46 results on '"Salmi, Juha"'
Search Results
2. Fluctuations of Attention During Self-paced Naturalistic Goal-Directed Behavior in Attention-Deficit/Hyperactivity Disorder
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Salmi, Juha, Merzon, Liya, Eräste, Tilda, Seesjärvi, Erik, Huhdanpää, Hanna, Aronen, Eeva T., Mannerkoski, Minna, MacInnes, W. Joseph, and Laine, Matti
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- 2024
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3. EPELI: a novel virtual reality task for the assessment of goal-directed behavior in real-life contexts
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Seesjärvi, Erik, Puhakka, Jasmin, Aronen, Eeva T., Hering, Alexandra, Zuber, Sascha, Merzon, Liya, Kliegel, Matthias, Laine, Matti, and Salmi, Juha
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- 2023
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4. Narrative simulation of social experiences in naturalistic context – A neurocinematic approach
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Tikka, Pia, Kaipainen, Mauri, and Salmi, Juha
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- 2023
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5. The Pursuit of Effective Working Memory Training: a Pre-registered Randomised Controlled Trial with a Novel Varied Training Protocol
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Ritakallio, Liisa, Fellman, Daniel, Jylkkä, Jussi, Waris, Otto, Lönnroth, Nelly, Nervander, Reidar, Salmi, Juha, and Laine, Matti
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- 2022
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6. Eye movement behavior in a real-world virtual reality task reveals ADHD in children
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Merzon, Liya, Pettersson, Kati, Aronen, Eeva T., Huhdanpää, Hanna, Seesjärvi, Erik, Henriksson, Linda, MacInnes, W. Joseph, Mannerkoski, Minna, Macaluso, Emiliano, and Salmi, Juha
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- 2022
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7. Brain structural alterations in autism and criminal psychopathy
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Noppari, Tuomo, Sun, Lihua, Lukkarinen, Lasse, Putkinen, Vesa, Tani, Pekka, Lindberg, Nina, Saure, Emma, Lauerma, Hannu, Tiihonen, Jari, Venetjoki, Niina, Salomaa, Marja, Rautio, Päivi, Hirvonen, Jussi, Salmi, Juha, and Nummenmaa, Lauri
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- 2022
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8. ADHD desynchronizes brain activity during watching a distracted multi-talker conversation
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Salmi, Juha, Metwaly, Mostafa, Tohka, Jussi, Alho, Kimmo, Leppämäki, Sami, Tani, Pekka, Koski, Anniina, Vanderwal, Tamara, and Laine, Matti
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- 2020
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9. The role of strategy use in working memory training outcomes
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Fellman, Daniel, Jylkkä, Jussi, Waris, Otto, Soveri, Anna, Ritakallio, Liisa, Haga, Sarah, Salmi, Juha, Nyman, Thomas J., and Laine, Matti
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- 2020
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10. Working memory updating training modulates a cascade of event-related potentials depending on task load
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Salmi, Juha, Vilà-Balló, Adrià, Soveri, Anna, Rostan, Carles, Rodríguez-Fornells, Antoni, Lehtonen, Minna, and Laine, Matti
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- 2019
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11. Tree architecture in young Scots pine: properties, spatial distribution and relationships of components of tree architecture.
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Kuuluvainen, Timo, Kanninen, Markku, and Salmi, Juha-Pekka
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Forestry ,SD1-669.5 - Abstract
The architecture of Scots pine ( L.) was studied in an eight-year-old progeny test. The measurements included characteristics of crown structure, spatial distribution of shoots and yield components. The spatial distribution of shoots showed striking between-tree differences, and two extreme distribution patterns were detected. One represented a non-layered structure with a vertically relative even shoot distribution, and the other a layered structure with a vertically highly uneven shoot distribution.Pinus sylvestris
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- 1988
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12. Developmental dyslexia susceptibility genes DNAAF4, DCDC2, and NRSN1 are associated with brain function in fluently reading adolescents and young adults.
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Rinne, Nea, Wikman, Patrik, Sahari, Elisa, Salmi, Juha, Einarsdóttir, Elisabet, Kere, Juha, and Alho, Kimmo
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- 2024
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13. Spontaneous memory strategies in a videogame simulating everyday memory tasks.
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Laine, Matti, Jylkkä, Jussi, Ritakallio, Liisa, Eräste, Tilda, Kangas, Suvi, Hering, Alexandra, Zuber, Sascha, Kliegel, Matthias, Fellman, Daniel, and Salmi, Juha
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EPISODIC memory ,EXECUTIVE function ,MEMORY ,PROSPECTIVE memory ,INDIVIDUAL differences ,NEURODIVERSITY ,MNEMONICS - Abstract
People can use different internal strategies to manage their daily tasks, but systematic research on these strategies and their significance for actual performance is still quite sparse. Here we examined self-reported internal strategy use with a 10-block version of the videogame EPELI (Executive Performance in Everyday LIving) in a group of 202 neurotypical adults of 18–50 years of age. In the game, participants perform lists of everyday tasks from memory while navigating in a virtual apartment. Open-ended strategy reports were collected after each EPELI task block, and for comparison also after an EPELI Instruction Recall task and a Word List Learning task assessing episodic memory. On average, 45% of the participants reported using some strategy in EPELI, the most common types being grouping (e.g., performing the tasks room by room), utilising a familiar action schema, and condensing information (e.g., memorising only keywords). Our pre-registered hypothesis on the beneficial effect of self-initiated strategy use gained support, as strategy users showed better performance on EPELI as compared with no strategy users. One of the strategies, grouping, was identified as a clearly effective strategy type. Block-by-block transitions suggested gradual stabilisation of strategy use over the 10 EPELI blocks. The proneness to use strategies showed a weak but reliable association between EPELI and Word List Learning. Overall, the present results highlight the importance of internal strategy use for understanding individual differences in memory performance, as well as the potential benefit for internal strategy employment when faced with everyday memory tasks. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Virtual reality tasks with eye tracking for mild spatial neglect assessment: a pilot study with acute stroke patients.
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Uimonen, Jenni, Villarreal, Sanna, Laari, Siiri, Arola, Anne, Ijäs, Petra, Salmi, Juha, and Hietanen, Marja
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Objective: Increasing evidence shows that traditional neuropsychological tests are insensitive for detecting mild unilateral spatial neglect (USN), lack ecological validity, and are unable to clarify USN in all different spatial domains. Here we present a new, fully immersive virtual reality (VR) task battery with integrated eye tracking for mild visual USN and extinction assessment in the acute state of stroke to overthrow these limitations. Methods: We included 11 right-sided stroke patients and 10 healthy controls aged 18−75 years. Three VR tasks named the Extinction, the Storage and the Shoot the target tasks were developed to assess USN. Furthermore, neuropsychological assessment examining various parts of cognitive functioning was conducted to measure general abilities. We compared VR and neuropsychological task performance in stroke patients – those with (USN+, n = 5) and without USN (USN−, n = 6) – to healthy controls (n = 10) and tentatively reported the usability of VR system in the acute state of stroke. Results: Patients had mostly mild neurological and USN symptoms. Nonetheless, we found several differences between the USN+ and healthy control groups in VR task performance. Compared to controls, USN+ patients showed visual extinction and asymmetry in gaze behavior and detection times in distinct spatial locations. Extinction was most evident in the extrapersonal space and delayed detection times on the extreme left and on the left upper parts. Also, USN+ patients needed more time to complete TMT A compared with USN− patients and TMT B compared with controls. VR system usability and acceptance were rated high; no relevant adverse effects occurred. Conclusion: New VR technology with eye tracking enables ecologically valid and objective assessment methods with various exact measures for mild USN and thus could potentially improve future clinical assessments. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Working memory training mostly engages general-purpose large-scale networks for learning
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Salmi, Juha, Nyberg, Lars, and Laine, Matti
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- 2018
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16. Neural signatures for active maintenance and interference during working memory updating
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Vilà-Balló, Adrià, Salmi, Juha, Soveri, Anna, Rodríguez-Fornells, Antoni, Lehtonen, Minna, and Laine, Matti
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- 2018
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17. Intuitive physics ability in systemizers relies on differential use of the internalizing system and long-term spatial representations
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Riekki, Tapani, Salmi, Juha, Svedholm-Häkkinen, Annika M., and Lindeman, Marjaana
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- 2018
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18. Distributed neural signatures of natural audiovisual speech and music in the human auditory cortex
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Salmi, Juha, Koistinen, Olli-Pekka, Glerean, Enrico, Jylänki, Pasi, Vehtari, Aki, Jääskeläinen, Iiro P., Mäkelä, Sasu, Nummenmaa, Lauri, Nummi-Kuisma, Katarina, Nummi, Ilari, and Sams, Mikko
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- 2017
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19. Fronto-parietal network supports context-dependent speech comprehension
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Smirnov, Dmitry, Glerean, Enrico, Lahnakoski, Juha M., Salmi, Juha, Jääskeläinen, Iiro P., Sams, Mikko, and Nummenmaa, Lauri
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- 2014
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20. Assessment of goal-directed behavior and prospective memory in adult ADHD with an online 3D videogame simulating everyday tasks.
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Jylkkä, Jussi, Ritakallio, Liisa, Merzon, Liya, Kangas, Suvi, Kliegel, Matthias, Zuber, Sascha, Hering, Alexandra, Laine, Matti, and Salmi, Juha
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PROSPECTIVE memory ,BEHAVIORAL assessment ,ACTION theory (Psychology) ,CONTINUOUS performance test ,ATTENTION-deficit hyperactivity disorder ,YOUTH with attention-deficit hyperactivity disorder - Abstract
The diagnosis of ADHD is based on real-life attentional-executive deficits, but they are harder to detect in adults than in children and objective quantitative measures reflecting these everyday problems are lacking. We developed an online version of EPELI 3D videogame for naturalistic and scalable assessment of goal-directed action and prospective memory in adult ADHD. In EPELI, participants perform instructed everyday chores in a virtual apartment from memory. Our pre-registered hypothesis predicted weaker EPELI performances in adult ADHD compared to controls. The sample comprised 112 adults with ADHD and 255 neurotypical controls comparable in age (mean 31, SD = 8 years), gender distribution (71% females) and educational level. Using web-browser, the participants performed EPELI and other cognitive tasks, including Conner's Continuous Performance Test (CPT). They also filled out questionnaires probing everyday executive performance and kept a 5-day diary of everyday prospective memory errors. Self-reported strategy use in the EPELI game was also examined. The ADHD participants' self-ratings indicated clearly more everyday executive problems than in the controls. Differences in the EPELI game were mostly seen in the ADHD participants' higher rates of task-irrelevant actions. Gender differences and a group × gender interaction was found in the number of correctly performed tasks, indicating poorer performance particularly in ADHD males. Discriminant validity of EPELI was similar to CPT. Strategy use strongly predicted EPELI performance in both groups. The results demonstrate the feasibility of EPELI for online assessment and highlight the role of impulsivity as a distinctive everyday life problem in adult ADHD. [ABSTRACT FROM AUTHOR]
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- 2023
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21. Assessment of goal-directed behavior with the 3D videogame EPELI: Psychometric features in a web-based adult sample.
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Jylkkä, Jussi, Ritakallio, Liisa, Merzon, Liya, Kangas, Suvi, Kliegel, Matthias, Zuber, Sascha, Hering, Alexandra, Salmi, Juha, and Laine, Matti
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BEHAVIORAL assessment ,ACTION theory (Psychology) ,PSYCHOMETRICS ,TEST validity ,PROSPECTIVE memory ,VIRTUAL communities - Abstract
EPELI (Executive Performance in Everyday LIving) is a recently developed gaming tool for objective assessment of goal-directed behavior and prospective memory (PM) in everyday contexts. This pre-registered study examined psychometric features of a new EPELI adult online version, modified from the original child version and further developed for self-administered web-based testing at home. A sample of 255 healthy adults completed EPELI where their task was to perform household chores instructed by a virtual character. The participants also filled out PM-related questionnaires and a diary and performed two conventional PM tasks and an intelligence test. We expected that the more "life-like" EPELI task would show stronger associations with conventional PM questionnaires and diary-based everyday PM reports than traditional PM tasks would do. This hypothesis did not receive support. Although EPELI was rated as more similar to everyday tasks, performance in it was not associated with the questionnaires and the diary. However, there were associations between time-monitoring behavior in EPELI and the traditional PM tasks. Taken together, online adult-EPELI was found to be a reliable method with high ecological face validity, but its convergent validity requires further research. [ABSTRACT FROM AUTHOR]
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- 2023
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22. Grandiosity, vulnerability, and narcissistic fluctuation: Examining reliability, measurement invariance, and construct validity of four brief narcissism measures.
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Henttonen, Pentti, Salmi, Juha, Peräkylä, Anssi, and Krusemark, Elizabeth A.
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NARCISSISM ,TEST validity ,PSYCHOMETRICS ,CONFIRMATORY factor analysis - Abstract
Continued interest in the distinction between grandiose narcissism, vulnerable narcissism and the fluctuation between grandiose and vulnerable states has expanded the repertoire of self-report instruments. The present study examined the psychometric properties of four brief narcissism measures [the Narcissistic Personality Inventory-13 (NPI-13), Hypersensitive Narcissism Scale (HSNS), Super-Brief Pathological Narcissism Inventory (SB-PNI), and the g-FLUX] in a Finnish sample of university students. Confirmatory factor analyses supported the reliability of the NPI-13, g-FLUX, SB-PNI Vulnerability, and two HSNS subfactors (Oversensitivity and Egocentrism). Tests of measurement invariance indicated the NPI-13, SB-PNI Vulnerability, HSNS Oversensitivity, and the g-FLUX perform similarly between males and females and are generally similar between individuals in younger and older age groups. Construct and predictive validity were evaluated by examining relations between narcissism measures and relevant criteria including psychopathology symptoms, self-esteem, well-being, five factor traits, and empathy. Results supported the construct validity of all four measures, while correlational profiles highlighted the convergence between the g-FLUX and measures of both grandiosity and vulnerability. The NPI-13 was most predictive of NPD symptoms, whereas vulnerable narcissism measures were most predictive of psychopathology. Results further establish the psychometric properties of the NPI-13, SB-PNI Vulnerability, HSNS Oversensitivity, Egocentrism, and provide new validation of the g-FLUX. [ABSTRACT FROM AUTHOR]
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- 2022
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23. Early life stress is associated with the default mode and fronto-limbic network connectivity among young adults.
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Ilomäki, Miro, Lindblom, Jallu, Salmela, Viljami, Flykt, Marjo, Vänskä, Mervi, Salmi, Juha, Tolonen, Tuija, Alho, Kimmo, Punamäki, Raija-Leena, and Wikman, Patrik
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DEFAULT mode network ,YOUNG adults ,FUNCTIONAL magnetic resonance imaging ,ADVERSE childhood experiences ,MENTAL illness - Abstract
Exposure to early life stress (ELS) is associated with a variety of detrimental psychological and neurodevelopmental effects. Importantly, ELS has been associated with regional alterations and aberrant connectivity in the structure and functioning of brain regions involved in emotion processing and self-regulation, creating vulnerability to mental health problems. However, longitudinal research regarding the impact of ELS on functional connectivity between brain regions in the default mode network (DMN) and fronto-limbic network (FLN), both implicated in emotion-related processes, is relatively scarce. Neuroimaging research on ELS has mostly focused on single nodes or bi-nodal connectivity instead of functional networks. We examined how ELS is associated with connectivity patterns within the DMN and FLN during rest in early adulthood. The participants (n = 86; 47 females) in the current functional magnetic resonance imaging (fMRI) study were young adults (18– 21 years old) whose families had participated in a longitudinal study since pregnancy. ELS was assessed both prospectively (parental reports of family relationship problems and mental health problems during pregnancy and infancy) and retrospectively (self-reported adverse childhood experiences). Inter-subject representational similarity analysis (IS-RSA) and multivariate distance matrix regression (MDMR) were used to analyze the association between ELS and the chosen networks. The IS-RSA results suggested that prospective ELS was associated with complex alterations within the DMN, and that retrospective ELS was associated with alterations in the FLN. MDMR results, in turn, suggested that that retrospective ELS was associated with DMN connectivity. Mean connectivity of the DMN was also associated with retrospective ELS. Analyses further showed that ELS-related alterations in the FLN were associated with increased connectivity between the prefrontal and limbic regions, and between different prefrontal regions. These results suggest that exposure to ELS in infancy might have long-lasting influences on functional brain connectivity that persist until early adulthood. Our results also speak for the importance of differentiating prospective and retrospective assessment methods to understand the specific neurodevelopmental effects of ELS. [ABSTRACT FROM AUTHOR]
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- 2022
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24. Quantifying ADHD Symptoms in Open-Ended Everyday Life Contexts With a New Virtual Reality Task.
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Seesjärvi, Erik, Puhakka, Jasmin, Aronen, Eeva T., Lipsanen, Jari, Mannerkoski, Minna, Hering, Alexandra, Zuber, Sascha, Kliegel, Matthias, Laine, Matti, and Salmi, Juha
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VIRTUAL reality ,ATTENTION-deficit hyperactivity disorder ,ACTION theory (Psychology) ,EVERYDAY life ,SYMPTOMS ,SPECIFIC language impairment in children - Abstract
Objective: To quantify goal-directed behavior and ADHD symptoms in naturalistic conditions, we developed a virtual reality task, EPELI (Executive Performance in Everyday LIving), and tested its predictive, discriminant and concurrent validity. Method: We collected EPELI data, conventional neuropsychological task data, and parent-ratings of executive problems and symptoms in 38 ADHD children and 38 typically developing controls. Results: EPELI showed predictive validity as the ADHD group exhibited higher percentage of irrelevant actions reflecting lower attentional-executive efficacy and more controller movements and total game actions, both indicative of hyperactivity-impulsivity. Further, the five combined EPELI measures showed excellent discriminant validity (area under curve 88 %), while the correlations of the EPELI efficacy measure with parent-rated executive problems (r =.57) and ADHD symptoms (r =.55) pointed to its concurrent validity. Conclusion: We provide a proof-of-concept validation for a new virtual reality tool for ecologically valid assessment of ADHD symptoms. [ABSTRACT FROM AUTHOR]
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- 2022
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25. Cognitive and motor loops of the human cerebro-cerebellar system
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Salmi, Juha, Pallesen, Karen Johanne, Neuvonen, Tuomas, Brattico, Elvira, Korvenoja, Antti, Salonen, Oili, and Carlson, Synnove
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Cognition -- Physiological aspects ,Cognition -- Research ,Motor ability -- Physiological aspects ,Motor ability -- Research ,Brain -- Research ,Health ,Psychology and mental health - Published
- 2010
26. Posterior Parietal Cortex Activity Reflects the Significance of Othersʼ Actions During Natural Viewing
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Salmi, Juha, Glerean, Enrico, Jääskeläinen, Iiro P., Lahnakoski, Juha M., Kettunen, Juho, Lampinen, Jouko, Tikka, Pia, and Sams, Mikko
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- 2014
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27. Orienting and maintenance of spatial attention in audition and vision: multimodal and modality-specific brain activations
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Salmi, Juha, Rinne, Teemu, Degerman, Alexander, Salonen, Oili, and Alho, Kimmo
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- 2007
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28. Selective attention to sound location or pitch studied with event-related brain potentials and magnetic fields
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Degerman, Alexander, Rinne, Teemu, Särkkä, Anna-Kaisa, Salmi, Juha, and Alho, Kimmo
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- 2008
29. Orienting and maintenance of spatial attention in audition and vision: an event-related brain potential study
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Salmi, Juha, Rinne, Teemu, Degerman, Alexander, and Alho, Kimmo
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- 2007
30. Working memory training restores aberrant brain activity in adult attention‐deficit hyperactivity disorder.
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Salmi, Juha, Soveri, Anna, Salmela, Viljami, Alho, Kimmo, Leppämäki, Sami, Tani, Pekka, Koski, Anniina, Jaeggi, Susanne M., and Laine, Matti
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ATTENTION-deficit hyperactivity disorder , *MNEMONICS , *SHORT-term memory , *COGNITIVE load , *RANDOMIZED controlled trials - Abstract
The development of treatments for attention impairments is hampered by limited knowledge about the malleability of underlying neural functions. We conducted the first randomized controlled trial to determine the modulations of brain activity associated with working memory (WM) training in adults with attention‐deficit hyperactivity disorder (ADHD). At baseline, we assessed the aberrant functional brain activity in the n‐back WM task by comparing 44 adults with ADHD with 18 healthy controls using fMRI. Participants with ADHD were then randomized to train on an adaptive dual n‐back task or an active control task. We tested whether WM training elicits redistribution of brain activity as observed in healthy controls, and whether it might further restore aberrant activity related to ADHD. As expected, activity in areas of the default‐mode (DMN), salience (SN), sensory‐motor (SMN), frontoparietal (FPN), and subcortical (SCN) networks was decreased in participants with ADHD at pretest as compared with healthy controls, especially when the cognitive load was high. WM training modulated widespread FPN and SN areas, restoring some of the aberrant activity. Training effects were mainly observed as decreased brain activity during the trained task and increased activity during the untrained task, suggesting different neural mechanisms for trained and transfer tasks. [ABSTRACT FROM AUTHOR]
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- 2020
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31. Disentangling the Role of Working Memory in Parkinson's Disease.
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Salmi, Juha, Ritakallio, Liisa, Fellman, Daniel, Ellfolk, Ulla, Rinne, Juha O., and Laine, Matti
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PARKINSON'S disease ,SHORT-term memory ,COGNITION disorders ,STRUCTURAL equation modeling ,SYMPTOMS ,MONTREAL Cognitive Assessment ,IMPULSE control disorders - Abstract
Working memory (WM) represents a core cognitive function with a major striatal contribution, and thus WM deficits, commonly observed in Parkinson's disease (PD), could also relate to many other problems in PD patients. Our online study aimed to determine the subdomains of WM that are particularly affected in PD and to clarify the links between WM and everyday cognitive deficits, other executive functions, psychiatric and PD symptoms, as well as early cognitive impairment. Fifty-two mild-to-moderate PD patients and 54 healthy controls performed seven WM tasks tapping selective updating, continuous monitoring, or maintenance of currently active information. Self-ratings of everyday cognition, depression, and apathy symptoms, as well as screenings of global cognitive impairment, were also collected. The data were analyzed using structural equation modeling. Of the three WM domains, only selective updating was directly predictive of PD group membership. More widespread WM deficits were observed only in relation to global cognitive impairment in PD patients. Self-rated everyday cognition or psychiatric symptoms were not linked to WM performance but correlated with each other. Our findings suggest that WM has a rather limited role in the clinical manifestation of PD. Nevertheless, due to its elementary link to striatal function, the updating component of WM could be a candidate for a cognitive marker of PD also in patients who are otherwise cognitively well-preserved. [ABSTRACT FROM AUTHOR]
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- 2020
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32. Training working memory updating in Parkinson's disease: A randomised controlled trial.
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Fellman, Daniel, Salmi, Juha, Ritakallio, Liisa, Ellfolk, Ulla, Rinne, Juha O., and Laine, Matti
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TRANSFER of training , *PARKINSON'S disease , *MNEMONICS , *SHORT-term memory , *OLDER people , *COGNITIVE rehabilitation - Abstract
Frontostriatal dysfunction in Parkinson's disease (PD) increases the risk for working memory (WM) impairment and depression, calling for counteractive measures. Computerised cognitive rehabilitation is a promising option, but targeted training protocols are lacking and lab-based training can be demanding due to the repeated visits. This study tested the feasibility and efficacy of home-based computerised training targeting mainly WM updating in PD. Fifty-two cognitively well-preserved PD patients were randomised to a WM training group and an active control group for five weeks of training (three 30-min sessions per week). WM training included three computerised adaptive WM tasks (two updating, one maintenance). The outcomes were examined pre- and post-training with trained and untrained WM tasks, tasks tapping other cognitive domains, and self-ratings of executive functioning and depression. Home-based training was feasible for the patients. The training group improved particularly on the updating training tasks, and showed posttest improvement on untrained WM tasks structurally similar to the trained ones. Moreover, their depression scores decreased compared to the controls. Our study indicates that patients with mild-to-moderate PD can self-administer home-based computerised WM training, and that they yield a similar transfer pattern to untrained WM tasks as has been observed in healthy older adults. [ABSTRACT FROM AUTHOR]
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- 2020
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33. Out of focus – Brain attention control deficits in adult ADHD.
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Salmi, Juha, Salmela, Viljami, Salo, Emma, Mikkola, Katri, Leppämäki, Sami, Tani, Pekka, Hokkanen, Laura, Laasonen, Marja, Numminen, Jussi, and Alho, Kimmo
- Subjects
- *
ATTENTION-deficit hyperactivity disorder , *BRAIN function localization , *FUNCTIONAL magnetic resonance imaging , *ATTENTION control , *AUDITORY selective attention , *CEREBELLUM - Abstract
Modern environments are full of information, and place high demands on the attention control mechanisms that allow the selection of information from one (focused attention) or multiple (divided attention) sources, react to changes in a given situation (stimulus-driven attention), and allocate effort according to demands (task-positive and task-negative activity). We aimed to reveal how attention deficit hyperactivity disorder (ADHD) affects the brain functions associated with these attention control processes in constantly demanding tasks. Sixteen adults with ADHD and 17 controls performed adaptive visual and auditory discrimination tasks during functional magnetic resonance imaging (fMRI). Overlapping brain activity in frontoparietal saliency and default-mode networks, as well as in the somato-motor, cerebellar, and striatal areas were observed in all participants. In the ADHD participants, we observed exclusive activity enhancement in the brain areas typically considered to be primarily involved in other attention control functions: During auditory-focused attention, we observed higher activation in the sensory cortical areas of irrelevant modality and the default-mode network (DMN). DMN activity also increased during divided attention in the ADHD group, in turn decreasing during a simple button-press task. Adding irrelevant stimulation resulted in enhanced activity in the salience network. Finally, the irrelevant distractors that capture attention in a stimulus-driven manner activated dorsal attention networks and the cerebellum. Our findings suggest that attention control deficits involve the activation of irrelevant sensory modality, problems in regulating the level of attention on demand, and may encumber top-down processing in cases of irrelevant information. [ABSTRACT FROM AUTHOR]
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- 2018
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34. No Effects of Stimulating the Left Ventrolateral Prefrontal Cortex with tDCS on Verbal Working Memory Updating.
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Lukasik, Karolina M., Lehtonen, Minna, Salmi, Juha, Meinzer, Marcus, Joutsa, Juho, and Laine, Matti
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PREFRONTAL cortex ,SHORT-term memory ,BRAIN stimulation - Abstract
The effects of transcranial direct current stimulation (tDCS) on dorsolateral prefrontal cortex functions, such as working memory (WM), have been examined in a number of studies. However, much less is known about the behavioral effects of tDCS over other important WM-related brain regions, such as the ventrolateral prefrontal cortex (VLPFC). In a counterbalanced within-subjects design with 33 young healthy participants, we examined whether online and offline single-session tDCS over VLPFC affects WM updating performance as measured by a digit 3-back task. We compared three conditions: anodal, cathodal and sham. We observed no significant tDCS effects on participants' accuracy or reaction times during or after the stimulation. Neither did we find any differences between anodal and cathodal stimulation. Largely similar results were obtained when comparing subgroups of high- and low-performing participants. Possible reasons for the lack of effects, including individual differences in responsiveness to tDCS, features of montage, task and sample characteristics, and the role of VLPFC in WM, are discussed. [ABSTRACT FROM AUTHOR]
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- 2018
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35. Reorganization of functionally connected brain subnetworks in high-functioning autism.
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Glerean, Enrico, Pan, Raj K., Salmi, Juha, Kujala, Rainer, Lahnakoski, Juha M., Roine, Ulrika, Nummenmaa, Lauri, Leppämäki, Sami, Nieminen‐von Wendt, Taina, Tani, Pekka, Saramäki, Jari, Sams, Mikko, and Jääskeläinen, Iiro P.
- Abstract
Previous functional connectivity studies have found both hypo- and hyper-connectivity in brains of individuals having autism spectrum disorder (ASD). Here we studied abnormalities in functional brain subnetworks in high-functioning individuals with ASD during free viewing of a movie containing social cues and interactions. Twenty-six subjects (13 with ASD) watched a 68-min movie during functional magnetic resonance imaging. For each subject, we computed Pearson's correlation between haemodynamic time-courses of each pair of 6-mm isotropic voxels. From the whole-brain functional networks, we derived individual and group-level subnetworks using graph theory. Scaled inclusivity was then calculated between all subject pairs to estimate intersubject similarity of connectivity structure of each subnetwork. Additional 54 individuals (27 with ASD) from the ABIDE resting-state database were included to test the reproducibility of the results. Between-group differences were observed in the composition of default-mode and ventro-temporal-limbic (VTL) subnetworks. The VTL subnetwork included amygdala, striatum, thalamus, parahippocampal, fusiform, and inferior temporal gyri. Further, VTL subnetwork similarity between subject pairs correlated significantly with similarity of symptom gravity measured with autism quotient. This correlation was observed also within the controls, and in the reproducibility dataset with ADI-R and ADOS scores. Our results highlight how the reorganization of functional subnetworks in individuals with ASD clarifies the mixture of hypo- and hyper-connectivity findings. Importantly, only the functional organization of the VTL subnetwork emerges as a marker of inter-individual similarities that co-vary with behavioral measures across all participants. These findings suggest a pivotal role of ventro-temporal and limbic systems in autism. Hum Brain Mapp 37:1066-1079, 2016. © 2015 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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36. Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder.
- Author
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Roine, Ulrika, Roine, Timo, Salmi, Juha, Nieminen-von Wendt, Taina, Tani, Pekka, Leppämäki, Sami, Rintahaka, Pertti, Caeyenberghs, Karen, Leemans, Alexander, and Sams, Mikko
- Subjects
AUTISM spectrum disorders ,BRAIN physiology ,BRAIN mapping - Abstract
Background: Recent brain imaging findings suggest that there are widely distributed abnormalities affecting the brain connectivity in individuals with autism spectrum disorder (ASD). Using graph theoretical analysis, it is possible to investigate both global and local properties of brain's wiring diagram, i.e., the connectome. Methods: We acquired diffusion-weighted magnetic resonance imaging data from 14 adult males with high-functioning ASD and 19 age-, gender-, and IQ-matched controls. As with diffusion tensor imaging-based tractography, it is not possible to detect complex (e.g., crossing) fiber configurations, present in 60-90% of white matter voxels; we performed constrained spherical deconvolution-based whole brain tractography. Unweighted and weighted structural brain networks were then reconstructed from these tractography data and analyzed with graph theoretical measures. Results: In subjects with ASD, global efficiency was significantly decreased both in the unweighted and the weighted networks, normalized characteristic path length was significantly increased in the unweighted networks, and strength was significantly decreased in the weighted networks. In the local analyses, betweenness centrality of the right caudate was significantly increased in the weighted networks, and the strength of the right superior temporal pole was significantly decreased in the unweighted networks in subjects with ASD. Conclusions: Our findings provide new insights into understanding ASD by showing that the integration of structural brain networks is decreased and that there are abnormalities in the connectivity of the right caudate and right superior temporal pole in subjects with ASD. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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37. Top-down controlled and bottom-up triggered orienting of auditory attention to pitch activate overlapping brain networks.
- Author
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Alho, Kimmo, Salmi, Juha, Koistinen, Sonja, Salonen, Oili, and Rinne, Teemu
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BRAIN stimulation , *AUDITORY perception , *BRAIN imaging , *SPATIOTEMPORAL processes , *BRAIN research , *ATTENTION - Abstract
A number of previous studies have suggested segregated networks of brain areas for top-down controlled and bottom-up triggered orienting of visual attention. However, the corresponding networks involved in auditory attention remain less studied. Our participants attended selectively to a tone stream with either a lower pitch or higher pitch in order to respond to infrequent changes in duration of attended tones. The participants were also required to shift their attention from one stream to the other when guided by a visual arrow cue. In addition to these top-down controlled cued attention shifts, infrequent task-irrelevant louder tones occurred in both streams to trigger attention in a bottom-up manner. Both cued shifts and louder tones were associated with enhanced activity in the superior temporal gyrus and sulcus, temporo-parietal junction, superior parietal lobule, inferior and middle frontal gyri, frontal eye field, supplementary motor area, and anterior cingulate gyrus. Thus, the present findings suggest that in the auditory modality, unlike in vision, top-down controlled and bottom-up triggered attention activate largely the same cortical networks. Comparison of the present results with our previous results from a similar experiment on spatial auditory attention suggests that fronto-parietal networks of attention to location or pitch overlap substantially. However, the auditory areas in the anterior superior temporal cortex might have a more important role in attention to the pitch than location of sounds. This article is part of a Special Issue entitled SI: Prediction and Attention . [ABSTRACT FROM AUTHOR]
- Published
- 2015
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38. Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome.
- Author
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Roine, Ulrika, Salmi, Juha, Roine, Timo, Nieminen-von Wendt, Taina, Leppämäki, Sami, Rintahaka, Pertti, Tani, Pekka, Leemans, Alexander, and Sams, Mikko
- Subjects
- *
ASPERGER'S syndrome , *NEUROLOGY , *AUTISM spectrum disorders , *MAGNETIC resonance , *PYRAMIDAL tract , *DIFFUSION magnetic resonance imaging - Abstract
Background: The aim of this study was to investigate potential differences in neural structure in individuals with Asperger syndrome (AS), high-functioning individuals with autism spectrum disorder (ASD). The main symptoms of AS are severe impairments in social interactions and restricted or repetitive patterns of behaviors, interests or activities. Methods: Diffusion weighted magnetic resonance imaging data were acquired for 14 adult males with AS and 19 age, sex and IQ-matched controls. Voxelwise group differences in fractional anisotropy (FA) were studied with tract-based spatial statistics (TBSS). Based on the results of TBSS, a tract-level comparison was performed with constrained spherical deconvolution (CSD)-based tractography, which is able to detect complex (for example, crossing) fiber configurations. In addition, to investigate the relationship between the microstructural changes and the severity of symptoms, we looked for correlations between FA and the Autism Spectrum Quotient (AQ), Empathy Quotient and Systemizing Quotient. Results: TBSS revealed widely distributed local increases in FA bilaterally in individuals with AS, most prominent in the temporal part of the superior longitudinal fasciculus, corticospinal tract, splenium of corpus callosum, anterior thalamic radiation, inferior fronto-occipital fasciculus (IFO), posterior thalamic radiation, uncinate fasciculus and inferior longitudinal fasciculus (ILF). CSD-based tractography also showed increases in the FA in multiple tracts. However, only the difference in the left ILF was significant after a Bonferroni correction. These results were not explained by the complexity of microstructural organization, measured using the planar diffusion coefficient. In addition, we found a correlation between AQ and FA in the right IFO in the whole group. Conclusions: Our results suggest that there are local and tract-level abnormalities in white matter (WM) microstructure in our homogenous and carefully characterized group of adults with AS, most prominent in the left ILF. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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39. Increased Coherence of White Matter Fiber Tract Organization in Adults with Asperger Syndrome: A Diffusion Tensor Imaging Study.
- Author
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Roine, Ulrika, Roine, Timo, Salmi, Juha, Nieminen‐Von Wendt, Taina, Leppämäki, Sami, Rintahaka, Pertti, Tani, Pekka, Leemans, Alexander, and Sams, Mikko
- Abstract
To investigate whether there are global white matter ( WM) differences between autistic and healthy adults, we performed diffusion tensor imaging ( DTI) in 14 male adults with Asperger syndrome ( AS) and 19 gender-, age-, and intelligence quotient-matched controls. We focused on individuals with high-functioning autism spectrum disorder ( ASD), AS, to decrease heterogeneity caused by large variation in the cognitive profile. Previous DTI studies of ASD have mainly focused on finding local changes in fractional anisotropy ( FA) and mean diffusivity ( MD), two indexes used to characterize microstructural properties of WM. Although the local or voxel-based approaches may be able to provide detailed information in terms of location of the observed differences, such results are known to be highly sensitive to partial volume effects, registration errors, or placement of the regions of interest. Therefore, we performed global histogram analyses of (a) whole-brain tractography results and (b) skeletonized WM masks. In addition to the FA and MD, the planar diffusion coefficient ( CP) was computed as it can provide more specific information of the complexity of the neural structure. Our main finding indicated that adults with AS had higher mean FA values than controls. A less complex neural structure in adults with AS could have explained the results, but no significant difference in CP was found. Our results suggest that there are global abnormalities in the WM tissue of adults with AS. Autism Res 2013, 6: 642-650. © 2013 International Society for Autism Research, Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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40. Naturalistic fMRI mapping reveals superior temporal sulcus as the hub for the distributed brain network for social perception.
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Lahnakoski, Juha M., Glerean, Enrico, Salmi, Juha, Jääskeläinen, Iiro P., Sams, Mikko, Hari, Riitta, and Nummenmaa, Lauri
- Subjects
BRAIN physiology ,SOCIAL interaction ,FUNCTIONAL magnetic resonance imaging ,NEURAL circuitry ,SOCIAL perception ,EMOTIONS - Abstract
Despite the abundant data on brain networks processing static social signals, such as pictures of faces, the neural systems supporting social perception in naturalistic conditions are still poorly understood. Here we delineated brain networks subserving social perception under naturalistic conditions in 19 healthy humans who watched, during 3-T functional magnetic resonance imaging (fMRI), a set of 137 short (approximately 16 s each, total 27min) audiovisual movie clips depicting pre-selected social signals. Two independent raters estimated how well each clip represented eight social features (faces, human bodies, biological motion, goal-oriented actions, emotion, social interaction, pain, and speech) and six filler features (places, objects, rigid motion, people not in social interaction, non-goal-oriented action, and non-human sounds) lacking social content. These ratings were used as predictors in the fMRI analysis. The posterior superior temporal sulcus (STS) responded to all social features but not to any non-social features, and the anterior STS responded to all social features except bodies and biological motion. We also found four partially segregated, extended networks for processing of specific social signals: (1) a fronto-temporal network responding to multiple social categories, (2) a fronto-parietal network preferentially activated to bodies, motion, and pain, (3) a temporo-amygdalar network responding to faces, social interaction, and speech, and (4) a fronto-insular network responding to pain, emotions, social interactions, and speech. Our results highlight the role of the pSTS in processing multiple aspects of social information, as well as the feasibility and efficiency of fMRI mapping under conditions that resemble the complexity of real life. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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41. Stimulus-Related Independent Component and Voxel-Wise Analysis of Human Brain Activity during Free Viewing of a Feature Film.
- Author
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Lahnakoski, Juha M., Salmi, Juha, Jaäskeläinen, Iiro P., Lampinen, Jouko, Glerean, Enrico, Tikka, Pia, and Sams, Mikko
- Subjects
- *
HEMODYNAMICS , *MAGNETIC resonance imaging , *NEUROSCIENCES , *INDEPENDENT component analysis , *MOTION pictures , *MAGNETIC fields - Abstract
Understanding how the brain processes stimuli in a rich natural environment is a fundamental goal of neuroscience. Here, we showed a feature film to 10 healthy volunteers during functional magnetic resonance imaging (fMRI) of hemodynamic brain activity. We then annotated auditory and visual features of the motion picture to inform analysis of the hemodynamic data. The annotations were fitted to both voxel-wise data and brain network time courses extracted by independent component analysis (ICA). Auditory annotations correlated with two independent components (IC) disclosing two functional networks, one responding to variety of auditory stimulation and another responding preferentially to speech but parts of the network also responding to non-verbal communication. Visual feature annotations correlated with four ICs delineating visual areas according to their sensitivity to different visual stimulus features. In comparison, a separate voxelwise general linear model based analysis disclosed brain areas preferentially responding to sound energy, speech, music, visual contrast edges, body motion and hand motion which largely overlapped the results revealed by ICA. Differences between the results of IC- and voxel-based analyses demonstrate that thorough analysis of voxel time courses is important for understanding the activity of specific sub-areas of the functional networks, while ICA is a valuable tool for revealing novel information about functional connectivity which need not be explained by the predefined model. Our results encourage the use of naturalistic stimuli and tasks in cognitive neuroimaging to study how the brain processes stimuli in rich natural environments. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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42. Brain networks of bottom-up triggered and top-down controlled shifting of auditory attention
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Salmi, Juha, Rinne, Teemu, Koistinen, Sonja, Salonen, Oili, and Alho, Kimmo
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AUDITORY evoked response , *BIOLOGICAL neural networks , *AUDITORY perception , *ATTENTION , *MAGNETIC resonance imaging of the brain , *PREFRONTAL cortex - Abstract
Abstract: During functional magnetic resonance imaging (fMRI), our participants selectively attended to tone streams at the left or right, and occasionally shifted their attention from one stream to another as guided by a centrally presented visual cue. Duration changes in the to-be-attended stream served as targets. Loudness deviating tones (LDTs) occurred infrequently in both streams to catch attention in a bottom-up manner, as indicated by their effects on reaction times to targets. LDTs activated the right temporo-parietal junction (TPJ), posterior parts of the left inferior/middle frontal gyrus (IFG/MFG), ventromedial parts of the superior parietal lobule (SPL), and left frontal eye field/premotor cortex (FEF/PMC). In addition, LDTs in the to-be-ignored sound stream were associated with enhanced activity in the ventromedial prefrontal cortex (VMPFC) possibly related to evaluation of the distracting event. Top-down controlled cue-guided attention shifts (CASs) activated bilateral areas in the SPL, intraparietal sulcus (IPS), FEF/PMC, TPJ, IFG/MFG, and cingulate/medial frontal gyrus, and crus I/II of the cerebellum. Thus, our results suggest that in audition top-down controlled and bottom-up triggered shifting of attention activate largely overlapping temporo-parietal, superior parietal and frontal areas. As the IPS, superior parts of the SPL, and crus I/II were activated specifically by top-down controlled attention shifts, and the VMPFC was specifically activated by bottom-up triggered attention shifts, our results also suggest some differences between auditory top-down controlled and bottom-up triggered shifting of attention. [Copyright &y& Elsevier]
- Published
- 2009
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43. Does sleep quality affect involuntary attention switching system?
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Salmi, Juha, Huotilainen, Minna, Pakarinen, Satu, Siren, Teo, Alho, Kimmo, and Aronen, Eeva T.
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SLEEP deprivation , *PATIENT monitoring , *EVOKED potentials (Electrophysiology) , *ELECTROENCEPHALOGRAPHY - Abstract
Abstract: We studied the relationship between sleep quality and quantity and subsequently recorded automatically evoked event-related potential (ERP) responses. In previous studies decrement of attentional processing has been associated with changes in sleep. Sleep is shown to associate also with ERPs elicited by unattended sound stream, however, there is no consensus on these effects. A recent study suggested that the early anterior P3a to novel stimuli in attended stream is attenuated and the late parietal P3a is strengthened by total sleep deprivation. We carried out 72-h consecutive actigraphy measurements in a naturalistic setting to collect information about variation in sleep duration, sleep onset latency, sleep efficiency, and percentage of sleep. MMN and P3a deflections to infrequent changes in sound duration and pitch in unattended sound stream were obtained in a separate recording session from the same subjects when they were awake. No significant correlations were found between sleep and MMN parameters, indicating that MMN is resistant to normal variation in sleep. However, P3a to both pitch and duration changes correlated positively with sleep onset latency, and P3a to duration changes correlated negatively with sleep efficiency and percentage of sleep. The correlation was higher in the posterior scalp areas. Our results suggest that the involuntary attention switching system, reflected by the P3a is sensitized as a function of decreased sleep quality. [Copyright &y& Elsevier]
- Published
- 2005
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44. Brain activity associated with selective attention, divided attention and distraction.
- Author
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Salo, Emma, Salmela, Viljami, Salmi, Juha, Numminen, Jussi, and Alho, Kimmo
- Subjects
- *
BRAIN physiology , *FUNCTIONAL magnetic resonance imaging , *ANALYSIS of variance , *TASK performance , *VISUAL perception - Abstract
Top-down controlled selective or divided attention to sounds and visual objects, as well as bottom-up triggered attention to auditory and visual distractors, has been widely investigated. However, no study has systematically compared brain activations related to all these types of attention. To this end, we used functional magnetic resonance imaging (fMRI) to measure brain activity in participants performing a tone pitch or a foveal grating orientation discrimination task, or both, distracted by novel sounds not sharing frequencies with the tones or by extrafoveal visual textures. To force focusing of attention to tones or gratings, or both, task difficulty was kept constantly high with an adaptive staircase method. A whole brain analysis of variance (ANOVA) revealed fronto-parietal attention networks for both selective auditory and visual attention. A subsequent conjunction analysis indicated partial overlaps of these networks. However, like some previous studies, the present results also suggest segregation of prefrontal areas involved in the control of auditory and visual attention. The ANOVA also suggested, and another conjunction analysis confirmed, an additional activity enhancement in the left middle frontal gyrus related to divided attention supporting the role of this area in top-down integration of dual task performance. Distractors expectedly disrupted task performance. However, contrary to our expectations, activations specifically related to the distractors were found only in the auditory and visual cortices. This suggests gating of the distractors from further processing perhaps due to strictly focused attention in the current demanding discrimination tasks. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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45. Selective attention to sound location or pitch studied with fMRI
- Author
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Degerman, Alexander, Rinne, Teemu, Salmi, Juha, Salonen, Oili, and Alho, Kimmo
- Subjects
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BRAIN research , *MAGNETIC resonance imaging , *ATTENTION , *AUDITORY perception , *PREFRONTAL cortex - Abstract
Abstract: We used 3-T functional magnetic resonance imaging to compare the brain mechanisms underlying selective attention to sound location and pitch. In different tasks, the subjects (N = 10) attended to a designated sound location or pitch or to pictures presented on the screen. In the Attend Location conditions, the sound location varied randomly (left or right), while the pitch was kept constant (high or low). In the Attend Pitch conditions, sounds of randomly varying pitch (high or low) were presented at a constant location (left or right). Both attention to location and attention to pitch produced enhanced activity (in comparison with activation caused by the same sounds when attention was focused on the pictures) in widespread areas of the superior temporal cortex. Attention to either sound feature also activated prefrontal and inferior parietal cortical regions. These activations were stronger during attention to location than during attention to pitch. Attention to location but not to pitch produced a significant increase of activation in the premotor/supplementary motor cortices of both hemispheres and in the right prefrontal cortex, while no area showed activity specifically related to attention to pitch. The present results suggest some differences in the attentional selection of sounds on the basis of their location and pitch consistent with the suggested auditory “what” and “where” processing streams. [Copyright &y& Elsevier]
- Published
- 2006
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46. Distributed neural signatures of natural audiovisual speech and music in the human auditory cortex.
- Author
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Koistinen, Olli-Pekka, Glerean, Enrico, Jylänki, Pasi, Vehtari, Aki, Jääskeläinen, Iiro P., Mäkelä, Sasu, Nummi, Ilari, Sams, Mikko, Salmi, Juha, Nummenmaa, Lauri, and Nummi-Kuisma, Katarina
- Subjects
- *
AUDITORY cortex , *AUDITORY perception , *ARTIFICIAL neural networks , *BAYESIAN analysis , *LOGISTIC regression analysis - Abstract
During a conversation or when listening to music, auditory and visual information are combined automatically into audiovisual objects. However, it is still poorly understood how specific type of visual information shapes neural processing of sounds in lifelike stimulus environments. Here we applied multi-voxel pattern analysis to investigate how naturally matching visual input modulates supratemporal cortex activity during processing of naturalistic acoustic speech, singing and instrumental music. Bayesian logistic regression classifiers with sparsity-promoting priors were trained to predict whether the stimulus was audiovisual or auditory, and whether it contained piano playing, speech, or singing. The predictive performances of the classifiers were tested by leaving one participant at a time for testing and training the model using the remaining 15 participants. The signature patterns associated with unimodal auditory stimuli encompassed distributed locations mostly in the middle and superior temporal gyrus (STG/MTG). A pattern regression analysis, based on a continuous acoustic model, revealed that activity in some of these MTG and STG areas were associated with acoustic features present in speech and music stimuli. Concurrent visual stimulus modulated activity in bilateral MTG (speech), lateral aspect of right anterior STG (singing), and bilateral parietal opercular cortex (piano). Our results suggest that specific supratemporal brain areas are involved in processing complex natural speech, singing, and piano playing, and other brain areas located in anterior (facial speech) and posterior (music-related hand actions) supratemporal cortex are influenced by related visual information. Those anterior and posterior supratemporal areas have been linked to stimulus identification and sensory-motor integration, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
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