19 results on '"Sabitov, Zhaxylyk"'
Search Results
2. Genetic Polymorphism of Y-Chromosome in Turkmen Population from Turkmenistan.
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Zhabagin, Maxat, Tashkarayeva, Assel, Bukayev, Alizhan, Zhunussova, Aigul, Ponomarev, Georgy, Tayshanova, Saltanat, Maxutova, Albina, Adamov, Dmitry, Balanovska, Elena, and Sabitov, Zhaxylyk
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POPULATION genetics ,HAPLOGROUPS ,GENETIC polymorphisms ,HAPLOTYPES ,GENETIC variation ,Y chromosome - Abstract
This study investigates the Y-chromosome genetic diversity of the Turkmen population in Turkmenistan, analyzing 23 Y-STR loci for the first time in a sample of 100 individuals. Combined with comparative data from Turkmen populations in Afghanistan, Iran, Iraq, Russia, and Uzbekistan, this analysis offers insights into the genetic structure and relationships among Turkmen populations across regions across Central Asia and the Near East. High haplotype diversity in the Turkmen of Turkmenistan is shaped by founder effects (lineage expansions) from distinct haplogroups, with haplogroups Q and R1a predominating. Subhaplogroups Q1a and Q1b identified in Turkmenistan trace back to ancient Y-chromosome lineages from the Bronze Age. Comparative analyses, including genetic distance (RST), median-joining network, and multidimensional scaling (MDS), highlight the genetic proximity of the Turkmen in Turkmenistan to those in Afghanistan and Iran, while Iraqi Turkmen display unique characteristics, aligning with Near Eastern populations. This study underscores the Central Asian genetic affinity across most Turkmen populations. It demonstrates the value of deep-sequencing Y-chromosome data in tracing the patrilineal history of Central Asia for future studies. These findings contribute to a more comprehensive understanding of Turkmen genetic ancestry and add new data to the ongoing study of Central Asian population genetics. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Authoritarian succession, rules, and conflicts: Tokayev's gambit and Kazakhstan's bloody January of 2022 (Qandy Qantar).
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Abishev, Gaziz, Kurmanov, Bakhytzhan, and Sabitov, Zhaxylyk
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AUTHORITARIANISM ,SUCCESSION planning ,INHERITANCE & succession ,SECONDARY analysis ,AMBITION - Abstract
The authoritarian succession literature indicates that non-democratic regimes install rules and institutions that supposedly ensure a smooth transition from ruler to a chosen successor. However, this scholarship cannot explain why some authoritarian successions happen as planned while others end in surprising violence. This article unpacks the puzzle of the transition of power from Nursultan Nazarbayev (1991–2019) to Kassym-Jomart Tokayev (2019–present) in autocratic Kazakhstan. Based on in-depth interviews with more than 15 informants and the analysis of media and secondary sources, we explore why and how the planned succession in Kazakhstan resulted in the bloodshed known as the 2022 Bloody January (Qandy Qantar). We demonstrate that two factors derailed the succession plan: the configuration of authoritarian rules and the presence of political ambitions of Tokayev. Our main argument is that the Nazarbayev succession plan led to elite disunity, escalating the political conflict into the violent 2022 Bloody January. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Medieval Super-Grandfather founder of Western Kazakh Clans from Haplogroup C2a1a2-M48
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Zhabagin, Maxat, Sabitov, Zhaxylyk, Tazhigulova, Inkar, Alborova, Irina, Agdzhoyan, Anastasiya, Wei, Lan-Hai, Urasin, Vadim, Koshel, Sergey, Mustafin, Kharis, Akilzhanova, Ainur, Li, Hui, Balanovsky, Oleg, and Balanovska, Elena
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- 2021
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5. Y-Chromosomal insights into the paternal genealogy of the Kerey tribe have called into question their descent from the Stepfather of Genghis Khan.
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Zhabagin, Maxat, Bukayev, Alizhan, Dyussenova, Zhanargul, Zhuraliyeva, Altyn, Tashkarayeva, Assel, Zhunussova, Aigul, Aidarov, Baglan, Darmenov, Akynkali, Akilzhanova, Ainur, Schamiloglu, Uli, and Sabitov, Zhaxylyk
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GENETIC genealogy ,GENETIC testing ,GENETIC variation ,TRIBES ,MONGOLS - Abstract
The Kerey is one of the prominent Kazakh tribes and has long been a subject of ethnographic scrutiny, with a lack of consensus on its origin and traditional genealogy. Their historical significance, intertwined with the emergence of the empire established by Genghis Khan, necessitates a comprehensive understanding of their genetic history. This study focuses on unraveling the genetic heritage of the Kerey tribe. We conducted a comprehensive analysis of Y-chromosome data from genetic genealogy as citizen science and genetic screening of 23 Y-STRs and 37 Y-SNPs on 207 males from the Kerey tribe within academic science. Our results reveal two prevalent phylogenetic lineages within the C2a1a3a-F3796 haplogroup, also known as the C2*-Star Cluster (C2*-ST), which is one of the founding paternal lineages of the ancient Niru'un clan of the Mongols: C2-FT411734 and C2-FT224144, corresponding to the Abak and Ashamaily clans. While indicating a common male ancestry for them, our findings challenge the notion that they are full siblings. Additionally, genetic diversity analysis of the Y-chromosomes in the Kerey tribe and Kazakhs confirms their kinship with the Uissun tribe but refutes the claim of the Abak clan's progenitor originating from this tribe. Furthermore, genetic evidence fails to support popular historical and ethnographic hypotheses regarding the Kerey tribe's kinship with the Uak, Sirgeli, Adai, Törtkara, Karakerey, and Kereyit Kazakh tribes. The absence of a genetic paternal connection with the Kereyt tribe raises doubts about the genealogical link between the Kerey tribe and the stepfather of Genghis Khan. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Development of the Kazakhstan Y-chromosome haplotype reference database: analysis of 27 Y-STR in Kazakh population
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Zhabagin, Maxat, Sarkytbayeva, Aliya, Tazhigulova, Inkar, Yerezhepov, Dauren, Li, Svetlana, Akilzhanov, Rakhmetolla, Yeralinov, Alibek, Sabitov, Zhaxylyk, and Akilzhanova, Ainur
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- 2019
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7. The medieval Mongolian roots of Y-chromosomal lineages from South Kazakhstan
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Zhabagin, Maxat, Sabitov, Zhaxylyk, Tarlykov, Pavel, Tazhigulova, Inkar, Junissova, Zukhra, Yerezhepov, Dauren, Akilzhanov, Rakhmetolla, Zholdybayeva, Elena, Wei, Lan-Hai, Akilzhanova, Ainur, Balanovsky, Oleg, and Balanovska, Elena
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- 2020
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8. Genetic polymorphism of 27 Y-STR loci in Kazakh populations from Central Kazakhstan.
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Ashirbekov, Yeldar, Zhunussova, Aigul, Abaildayev, Arman, Bukayeva, Ayagoz, Sabitov, Zhaxylyk, and Zhabagin, Maxat
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POPULATION genetics ,GENETIC variation ,HAPLOGROUPS ,HAPLOTYPES ,GENETIC profile ,FORENSIC sciences - Abstract
Background: The haplotypes from Northern, Southern, Eastern, and Western Kazakhstan, analysed for 27 Y-STR loci, have been contributed to the Y-Chromosome STR Haplotype Reference Database, while the genetic profile of Central Kazakhstan remains inadequately explored. Aim: To investigate the genetic diversity of 27 Y-STR loci in the Kazakh populations from Central Kazakhstan. Subjects and methods: A total of 112 unrelated Central Kazakh males were genotyped via the Yfiler Plus kit. Data analysis yielded haplotype and allele frequencies, and forensic parameters. Genetic distances were graphically represented by a multidimensional scaling plot, with genetic linkages further elucidated through Nei's distance dendrograms and Median-joining networks. Results: A total of 102 haplotypes were detected, of which 96 were unique. The haplotype diversity and discrimination capacity were 0.997 and 0.91, respectively. Central Kazakhstan displays a unique cluster in analyses, underscoring its distinct Y-chromosome diversity compared to other Kazakh regions. The analysis of the Naiman tribe, predominantly residing in Central, Southern and Eastern Kazakhstan, revealed three genetic clusters of distinct haplogroups associated with their clans. Conclusions: The identified haplotypes will enhance the existing reference database for Y-chromosomal studies in Kazakhstan, offering a robust tool for future research in population genetics, forensic science and genetic genealogy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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9. Digital media consumption and voting among Central Asian youth: why democratic context matters.
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Bekmagambetov, Amanzhol, Gainous, Jason, Wagner, Kevin M., Sabitov, Zhaxylyk, Rodionov, Adil, and Kleinsteuber, Bryce
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DIGITAL media ,YOUTHS' attitudes ,DEMOCRACY ,POLITICAL participation ,ELECTIONS - Abstract
A wealth of research examines the relationship between digital media consumption and political participation. Research typically defines participation broadly and focuses on Western contexts. We seek to add to the understanding of this relationship by focusing more directly on the relationship between digital media consumption and the propensity to vote among young people in a less democratic context. To do so, we examine a set of Central Asian countries (Kazakhstan, Kyrgyzstan, Tajikistan and Uzbekistan) that have varying degrees of democratization. We test whether digital media consumption stimulates voting among respondents aged 18-30, and if this is contingent on how free and fair are the elections. Our results suggest that in the most democratic country, Kyrgyzstan, the relationship between digital media use and the propensity to vote is relatively flat while digital media use in less democratic countries, overall, is associated with a decrease in the propensity to vote. [ABSTRACT FROM AUTHOR]
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- 2023
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10. Genetic polymorphism of 27 Y-STR loci in Kazakh populations from Eastern Kazakhstan.
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Ashirbekov, Yeldar, Nogay, Anastassiya, Abaildayev, Arman, Zhunussova, Aigul, Sabitov, Zhaxylyk, and Zhabagin, Maxat
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LOCUS (Genetics) ,GENETIC polymorphisms ,HAPLOTYPES ,DATABASES ,GENE frequency ,Y chromosome - Abstract
The establishment of a national haplotype database is important for forensic and genetic applications and requires studying genetic polymorphisms at Y-STR sites. However, the genetic structure of the Eastern Kazakhstan population is poorly characterised. To investigate the genetic polymorphisms of 27 Y-STR loci in the Kazakh population from Eastern Kazakhstan and analyse the population genetic relationships of the Eastern Kazakhs with other populations. The Yfiler Plus kit was utilised to genotype 246 healthy, unrelated males from Eastern Kazakhstan. Based on the raw data, haplotype and allele frequencies along with forensic parameters were calculated, and an MDS plot was constructed. A total of 207 haplotypes were detected, of which 186 were unique. The haplotype diversity and discrimination capacity were 0.997 and 0.841, respectively. Population comparisons showed that Eastern Kazakhs have close genetic relationships with Kazakhs from Xinjiang, China. At the same time, a difference was found between the studied population and the previous one in the same part of Kazakhstan. The obtained haplotypes will help to expand the Kazakhstan Y-chromosome reference database and will be useful for future genetic research and forensic applications. [ABSTRACT FROM AUTHOR]
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- 2023
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11. Economic Growth and the Feminisation of Political Science in Kazakhstan: A Leaky Pipeline?
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Rodionov, Adil, Sabitov, Zhaxylyk, Gainous, Jason, Wagner, Kevin M., Bekmagambetov, Amanzhol, and Rodionova, Kamilya
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POLITICAL science , *OCCUPATIONAL prestige , *ECONOMIC expansion , *EMPLOYMENT , *GENDER inequality - Abstract
Academia, in much of the world, has long been disproportionately populated by men. This pattern, at least in the social sciences, may be changing. We explore the shifting gender gap in political science in Kazakhstan, and then set out to explore potential determinants of the changes as well as the resulting employment patterns. We use time-series data to demonstrate that a rising GDP, shifting fertility rates, occupational prestige and a growing population are related to the increase in the number of women entering political science in Kazakhstan, which, nevertheless, has not resulted in employment parity. [ABSTRACT FROM AUTHOR]
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- 2023
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12. Kazak mitochondrial genomes provide insights into the human population history of Central Eurasia.
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Askapuli, Ayken, Vilar, Miguel, Garcia-Ortiz, Humberto, Zhabagin, Maxat, Sabitov, Zhaxylyk, Akilzhanova, Ainur, Ramanculov, Erlan, Schamiloglu, Uli, Martinez-Hernandez, Angelica, Contreras-Cubas, Cecilia, Barajas-Olmos, Francisco, Schurr, Theodore G., Zhumadilov, Zhaxybay, Flores-Huacuja, Marlen, Orozco, Lorena, Hawks, John, and Saitou, Naruya
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MITOCHONDRIAL DNA ,GENETIC profile ,MITOCHONDRIA ,PREHISTORIC peoples ,HUMAN beings ,GENE flow ,GENOMES - Abstract
As a historical nomadic group in Central Asia, Kazaks have mainly inhabited the steppe zone from the Altay Mountains in the East to the Caspian Sea in the West. Fine scale characterization of the genetic profile and population structure of Kazaks would be invaluable for understanding their population history and modeling prehistoric human expansions across the Eurasian steppes. With this mind, we characterized the maternal lineages of 200 Kazaks from Jetisuu at mitochondrial genome level. Our results reveal that Jetisuu Kazaks have unique mtDNA haplotypes including those belonging to the basal branches of both West Eurasian (R0, H, HV) and East Eurasian (A, B, C, D) lineages. The great diversity observed in their maternal lineages may reflect pivotal geographic location of Kazaks in Eurasia and implies a complex history for this population. Comparative analyses of mitochondrial genomes of human populations in Central Eurasia reveal a common maternal genetic ancestry for Turko-Mongolian speakers and their expansion being responsible for the presence of East Eurasian maternal lineages in Central Eurasia. Our analyses further indicate maternal genetic affinity between the Sherpas from the Tibetan Plateau with the Turko-Mongolian speakers. [ABSTRACT FROM AUTHOR]
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- 2022
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13. Genetic Polymorphism of 27 Y-STR Loci in the Western Kazakh Tribes from Kazakhstan and Karakalpakstan, Uzbekistan.
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Ashirbekov, Yeldar, Sabitov, Zhaxylyk, Aidarov, Baglan, Abaildayev, Arman, Junissova, Zukhra, Cherusheva, Alena, Saidamarova, Viktoriya V., Sharipov, Kamalidin, Ramankulov, Yerlan, and Zhabagin, Maxat
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GENETIC polymorphisms , *LOCUS (Genetics) , *POPULATION genetics , *TRIBES , *HAPLOTYPES , *LOCUS (Mathematics) - Abstract
Data on the genetic polymorphism of 27 Y-STR in Kazakhs of the Junior Zhuz has been presented and analyzed in relation to forensic features. A total of 464 representatives of the Western Kazakh tribes of Kazakhstan (Western Kazakhs, n = 405) and Uzbekistan (Karakalpakstan Kazakhs, n = 59) were examined by the Yfiler Plus set. The data are available in the YHRD under accession numbers YA006010 and YA006009. Genetic analysis (AMOVA and MDS) did not show significant differences between the two groups (Kazakhstan and Karakalpakstan Kazakhs) in terms of Y-chromosome diversity. Both groups are characterized by haplogroup C2a1a2 as a founder effect, which dominated two of the three tribes: Alimuly (67%), Baiuly (74.6%), and Zhetiru (25.8%). At the same time, the phylogenetic network for each tribe found its own clusters within C2a1a2. Western Kazakhs and Karakalpakstan Kazakhs present high values of unique haplotypes (84.44% and 96.61%), discrimination capacity (90.37% and 98.30%), and haplotype diversity (0.9991 and 0.9994). A set of 27 Y-STR loci distinguishes closely related individuals within the Western Kazakh tribes quite well. It is suitable for forensic application, and is also optimal for population genetics studies. [ABSTRACT FROM AUTHOR]
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- 2022
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14. Ancient Components and Recent Expansion in the Eurasian Heartland: Insights into the Revised Phylogeny of Y-Chromosomes from Central Asia.
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Zhabagin, Maxat, Wei, Lan-Hai, Sabitov, Zhaxylyk, Ma, Peng-Cheng, Sun, Jin, Dyussenova, Zhanargul, Balanovska, Elena, Li, Hui, and Ramankulov, Yerlan
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Y chromosome ,MICROSATELLITE repeats ,SINGLE nucleotide polymorphisms ,PHYLOGENY ,UIGHUR (Turkic people) - Abstract
In the past two decades, studies of Y chromosomal single nucleotide polymorphisms (Y-SNPs) and short tandem repeats (Y-STRs) have shed light on the demographic history of Central Asia, the heartland of Eurasia. However, complex patterns of migration and admixture have complicated population genetic studies in Central Asia. Here, we sequenced and analyzed the Y-chromosomes of 187 male individuals from Kazakh, Kyrgyz, Uzbek, Karakalpak, Hazara, Karluk, Tajik, Uyghur, Dungan, and Turkmen populations. High diversity and admixture from peripheral areas of Eurasia were observed among the paternal gene pool of these populations. This general pattern can be largely attributed to the activities of ancient people in four periods, including the Neolithic farmers, Indo-Europeans, Turks, and Mongols. Most importantly, we detected the consistent expansion of many minor lineages over the past thousand years, which may correspond directly to the formation of modern populations in these regions. The newly discovered sub-lineages and variants provide a basis for further studies of the contributions of minor lineages to the formation of modern populations in Central Asia. [ABSTRACT FROM AUTHOR]
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- 2022
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15. Genomic analyses inform on migration events during the peopling of Eurasia
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Pagani, Luca, Lawson, Daniel John, Jagoda, Evelyn, Mrseburg, Alexander, Eriksson, Anders, Mitt, Mario, Clemente, Florian, Hudjashov, Georgi, DeGiorgio, Michael, Saag, Lauri, Wall, Jeffrey D., Cardona, Alexia, Mgi, Reedik, Sayres, Melissa A. Wilson, Kaewert, Sarah, Inchley, Charlotte, Scheib, Christiana L., Jrve, Mari, Karmin, Monika, Jacobs, Guy S., Antao, Tiago, Iliescu, Florin Mircea, Kushniarevich, Alena, Ayub, Qasim, Tyler-Smith, Chris, Xue, Yali, Yunusbayev, Bayazit, Tambets, Kristiina, Mallick, Chandana Basu, Saag, Lehti, Pocheshkhova, Elvira, Andriadze, George, Muller, Craig, Westaway, Michael C., Lambert, David M., Zoraqi, Grigor, Turdikulova, Shahlo, Dalimova, Dilbar, Sabitov, Zhaxylyk, Sultana, Gazi Nurun Nahar, Lachance, Joseph, Tishkoff, Sarah, Momynaliev, Kuvat, Isakova, Jainagul, Damba, Larisa D., Gubina, Marina, Nymadawa, Pagbajabyn, Evseeva, Irina, Atramentova, Lubov, Utevska, Olga, Ricaut, Franois-Xavier, Brucato, Nicolas, Sudoyo, Herawati, Letellier, Thierry, Cox, Murray P., Barashkov, Nikolay A., karo, Vedrana, Mulahasanovic, Lejla, Primorac, Dragan, Sahakyan, Hovhannes, Mormina, Maru, Eichstaedt, Christina A., Lichman, Daria V., Abdullah, Syafiq, Chaubey, Gyaneshwer, Wee, Joseph T. S., Mihailov, Evelin, Karunas, Alexandra, Litvinov, Sergei, Khusainova, Rita, Ekomasova, Natalya, Akhmetova, Vita, Khidiyatova, Irina, Marjanovi, Damir, Yepiskoposyan, Levon, Behar, Doron M., Balanovska, Elena, Metspalu, Andres, Derenko, Miroslava, Malyarchuk, Boris, Voevoda, Mikhail, Fedorova, Sardana A., Osipova, Ludmila P., Lahr, Marta Mirazn, Gerbault, Pascale, Leavesley, Matthew, Migliano, Andrea Bamberg, Petraglia, Michael, Balanovsky, Oleg, Khusnutdinova, Elza K., Metspalu, Ene, Thomas, Mark G., Manica, Andrea, Nielsen, Rasmus, Villems, Richard, Willerslev, Eske, Kivisild, Toomas, and Metspalu, Mait
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DNA sequencing -- Methods ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Author(s): Luca Pagani (corresponding author) [1, 2, 3]; Daniel John Lawson [4]; Evelyn Jagoda [2, 5]; Alexander Mrseburg [2]; Anders Eriksson [6, 7]; Mario Mitt [8, 9]; Florian Clemente [2, [...]
- Published
- 2016
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16. Genetic polymorphism of 27 Y-STR loci in Kazakh populations from Northern Kazakhstan.
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Ashirbekov, Yeldar, Abaildayev, Arman, Neupokoyeva, Alena, Sabitov, Zhaxylyk, and Zhabagin, Maxat
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GENETIC polymorphisms ,SHORT tandem repeat analysis ,LOCUS (Genetics) ,POPULATION genetics ,FORENSIC genetics ,HAPLOTYPES ,GENETIC distance ,Y chromosome ,ALLELES - Abstract
Previous studies of the genetic polymorphism of the Y-chromosome of Kazakhs were focussed on the Eastern, Central, Southern, and Western regions of Kazakhstan. In addition, many of these studies were limited to 17 Y-STR loci from the Yfiler. To enrich the existing Kazakhstan Y-chromosome Haplotype Reference Database from the Northern Kazakh population data by a wide set of 27 Y-STR and investigate the population genetic relationships with previously published data. Twenty-seven Y-STR loci from the Yfiler Plus PCR Amplification Kit were analysed in 382 healthy unrelated Kazakh males from Northern Kazakhstan. Genetic polymorphism was analysed using Arlequin software. A total of 326 distinct haplotypes of the 27 Y-STR loci were observed in 382 individuals. The discrimination capacity (0.9982) and haplotype diversity (0.8534) were computed. A total of 168 alleles at single-copy loci were observed and their frequencies ranged from 0.003–0.843. The pairwise genetic distance (R
ST ) showed that the Northern Kazakh population is genetically distinct from the Chinese Kazakh population. Genetic polymorphism shows that the potential value of 27 Y-STR loci for forensic casework in the Northern Kazakh population and the current findings might be beneficial for paternal lineages in the study of population genetics. [ABSTRACT FROM AUTHOR]- Published
- 2022
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17. Critical social media information flows: political trust and protest behaviour among Kazakhstani college students.
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Bekmagambetov, Amanzhol, Wagner, Kevin M., Gainous, Jason, Sabitov, Zhaxylyk, Rodionov, Adil, and Gabdulina, Bagysh
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ONLINE social networks ,SOCIAL media ,COLLEGE students ,PUBLIC demonstrations ,COLLECTIVE action - Abstract
In political regimes where traditional mass media are under state control, social networking sites may be the only place where citizens are exposed to and exchange dissident information. Despite all the attempts, complete control of social media seems to be implausible. We argue that the critical information that people see, read and share online undermines their trust in political institutions. This diminishing trust may threaten the legitimacy of the ruling regime and stimulate protest behaviour. We rely on original survey data of Kazakhstani college students to confirm these expectations. The data are unique in that they directly measure exposure to critical/dissident information, as opposed to simply assuming it. The analysis leverages Coarsened Exact Matching to simulate experimental conditions. This allows us to better identify the consequential mechanism and the attitudinal precursor by which social media influence protest in an authoritarian context. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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18. Deep Phylogenetic Analysis of Haplogroup G1 Provides Estimates of SNP and STR Mutation Rates on the Human Y-Chromosome and Reveals Migrations of Iranic Speakers.
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Balanovsky, Oleg, Zhabagin, Maxat, Agdzhoyan, Anastasiya, Chukhryaeva, Marina, Zaporozhchenko, Valery, Utevska, Olga, Highnam, Gareth, Sabitov, Zhaxylyk, Greenspan, Elliott, Dibirova, Khadizhat, Skhalyakho, Roza, Kuznetsova, Marina, Koshel, Sergey, Yusupov, Yuldash, Nymadawa, Pagbajabyn, Zhumadilov, Zhaxybay, Pocheshkhova, Elvira, Haber, Marc, A. Zalloua, Pierre, and Yepiskoposyan, Levon
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SINGLE nucleotide polymorphisms ,GENETIC mutation ,Y chromosome ,PHYLOGENY ,SHORT tandem repeat analysis ,BIOMARKERS - Abstract
Y-chromosomal haplogroup G1 is a minor component of the overall gene pool of South-West and Central Asia but reaches up to 80% frequency in some populations scattered within this area. We have genotyped the G1-defining marker M285 in 27 Eurasian populations (n= 5,346), analyzed 367 M285-positive samples using 17 Y-STRs, and sequenced ~11 Mb of the Y-chromosome in 20 of these samples to an average coverage of 67X. This allowed detailed phylogenetic reconstruction. We identified five branches, all with high geographical specificity: G1-L1323 in Kazakhs, the closely related G1-GG1 in Mongols, G1-GG265 in Armenians and its distant brother clade G1-GG162 in Bashkirs, and G1-GG362 in West Indians. The haplotype diversity, which decreased from West Iran to Central Asia, allows us to hypothesize that this rare haplogroup could have been carried by the expansion of Iranic speakers northwards to the Eurasian steppe and via founder effects became a predominant genetic component of some populations, including the Argyn tribe of the Kazakhs. The remarkable agreement between genetic and genealogical trees of Argyns allowed us to calibrate the molecular clock using a historical date (1405 AD) of the most recent common genealogical ancestor. The mutation rate for Y-chromosomal sequence data obtained was 0.78×10
-9 per bp per year, falling within the range of published rates. The mutation rate for Y-chromosomal STRs was 0.0022 per locus per generation, very close to the so-called genealogical rate. The “clan-based” approach to estimating the mutation rate provides a third, middle way between direct farther-to-son comparisons and using archeologically known migrations, whose dates are subject to revision and of uncertain relationship to genetic events. [ABSTRACT FROM AUTHOR]- Published
- 2015
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19. Mitochondrial and Y-chromosomal profile of the Kazakh population from East Kazakhstan.
- Author
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Tarlykov, Pavel V., Zholdybayeva, Elena V., Akilzhanova, Ainur R., Nurkina, Zhannur M., Sabitov, Zhaxylyk M., Rakhypbekov, Tolebay K., and Ramanculov, Erlan M.
- Subjects
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Y chromosome , *MITOCHONDRIAL DNA , *KAZAKHS , *NUCLEOTIDE sequence , *LOCUS (Genetics) , *HAPLOTYPES - Abstract
Aim To study the genetic relationship of Kazakhs from East Kazakhstan to other Eurasian populations by examining paternal and maternal DNA lineages. Methods Whole blood samples were collected in 2010 from 160 unrelated healthy Kazakhs residing in East Kazakhstan. Genomic DNA was extracted with WizardR genomic DNA Purification Kit. Nucleotide sequence of hypervariable segment I of mitochondrial DNA (mtDNA) was determined and analyzed. Seventeen Y-short tandem repeat (STR) loci were studied in 67 samples with the Amp- FiSTR Y-filer PCR Amplification Kit. In addition, mtDNA data for 2701 individuals and Y-STR data for 677 individuals were retrieved from the literature for comparison. Results There was a high degree of genetic differentiation on the level of mitochondrial DNA. The majority of maternal lineages belonged to haplogroups common in Central Asia. In contrast, Y-STR data showed very low genetic diversity, with the relative frequency of the predominant haplotype of 0.612. Conclusion The results revealed different migration patterns in the population sample, showing there had been more migration among women. mtDNA genetic diversity in this population was equivalent to that in other Central Asian populations. Genetic evidence suggests the existence of a single paternal founder lineage in the population of East Kazakhstan, which is consistent with verbal genealogical data of the local tribes. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
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