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Your search keyword '"Sabogal Guaqueta, Angelica"' showing total 14 results
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3. Mitochondrial transplantation rescues neuronal cells from ferroptosis

Author

Chen, Tingting, Majerníková, Nad'a, Marmolejo-Garza, Alejandro, Trombetta-Lima, Marina, Sabogal-Guáqueta, Angélica María, Zhang, Yuequ, ten Kate, Ruth, Zuidema, Minte, Mulder, Patty P.M.F.A., den Dunnen, Wilfred, Gosens, Reinoud, Verpoorte, Elisabeth, Culmsee, Carsten, Eisel, Ulrich L.M., and Dolga, Amalia M.

Published
2023
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13. Identification and characterization of a small molecule that activates thiosulfate sulfurtransferase and stimulates mitochondrial respiration.

Author

Al‐Dahmani, Zeyana M., Hadian, Mojgan, Ruiz‐Moreno, Angel J., Maria, Sabogal‐Guaqueta Angelica, Batista, Fernando A., Zhang, Ran, Luo, Yang, Sadremomtaz, Afsaneh, van der Straat, Robin, Spoor, Mette, Dolga, Amalia M., Dekker, Frank J., S S, Alexander Dömling, van Goor, Harry, and Groves, Matthew R.

Abstract

The enzyme Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), is a positive genetic predictor of diabetes type 2 and obesity. As increased TST activity protects against the development of diabetic symptoms in mice, an activating compound for TST may provide therapeutic benefits in diabetes and obesity. We identified a small molecule activator of human TST through screening of an inhouse small molecule library. Kinetic studies in vitro suggest that two distinct isomers of the compound are required for full activation as well as an allosteric mode of activation. Additionally, we studied the effect of TST protein and the activator on TST activity through mitochondrial respiration. Molecular docking and molecular dynamics (MD) approaches supports an allosteric site for the binding of the activator, which is supported by the lack of activation in the Escherichia coli. mercaptopyruvate sulfurtransferase. Finally, we show that increasing TST activity in isolated mitochondria increases mitochondrial oxygen consumption. [ABSTRACT FROM AUTHOR]

Published
2023
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