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Structural studies in active caldera systems are widely used in geothermal exploration to reconstruct volcanological conceptual models. Active calderas are difficult settings to perform such studies mostly because of the highly dynamic environment, dominated by fast accumulation of primary and secondary volcanic deposits, the variable and transient rheology of the shallow volcanic pile, and the continuous feedbacks between faulting, secondary porosity creation, and geothermal fluid circulation, alteration and cementation that tend to obliterate the tectonic deformation structures. In addition, deformation structures can be also caused by near- and far-field stress regimes, which include magmatic intrusions at various depths, the evolving topography and regional tectonics. A lack of consideration of all these factors may severely underpin the reliability of structural studies. By rebutting and providing a detailed discussion of all the points raised by the comment of Norini and Groppelli (2020) to the Urbani et al. (2020) paper, we take the opportunity to specify the scientific rationale of our structural fieldwork and strengthen its relevance for geothermal exploration and exploitation in active caldera geothermal systems in general and, particularly, for the Holocene history of deformation and geothermal circulation in the Los Humeros caldera. At the same time, we identify several major flaws in the approach and results presented in Norini and Groppelli (2020), such as (1) the lack of an appropriate ranking of the deformation structures considering an inventory method for structural analysis; (2) the misinterpretation and misquoting of Urbani et al. (2020) and other relevant scientific literature; and (3) irrelevant and contradictory statements within their comment.

The European Alps stretch over a range of climate zones which affect the spatial distribution of snow. Previous analyses of station observations of snow were confined to regional analyses. Here, we present an Alpine-wide analysis of snow depth from six Alpine countries – Austria, France, Germany, Italy, Slovenia, and Switzerland – including altogether more than 2000 stations of which more than 800 were used for the trend assessment. Using a principal component analysis and k-means clustering, we identified five main modes of variability and five regions which match the climatic forcing zones: north and high Alpine, north-east, north-west, south-east, and south and high Alpine. Linear trends of monthly mean snow depth between 1971 and 2019 showed decreases in snow depth for most stations from November to May. The average trend among all stations for seasonal (November to May) mean snow depth was −8.4 % per decade, for seasonal maximum snow depth −5.6 % per decade, and for seasonal snow cover duration −5.6 % per decade. Stronger and more significant trends were observed for periods and elevations where the transition from snow to snow-free occurs, which is consistent with an enhanced albedo feedback. Additionally, regional trends differed substantially at the same elevation, which challenges the notion of generalizing results from one region to another or to the whole Alps. This study presents an analysis of station snow depth series with the most comprehensive spatial coverage in the European Alps to date.

Abstract Background Ficus carica is an edible fruit, belonging to the Moraceae family, rarely described as cause of food allergy. We describe the first case of fig allergy that occurred as a cross-reactivity between fig and Derp 1. Case presentation We present a case of a 10-years-old-girl, with a history of no-seasonal mild intermittent rhinitis, who experienced an immediate reaction after ingestion of a fresh fig. Skin prick tests (SPT) with commercial extracts of food, airborne allergens, latex and panallergens (profilin, PR-10 and lipid transfer protein) were performed. SPT revealed a sensitization only for dermatophagoides farina and dermatophagoides pteronyssinus which was then confirmed with by specific IgE assay (UniCAP, Phadia, Uppsala, Sweden). We also carried out a positive SPT with a commercial fig allergen (Lofarma, Milan, Italy) and prick-by-prick (PBP) both with skin and pulp of green raw and cooked fig. Fig specific serum IgE levels were 1.08 U/ml and specific IgE for rDer p1 was 16.20 U/ml (total serum IgE = 377 U/ml). In contrast specific IgE levels for latex, LTP, profilin, PR-10 and pollen allergens were negative. Conclusion The ficin, the major fig allergen, belongs to cysteine protease family like Der p 1. The symptoms presented by our patient could be related to a cross reactivity between these two proteins which present a structural homology.

Resurgent calderas are excellent targets for geothermal exploration, as they are associated with the shallow emplacement of magma, resulting in widespread and long-lasting hydrothermal activity. Resurgence is classically attributed to the uplift of a block or dome resulting from the inflation of the collapse-forming magma chamber due to the intrusion of new magma. The Los Humeros volcanic complex (LHVC; Mexico) consists of two nested calderas: the outer and older Los Humeros formed at 164 ka and the inner Los Potreros formed at 69 ka. The latter is resurgent and currently the site of an active and exploited geothermal field (63 MWe installed). Here we aim to better define the characteristics of the resurgence in Los Potreros by integrating fieldwork with analogue models and evaluating the spatio-temporal evolution of the deformation as well as the depth and extent of the intrusions responsible for the resurgence, which may also represent the local heat source(s). Structural field analysis and geological mapping show that the floor of the Los Potreros caldera is characterized by several lava domes and cryptodomes (with normal faulting at the top) that suggest multiple deformation sources localized in narrow areas. Analogue experiments are used to define the possible source of intrusion responsible for the observed surface deformation. We apply a tested relationship between the surface deformation structures and depth of elliptical sources to our experiments with sub-circular sources. We found that this relationship is independent of the source and surface dome eccentricity, and we suggest that the magmatic sources inducing the deformation in Los Potreros are located at very shallow depths (hundreds of metres), which is in agreement with the well data and field observations. We propose that the recent deformation at LHVC is not a classical resurgence associated with the bulk inflation of a deep magma reservoir; rather, it is related to the ascent of multiple magma bodies at shallow crustal conditions ( km depth). A similar multiple source model of the subsurface structure has also been proposed for other calderas with an active geothermal system (Usu volcano, Japan), suggesting that the model proposed may have wider applicability.

Understanding the anatomy of magma plumbing systems of active volcanoes is essential not only for unraveling magma dynamics and eruptive behaviors but also to define the geometry, depth, and temperature of the heat sources for geothermal exploration. The Pleistocene–Holocene Los Humeros volcanic complex is part of the eastern Trans-Mexican Volcanic Belt (central Mexico), and it constitutes one of the most important exploited geothermal fields in Mexico with ca. 90 MW of produced electricity. With the aim to decipher the anatomy (geometry and structure) of the magmatic plumbing system feeding the geothermal field at Los Humeros, we carried out a field-based petrological and thermobarometric study of the exposed Holocene lavas. Textural analysis, whole-rock major-element data, and mineral chemistry are integrated with a suite of mineral-liquid thermobarometric models. Our results support a scenario characterized by a heterogeneous multilayered system, comprising a deep (depth of ca. 30 km) basaltic reservoir feeding progressively shallower and smaller discrete magma stagnation layers and batches, up to shallow-crust conditions (depth of ca. 3 km). The evolution of melts in the feeding system is mainly controlled by differentiation processes through fractional crystallization (plagioclase + clinopyroxene + olivine + spinel). We demonstrate the inadequacy of the existing conceptual models, where a single voluminous melt-controlled magma chamber (or “Standard Model”) at shallow depths was proposed for the magmatic plumbing system at Los Humeros. We instead propose a magmatic plumbing system made of multiple, more or less interconnected, magma transport and storage layers within the crust, feeding small (ephemeral) magma chambers at shallow-crustal conditions. This revised scenario provides a new configuration of the heat source feeding the geothermal reservoir at Los Humeros, and it should be taken into account to drive future exploration and exploitation strategies.

Allergic diseases, such as respiratory, cutaneous, and food allergy, have dramatically increased in prevalence over the last few decades. Increasing use of antibiotics has been linked with dysbiosis and enhanced prevalence of allergies and asthma. Despite the clear involvement of the microbiome in atopic disease, it remains to be determined whether microbial alterations are a cause or a consequence of the disease. Human microbiota is defined as the multitude of microorganisms that live in or are associated with a variety of human tissues: the gut, respiratory tract, skin and genital tract. Recent advances in metagenomic sequencing and bioinformatics have enabled detailed characterization of these vital microbial communities and their role in different diseases. In particular, the relationship of microbiota with immune responses and immunological or allergic diseases is well known. The composition of gut, respiratory and skin microbiota can influence systemic inflammatory responses that mediate food allergy, rhinitis, asthma, immunodeficiency diseases, atopic dermatitis and chronic urticaria. This review discusses the role of microbiota in the major allergic Type 2 diseases evaluating the composition of the main commensal bacteria species and their relation with these pathologies.

Rheumatological systemic autoimmune diseases, such as connective tissue diseases, rheumatoid arthritis or spondyloarthritis, are characterized by the presence of joint involvement associated with extra-articular manifestations. Among them, cutaneous diseases are often the most relevant and representative clinical manifestation, as in psoriatic arthritis, scleroderma or systemic lupus erythematosus. In this context, it is useful for rheumatologists to understand better skin diseases and their histopathological features. Evaluation of skin biopsy specimens can be helpful not only to confirm the diagnosis in both classic and clinically atypical variants, but also to improve further our knowledge of the pathogenetic mechanisms and the close link between skin and articular diseases. In this review, we discuss the clinical features, diagnostic evaluation and the histopathological features of skin manifestation of the most relevant rheumatological autoimmune diseases.

Dried stoned olive pomace (DSOP) was administered to dairy water buffaloes, and their productive performance and milk composition were analysed. Sixteen pluriparous lactating buffaloes were divided into two uniform groups (control and experimental), taking into consideration the following parameters: milk production (2,192 and 2,102 kg) and duration of lactation (254 and 252 d) of the previous year, distance from calving (51 and 43 d), milk production (9.71 and 10.18 kg/d), body condition score (BCS) (6.44 and 6.31) and weight (617 and 653 kg) at the beginning of the trial. Both diets had the same formulation: second cut alfalfa hay 20%, corn silage 42%, concentrate 38% but the two concentrates differed in their formulation, the experimental one contained 15.50% of DSOP as fed. The employed DSOP showed high amounts of secoiridoids, such as 3,4-dihydroxyphenylethanol (3,4-DHPEA) (1.2 g/kg DM), 3,4-dihydroxyphenylethanol-elenolic acid di-aldehyde (3,4-DHPEA-EDA) (12.6 g/kg DM), p-hydroxyphenylethanol-elenolic acid di-aldehyde (p-HPEA-EDA) (5.6 g/kg DM) and lignans, which are known to be powerful bioactive compounds. The control diet had an energy-protein content of 0.86 Milk FU/kg DM and 143.3 g/kg DM of crude protein, whereas the experimental diet of 0.87 Milk FU/kg DM and 146.6 g/kg DM of crude protein. Each animal of the two groups received 17 kg DM/d and each buffalo of the experimental group, by way of the concentrate, ingested 1.05 kg DM/d of DSOP. The trial lasted 40 days. No significant difference was found between the BCS (6.41 and 6.53), live weight (625.93 and 662.50 kg) and milk production (9.69 and 10.08 kg/d) of the two groups, as was the case for fat, protein, lactose, pH and coagulating parameters of the two milks. The milk fat of the experimental group had a significantly higher content of total tocopherols (10.45 vs 8.60 μg/g, p

Objectives: Autologous hematopoietic stem cell transplantation (HSCT) is a treatment option which may be considered for severe diffuse cutaneous systemic sclerosis (dcSSc) patients not responding to cyclophophamide (CY). We present two cases of dcSSc not responding to CY >10 g who were successfully treated with HSCT. Patients and methods: Two dcSSc patients were unresponsive to monthly i.v. pulse of CYC (0.75 g m2). Both patients had significant reduction of DLCO and mild-moderate pulmonary hypertension and HSCT was considered due to the rapid progression of the disease. Following informed consent and ethics committee approval, HSCT was performed. Mobilisation was performed with CY 4g/m2 and recombinant human granulocyte colony stimulating factor (rHu GCSF) followed by a successful apheresis (CD34+ cells, >7X106). Conditioning regimens were: CY 100mg/kg body weight plus thiotepa 10 mg/ kg in the first patient and CY 200 mg/kg in the second. Both graft products were CD34 selected. No arrythmias occurred during the procedure and no other severe side effects were observed during hospitalisation. Results: Follow up: Patients underwent a monthly follow up with physical examination, pulmonary function tests and echocardiography every 3 months. Chest CT has been performed 6 months post transplantation. The following was observed: skin score (from 40 to 10 for the first patient and from 38 to 12 for the second one), LVEF and pulmonary function remained stable, PAP decreased from 45 mmHg to 35 mmHg and from 40 to 32 mmHg. No late complications or cardiac toxicity was observed. Conclusion: These two dcSSc cases demonstrate that HSCT may be successfully performed without serious side effects in cases in whom despite a cumulative CY dose was ineffective. This suggests an “immunological threshold” effect which may be exploited in other severe, therapy refractory autoimmune cases.