38 results on '"Salemi, Vera Maria Cury"'
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2. COMPARACAO DO TESTE DE 1RM NO AGACHAMENTO COM BARRA GUIADA E BARRA LIVRE/Comparison of 1rm test on guiding bar and free bar
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Miranda, Douglas Pinheiro, de Carvalho Alves, Carlos Roberto, Alves, Júlio César Camargo, and Salemi, Vera Maria Cury
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- 2019
3. Left ventricular assessment in patients with systemic light chain amyloidosis: a 3-dimensional speckle tracking transthoracic echocardiographic study
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Pradel, Sarah, Magne, Julien, Jaccard, Arnaud, Fadel, Bahaa M., Boulogne, Cyrille, Salemi, Vera Maria Cury, Damy, Thibaud, Aboyans, Victor, and Mohty, Dania
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- 2019
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4. Morphological and functional cardiac alterations in children with congenital Zika syndrome and severe neurological deficits.
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Barbosa, Imara Correia de Queiroz, de Paula Gomes, Luizabel, de Almeida Feitosa, Israel Nilton, Botelho, Luís Fábio Barbosa, Barbosa, Bruno Robalinho Cavalcanti, Barbosa, Alex, Araújo, André Telis de Vilela, Melo, Marcelo Dantas Tavares de, Melo, Adriana Suely de Oliveira, and Salemi, Vera Maria Cury
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ZIKA virus infections ,RIGHT heart atrium ,SINUS arrhythmia ,TROPONIN I ,ZIKA virus ,MITRAL valve insufficiency ,ARTHROGRYPOSIS - Abstract
Introduction: Zika virus infection during pregnancy causes fetal microcephaly and brain damage. Congenital Zika syndrome (CZS) is characterized by systemic involvement with diffuse muscle impairment, a high frequency of arthrogryposis, and microphthalmia. Cardiac impairment in CZS has rarely been evaluated. Our study assessed morphology and biventricular cardiac function in children with CZS and advanced neurological dysfunction. Methods: This cross-sectional study was conducted on 52 children with CZS (Zika group; ZG) and 25 healthy children (control group; CG) in Paraiba, Brazil. Clinical evaluation, electrocardiogram (EKG), and transthoracic echocardiogram (TTE) were performed on all children. Additionally, troponin I and natriuretic peptide type B (BNP) levels, the degree of cerebral palsy, and neuroimaging findings were assessed in the ZG group. Results: The median age of the study population was 5 years in both groups, and 40.4% (ZG) and 60% (CG) were female. The most prevalent electrocardiographic alteration was sinus arrhythmia in both the ZG (n = 9, 17.3%) and CG (n = 4, 16%). The morphological parameters adjusted for Z score were as follows: left ventricular (LV) end-diastolic diameter in ZG: -2.36 [-5.10, 2.63] vs. CG: -1.07 [-3.43, 0.61], p<0.001); ascending aorta (ZG: -0.09 [-2.08, 1.60] vs. CG: 0.43 [-1.47, 2.2], p = 0.021); basal diameter of the right ventricle (RV) (ZG: -2.34 [-4.90, 0.97] vs. CG: -0.96 [-2.21, 0.40], p<0.01); and pulmonary artery dimension (ZG: -2.13 [-5.99, 0.98] vs. CG: -0.24 [-2.53, 0.59], p<0.01). The ejection fractions (%) were 65.7 and 65.6 in the ZG and CG, respectively (p = 0.968). The left atrium volume indices (mL/m
2 ) in the ZG and CG were 13.15 [6.80, 18.00] and 18.80 [5.90, 25.30] (p<0.01), respectively, and the right atrium volume indices (mL/m2 ) were 10.10 [4.90, 15.30] and 15.80 [4.10, 24.80] (p<0.01). The functional findings adjusted for Z score were as follows: lateral systolic excursion of the mitral annular plane (MAPSE) (ZG: 0.36 [-2.79, 4.71] vs. CG: 1.79 [-0.93, 4.5], p = 0.001); tricuspid annular plane systolic excursion (TAPSE) (ZG: -2.43 [-5.47, 5.09] vs. CG: 0.07 [-1.98, 3.64], p<0.001); and the S' of the RV (ZG: 1.20 [3.35, 2.90] vs. CG: -0.20 [-2.15, 1.50], p = 0.0121). No differences in biventricular strain measurements were observed between the groups. Troponin I and BNP levels were normal in in the ZG. Grade V cerebral palsy and subcortical calcification were found in 88.6% and 97.22% of children in the ZG group, respectively. Conclusion: A reduction in cardiac dimensions and functional changes were found in CZS patients, based on the TAPSE, S' of the RV, and MAPSE, suggesting the importance of cardiac evaluation and follow-up in this group of patients. Author summary: Congenital Zika syndrome (CZS) occurs in the fetuses of mothers infected with the Zika virus during pregnancy, especially in the third trimester. The main findings are microcephaly and other neurological defects; however, several systemic effects have also been reported. Cardiac manifestations have rarely been evaluated. In this study, we compared cardiac anatomy and function between 52 children with CZS and 25 healthy children using electrocardiograms, echocardiograms, and biomarkers. We also assessed the degree of cerebral palsy and neuroimaging findings in the affected group. The hearts of the CZS patients were smaller and demonstrated functional alterations in comparison with those of the control individuals. Neurological impairment in the CZS patients was severe. The early detection of cardiac alterations highlights the need for cardiac evaluation and follow-up in this patient group. [ABSTRACT FROM AUTHOR]- Published
- 2023
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5. Erythropoietin reduces collagen deposition after myocardial infarction but does not improve cardiac function
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Pessoa, Fernanda Gallinaro, Mady, Charles, Fonseca, Keila Cardoso Barbosa, de Oliveira-Fonoff, Adriana Morgan, Salemi, Vera Maria Cury, Jordao, Mauncio Rodrigues, Fernandes, Fabio, and Ramires, Felix Jose Alvarez
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Heart attack -- Physiological aspects ,Collagen -- Physiological aspects ,Erythropoietin -- Physiological aspects ,Biological sciences - Abstract
Myocardial remodeling includes inappropriate collagen deposition in the interstitium. Erythropoietin (EPO) may have cardioprotective effects. We aimed to assess the role of EPO on myocardial remodeling during the chronic phase. We studied 60 Wistar rats divided into the following groups: control (CT), control + EPO (CT + EPO), myocardial infarction + EPO (MI + EPO), and myocardial infarction (MI). The interstitial collagen volume fraction (ICVF) was quantified and echocardiography was performed. We quantified asymmetric dimethylarginine and glutathione by ELISA, and used real-time PCR to assess apoptosis and inflammation. Western blotting was used to evaluate inflammatory proteins and tissue inhibitors of metalloproteinases (TIMPs), and TUNEL staining was used to detect apoptosis. For matrix metalloproteinases (MMPs), we performed zymography. Parametric and nonparametric analyses were performed according to normality testing. ICVF was greater in MI groups (p < 0.001) and was attenuated by EPO (p = 0.05). The MMP-2 did not show any difference between groups. The TIMP-1 and TIMP-2 did not have difference between groups. The MI groups had worse fraction shortening (p < 0.001), without EPO protection (p = 0.666). The MI groups had increased left ventricle diastolic dimension (p < 0.001) without EPO attenuation (p = 0.79). EPO did not act on oxidative stress. Apoptosis and inflammation were not modulated by EPO. We concluded that EPO attenuated interstitial collagen accumulation, but did not protect from heart dilation or dysfunction. Key words: erythropoietin, ventricular remodeling, fibrosis, myocardial infarction, inflammation, oxidative stress. Resume : Le remodelage du myocarde comprend le depot inapproprie de collagene dans le tissu interstitiel. Par ailleurs, l'erythropoietine (EPO) pourrait avoir des effets cardioprotecteurs. Nous visions a evaluer le role de l'EPO sur le remodelage du myocarde pendant la phase chronique. Nous avons etudie 60 rats Wistar repartis dans les groupes suivants: temoin (T), temoin + EPO (T + EPO), infarctus du myocarde + EPO (IM + EPO) et infarctus du myocarde (IM). Nous avons quantifie la fraction volumique du collagene interstitiel (FVCI) et effectue une echocardiographie. En vue d'evaluer l'apoptose et l'inflammation, nous avons quantifie les taux de dymethylarginine asymetrique et de glutathion a l'aide des techniques d'ELISA et de PCR en temps reel. Nous avons utilise l'immunobuvardage de Western pour evaluer les taux de proteines inflammatoires et d'inhibiteurs des metalloproteinases tissulaires (TIMP), ainsi que la technique de marquage TUNEL pour deceler l'apoptose. Pour les metalloproteinases matricielles (MMP), nous avons effectue une zymographie. Nous avons enfin effectue des analyses parametriques et non parametriques en fonction de tests de distribution normale. La FVCI etait plus elevee dans les groupes IM (p < 0,001) et diminuait avec l'EPO (p = 0,05). Les taux de MMP-2 ne se sont pas reveles differents entre les groupes. L'activite de TIMP-1 et de TIMP-2 n'etait pas differente entre les groupes non plus. En fait, la fraction de raccourcissement etait moins avantageuse dans les groupes IM (p < 0,001), sans protection liee a l'EPO (p = 0,666). Et la dimension du ventricule gauche en diastole etait plus elevee dans les groupes IM (p < 0,001), sans attenuation liee a l'EPO non plus (p = 0,79). Enfin, l'EPO n'avait aucun effet sur le stress oxydatif et elle ne participait pas a la modulation de l'apoptose ni de l'inflammation. Nous en sommes arrives a la conclusion que l'EPO permettait de diminuer l'accumulation de collagene dans le tissu interstitiel, mais qu'elle n'entramait pas de protection contre la dilatation du creur ni contre son dysfonctionnement. [Traduit par la Redaction] Mots-cles: erythropoietine, remodelage des ventricules, fibrose, infarctus du myocarde, inflammation, stress oxydatif., Introduction Myocardial remodeling is responsible for cardiac dysfunction that results in heart failure. Interstitial collagen deposition into the myocardium has a pivotal role in this scenario. Inflammation, oxidative stress, and [...]
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- 2018
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6. Influencia do volume semanal e do treinamento resistido sobre a incidencia de lesao em corredores de rua
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Rios, Edmar Tiago, Rodrigues, Fernando Campos, Rocha, Leonardo Ferreira, Salemi, Vera Maria Cury, and Miranda, Douglas Pinheiro
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- 2017
7. Differential effects of variation in athletes training on myocardial morphophysiological adaptation in men: Focus on 123I-MIBG assessed myocardial sympathetic activity
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Miranda, Douglas Pinheiro, dos Santos, Marcelo José, Salemi, Vera Maria Cury, de Oliveira, Edmundo Pereira Caparelli, Verberne, Hein J., and da Rocha, Euclides Timóteo
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- 2014
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8. Exercise-Induced Decrease in Myocardial High-Energy Phosphate Metabolites in Patients With Chagas Heart Disease
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Betim Paes Leme, Ana Maria, Salemi, Vera Maria Cury, Weiss, Robert G., Parga, Jose Rodrigues, Ianni, Bárbara Maria, Mady, Charles, and Kalil-Filho, Roberto
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- 2013
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9. Effect of Colchicine on Myocardial Injury Induced by Trypanosoma cruzi in Experimental Chagas Disease
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Fernandes, Fábio, Ramires, Felix José Alvarez, Ianni, Barbara Maria, Salemi, Vera Maria Cury, Oliveira, Adriana Morgan, Pessoa, Fernanda Gallinaro, Canzian, Mauro, and Mady, Charles
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- 2012
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10. Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
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Mostarda, Cristiano, Moraes-Silva, Ivana Cinthya, Salemi, Vera Maria Cury, Machi, Jacqueline Freire, Rodrigues, Bruno, De Angelis, Kátia, de Moura Azevedo Farah, Vera, and Irigoyen, Maria Claudia
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- 2012
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11. An unusual association of endomyocardial fibrosis and hypertrophic cardiomyopathy in a patient with heart failure
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Salemi, Vera Maria Cury, D'andretta Iglezias, Silvia, Benvenuti, Luiz Alberto, Filho, Júlio César Ayres Ferreira, Rochitte, Carlos Eduardo, Shiozaki, Afonso Akio, and Mady, Charles
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- 2012
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12. The effect of beta-blockade on myocardial remodelling in Chagas' cardiomyopathy
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de Souza Pimentel, Walace, Ramires, Felix José Alvarez, Ianni, Barbara Maria, Salemi, Vera Maria Cury, Bilate, Angelina Morand Bianchi, Cunha-Neto, Edécio, de Oliveira, Adriana Morgan, Fernandes, Fábio, and Mady, Charles
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- 2012
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13. Endothelial and Non-Endothelial Coronary Blood Flow Reserve and Left Ventricular Dysfunction in Systemic Hypertension
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Rocha, Aloísio Marchi, Salemi, Vera Maria Cury, Neto, Pedro Alves Lemos, Matsumoto, Afonso Yoshikiro, Pereira, Valéria Fontenelle Angelim, Fernandes, Fábio, Nastari, Luciano, and Mady, Charles
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- 2009
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14. Does Quantitative Left Ventricular Regional Wall Motion Change after Fibrous Tissue Resection in Endomyocardial Fibrosis?
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Salemi, Vera Maria Cury, Fernandes, Fabio, Sirvente, Raquel, Nastari, Luciano, Rosa, Leonardo Vieira, Ferreira, Cristiano A., Pena, José Luiz Barros, Picard, Michael H., and Mady, Charles
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- 2009
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15. Endomyocardial fibrosis of the right ventricle in a patient with schistosomiasis: a case report.
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Romero, Cristhian Espinoza, Lima, Ivna Cunha Vieira, Hotta, Viviane Tiemi, Bocchi, Edimar Alcides, and Salemi, Vera Maria Cury
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CARDIAC amyloidosis ,CARDIAC magnetic resonance imaging ,SCHISTOSOMIASIS ,MAGNETIC resonance imaging ,PATIENTS' rights ,FIBROSIS - Abstract
Background Endomyocardial fibrosis (EMF) is a rare and underdiagnosed cause of restrictive cardiomyopathy. Its aetiology is not yet defined and could be caused by the influence of different clinical factors that seem to combine with genetic aspects of individuals susceptible to an inflammatory process that leads to formation of fibrosis. Case summary We describe a case of a 50-year-old man from the northeastern region of Brazil, where there is high prevalence of schistosomiasis. He presented to our centre with symptoms of right heart failure. The echocardiogram showed normal left ventricular ejection fraction. Right ventricular had normal systolic function but in the apical region was filled with a homogeneous and hypoechoic image causing obliteration and restriction of the apex. The late gadolinium enhancement with cardiac magnetic resonance showed diffuse and heterogeneous subendocardial fibrosis in the right ventricle apex consistent with EMF, but declined endocardiectomy. Discussion This report presents an interesting case of EMF and schistosomiasis simultaneously. The hypothesis of parasitosis as a probable cause of EMF was raised by helminth-induced hypereosinophilia. Complementary imaging tests such as magnetic resonance imaging and echocardiography, in addition to clinical and epidemiological suspicion, are essential for its diagnosis. Early surgical resolution becomes crucial for long-term survival. [ABSTRACT FROM AUTHOR]
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- 2022
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16. Endomyocardial fibrosis: pathological and molecular findings of surgically resected ventricular endomyocardium
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Iglezias, Silvia D’Andretta, Benvenuti, Luiz Alberto, Calabrese, Fiorella, Salemi, Vera Maria Cury, Silva, Ana Maria Gonçalves, Carturan, Elisa, de Oliveira, Sergio Almeida, Thiene, Gaetano, and De Brito, Thales
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- 2008
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17. Type III glycogen storage disease mimicking hypertrophic cardiomyopathy
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Salemi, Vera Maria Cury, Demarchi, Léa Maria Macruz Ferreira, Cabeda, Estêvan Vieira, Wagenführ, Jaqueline, and Tanaka, Ana Cristina
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- 2012
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18. Mycobacterium avium causing cardiac tamponade in an immunocompetent patient
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Salemi, Vera Maria Cury, Nicodemo, Antonio Carlos, Mitteldorf, Cristina Aparecida Troques, Rosa, Leonardo Vieira, and Kalil Filho, Roberto
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- 2011
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19. A machine learning framework for the evaluation of myocardial rotation in patients with noncompaction cardiomyopathy.
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Tavares de Melo, Marcelo Dantas, Araujo-Filho, Jose de Arimatéia Batista, Barbosa, José Raimundo, Rocon, Camila, Miranda Regis, Carlos Danilo, dos Santos Felix, Alex, Kalil Filho, Roberto, Bocchi, Edimar Alcides, Hajjar, Ludhmila Abrahão, Tabassian, Mahdi, D'hooge, Jan, and Salemi, Vera Maria Cury
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MAGNETIC resonance imaging ,MACHINE learning ,RANDOM forest algorithms ,ARTIFICIAL neural networks ,VENTRICULAR ejection fraction - Abstract
Aims: Noncompaction cardiomyopathy (NCC) is considered a genetic cardiomyopathy with unknown pathophysiological mechanisms. We propose to evaluate echocardiographic predictors for rigid body rotation (RBR) in NCC using a machine learning (ML) based model. Methods and results: Forty-nine outpatients with NCC diagnosis by echocardiography and magnetic resonance imaging (21 men, 42.8±14.8 years) were included. A comprehensive echocardiogram was performed. The layer-specific strain was analyzed from the apical two-, three, four-chamber views, short axis, and focused right ventricle views using 2D echocardiography (2DE) software. RBR was present in 44.9% of patients, and this group presented increased LV mass indexed (118±43.4 vs. 94.1±27.1g/m
2 , P = 0.034), LV end-diastolic and end-systolic volumes (P< 0.001), E/e' (12.2±8.68 vs. 7.69±3.13, P = 0.034), and decreased LV ejection fraction (40.7±8.71 vs. 58.9±8.76%, P < 0.001) when compared to patients without RBR. Also, patients with RBR presented a significant decrease of global longitudinal, radial, and circumferential strain. When ML model based on a random forest algorithm and a neural network model was applied, it found that twist, NC/C, torsion, LV ejection fraction, and diastolic dysfunction are the strongest predictors to RBR with accuracy, sensitivity, specificity, area under the curve of 0.93, 0.99, 0.80, and 0.88, respectively. Conclusion: In this study, a random forest algorithm was capable of selecting the best echocardiographic predictors to RBR pattern in NCC patients, which was consistent with worse systolic, diastolic, and myocardium deformation indices. Prospective studies are warranted to evaluate the role of this tool for NCC risk stratification. [ABSTRACT FROM AUTHOR]- Published
- 2021
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20. Diagnostic Accuracy of Dobutamine Stress Echocardiography for Detection of Cardiac Allograft Vasculopathy in Orthotopic Heart Transplant Patients.
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Mahmoodurrahman, Mohammed, Marek, Josef, Juhardeen, Hamzah Ruxshan, Al Otaibi, Talal, Salemi, Vera Maria Cury, Echahidi, Najmeddine, Al Buraiki, Jehad, Fadel, Bahaa M., and Mohty, Dania
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Objective: Cardiac allograft vasculopathy is one of the leading causes of late graft failure and subsequent death in orthotopic heart transplant. Although invasive coronary angiography is the gold standard modality for detection of cardiac allograft vasculopathy, dobutamine stress echocardiography has been recently frequently used as an alternative. Our aim was to evaluate the diagnostic performance of dobutamine stress echocardiography for detection of cardiac allograft vasculopathy in transplant patients. Methods: A retrospective analysis was conducted using a total of 150 dobutamine stress echocardiographic exams that were performed on 99 patients in our institution, with paired coronary angiogram and no acute rejection, within a median of 538 [interquartile range 371e816] days. Sensitivity and specificity of dobutamine echocardiography to detect allograft vasculopathy was evaluated. Allograft vasculopathy was defined as Grade 1 or higher based on ISHLT criteria. A positive dobutamine stress echo result was defined by new or worsening wall motion abnormality. Results: Median age of the population at transplant was 34 [interquartile range 22-46] years; 76 (77%) patients were male. Allograft vasculopathy was present in 31 (20.6%) out of 150 coronary angiograms. Only 7 (4.6%) of that number were positive on dobutamine stress echocardiography. Sensitivity and specificity for allograft vasculopathy detection was 3% and 94%, respectively. Out of 7 false positive dobutamine stress echocardiograms, two were in patients with myocardial bridging. Two patients with mild acute rejection had both negative dobutamine stress echo. Conclusions: Overall, positivity of dobutamine stress echocardiography in patients after heart transplant is low. It has high specificity, but very low sensitivity for detection of cardiac allograft vasculopathy. Dobutamine stress echocardiography should only be cautiously used as an alternative to coronary angiography. [ABSTRACT FROM AUTHOR]
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- 2021
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21. Delayed enhancement by multidetector computed tomography in endomyocardial fibrosis
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Senra, Tiago, Shiozaki, Afonso Akio, Salemi, Vera Maria Cury, and Rochitte, Carlos Eduardo
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- 2008
22. Pulmonary Hypertension in Obese Mice Is Accompanied by a Reduction in PPAR-γ Expression in Pulmonary Artery.
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Gonçalves, Any Elisa de Souza Schmidt, Rocha, Guilherme Zweig, Marin, Rodrigo, Camargo, Rafael Ludemann, Santos, Andrey dos, Carmo, Helison do, Guadagnini, Dioze, Petrucci, Orlando, Moysés, Zenaide Providello, Salemi, Vera Maria Cury, Oliveira, Alexandre Gabarra, and Saad, Mario José Abdalla
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PULMONARY artery ,PULMONARY hypertension ,INSULIN resistance ,CARDIOVASCULAR diseases risk factors ,OBESITY - Abstract
Obesity and insulin resistance (IR) are well-studied risk factors for systemic cardiovascular disease, but their impact on pulmonary hypertension (PH) is not well clarified. This study aims to investigate if diet-induced obesity induces PH and if peroxisome-proliferator-activated receptor (PPAR-γ) and/or endoplasmic reticulum (ER) stress are involved in this process. Mice were maintained on a high-fat diet (HFD) for 4 months, and IR and PH were confirmed. In a separate group, after 4 months of HFD, mice were treated with pioglitazone (PIO) or 4-phenylbutyric acid for the last month. The results demonstrated that HFD for at least 4 months is able to increase pulmonary artery pressure, which is maintained, and this animal model can be used to investigate the link between IR and PH, without changes in ER stress in the pulmonary artery. There was also a reduction in circulating adiponectin and in perivascular adiponectin expression in the pulmonary artery, associated with a reduction in PPAR-γ expression. Treatment with PIO improved IR and PH and reversed the lower expression of adiponectin and PPAR-γ in the pulmonary artery, highlighting this drug as potential benefit for this poorly recognized complication of obesity. [ABSTRACT FROM AUTHOR]
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- 2021
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23. Worsening of heart failure by coronavirus disease 2019 is associated with high mortality.
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Bocchi, Edimar Alcides, Lima, Ivna Girard Cunha Vieira, Biselli, Bruno, Salemi, Vera Maria Cury, Ferreira, Silvia Moreira Ayub, Chizzola, Paulo Roberto, Munhoz, Robinson Tadeu, Pessoa, Ranna Santos, Cardoso, Francisco Akira Malta, Bello, Mariana Vieira de Oliveira, Hajjar, Ludhmila Abrahão, and Gomes, Brenno Rizerio
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HEART failure patients ,SARS-CoV-2 ,CARDIOGENIC shock - Abstract
Aims: Patients with advanced heart failure (HF) with reduced left ventricular ejection fraction (HFrEF) and concurrent coronavirus disease 2019 (COVID‐19) might have a higher risk of severe events. Methods and results: We retrospectively studied 16 patients with advanced HFrEF who developed COVID‐19 between 1 March and 29 May 2020. Follow‐up lasted until 30 September. Ten patients previously hospitalized with decompensated HFrEF were infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) during hospitalization. Six patients undergoing ambulatory care at initiation of COVID‐19 symptoms were hospitalized because of advanced HFrEF. All patients who experienced worsening of HFrEF due to COVID‐19 required higher doses or introduction of additional inotropic drugs or intra‐aortic balloon pump in the intensive care unit. The mean intravenous dobutamine dose before SARS‐CoV‐2 infection in previously hospitalized patients (n = 10) and the median (inter‐quartile range) peak intravenous dobutamine dose during SARS‐CoV‐2 infection in all patients (n = 16) were 2 (0–7) μg/kg/min and 20 (14–20) (P < 0.001), respectively. During follow‐up, 56% underwent heart transplantation (n = 2) or died (n = 7). Four patients died during hospitalization from mixed shock consequent to severe acute respiratory syndrome with inflammatory storm syndrome associated with septic and cardiogenic shock during COVID‐19. After COVID‐19 recovery, two patients died from mixed septic and cardiogenic shock and one from sustained ventricular tachycardia and cardiogenic shock. Five patients were discharged from hospital to ambulatory care. Four were awaiting heart transplantation. Conclusion: Worsening of advanced HF by COVID‐19 is associated with high mortality. This report highlights the importance of preventing COVID‐19 in patients with advanced HF. [ABSTRACT FROM AUTHOR]
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- 2021
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24. Biventricular imaging markers to predict outcomes in non‐compaction cardiomyopathy: a machine learning study.
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Rocon, Camila, Tabassian, Mahdi, Tavares de Melo, Marcelo Dantas, Araujo Filho, Jose Arimateia, Grupi, Cesar José, Parga Filho, Jose Rodrigues, Bocchi, Edimar Alcides, D'hooge, Jan, and Salemi, Vera Maria Cury
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CARDIOMYOPATHIES ,HEART diseases ,HEART failure - Abstract
Aims: Left ventricular non‐compaction cardiomyopathy (LVNC) is a genetic heart disease, with heart failure, arrhythmias, and embolic events as main clinical manifestations. The goal of this study was to analyse a large set of echocardiographic (echo) and cardiac magnetic resonance imaging (CMRI) parameters using machine learning (ML) techniques to find imaging predictors of clinical outcomes in a long‐term follow‐up of LVNC patients. Methods and results: Patients with echo and/or CMRI criteria of LVNC, followed from January 2011 to December 2017 in the heart failure section of a tertiary referral cardiologic hospital, were enrolled in a retrospective study. Two‐dimensional colour Doppler echocardiography and subsequent CMRI were carried out. Twenty‐four hour Holter monitoring was also performed in all patients. Death, cardiac transplantation, heart failure hospitalization, aborted sudden cardiac death, complex ventricular arrhythmias (sustained and non‐sustained ventricular tachycardia), and embolisms (i.e. stroke, pulmonary thromboembolism and/or peripheral arterial embolism) were registered and were referred to as major adverse cardiovascular events (MACEs) in this study. Recruited for the study were 108 LVNC patients, aged 38.3 ± 15.5 years, 48.1% men, diagnosed by echo and CMRI criteria. They were followed for 5.8 ± 3.9 years, and MACEs were registered. CMRI and echo parameters were analysed via a supervised ML methodology. Forty‐seven (43.5%) patients had at least one MACE. The best performance of imaging variables was achieved by combining four parameters: left ventricular (LV) ejection fraction (by CMRI), right ventricular (RV) end‐systolic volume (by CMRI), RV systolic dysfunction (by echo), and RV lower diameter (by CMRI) with accuracy, sensitivity, and specificity rates of 75.5%, 77%, 75%, respectively. Conclusions: Our findings show the importance of biventricular assessment to detect the severity of this cardiomyopathy and to plan for early clinical intervention. In addition, this study shows that even patients with normal LV function and negative late gadolinium enhancement had MACE. ML is a promising tool for analysing a large set of parameters to stratify and predict prognosis in LVNC patients. [ABSTRACT FROM AUTHOR]
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- 2020
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25. Maximal functional capacity in patients with Chagas' cardiomyopathy without congestive heart failure
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Mady, Charles, Ianni, Barbara Maria, Arteaga, Edmundo, Salemi, Vera Maria Cury, and de Carvalho Frimm, Clovis
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- 2000
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26. Use of sacubitril/valsartan in non‐compaction cardiomyopathy: a case report.
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Bonatto, Marcely Gimenes, Albanez, Rodrigo, Salemi, Vera Maria Cury, and Moura, Lídia Zytynski
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HEART failure ,VALSARTAN ,ECHOCARDIOGRAPHY - Abstract
The use of sacubitril/valsartan significantly reduces death or hospitalization in patients with ejection fraction < 40%. There is no study evaluating this drug effects in non‐compaction cardiomyopathy (NCCM) individuals. The aim of this article is to report a case of a patient with NCCM initially refractory to gold standard treatment and afterwards treated with sacubitril/valsartan and its improvements. This is a case report of a 48‐year‐old woman, presenting with NCCM heart failure, who had received standard guideline‐directed medical therapy for 18 months without any improvement in clinical and echocardiographic parameters. After that period, sacubitril/valsartan was initiated. After 18 months of refractory usage of guideline‐directed medical therapy, sacubitril/valsartan was started, and significant change in functional class (III to I) and important ventricular remodelling were achieved with an improvement of 29% in the ejection fraction, reduction of 7 mm in ventricular diastolic diameter, and mild to none mitral valve functional regurgitation. In this case report, sacubitril/valsartan use was associated with improvement of echocardiographic and clinical parameters in a patient with NCCM. [ABSTRACT FROM AUTHOR]
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- 2020
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27. Prognosis and risk stratification in patients with decompensated heart failure receiving inotropic therapy.
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Gomes, Clara, Terhoch, Caíque Bueno, Ayub-Ferreira, Silvia Moreira, Conceição-Souza, Germano Emilio, Salemi, Vera Maria Cury, Chizzola, Paulo Roberto, Oliveira Jr, Mucio Tavares, Lage, Silvia Helena Gelas, Frioes, Fernando, Bocchi, Edimar Alcides, and Issa, Victor Sarli
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- 2018
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28. Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause.
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Sanches, Iris Callado, Buzin, Morgana, Conti, Filipe Fernandes, Dias, Danielle da Silva, Santos, Camila Paixão dos, Sirvente, Raquel, Salemi, Vera Maria Cury, Llesuy, Susana, Irigoyen, Maria-Cláudia, and De Angelis, Kátia
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AEROBIC exercises ,ISOMETRIC exercise ,HEART diseases ,DIABETES ,MENOPAUSE - Abstract
The study aimed at evaluating the effects of combined aerobic and resistance exercise training on cardiac morphometry and function, oxidative stress and inflammatory parameters in diabetic ovariectomized rats. For this, female Wistar rats (10 weeks-old) were divided into 4 groups (n = 8): euglycemic (E), diabetic (streptozotocin, 50 mg/kg, iv) (D), diabetic ovariectomized (DO) and trained diabetic ovariectomized (TDO). The combined exercise training was performed on a treadmill and in a ladder adapted to rats (8 weeks, at 40–60% of maximal capacity). The left ventricle (LV) morphometry and function were evaluated by echocardiography. Oxidative stress and inflammatory markers were measured on ventricles tissue. The sedentary diabetic animals (D and DO) showed impaired systolic and diastolic functions, as well as increased cardiac overload, evaluated by myocardial performance index (MPI- D: 0.32 ± 0.05; DO: 0.39 ± 0.13 vs. E: 0.25 ± 0.07), in relation to E group. Systolic and MPI dysfunctions were exacerbated in DO when compared to D group. The DO group presented higher protein oxidation and TNF-α/IL-10 ratio than D groups. Glutathione redox ratio (GSH/GSSG) and IL-10 were decreased in both D and DO groups when compared to E group. Exercise training improved exercise capacity, systolic and diastolic functions and MPI (0.18±0.11). The TDO group showed reduced protein oxidation and TNF-α/IL-10 ratio and increased GSH/GSSG and IL-10 in relation to the DO group. These results showed that combined exercise training was able to attenuate the cardiac dysfunctions, probably by reducing inflammation and oxidative stress in an experimental model of diabetes and menopause. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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29. Clinical findings and prognosis of patients hospitalized for acute decompensated heart failure: Analysis of the influence of Chagas etiology and ventricular function.
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Terhoch, Caíque Bueno, Moreira, Henry Fukuda, Ayub-Ferreira, Silvia Moreira, Conceição-Souza, Germano Emilio, Salemi, Vera Maria Cury, Chizzola, Paulo Roberto, JrOliveira, Mucio Tavares, Lage, Silvia Helena Gelas, Bocchi, Edimar Alcides, and Issa, Victor Sarli
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HEART failure patients ,HOSPITAL patients ,ETIOLOGY of diseases ,HEART function tests ,CLINICAL trials - Abstract
Aims: Explore the association between clinical findings and prognosis in patients with acute decompensated heart failure (ADHF) and analyze the influence of etiology on clinical presentation and prognosis. Methods and results: Prospective cohort of 500 patients admitted with ADHF from Aug/2013-Feb/2016; patients were predominantly male (61.8%), median age was 58 (IQ
25-75% 47–66 years); etiology was dilated cardiomyopathy in 141 (28.2%), ischemic heart disease in 137 (27.4%), and Chagas heart disease in 113 (22.6%). Patients who died (154 [30.8%]) or underwent heart transplantation (53[10.6%]) were younger (56 years [IQ25-75% 45–64 vs 60 years, IQ25-75% 49–67], P = 0.032), more frequently admitted for cardiogenic shock (20.3% vs 6.8%, P<0.001), had longer duration of symptoms (14 days [IQ25-75% 4–32.8 vs 7.5 days, IQ25-75% 2–31], P = 0.004), had signs of congestion (90.8% vs 76.5%, P<0.001) and inadequate perfusion more frequently (45.9% vs 28%, P<0.001), and had lower blood pressure (90 [IQ25-75% 80–100 vs 100, IQ25-75% 90–120], P<0.001). In a logistic regression model analysis, systolic blood pressure (P<0.001, OR 0.97 [95%CI 0.96–0.98] per mmHg) and jugular distention (P = 0.004, OR 1.923 [95%CI 1.232–3.001]) were significant. Chagas patients were more frequently admitted for cardiogenic shock (15%) and syncope/arrhythmia (20.4%). Pulmonary congestion was rare among Chagas patients and blood pressure was lower. The rate of in-hospital death or heart transplant was higher among patients with Chagas (50.5%). Conclusions: A physical exam may identify patients at higher risk in a contemporaneous population. Our findings support specific therapies targeted at Chagas patients in the setting of ADHF. [ABSTRACT FROM AUTHOR]- Published
- 2018
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30. Dysregulation of Autonomic Nervous System in Chagas’ Heart Disease Is Associated with Altered Adipocytokines Levels.
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Barbosa-Ferreira, João Marcos, Mady, Charles, Ianni, Barbara Maria, Lopes, Heno Ferreira, Ramires, Felix José Alvarez, Salemi, Vera Maria Cury, Grupi, Cesar José, Hachul, Denise Tessariol, and Fernandes, Fábio
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AUTONOMIC nervous system ,HEART diseases ,ADIPOKINES ,CHAGAS' disease ,INFLAMMATION ,LEFT heart ventricle ,TUMOR necrosis factors - Abstract
Background: Chagas disease (CD) induces autonomic dysfunction and inflammatory activity, which may promote metabolic abnormalities. We studied metabolism and his correlation with Autonomic Nervous System (ANS) and inflammation in CD. Methods and Results: Sixty subjects were divided into 4 groups: control group (CG), IF (indeterminate form) group; ECG group (ECG abnormalities and normal left ventricular systolic function), and LVD group (left ventricular sistolic dysfunction). Levels of adiponectin, leptin, insulin, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were assayed in serum samples by ELISA. ANS was assessed by heart rate variability in frequency domain in 24-hour Holter and postural tilt test (rest and orthostatic position). High frequency (HFr) component values were used to estimate parasympathetic activity and low frequency (LFr) component, sympathetic activity. Analyzes were made of the correlations of each of the metabolic parameters (leptin and adiponectin) with the inflammatory cytokines (interleukin-6 and TNF- alpha) and with the ANS assessment measurements. No significant differences were observed in leptin and insulin levels. Adiponectin was higher in ECG and LVD groups: [CG = 4766.5 (5529.5), IF = 4003.5 (2482.5), ECG = 8376.5 (8388.5), LVD = 8798 (4188.0) ng/mL, p<0.001)]. IL-6 and TNF-alpha were higher in LVD group: [IL-6: CG = 1.85 (6.41); IF = 1.58 (1.91); ECG = 1.0 (1.57); LVD= 31.44 (72.19) pg/ml; p = 0.001. TNF-alpha: CG = 22.57 (88.2); IF = 19.31 (33.16); ECG = 12.45 (3.07); LVD = 75.15 (278.57) pg/ml; p = 0.04]. Adiponectin levels had a positive association with the HFr component (r = 0.539; p = 0.038) and an inverse association with the LFr component (r = - 0.539; p = 0.038) in ECG group. Leptin levels had a negative association with the HFr component (r= - 0.632; p = 0.011) and a positive association with the LFr component (r = 0.632; p = 0.011) in LVD group. Conclusions: We found increased adiponectin levels in Chagas’ heart disease with systolic dysfunction and in patients with ECG abnormalities and normal systolic function at rest. Adipocytokines levels (adiponectin and leptin) were associated with ANS parameters in Chagas’ heart disease. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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31. Differential effects of variation in athletes training on myocardial morphophysiological adaptation in men: focus on ¹²³I-MIBG assessed myocardial sympathetic activity.
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Miranda, Douglas Pinheiro, Dos Santos, Marcelo José, Salemi, Vera Maria Cury, de Oliveira, Edmundo Pereira Caparelli, Verberne, Hein J, and da Rocha, Euclides Timóteo
- Abstract
Purpose: High intensity systematic physical training leads to myocardial morphophysiological adaptations. The goal of this study was to investigate if differences in training were correlated with differences in cardiac sympathetic activity.Methods: 58 males (19-47 years), were divided into three groups: strength group (SG), (20 bodybuilders), endurance group (EG), (20 endurance athletes), and a control group (CG) comprising 18 healthy non-athletes. Cardiac sympathetic innervation was assessed by planar myocardial (123)I-metaiodobenzylguanidine scintigraphy using the early and late heart to mediastinal (H/M) ratio, and washout rate (WR).Results: Left ventricular mass index was significantly higher both in SG (P < .001) and EG (P = .001) compared to CG without a statistical significant difference between SG and EG (P = .417). The relative wall thickness was significantly higher in SG compared to CG (P < .001). Both left ventricular ejection fraction and the peak filling rate showed no significant difference between the groups. Resting heart rate was significantly lower in EG compared to CG (P = .006) and SG (P = .002). The late H/M ratio in CG was significantly higher compared to the late H/M for SG (P = .003) and EG (P = .004). However, WR showed no difference between the groups. There was no significant correlation between the parameters of myocardial sympathetic innervation and parameters of left ventricular function.Conclusions: Strength training resulted in a significant increase in cardiac dimensions. Both strength and endurance training seem to cause a reduction in myocardial sympathetic drive. However, myocardial morphological and functional adaptations to training were not correlated with myocardial sympathetic activity. [ABSTRACT FROM AUTHOR]- Published
- 2014
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32. Effects of Exercise Training on Circulating and Skeletal Muscle Renin-Angiotensin System in Chronic Heart Failure Rats.
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Gomes-Santos, Igor Lucas, Fernandes, Tiago, Couto, Gisele Kruger, Ferreira-Filho, Julio César Ayres, Salemi, Vera Maria Cury, Fernandes, Fernanda Barrinha, Casarini, Dulce Elena, Brum, Patricia Chakur, Rossoni, Luciana Venturini, de Oliveira, Edilamar Menezes, and Negrao, Carlos Eduardo
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EXERCISE physiology ,SKELETAL muscle ,RENIN-angiotensin system ,HEART failure ,ISCHEMIA ,CORONARY arteries ,GENE expression - Abstract
Background: Accumulated evidence shows that the ACE-AngII-AT1 axis of the renin-angiotensin system (RAS) is markedly activated in chronic heart failure (CHF). Recent studies provide information that Angiotensin (Ang)-(1–7), a metabolite of AngII, counteracts the effects of AngII. However, this balance between AngII and Ang-(1–7) is still little understood in CHF. We investigated the effects of exercise training on circulating and skeletal muscle RAS in the ischemic model of CHF. Methods/Main Results: Male Wistar rats underwent left coronary artery ligation or a Sham operation. They were divided into four groups: 1) Sedentary Sham (Sham-S), 2) exercise-trained Sham (Sham-Ex), sedentary CHF (CHF-S), and exercise-trained CHF (CHF-Ex). Angiotensin concentrations and ACE and ACE2 activity in the circulation and skeletal muscle (soleus and plantaris) were quantified. Skeletal muscle ACE and ACE2 protein expression, and AT1, AT2, and Mas receptor gene expression were also evaluated. CHF reduced ACE2 serum activity. Exercise training restored ACE2 and reduced ACE activity in CHF. Exercise training reduced plasma AngII concentration in both Sham and CHF rats and increased the Ang-(1–7)/AngII ratio in CHF rats. CHF and exercise training did not change skeletal muscle ACE and ACE2 activity and protein expression. CHF increased AngII levels in both soleus and plantaris muscle, and exercise training normalized them. Exercise training increased Ang-(1–7) in the plantaris muscle of CHF rats. The AT1 receptor was only increased in the soleus muscle of CHF rats, and exercise training normalized it. Exercise training increased the expression of the Mas receptor in the soleus muscle of both exercise-trained groups, and normalized it in plantaris muscle. Conclusions: Exercise training causes a shift in RAS towards the Ang-(1–7)-Mas axis in skeletal muscle, which can be influenced by skeletal muscle metabolic characteristics. The changes in RAS circulation do not necessarily reflect the changes occurring in the RAS of skeletal muscle. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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33. Hyperglycaemia protects the heart after myocardial infarction: aspects of programmed cell survival and cell death.
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Malfitano, Christiane, Alba Loureiro, Tatiana C., Rodrigues, Bruno, Sirvente, Raquel, Salemi, Vera Maria Cury, Rabechi, Nara B., Lacchini, Silvia, Curi, Rui, and Irigoyen, Maria Claudia C.
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THERAPEUTICS ,HEART diseases ,HYPERGLYCEMIA ,MYOCARDIAL infarction ,APOPTOSIS ,ISCHEMIA prevention ,NEOVASCULARIZATION ,DIABETES ,PHYSIOLOGY - Abstract
Aims: Exposure to a high glucose medium or diabetes has been found to protect the heart against ischaemia. The activation of antiapoptotic and proliferative factors seems to be involved in this cardioprotection. This study was designed to evaluate the role of hyperglycaemia in cardiac function, programmed cell survival, and cell death in diabetic rats after myocardial infarction (MI). [ABSTRACT FROM PUBLISHER]
- Published
- 2010
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34. An unusual case of angina pectoris: a patient with isolated non-compaction of the left ventricular myocardium.
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Dabarian, André L., Mady, Charles, Rochitte, Carlos E., Shiozaki, Afonso A., Lemos, Pedro A., and Salemi, Vera Maria Cury
- Abstract
A 29-year-old white woman with typical angina pectoris presented diastolic dysfunction and was suggestive of isolated non-compaction of the ventricular myocardium (INCM) by echocardiography. Cardiac catheterization disclosed normal coronary arteries. Cardiovascular magnetic resonance (CMR) depicted prominent left ventricular INCM areas with non-compaction/compaction ratio of 3.7, and dipiridamol CMR demonstrated global perfusion defect at stress and normal perfusion at rest. Adenosine-induced vasodilation showed subnormal coronary velocity flow reserve in the right, left circumflex, and left anterior descending coronary arteries. The evidence of our case indicates that patients with INCM may present angina pectoris and, probably, relative chronic myocardial ischaemia related to a impaired microvascular function is responsible for this symptom as demonstrated invasively here. It is a possible mechanism for progressive myocardial dysfunction seen in these patients. [ABSTRACT FROM PUBLISHER]
- Published
- 2008
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35. Recovery of systolic and diastolic function after ablation of incessant supraventricular tachycardia
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Salemi, Vera Maria Cury, Arteaga, Edmund, and Mady, Charles
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ARRHYTHMIA , *HEART failure , *TACHYCARDIA , *ELECTRIC countershock , *ATRIAL fibrillation - Abstract
Abstract: We report a case of a 26-year-old woman who presented to our hospital with arrhythmia and heart failure. She had an incessant supraventricular tachycardia, which was not reversible with electrical cardioversion. Echocardiogram showed a severe LV systolic and diastolic dysfunction. After radiofrequency catheter ablation, LV function returned to normal. This article is intended to show a case with tachycardiomyopathy, which is considered the most frequently unrecognized curable cause of heart failure, and to demonstrate that early treatment allows the recovery to a normal LV systolic and diastolic function, preventing irreversible structural cardiac damage. It is very likely that some patients with idiopathic dilated cardiomyopathy and chronic atrial fibrillation or other chronic arrhythmia actually have a curable tachycardiomyopathy. [Copyright &y& Elsevier]
- Published
- 2005
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36. 166 EXERCISE TRAINING PREVENTS METABOLIC AND CARDIAC FUNCTION ALTERATIONS INDUCED BY METABOLIC SYNDROME IN RATS.
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Mostarda, Cristiano, Moraes-Silva, Ivana Cyntia, Salemi, Vera Maria Cury, Machi, Jacqueline Freire, Souza, Leandro Eziquiel, Nascimento, Ademir, dos Santos, Fernando, Farah, Vera de Moura Azevedo, and Irigoyen, Maria Claudia
- Published
- 2012
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37. Down-regulation of fibroblast growth factor 2 and its co-receptors heparan sulfate proteoglycans by resveratrol underlies the improvement of cardiac dysfunction in experimental diabetes.
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Strunz, Célia Maria Cássaro, Roggerio, Alessandra, Cruz, Paula Lázara, Pacanaro, Ana Paula, Salemi, Vera Maria Cury, Benvenuti, Luiz Alberto, Mansur, Antonio de Pádua, and Irigoyen, Maria Cláudia
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FIBROBLAST growth factor 2 , *HEPARAN sulfate proteoglycans , *HEART diseases , *THERAPEUTICS , *RESVERATROL , *EXPERIMENTAL diabetes , *DOWNREGULATION , *ANIMAL experimentation , *ANIMALS , *BIOCHEMISTRY , *DIABETES , *GENES , *GLYCOPROTEINS , *GROWTH factors , *HEART , *PHENOMENOLOGY , *POLYSACCHARIDES , *RATS , *STILBENE - Abstract
Cardiac remodeling in diabetes involves cardiac hypertrophy and fibrosis, and fibroblast growth factor 2 (FGF2) is an important mediator of this process. Resveratrol, a polyphenolic antioxidant, reportedly promotes the improvement of cardiac dysfunction in diabetic rats. However, little information exists linking the amelioration of the cardiac function promoted by resveratrol and the expression of FGF2 and its co-receptors, heparan sulfate proteoglycans (HSPGs: Glypican-1 and Syndecan-4), in cardiac muscle of Type 2 diabetic rats. Diabetes was induced experimentally by the injection of streptozotocin and nicotinamide, and the rats were treated with resveratrol for 6 weeks. According to our results, there is an up-regulation of the expression of genes and/or proteins of Glypican-1, Syndecan-4, FGF2, peroxisome proliferator-activated receptor gamma and AMP-activated protein kinase in diabetic rats. On the other hand, resveratrol treatment promoted the attenuation of left ventricular diastolic dysfunction and the down-regulation of the expression of all proteins under study. The trigger for the changes in gene expression and protein synthesis promoted by resveratrol was the presence of diabetes. The negative modulation conducted by resveratrol on FGF2 and HSPGs expression, which are involved in cardiac remodeling, underlies the amelioration of cardiac function. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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- View/download PDF
38. Cardiac and pulmonary arterial remodeling after sinoaortic denervation in normotensive rats
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Flues, K., Moraes-Silva, I.C., Mostarda, C., Souza, P.R.M., Diniz, G.P., Moreira, E.D., Piratello, A.C., Chaves, M.L. Barreto, De Angelis, K., Salemi, Vera Maria Cury, Irigoyen, M.C., and Caldini, E.G.
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ARTERIES , *PULMONARY artery , *DENERVATION , *LABORATORY rats , *BLOOD pressure , *BAROREFLEXES , *ECHOCARDIOGRAPHY - Abstract
Abstract: Blood pressure variability (BPV) and baroreflex dysfunction may contribute to end-organ damage process. We investigated the effects of baroreceptor deficit (10weeks after sinoaortic denervation — SAD) on hemodynamic alterations, cardiac and pulmonary remodeling. Cardiac function and morphology of male Wistar intact rats (C) and SAD rats (SAD) (n=8/group) were assessed by echocardiography and collagen quantification. BP was directly recorded. Ventricular hypertrophy was quantified by the ratio of left ventricular weight (LVW) and right ventricular weight (RVW) to body weight (BW). BPV was quantified in the time and frequency domains. The atrial natriuretic peptide (ANP), alpha-skeletal actin (α-skelectal), collagen type I and type III genes mRNA expression were evaluated by RT-PCR. SAD did not change BP, but increased BPV (11±0.49 vs. 5±0.3mmHg). As expected, baroreflex was reduced in SAD. Pulmonary artery acceleration time was reduced in SAD. In addition, SAD impaired diastolic function in both LV (6.8±0.26 vs. 5.02±0.21mmHg) and RV (5.1±0.21 vs. 4.2±0.12mmHg). SAD increased LVW/BW in 9% and RVW/BW in 20%, and augmented total collagen (3.8-fold in LV, 2.7-fold in RV, and 3.35-fold in pulmonary artery). Also, SAD increased type I (~6-fold) and III (~5-fold) collagen gene expression. Denervation increased ANP expression in LV (75%), in RV (74%) and increased α-skelectal expression in LV (300%) and in RV (546%). Baroreflex function impairment by SAD, despite not changing BP, induced important adjustments in cardiac structure and pulmonary hypertension. These changes may indicate that isolated baroreflex dysfunction can modulate target tissue damage. [Copyright &y& Elsevier]
- Published
- 2012
- Full Text
- View/download PDF
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