. A manual function test (MFT) for ‘grasp and pinch’ and ‘hand activities’; a manual muscle test (MMT) for ‘grasp’, ‘release’, and ‘abductor pollicis brevis (APB)’; and the Modified Ashworth Scale for finger flexion were performed and measured before and immediately after combined therapy as well as 2 weeks after combined therapy. Results Thirty-two patients with hand weakness were enrolled in this study. The intervention group patients showed more improvements in grasp MMT and MMT APB tested immediately after combined therapy. However, the changes in all measurements were not significantly different between the two groups 2 weeks after the combined therapy. In both groups, hand functions improved significantly immediately after combined therapy and 2 weeks after combined therapy. Conclusion Hand training immediately after low-frequency rTMS showed more rapid improvement in the motor power of hands than hand training conducted 2 hours after low-frequency rTMS. Our results suggest that conducting hand training immediately after low-frequency rTMS could be an improved useful therapeutic option in subacute stroke patients.
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- 2018
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17. Effect of Caregiver Driven Robot-Assisted In-Ward Training in Subacute Stroke Patients: A Case Series
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Sang Beom Kim, Kyeong Woo Lee, Jong Hwa Lee, Sook Joung Lee, Jin Gee Park, and Joo Won Park
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Stroke rehabilitation ,Stroke ,Robot ,Medicine - Abstract
ObjectiveTo evaluate the effect of caregiver driven robot-assisted in-ward training in subacute stroke patients.MethodsA retrospective evaluation was performed for patients treated with caregiver driven robot-assisted in-ward training to retain gait function from June 2014 and December 2016. All patients received more than 2 weeks of caregiver driven robot-assisted in-ward training after undergoing conventional programs. The robot was used as a sitting device, a standing frame, or a high-walker depending on functional status of the patient. Patients were evaluated before and after robot training. Patient records were assessed by Korean version of Modified Barthel Index (K-MBI), Functional Independence Measure (FIM), and Functional Ambulation Category (FAC).ResultsInitially, patients used the robot as a sitting device (n=6), a standing frame (n=7), or a partial body-weight support high-walker (n=2). As patient functions were improved, usage level of the robot was changed to the next level. At the end of the treatment, the robot was used as a sitting device (n=1), a standing frame (n=6), or high-walker (n=8). Scores of K-MBI (Δ17.47±10.72) and FIM (Δ19.80±12.34) were improved in all patients.ConclusionPatients' usage level of the robot and functional scores were improved. Therefore, performing additional caregiver driven robot-assisted in-ward training is feasible and beneficial for subacute stroke patients.
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- 2018
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18. Usefulness of Early Videofluoroscopic Swallowing Study in Acute Stroke Patients With Dysphagia
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Sang Beom Kim, Sook Joung Lee, Kyeong Woo Lee, Jong Hwa Lee, and Dong Won Kim
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Acute stroke ,Dysphagia ,Early videofluoroscopic swallowing study ,Diet modification ,Medicine - Abstract
ObjectiveTo demonstrate the usefulness of early videofluoroscopic swallowing study (VFSS) and to investigate change patterns in dietary methods in stroke patients with dysphagia.MethodsThe VFSS was performed within 7 days of stroke onset in neurologically stable patients. The patients were divided into three groups according to type of brain lesion: cortical lesion (CL), subcortical lesion (SCL), and brainstem/cerebellar lesion (BCL). Based on the VFSS results, this study investigated change patterns in feeding method and discrepancies in the aspiration risk predicted by the Water Swallowing Test (WST) and the VFSS. Complications, such as aspiration pneumonia, were also evaluated.ResultsA total of 163 patients met the inclusion criteria and the VFSS was performed within 7 days of stroke. Patients considered at risk for aspiration (Penetration-Aspiration Scale [PAS] scores of 6 to 8) were found in all three groups using the VFSS (47.5% of the CL group, 59.3% of the SCL group, and 47.9% of the BCL group). After early VFSS, 79.7% of the patients were assessed to require restricted feeding methods. A 19.0% discrepancy was found between the WST and VFSS results. At 3-week follow-up after the VFSS, aspiration pneumonia was observed in 12 patients (7.4%) with restricted feeding methods.ConclusionEarly VFSS during the acute period can facilitate determination of the most appropriate feeding method, and support effective dysphagia management for stroke patients.
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- 2018
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19. Clinical and Neuroimaging Features in Charcot–Marie–Tooth Patients with GNB4 Mutations
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Hye Mi Kwon, Hyun Su Kim, Sang Beom Kim, Jae Hong Park, Da Eun Nam, Ah Jin Lee, Soo Hyun Nam, Soohyun Hwang, Ki Wha Chung, and Byung-Ok Choi
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Charcot–Marie–Tooth disease ,CMTDIF ,GNB4 ,peripheral neuropathy ,neuroimaging ,Science - Abstract
Charcot–Marie–Tooth disease (CMT) is the most common inherited peripheral neuropathy. Mutations in the GNB4 gene cause dominant intermediate CMT type F (CMTDIF). The aim of this study is to investigate phenotypic heterogeneities and characteristics of CMT patients with GNB4 mutations. We enrolled 1143 Korean CMT families and excluded 344 families with a PMP22 duplication. We further analyzed the 799 remaining families to find their GNB4 mutations using whole-exome sequencing (WES). We identified two mutations (p.Gly77Arg and p.Lys89Glu) in three families, among which a heterozygous p.Gly77Arg mutation was novel. In addition, a significant uncertain variant (p.Thr177Asn) was observed in one family. The frequency of the GNB4 mutation in the Korean population is 0.38% in PMP22 duplication-negative families. All three families showed de novo mutation. Electrophysiological findings regarding the p.Lys89Glu mutation showed that the motor nerve conduction velocity (MNCV) of the median nerve was markedly reduced, indicating demyelinating neuropathy, and sural nerve biopsy revealed severe loss of myelinated axons with onion bulb formation. Lower extremity Magnetic Resonance Imaging (MRI) demonstrated relatively more severe intramuscular fat infiltrations in demyelinating type (p.Lys89Glu mutation) patients compared to intermediate type (p.Gly77Arg mutation) patients. The anterolateral and superficial posterior compartment muscles of the distal calf were preferentially affected in demyelinating type patients. Therefore, it seems that the investigated GNB4 mutations do cause not only the known intermediate type but also demyelinating-type neuropathy. We first presented three Korean families with GNB4 mutations and found phenotypic heterogeneities of both intermediate and demyelinating neuropathy. We suggest that those findings are useful for the differential diagnosis of CMT patients with unknown GNB4 variants.
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- 2021
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20. Effects of disulfide bridges and backbone connectivity on water sorption by protein matrices
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Sang Beom Kim, Rakesh S. Singh, Prem K. C. Paul, and Pablo G. Debenedetti
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Medicine ,Science - Abstract
Abstract Understanding the water sorption behavior of protein powders is important in applications such as the preservation of protein-based pharmaceuticals. Most globular proteins exhibit a characteristic sigmoidal water adsorption isotherm at ambient conditions. However, it is not well understood how water sorption behavior is influenced by intrinsic factors that are related to structural properties of proteins. We investigate computationally how structural constraints on proteins influence the water sorption isotherms of amorphous protein powders. Specifically, we study the effects of non-local disulfide linkages and backbone connectivity using pheromone ER-23 and lysozyme as model proteins. We find that non-local disulfide linkages can significantly restrict structural changes during hydration and dehydration, and this in turn greatly reduces the extent of hysteresis between the adsorption and desorption branches. Upon removing the backbone connectivity by breaking all peptide bonds in lysozyme, we find that the hysteresis shifts towards the lower humidity regime, and the water uptake capacity is significantly enhanced. We attribute these changes to the higher aggregation propensity of the constraint-free amino acids in dehydrated condition, and the formation of a spanning water network at high hydration levels.
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- 2017
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21. Prognostic factors for tracheostomy early decannulation in acquired brain injury patients.
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Jong Hwa Lee, Sang Beom Kim, Kyeong Woo Lee, and Soo Hwan Kim
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- 2024
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22. Prosthetic treatment combined with speech therapy improved pronunciation problems caused by palatal incompetence: A case report.
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Sang-Beom Kim, Cheong-Hee Lee, Kim, Sang-Beom, and Lee, Cheong-Hee
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SPEECH therapy ,VELOPHARYNGEAL insufficiency ,VOICE disorders ,PALATE tumors ,QUALITY of life - Abstract
This is a case report of a patient with soft palate muscle weakness that caused difficulties with phonation. A provisional palatal lift prosthesis (PLP) was developed, and the patient underwent simultaneous speech therapy. The elevation level of the palatal lift was subjectively assessed along with nasalance analysis and the Urimal Test of Articulation and Phonation results. The final PLP was applied to improve comfort and efficiency, and the patient continually underwent regular speech therapy. The patient showed satisfactory improvement in speech and pronunciation. PLP development combined with speech therapy can improve the accuracy of pronunciation in patients with palatal incompetence, thereby improving quality of life. [ABSTRACT FROM AUTHOR]
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- 2021
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23. Magnetic shielding performance of thin metal sheets near power cables
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Sang-Beom Kim, Joon-Young Soh, Koo-Yong Shin, Jin-Hye Jeong, and Sung-Ho Myung
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Eddy currents (Electric) -- Measurement ,Electrical cables -- Magnetic properties ,Electrical cables -- Electric properties ,Magnetic fields -- Analysis ,Magnetic shielding -- Analysis ,Business ,Electronics ,Electronics and electrical industries - Published
- 2010
24. Systematic characterization of protein folding pathways using diffusion maps: Application to Trp-cage miniprotein.
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Sang Beom Kim, Dsilva, Carmeline J., Kevrekidis, Ioannis G., and Debenedetti, Pablo G.
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MOLECULAR dynamics , *PROTEIN folding , *MOLECULAR structure , *AMINO acids , *DIFFUSION , *STANDARD deviations - Abstract
Understanding the mechanisms by which proteins fold from disordered amino-acid chains to spatially ordered structures remains an area of active inquiry. Molecular simulations can provide atomistic details of the folding dynamics which complement experimental findings. Conventional order parameters, such as root-mean-square deviation and radius of gyration, provide structural information but fail to capture the underlying dynamics of the protein folding process. It is therefore advantageous to adopt a method that can systematically analyze simulation data to extract relevant structural as well as dynamical information. The nonlinear dimensionality reduction technique known as diffusion maps automatically embeds the high-dimensional folding trajectories in a lower-dimensional space from which one can more easily visualize folding pathways, assuming the data lie approximately on a lower-dimensional manifold. The eigenvectors that parametrize the low-dimensional space, furthermore, are determined systematically, rather than chosen heuristically, as is done with phenomenological order parameters. We demonstrate that diffusion maps can effectively characterize the folding process of a Trp-cage miniprotein. By embedding molecular dynamics simulation trajectories of Trp-cage folding in diffusion maps space, we identify two folding pathways and intermediate structures that are consistent with the previous studies, demonstrating that this technique can be employed as an effective way of analyzing and constructing protein folding pathways from molecular simulations. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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25. Short hairpin RNA treatment improves gait in a mouse model of Charcot‑Marie‑Tooth disease type 1A.
- Author
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HYUN MYUNG DOO, YOUNG BIN HONG, JIYOU HAN, HYO WON MOON, HYUN HWANG, GEON KWAK, SOO HYUN NAM, SANG BEOM KIM, KI WHA CHUNG, JONG HYUN KIM, and BYUNG‑OK CHOI
- Subjects
CHARCOT-Marie-Tooth disease ,RECTUS femoris muscles ,MUSCLE regeneration ,PERIPHERAL nervous system ,HAIRPIN (Genetics) ,HINDLIMB - Abstract
Charcot‑Marie‑Tooth disease (CMT) is the most common inherited neurological disorder of the peripheral nervous system. The major subtype, CMT type 1A (CMT1A), accounts for ~40% of CMT cases and is characterized by distal muscle atrophy and gait disturbances. Short hairpin (sh) RNA sequences are potentially advantageous therapeutic tools for distal muscle atrophy‑induced gait disturbance. Therefore, the current study focused on the effects of an optimal shRNA injection using the myostatin (mstn) gene inhibition system. shLenti‑Mstn A demonstrated significant suppression of endogenous mstn gene expression (>40%) via RT‑qPCR following direct injection into the gastrocnemius and rectus femoris of the hind limb in C22 mice. The results also reported that shLenti‑Mstn A treatment increased muscle mass and size of the hind limbs compared with mock‑treated mice via measurement of the mass of injected muscles and magnetic resonance imaging study. Furthermore, electrophysiological measurement using a Nicolet Viking Quest device revealed significantly improved compound muscle action potential (CMAP) in shLenti‑Mstn A‑treated mice compared with the mock group (P<0.05) whereas nerve conduction velocity (NCV) showed no difference between groups. The shLenti‑Mstn A treatment directly affected increased muscle regeneration, including mass and size, but not regeneration of peripheral nerve. Additionally, shLenti‑Mstn A treatment significantly enhanced mobility, including locomotor coordination (P<0.01) and grip strength of the hindlimbs (P<0.01). Furthermore, MotoRater analysis using real‑time recording with a high‑speed camera revealed that shLenti‑Mstn‑treated mice exhibited an improved walking pattern in terms of step length, base support and duty factor compared with the mock group. It was hypothesized that treatment with shLenti‑Mstn A may provide a novel therapeutic strategy for improving gait in patients with CMT1A. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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26. EFFECTS OF MECHANICAL INSPIRATION AND EXPIRATION EXERCISE ON VELOPHARYNGEAL INCOMPETENCE IN SUBACUTE STROKE PATIENTS.
- Author
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Kyung Won JANG, Sook Joung LEE, Sang Beom KIM, Kyeong Woo LEE, Jong Hwa LEE, and Jin Gee PARK
- Published
- 2019
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27. Relationship between adverse events and antiplatelet drug resistance in neurovascular intervention: a meta-analysis.
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Eun Jung Shim, Chang-Woo Ryu, Soonchan Park, Han Na Lee, Hee Sup Shin, and Sang-Beom Kim
- Subjects
THROMBOEMBOLISM risk factors ,PLATELET aggregation inhibitors ,ANEURYSM surgery ,CONFIDENCE intervals ,DRUG resistance ,HEMORRHAGE ,META-analysis ,NEUROSURGERY ,SURGICAL stents ,SURGICAL complications ,SYSTEMATIC reviews ,DISEASE prevalence ,ODDS ratio ,THERAPEUTICS - Abstract
Background This meta-analysis aimed to evaluate the association between antiplatelet resistance and the risk of procedure-related complications in neurovascular interventions. Methods We identified relevant articles by searching electronic databases and reviewed the reference lists of selected papers. The risk of adverse events between antiplatelet responders and hyporesponders during neurointervention was compared in eligible clinical studies. risk ratios (RRs) and 95% cis were pooled using a random-effects meta-analysis. Results Of 2134 potentially relevant studies, our search identified 15 studies enrolling a total of 2365 patients. Pooled rrs showed thromboembolic events (TEE) were more frequent in hyporesponders (RR 2.634, 95% CI 1.465 to 4.734). however, hemorrhagic complications did not differ between the two groups (RR 1.236, 95% CI 0.642 to 2.380). in subgroup analysis, hyporesponders showed a higher prevalence of TEE with standard antiplatelet medication, but there was no obvious difference in TEE between the two arms when using a modified antiplatelet medication (RR 3.645, 95% CI 1.537 to 8.646; and RR 1.877, 95% CI 0.749 to 4.751). studies using stent placement for aneurysms showed a higher TEE rate in hyporesponders (RR 3.221, 95% CI 1.899 to 5.464). Conclusion antiplatelet resistance was significantly associated with TEE in neurointervention, and this adverse event was associated with individually-intensified antiplatelet medication as well as the type of neurointerventional procedure. Our findings support the use of antiplatelet resistance assays and tailored antiplatelet medications in neurovascular stent placement as a management strategy to reduce thromboembolic risk. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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28. Effect of Robot-Assisted Game Training on Upper Extremity Function in Stroke Patients.
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Kyeong Woo Lee, Sang Beom Kim, Jong Hwa Lee, Sook Joung Lee, and Jin Wan Kim
- Subjects
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STROKE rehabilitation , *MEDICAL function tests , *APPLIED kinesiology , *MEDICAL robotics , *MOTOR ability - Abstract
Objective To determine the effects of combining robot-assisted game training with conventional upper extremity rehabilitation training (RCT) on motor and daily functions in comparison with conventional upper extremity rehabilitation training (OCT) in stroke patients. Methods Subjects were eligible if they were able to perform the robot-assisted game training and were divided randomly into a RCT and an OCT group. The RCT group performed one daily session of 30 minutes of robotassisted game training with a rehabilitation robot, plus one daily session of 30 minutes of conventional rehabilitation training, 5 days a week for 2 weeks. The OCT group performed two daily sessions of 30 minutes of conventional rehabilitation training. The effects of training were measured by a Manual Function Test (MFT), Manual Muscle Test (MMT), Korean version of the Modified Barthel Index (K-MBI) and a questionnaire about satisfaction with training. These measurements were taken before and after the 2-week training. Results Both groups contained 25 subjects. After training, both groups showed significant improvements in motor and daily functions measured by MFT, MMT, and K-MBI compared to the baseline. Both groups demonstrated similar training effects, except motor power of wrist flexion. Patients in the RCT group were more satisfied than those in the OCT group. Conclusion There were no significant differences in changes in most of the motor and daily functions between the two types of training. However, patients in the RCT group were more satisfied than those in the OCT group. Therefore, RCT could be a useful upper extremity rehabilitation training method. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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29. Effect of Upper Extremity Robot-Assisted Exercise on Spasticity in Stroke Patients.
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Kyeong Woo Lee, Sang Beom Kim, Jong Hwa Lee, Sook Joung Lee, and Seung Wan Yoo
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MEDICAL robotics , *STROKE patients , *SPASTICITY , *REHABILITATION , *OCCUPATIONAL therapy , *MEDICAL care - Abstract
Objective To determine the efficacy of a stretching and strengthening exercise program using an upper extremity robot, as compared with a conventional occupational therapy program for upper extremity spasticity in stroke patients. Methods Subjects were randomly divided into a robot-assisted therapy (RT) group and a conventional rehabilitation therapy (CT) group. RT group patients received RT and CT once daily for 30 minutes each, 5 days a week, for 2 weeks. RT was performed using an upper-extremity robot (Neuro-X; Apsun Inc., Seoul, Korea), and CT was administered by occupational therapists. CT group patients received CT alone twice daily for 30 minutes, 5 days a week, for 2 weeks. Modified Ashworth Scale (MAS) was used to measure the spasticity of upper extremity. Manual muscle tests (MMT), Manual Function Tests (MFT), Brunnstrom stage, and the Korean version of Modified Barthel Index (K-MBI) were used to measure the strength and function of upper extremity. All measurements were obtained before and after 2-week treatment. Results The RT and CT groups included 22 subjects each. After treatment, both groups showed significantly lower MAS scores and significant improvement in the MMT, MFT, Brunnstrom stage, and K-MBI scores. Treatment effects showed no significant differences between the two groups. Conclusion RT showed similar treatment benefits on spasticity, as compared to CT. The study results suggested that RT could be a useful method for continuous, repeatable, and relatively accurate range of motion exercise in stroke patients with spasticity. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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30. The Effect of an Upper Limb Rehabilitation Robot on Hemispatial Neglect in Stroke Patients.
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Yoon Sik Choi, Kyeong Woo Lee, Jong Hwa Lee, Sang Beom Kim, Gyu Tae Park, and Sook Joung Lee
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PERCEPTUAL disorders ,ROBOTICS ,STROKE ,ARM ,RANGE of motion of joints ,EXERCISE ,THERAPEUTICS - Abstract
Objective To investigate the effectiveness of an upper limb rehabilitation robot therapy on hemispatial neglect in stroke patients. Methods Patients were randomly divided into an upper limb rehabilitation robot treatment group (robot group) and a control group. The patients in the robot group received left upper limb training using an upper limb rehabilitation robot. The patients sat on the right side of the robot, so that the monitor of the robot was located on the patients' left side. In this position, patients could focus continuously on the left side. The control group received conventional neglect treatment, such as visual scanning training and range of motion exercises, administered by occupational therapists. Both groups received their respective therapies for 30 minutes a day, 5 days a week for 3 weeks. Several tests were used to evaluate treatment effects before and after the 3-week treatment. Results In total, 38 patients (20 in the robot group and 18 in the control group) completed the study. After completion of the treatment sessions, both groups showed significant improvements in the Motor-Free Visual Perception Test 3rd edition (MVPT-3), the line bisection test, the star cancellation test, the Albert's test, the Catherine Bergego scale, the Mini-Mental State Examination and the Korean version of Modified Barthel Index. The changes in all measurements showed no significant differences between the two groups. Conclusion This present study showed that the upper limb robot treatment had benefits for hemispatial neglect in stroke patients that were similar to conventional neglect treatment. The upper limb robot treatment could be a therapeutic option in the treatment of hemispatial neglect after stroke. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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31. Recessive optic atrophy, sensorimotor neuropathy and cataract associated with novel compound heterozygous mutations in OPA1.
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JINHO LEE, SUNG-CHUL JUNG, YOUNG BIN HONG, JEONG HYUN YOO, HEASOO KOO, JA HYUN LEE, HYUN DAE HONG, SANG-BEOM KIM, KI WHA CHUNG, and BYUNG-OK CHO
- Subjects
LEBER'S hereditary optic atrophy ,NEUROPATHY ,CATARACT ,GENETIC mutation ,PATHOLOGY ,ELECTROPHYSIOLOGY - Abstract
Mutations in the optic atrophy 1 gene (OPA1) are associated with autosomal dominant optic atrophy and 20% of patients demonstrate extra-ocular manifestations. In addition to these autosomal dominant cases, only a few syndromic cases have been reported thus far with compound heterozygous OPA1 mutations, suggestive of either recessive or semi-dominant patterns of inheritance. The majority of these patients were diagnosed with Behr syndrome, characterized by optic atrophy, ataxia and peripheral neuropathy. The present study describes a 10-year-old boy with Behr syndrome presenting with early-onset severe optic atrophy, sensorimotor neuropathy, ataxia and congenital cataracts. He had optic atrophy and was declared legally blind at six years old. Electrophysiological, radiological, and histopathological findings were compatible with axonal sensorimotor polyneuropathy. At birth, he presented with a congenital cataract, which has not been previously described in patients with OPA1 mutations. Whole exome sequencing indicated a pair of novel compound heterozygous mutations: p.L620fs*13 (c.1857-1858delinsT) and p.R905Q (c.G2714A). Neither mutation was observed in controls (n=300), and thus, they were predicted to be pathogenic by multiple in silico analyses. The mutation sites were highly conserved throughout different vertebrate species. The patients parents did not have any ophthalmic or neurologic symptoms and the results of electrophysiological studies were normal, suggestive of an autosomal recessive pattern of inheritance. The present study identified novel compound heterozygous OPA1 mutations in a patient with recessive optic atrophy, sensorimotor neuropathy and congenital cataracts, indicating an expansion of the clinical spectrum of pathologies associated with OPA1 mutations. Thus, OPA1 gene screening is advisable in the workup of patients with recessive optic atrophy, particularly with Behr syndrome and cataracts. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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32. The Functional Dysphagia Scale Is a Useful Tool for Predicting Aspiration Pneumonia in Patients With Parkinson Disease.
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Jong Hwa Lee, Kyeong Woo Lee, Sang Beom Kim, Sook Joung Lee, Sang Myung Chun, and Sung Moon Jung
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DEGLUTITION disorders ,ASPIRATION pneumonia ,FUNCTIONAL assessment of Parkinson's disease patients ,FLUOROSCOPY ,MINI-Mental State Examination ,DIAGNOSIS - Abstract
Objective To describe the correlation between the functional dysphagia scale and aspiration pneumonia and which characteristics influence the occurrence of aspiration pneumonia in patients with idiopathic Parkinson disease. Methods Fifty-three patients with idiopathic Parkinson disease were prospectively evaluated in this study. Disease severity and functional status were measured by modified Hoehn and Yahr (H&Y) staging, Schwab and England activities of daily living (S-E ADL) scale and Korean version of Mini-Mental State Examination (K-MMSE). Swallowing function was evaluated by the functional dysphagia scale (FDS) and the penetration-aspiration scale (PAS) based on a videofluoroscopic swallowing study. The patients were followed up for 3 months and divided into two groups according to the occurrence of aspiration pneumonia. The correlation between the variables and aspiration pneumonia was analyzed. Results Eight patients of the 53 patients were allocated to the aspiration pneumonia group and 45 patients to the non-aspiration pneumonia group. The patients in the aspiration pneumonia group had significantly higher H&Y staging, and scored lower on S-E ADL scale and K-MMSE. The patients in the aspiration pneumonia group had significantly higher scores on FDS and PAS. A multiple logistic regression analysis showed that the S-E ADL scale and the FDS were associated with the occurrence of aspiration pneumonia in the patients with Parkinson disease. Conclusion Given that the FDS can quantitatively assess the functional problems associated with dysphagia, it can be clinically effective in predicting the occurrence of aspiration pneumonia, and the FDS and the S-E ADL scale could be predictive variables for aspiration pneumonia in patients with Parkinson disease. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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33. A novel homozygous MPV17 mutation in two families with axonal sensorimotor polyneuropathy.
- Author
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Yu-Ri Choi, Young Bin Hong, Sung-Chul Jung, Ja Hyun Lee, Ye Jin Kim, Hyung Jun Park, Jinho Lee, Heasoo Koo, Ji-Su Lee, Dong Hwan Jwa, Namhee Jung, So-Youn Woo, Sang-Beom Kim, Ki Wha Chung, Byung-Ok Choi, Choi, Yu-Ri, Hong, Young Bin, Jung, Sung-Chul, Lee, Ja Hyun, and Kim, Ye Jin
- Subjects
PERIPHERAL neuropathy ,SENSORIMOTOR cortex ,GENETIC mutation ,MITOCHONDRIAL DNA depletion syndromes ,NEURONS ,NUCLEOTIDE sequencing ,GENETIC testing - Abstract
Background: Mutations in MPV17 cause the autosomal recessive disorder mitochondrial DNA depletion syndrome 6 (MTDPS6), also called Navajo neurohepatopathy (NNH). Clinical features of MTDPS6 is infantile onset of progressive liver failure with seldom development of progressive neurologic involvement.Methods: Whole exome sequencing (WES) was performed to isolate the causative gene of two unrelated neuropathy patients (9 and 13 years of age) with onset of the syndrome. Clinical assessments and biochemical analysis were performed.Results: A novel homozygous mutation (p.R41Q) in MPV17 was found by WES in both patients. Both showed axonal sensorimotor polyneuropathy without liver and brain involvement, which is neurophysiologically similar to axonal Charcot-Marie-Tooth disease (CMT). A distal sural nerve biopsy showed an almost complete loss of the large and medium-sized myelinated fibers compatible with axonal neuropathy. An in vitro assay using mouse motor neuronal cells demonstrated that the abrogation of MPV17 significantly affected cell integrity. In addition, the expression of the mutant protein affected cell proliferation. These results imply that both the loss of normal function of MPV17 and the gain of detrimental effects of the mutant protein might affect neuronal function.Conclusion: We report a novel homozygous mutation in MPV17 from two unrelated patients harboring axonal sensorimotor polyneuropathy without hepatoencephalopathy. This report expands the clinical spectrum of diseases caused by mutations of MPV17, and we recommend MPV17 gene screening for axonal peripheral neuropathies. [ABSTRACT FROM AUTHOR]- Published
- 2015
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34. Voluntary Cough and Swallowing Function Characteristics of Acute Stroke Patients Based on Lesion Type.
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Sook Joung Lee, Kyeong Woo Lee, Sang Beom Kim, Jong Hwa Lee, and Min Kyu Park
- Abstract
Objective: To investigate the relation between voluntary cough and swallowing functions according to the type of lesion in patients with acute stroke. Design: Cross-sectional study. Setting: University rehabilitation hospital. Participants: Acute stroke patients with dysphagia symptoms (N = 397). Interventions: Not applicable. Main Outcome Measures: A peak cough flow meter was used to measure voluntary coughing ability. Swallowing function was evaluated using the functional dysphagia scale and the penetration-aspiration scale based on the results of a videofluoroscopic swallowing study. Stroke lesions were divided into one of the following 3 categories: cortical, subcortical, and brainstem. These evaluations were performed within 2 weeks after stroke onset. Results: Of the enrolled 397 patients. 207 patients were classified as cortical stroke. 106 patients were classified as subcortical stroke, and 84 patients were classified as brainstem stroke. Among the subscores of the functional dysphagia scale, the amount of pharyngeal residue negatively correlated with peak cough flow meter results across all stroke lesion types. In the brainstem lesion, peak cough flow and penetration-aspiration scale scores were high compared with other lesions, but these 2 functions did not show a correlation. Conclusions: This study revealed that large amounts of pharyngeal residue correlated with weak voluntary cough ability in all stroke lesion groups. We also showed a discrepancy between 2 functions in the brainstem lesion group. Our results suggest that voluntary coughing exercises could be a helpful therapeutic option for dysphagia to prevent pulmonary complications in some types of patients with stroke. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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35. A Survey of Caregivers' Knowledge About Caring for Stroke Patients.
- Author
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Kyeong Woo Lee, Su Jin Choi, Sang Beom Kim, Jong Hwa Lee, and Sook Joung Lee
- Subjects
STROKE treatment ,CAREGIVERS ,HEALTH care teams ,HOSPITAL care ,MEDICAL rehabilitation - Abstract
Objective: To investigate how much formal caregivers know about caring for stroke patients, and whether they adequately provide it. Methods: Formal caregivers, who worked for stroke patients at 8 hospitals (including 4 university hospitals, 2 rehabilitation hospitals, and 2 convalescent hospitals) participated in this study. The survey was based on a selfreport questionnaire, with 6 categories containing a total of 48 questions about the specific care of stroke patients: the demographic characteristics of the caregivers, bed positioning, the provision of meals, position changes and transfers, the range of motion exercises, and caregiver training. Results: A total of 217 caregivers were surveyed, and they were distributed as follows: 41% came from the university hospitals, 35% came from the rehabilitation hospitals, and 24% came from the convalescent hospitals. The percentages of correct answers were distributed as follows: 64.3% for bed positioning, 74.3% for providing meals, and 62.4% for position change and transfer. The total and subscale scores of the caregivers working at convalescent hospitals were significantly lower than those of the caregivers working at the other types of hospitals (p<0.05). Only 7.8% of the total participants received training on a regular basis. The caregivers obtained most of the information from caregiver associations (58.1%), and the majority of the caregivers (65.4%) were willing to receive training. Conclusion: About one third (33.8%) of caregivers did not have adequate knowledge of how to properly care for stroke patients; in fact, a significant number of caregivers demonstrated inappropriate and insufficient knowledge in several areas. It is assumed that the provision of regular training, by rehabilitation experts, will improve the professionalism and knowledge of the caregivers, and positively affect patient outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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36. Complete Tumor Resection for a Hepatocellular Carcinoma Secreting Parathyroid Hormone-related Peptide.
- Author
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Eun Kyoung Kim, Jin Su Kim, Ki Chul Shin, Gil Tae Lee, Chul Ju Han, Sang Beom Kim, and Yun Hyi Ku
- Published
- 2015
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37. Results of Gender-Specific Total Knee Arthroplasty: Comparative Study with Traditional Implant in Female Patients.
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Jong-Min Kim, Sang-Beom Kim, Dae-Hee Lee, Bum-Sik Lee, and Seong-Il Bin
- Subjects
- *
TOTAL knee replacement , *GENDER differences (Psychology) , *ARTIFICIAL implants , *COMPARATIVE studies , *MEDICAL radiology , *OSTEOARTHRITIS - Abstract
Purpose: To compare the incidence of overhang between two distinct femoral components and whether there is clinical and radiological benefit of gender-specific implants in short-term follow-up. Materials and Methods: One hundred and four knees in consecutive 66 female patients who underwent primary total knee arthroplasty due to primary osteoarthritis were included in this study. Overhang was measured and recorded in every cut surface of femur with both gender-specific and traditional trial femoral components respectively in every patient. Then, the knees were divided into two groups according to the type of the permanent femoral component they received. Clinical and radiological outcomes were compared between 2 groups at minimum 3 years after operation. Results: Mean follow-up duration was 41.3 months (range, 36 to 50 months). Sixty two knees (59.6%) showed femoral overhang at least in one area with a traditional trial component, while 26 knees (25.0%) did with a gender-specific trial component (p<0.001). In terms of range of motion, Hospital for Special Surgery knee score, radiographic result, patella tilt angle and displacement, no significant difference was observed between two groups. Conclusions: The use of gender-specific implants substantially reduced the incidence of femoral overhang but did not demonstrate any clinical, functional or radiologic benefit in short-term follow-up. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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38. Mutations in the PLEKHG5 gene is relevant with autosomal recessive intermediate Charcot-Marie-Tooth disease.
- Author
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Hyeon Jin Kim, Young Bin Hong, Jin-Mo Park, Yu-Ri Choi, Ye Jin Kim, Bo Ram Yoon, Heasoo Koo, Jeong Hyun Yoo, Sang Beom Kim, Minhwa Park, Ki Wha Chung, and Byung-Ok Choi
- Subjects
CHARCOT-Marie-Tooth disease ,MOTOR neuron diseases ,NEUROPATHY ,NUCLEOTIDE exchange factors ,MAGNETIC resonance imaging - Abstract
Background: Mutations in the Pleckstrin homology domain-containing, family G member 5 (PLEKHG5) gene has been reported in a family harboring an autosomal recessive lower motor neuron disease (LMND). However, the PLEKHG5 mutation has not been described to cause Charcot-Marie-Tooth disease (CMT). Methods: To identify the causative mutation in an autosomal recessive intermediate CMT (RI-CMT) family with childhood onset, whole exome sequencing (WES), histopathology, and lower leg MRIs were performed. Expression and activity of each mutant protein were analyzed. Results: We identified novel compound heterozygous (p.Thr663Met and p.Gly820Arg) mutations in the PLEKHG5 gene in the present family. The patient revealed clinical manifestations of sensory neuropathy. Fatty replacements in the distal lower leg muscles were more severe than in the thigh muscles. Although the symptoms and signs of this patient harboring slow nerve conduction velocities suggested the possibility of demyelinating neuropathy, a distal sural nerve biopsy was compatible with axonal neuropathy. Immunohistochemical analysis revealed that the patient has a low level of PLEKHG5 in the distal sural nerve and an in vitro assay suggested that the mutant proteins have a defect in activating the NF-κB signaling pathway. Conclusions: This study identifies compound heterozygous PLEKHG5 mutations as the cause of RI-CMT. We suggest that PLEKHG5 might play a role in the peripheral motor and sensory nervous system. This study expands the phenotypic spectrum of PLEKHG5 mutations [ABSTRACT FROM AUTHOR]
- Published
- 2013
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39. Midterm Outcomes After Meniscal Allograft Transplantation: Comparison of Cases With Extrusion Versus Without Extrusion.
- Author
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Dae-Hee Lee, Sang-Beom Kim, Tae-Ho Kim, Eun-Jong Cha, and Seong-Il Bin
- Subjects
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MENISCUS surgery , *COHORT analysis , *CARTILAGE injuries , *TRANSPLANTATION of organs, tissues, etc. , *SURGICAL complications , *RADIOSCOPIC diagnosis , *MAGNETIC resonance imaging , *MEDICAL radiology , *STIFLE joint - Abstract
Background: Although graft extrusion is of concern after meniscal allograft transplantation (MAT), the correlation between extrusion and clinicoradiological outcomes remains unclear. Hypothesis: Patients with graft extrusion after MAT have worse clinical outcomes and greater arthritic change than those without graft extrusion. Study Design: Cohort study; Level of evidence, 3. Methods: Forty-three patients underwent MAT between 1999 and 2004. Grafts were classified as either nonextruded (<3 mm) or extruded (≥3 mm) according to 1-year postoperative magnetic resonance imaging (MRI) findings. The mean patient age at the time of surgery was 33.5 years (range, 17-43 years), and themean follow-up period was 5.1 years (range, 3.5-8.3 years). The Lysholm score was used to evaluate knee function. In addition, preoperative and postoperative (final follow-up) measurements were taken to determine the absolute and relative (affected side/normal side) joint space width (JSW) on a standing 45° flexion posteroanterior view. Results: Magnetic resonance imaging at 1 year showed the mean graft subluxation was 3.03±0.872 mm across all patients. Twenty-six knees (60%) were classified as nonextruded and 17 (40%) as extruded. No statistical difference was found between these 2 groups regarding Lysholm score improvement after MAT. Overall, absolute and relative JSWs were slightly narrower postoperatively compared with preoperatively across all patients (mean absolute difference, 0.283 mm; mean relative difference; 4.79%; P<.001). However, extruded and nonextruded knees were similar in terms of absolute (P = .764) and relative (P = .482) JSW after MAT. The amount of extrusion did not correlate with Lysholm score or the relative difference between preoperative and postoperative JSW across all patients or in either group. Conclusion: Joint space width was slightly narrower after MAT. Extrusion had no effect on 5-year clinical or radiological outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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40. Effect of Tension Coating on Iron Loss at Frequencies Below 1 kHz in Thin-Gauged 3 % Si-Fe Sheets.
- Author
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Seong-Soo Cho, Sang-Beom Kim, Joon-Young Soh, and Sang-Ok Han
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METAL coating , *ELECTROMAGNETIC induction , *FORSTERITE , *HYSTERESIS , *IRON - Abstract
Effect of tension coating on iron loss has been investigated as a function of excitation induction and frequency in thin-gauged 3% silicon steel sheets and iron loss after tension coating has been evaluated by loss separation method. In order to additionally reduce iron loss, tension coating without forsterite base coating was applied on surfaces of the thin grain-oriented sheets. Reduction in total loss due to the tension coating results from combination of hysteresis loss and anomalous loss, but the latter plays a major role in the loss reduction. The coated sheets show a maximum iron loss reduction of 18% at an excitation induction of 1.0 T and an excitation frequency of 60 Hz. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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41. Change of Dynamic Gastrocnemius and Soleus Muscle Length After Block of Spastic Calf Muscle in Cerebral Palsy.
- Author
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Moon Suk Bang, Sun Gun Chung, Sang Beom Kim, and Sang-Jun Kim
- Published
- 2002
42. Metabolism of flupyrazofos in the isolated perfused rat liver.
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Chang Kyun Jeong, Hee-Yong Lee, Sang Beom Kim, Seong Jin Choi, Jeong-Han Kim, Kyun Kim, Sang Seop Han, and Hye Suk Lee
- Subjects
INSECTICIDES ,METABOLITES ,LABORATORY rats ,PERFUSION - Abstract
Investigates the hepatic metabolism and disposition of flupyrazofos and its metabolite 1-phenyl-3-trifluoromethyl-5-hydroxypyrazole (PTMHP) using isolated perfused rat liver. Assessment of the extent of PTMHP formation in isolated perfused rat liver; Comparison of the rate of PTMHP and PTMHP conjugate recovery with the rate of flupyrazofos elimination.
- Published
- 2001
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43. Optimal Bulk Content of Sulfur for High Magnetic Induction in Inhibitor-Free 3% Si-Fe Strips.
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Sang-Beom Kim, Joon-Young Soh, and Nam Hoe Heo
- Subjects
- *
SULFUR , *ELECTROMAGNETIC induction , *MAGNETIC fields , *MAGNETIC properties , *ELECTROMAGNETISM - Abstract
Effects of bulk content of sulfur on final texture and magnetic induction have been investigated in 3% silicon iron strips. Within the tested range of sulfur content from 11 to 92 ppm, too high or low sulfur contents resulted in a poor magnetic induction arising from no or a limited {110} texture. A weak {110} texture at a high sulfur content is due to the prolonged time period of {100} or {111} grain growth. Despite the shortened time period of selective growth of {100} or {111} grains, also the weak {110} texture at a low sulfur content is probably attributed to a weak grain boundary pinning effect of the weakly segregated sulfur. A moderate sulfur content provides an appropriate pinning effect enough to suppress {100} or {111} selective growth, finally resulting in a sharp {110} texture. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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44. Adult living donor liver transplantation using right posterior segment.
- Author
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Seong Hoon Kim, Kyung-Suk Suh, Sang Beom Kim, Hyuk-Joon Lee, and Kuhn Uk Lee
- Subjects
LIVER transplantation ,HEPATECTOMY ,LIVING organ donors ,TOMOGRAPHY - Abstract
Varying circumstances call for various types of donor hepatectomy. We report here on an unusual type of donor hepatectomy, right posterior segmentectomy. A 46-year-old sister of the recipient was the donor. Her preoperative CT showed that the right anterior portal vein originated from the umbilical portion of the left portal vein. Intraoperative cholangiography revealed that the right posterior hepatic duct joined the common hepatic duct in the extrahepatic area. Right posterior segmentectomy was performed without transfusion in the donor. The postoperative course proceeded favorably in both donor and recipient until postoperative day 41, when the recipient unexpectedly expired as a result of cerebral hemorrhage. The donor was discharged with good liver function. We can conclude that the right posterior segment of the donor can be used as a graft, when the volume of left liver is not enough for both donor and recipient, or the vascular structures favor right posterior segmentectomy. [ABSTRACT FROM AUTHOR]
- Published
- 2003
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45. A micro-chip initiator with controlled combustion reactivity realized by integrating Al/CuO nanothermite composites on a microhotplate platform.
- Author
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Ji Young Ahn, Hyung Woo Lee, Jong Man Kim, Soo Hyung Kim, Sang Beom Kim, Ji Hoon Kim, Nam Su Jang, and Dae Hyun Kim
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MICROELECTROMECHANICAL systems ,ALUMINUM ,COPPER oxide ,METALLIC composites ,COMBUSTION - Abstract
The interfacial contact area between the fuel and oxidizer components plays an important role in determining the combustion reactivity of nanothermite composites. In addition, the development of compact and reliable ignition methods can extend the applicability of nanothermite composites to various thermal engineering fields. In this study we report the development of a micro-chip initiator with controlled combustion reactivity using concepts usually applied to microelectromechanical systems (MEMS) and simple nanofabrication processes. The nanothermite composites fabricated in this study consisted of aluminum nanoparticles (Al NPs) as the fuel and copper oxide nanoparticles (CuO NPs) as the oxidizer accumulated on a silicon oxide substrate with a serpentine-shaped gold (Au) electrode. The micro-chip initiator rapidly ignited and exploded when minimal current was supplied. The effects of stacking structures of Al and CuO-based multilayers on the combustion properties were systematically investigated in terms of the pressurization rate, peak explosion time, and heat flow. Pressurization rates of 0.004–0.025 MPa μs
−1 and heat flows of 2.0–3.8 kJ g−1 with a commonly fast response time of less than 20 ms could be achieved by simply changing the interfacial structures of the Al and CuO multilayers. The controllability of combustion reactivity of micro-chip initiator can be made for general nanothermite composites composed of Al and various metal oxides (e.g. Fe2 O3 , CuO, KMnO4 , etc). The micro-chip initiator fabricated in this study was reliable, compact, and proved to be a versatile platform, exhibiting controlled combustion reactivity and fast response time, which could be used for various civilian and military thermal engineering applications, such as in initiators and propulsion, welding, and ordinance systems. [ABSTRACT FROM AUTHOR]- Published
- 2016
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46. The characteristics of current and voltage in an external electrode fluorescent lamp.
- Author
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Guangsup Cho, Joo-Young Lee, Dae-Heung Lee, Sang-Beom Kim, Je-Huan Koo, Bong-Soo Kim, June-Gill Kang, Eun-Ha Choi, Yang, S.C., and Lee, U.W.
- Published
- 2004
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47. Cut-Off Value of Voluntary Peak Cough Flow in Patients with Parkinson’s Disease and Its Association with Severe Dysphagia: A Retrospective Pilot Study
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Kyeong-Woo Lee, Sang-Beom Kim, Jong-Hwa Lee, and Seong-Woo Kim
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Parkinson’s disease ,aspiration ,dysphagia ,peak cough flow ,Medicine (General) ,R5-920 - Abstract
Background and Objectives. Swallowing and coughing reflexes are both closely associated with airway protection. Peak cough flow (PCF) is associated with dysphagia in several neurogenic diseases. In this study, we aimed to analyze the relationship between PCF and aspiration in Parkinson’s disease (PD) and determine the cut-off value of PCF. Materials and Methods. We retrospectively analyzed the records of patients with PD who underwent a videofluoroscopic swallowing study and checked for PCF. A total of 219 patients were divided into an aspiration group (n = 125) and a non-aspiration group (n = 94). Results. Significantly lower PCF values were observed in the aspiration group compared to the non-aspiration group (132.63 ± 83.62 vs. 181.38 ± 103.92 L/min, p < 0.001). Receiver operating characteristic curve analysis revealed that a PCF cut-off value of 153 L/min (area under the receiver operating characteristic curve, 0.648; sensitivity, 73.06%; specificity, 51.06%) was associated with aspiration in PD. Additionally, a univariate analysis showed that the male sex, lower body mass indexes, higher Hoehn and Yahr scales, and PCF values of ≤153 L/min indicated an increased risk of aspiration. Conclusions. Through a multivariate analysis, we demonstrated that a PCF value ≤153 L/min was associated with an increased risk of aspiration (odds ratio 3.648; 1.797–7.407), highlighting that a low PCF is a risk factor for aspiration in patients with PD.
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- 2023
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48. Long-Term Effects of Extracorporeal Shock Wave Therapy on Breast Cancer-Related Lymphedema
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Jong-Hwa Lee, Sang-Beom Kim, Kyeong-Woo Lee, and Won-Wook Ha
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breast cancer related lymphedema ,extracorporeal shockwave therapy ,fibrosis ,long-term effect ,Medicine - Abstract
Extracorporeal shock wave therapy (ESWT) can reduce breast cancer-related lymphedema (BCRL). However, evidence of the long-term effectiveness of ESWT on BCRL is sparse. The aim of the study was to investigate whether ESWT has long-term effects on BCRL. We enrolled patients with stage 2 lymphedema. The 28 female patients were randomly divided into the ESWT group (n = 14) and the control group (n = 14). ESWT was applied thrice a week for a total of 3 weeks with an intensity of 0.056 to 0.068 mJ/mm2 and a frequency of 4 Hz. Complex decongestive therapy (CDT) was applied in both groups. The arm circumference, fluid volume, ratio of water content, and skin thickness were measured. Patients were evaluated at before treatment, 3 weeks after ESWT completion, and 3 months post-ESWT completion. The ESWT group, the circumference of the whole arm, volume, ratio of water content, QuickDASH score, and skin thickness showed statistically significant improvement at 3 weeks and 3 months post-treatment. When comparing the changes in measurement between the two groups at 3 weeks and 3 months post-treatment, ESWT group showed statistically significant improvement in circumference (cm) below the elbow, ratio of water content and skin thickness at 3 weeks and 3 months post treatment. Overall, ESWT improved lymphedema in patients with stage 2 BCRL, and the effects persisted for at least 3 months. Therefore, ESWT may be an additional treatment method for patients with lymphedema.
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- 2022
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49. Organized Comprehensive Stroke Center is Associated with Reduced Mortality: Analysis of Consecutive Patients in a Single Hospital
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Dae-Hyun Kim, Jae-Kwan Cha, Hyo-Jin Bae, Hyun-Seok Park, Jae-Hyung Choi, Myung-Jin Kang, Byoung-Gwon Kim, Jae-Taeck Huh, and Sang-Beom Kim
- Subjects
stroke center ,acute ischemic stroke ,stroke care organization ,stroke mortality ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background and PurposeOrganized inpatient stroke care is one of the most effective therapies for improving patient outcomes. Many stroke centers have been established to meet this need, however, there are limited data on the effectiveness of these organized comprehensive stroke center (CSC) in the real-world setting. Our aim is to determine whether inpatient care following the establishment of CSC lowers mortality of patients with acute ischemic stroke (AIS).MethodsBased on a prospective stroke registry, we identified AIS patients hospitalized before and after the establishment of a CSC. We observed all-cause mortality within 30 days from time of admission. Logistic regression was used to determine whether the establishment of the CSC affects independently the 30-day all-cause mortality.ResultsA total of 3,117 consecutive patients with AIS were admitted within seven days after the onset of the symptoms. Unadjusted 30-day mortality was lower for patients admitted to our hospital after the establishment of the CSC than before (5.9% vs. 8.2%, P=0.012). Advanced age, female gender, previous coronary artery disease, non-smoking, stroke subtype, admission on a holiday, referral from other hospitals, high NIHSS on admission, and admission before the establishment of CSC were associated with increased 30-day stroke case fatality. After adjustment for these factors, stroke inpatient care subsequent to the establishment of the CSC was independently associated with lower 30-day mortality (OR, 0.57; 95% CI, 0.412-0.795).ConclusionsPatients treated after the establishment of a CSC had lower 30-mortality rates than ever before, even adjusting for the differences in the baseline characteristics. The present study reveals that organized stroke care in a CSC might improve the outcome after AIS.
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- 2013
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50. Acute Ischemic Stroke in a Patient with a Native Valvular Strand
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Hak Young Rhee, Hye-Yeon Choi, Sang-Beom Kim, Won-Chul Shin, and Sung Hun Kim
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Acute ischemic stroke ,Antiplatelet treatment ,Cardioembolism ,Lambl’s excrescences ,Stroke mechanisms ,Valvular strands ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Valvular strands are known to be a potential source of cardioembolism but the natural history of native valvular strands has not yet been fully outlined. We report a case of ischemic stroke in a patient with a native valvular strand of the aortic valve and the patient’s clinical course. A previously healthy 21-year-old man suffered acute cerebral infarction in the right posterior cerebral artery territory. On echocardiography, there was a strand-like, oscillating mass on the left coronary cusp of the aortic valve. The patient received 100 mg aspirin daily and the valvular strand was not found on subsequent transthoracic echocardiography performed 10 days after the first examination. Serial echocardiographic examinations have been performed since the stroke and failed to find any abnormality. The patient did not suffer a recurrent stroke over a 3-year follow-up period.
- Published
- 2010
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