11 results on '"Rose, Matthew F."'
Search Results
2. Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math 1.
- Author
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Rose, Matthew F., Ahmad, Kaashif A., ThaIIer, Christina, and Zoghbi, Huda Y.
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TRANSCRIPTION factors , *NEURONS , *PROPRIOCEPTION , *INTEROCEPTION , *NEUROTRANSMITTERS , *RHOMBENCEPHALON , *AROUSAL (Physiology) - Abstract
Hindbrain networks important for sensation and arousal contain diverse neuronal populations with distinct projections, yet share specific characteristics such as neurotransmitter expression. The relationship between the function of these neurons, their developmental origin, and the timing of their migration remains unclear. Mice lacking the proneural transcription factor Math 1 (Atoh 1) lose neurons essential for hearing, balance, and unconscious proprioception. By using a new, inducible Math Cre*PR allele, we found that Math 1 is also required for the conscious proprioceptive system, including excitatory projection neurons of the dorsal column nuclei and for vital components of the interoceptive system, such as Barrington's nucleus, that is closely associated with arousal. In addition to specific networks, Math I lineages shared specific neurotransmitter expression, including glutamate, acetylcholine, somatostatin, corticotropin releasing hormone, and nitric oxide. These findings identify twenty novel Math I lineages and indicate that the Math I network functions partly as an interface for conscious (early-born) and unconscious (late-born) proprioceptive inputs to the cortex and cerebellum, respectively. In addition, these data provide previously unsuspected genetic and developmental links between proprioception, interoception, hearing, and arousal. [ABSTRACT FROM AUTHOR]
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- 2009
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3. Math1 Is Essential for the Development of Hindbrain Neurons Critical for Perinatal Breathing
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Rose, Matthew F., Ren, Jun, Ahmad, Kaashif A., Chao, Hsiao-Tuan, Klisch, Tiemo J., Flora, Adriano, Greer, John J., and Zoghbi, Huda Y.
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TRANSCRIPTION factors , *PROPRIOCEPTION , *AROUSAL (Physiology) , *HYPOVENTILATION , *RHOMBENCEPHALON , *RESPIRATION , *PERINATOLOGY , *LABORATORY mice , *GENETIC disorders - Abstract
Summary: Mice lacking the proneural transcription factor Math1 (Atoh1) lack multiple neurons of the proprioceptive and arousal systems and die shortly after birth from an apparent inability to initiate respiration. We sought to determine whether Math1 was necessary for the development of hindbrain nuclei involved in respiratory rhythm generation, such as the parafacial respiratory group/retrotrapezoid nucleus (pFRG/RTN), defects in which are associated with congenital central hypoventilation syndrome (CCHS). We generated a Math1-GFP fusion allele to trace the development of Math1-expressing pFRG/RTN and paratrigeminal neurons and found that loss of Math1 did indeed disrupt their migration and differentiation. We also identified Math1-dependent neurons and their projections near the pre-Bötzinger complex, a structure critical for respiratory rhythmogenesis, and found that glutamatergic modulation reestablished a rhythm in the absence of Math1. This study identifies Math1-dependent neurons that are critical for perinatal breathing that may link proprioception and arousal with respiration. [Copyright &y& Elsevier]
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- 2009
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4. Math1 Expression Redefines the Rhombic Lip Derivatives and Reveals Novel Lineages within the Brainstem and Cerebellum
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Wang, Vincent Y., Rose, Matthew F., and Zoghbi, Huda Y.
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NEURONS , *CELLS , *BRAIN stem , *AUDITORY pathways - Abstract
Summary: The rhombic lip (RL) is an embryonic proliferative neuroepithelium that generates several groups of hindbrain neurons. However, the precise boundaries and derivatives of the RL have never been genetically identified. We use β-galactosidase expressed from the Math1 locus in Math1-heterozygous and Math1-null mice to track RL-derived cells and to evaluate their developmental requirements for Math1. We uncover a Math1-dependent rostral rhombic-lip migratory stream (RLS) that generates some neurons of the parabrachial, lateral lemniscal, and deep cerebellar nuclei, in addition to cerebellar granule neurons. A more caudal Math1-dependent cochlear extramural stream (CES) generates the ventral cochlear nucleus and cochlear granule neurons. Similarly, mossy-fiber precerebellar nuclei require Math1, whereas the inferior olive and locus coeruleus do not. We propose that Math1 expression delimits the extent of the rhombic lip and is required for the generation of the hindbrain superficial migratory streams, all of which contribute neurons to the proprioceptive/vestibular/auditory sensory network. [Copyright &y& Elsevier]
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- 2005
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5. ARID1A and TERT promoter mutations in dedifferentiated meningioma.
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Abedalthagafi, Malak S., Bi, Wenya Linda, Merrill, Parker H., Gibson, William J., Rose, Matthew F., Du, Ziming, Francis, Joshua M., Du, Rose, Dunn, Ian F., Ligon, Azra H., Beroukhim, Rameen, and Santagata, Sandro
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TELOMERASE reverse transcriptase , *GENETIC mutation , *MENINGIOMA , *DEATH rate , *CANCER invasiveness , *HISTOPATHOLOGY , *NUCLEOTIDE sequencing , *COMPARATIVE genomic hybridization , *PATIENTS - Abstract
Unlike patients with World Health Organization (WHO) grade I meningiomas, which are considered benign, patients with WHO grade III meningiomas have very high mortality rates. The principles underlying tumor progression in meningioma are largely unknown, yet a detailed understanding of these mechanisms will be required for effective management of patients with these high grade lethal tumors. We present a case of an intraventricular meningioma that at first presentation displayed remarkable morphologic heterogeneity—composed of distinct regions independently fulfilling histopathologic criteria for WHO grade I, II, and III designations. The lowest grade regions had classic meningothelial features, while the highest grade regions were markedly dedifferentiated. Whereas progression in meningiomas is generally observed during recurrence following radiation and systemic medical therapies, the current case offers us a snapshot of histologic progression and intratumoral heterogeneity in a native pretreatment context. Using whole exome sequencing and high resolution array-based comparative genomic hybridization, we observed marked genetic heterogeneity between the various areas. Notably, in the higher grade regions we found increased aneuploidy with progressive loss of heterozygosity, the emergence of mutations in the TERT promoter, and compromise of ARID1A . These findings provide new insights into intratumoral heterogeneity in the evolution of malignant phenotypes in anaplastic meningiomas and potential pathways of malignant progression. [ABSTRACT FROM AUTHOR]
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- 2015
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6. New Insights Into the Development of Infantile Intraocular Medulloepithelioma.
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JAKOBIEC, FREDERICK A., TRIEF, DANIELLE, RASHID, ALIA, ROSE, MATTHEW F., MINCKLER, DON, VANDERVEEN, DEBORAH, and MUKAI, SHIZUO
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CILIARY body , *CONGENITAL disorders , *HISTOPATHOLOGY , *TRANSCRIPTION factors , *BIOMARKERS , *NEOVASCULARIZATION , *IMMUNOHISTOCHEMISTRY , *TUMORS ,EPITHELIAL cell tumors - Abstract
PURPOSE: To define the maturational sequence of 3 infantile intraocular medulloepitheliomas. DESIGN: Retrospective clinicohistopathologic and immunohistochemical study. METHODS: Immunoreactivity of paraffin sections for CRX (cone-rod homebox transcription factor) and NeuN (biomarker for neuronal differentiation) were investigated together with other biomarkers, including S100, glial fibrillary acidic protein, epithelial membrane antigen, and various cytokeratins. RESULTS: Three infants (aged 1, 6, and 8 months) had iris neovascularization, 2 had anterior ciliary body tumors, and 1 a posterior tumor associated with a retinochoroidal coloboma. Each tumor displayed a premedullary monolayer of cuboidal epithelium that was S100+, NeuN-, and CRX- and that transitioned into a multilaminar medullary epithelium forming neurotubules with adluminal cells that were CRX+. NeuN first appeared in ablumenal neurotubular cells in 1 tumor and was also discovered among neuroblast-appearing cells in another. The third tumor associated with a coloboma was CRX- and NeuN-. CONCLUSIONS: A simple premedullary epithelial monolayer appears to be the fundamental source for the tumor and its multilaminar medullary epithelium. CRX+ and NeuN- cells within the multilayered medullary layer approximate expression patterns similar to those found in retinal development and differentiation. Discovery of these biomarkers in the neoplastic ciliary epithelium in a small number of tumors indicates preliminarily that the most anterior layers of the optic cup have a retained retinal and neuroglial differentiation potentiality. The third case was CRX- and NeuN- and possibly arose from embryonic pigment epithelium at the edge of the retinochoroidal coloboma. These immunohistochemical findings offer histogenetic and potential diagnostic insights. [ABSTRACT FROM AUTHOR]
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- 2014
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7. The Atoh1-lineage gives rise to hair cells and supporting cells within the mammalian cochlea
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Driver, Elizabeth Carroll, Sillers, Laura, Coate, Thomas M., Rose, Matthew F., and Kelley, Matthew W.
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HAIR cells , *COCHLEA , *TRANSCRIPTION factors , *CELL differentiation , *NOTCH genes , *CELLULAR signal transduction , *GENE expression - Abstract
Abstract: The organ of Corti, located within the mammalian cochlea, contains a precise mosaic of hair cells (HC) and supporting cells (SC), the patterning of which is critical for auditory function. Progenitors of HCs and SCs are found in the same post-mitotic region of the cochlear duct during early stages of cochlear development, and both HCs and SCs are absent in mice lacking the transcription factor Atoh1. Based on existing data, Atoh1 is thought to be the earliest determinant of HC fate, and to have a cell-autonomous role in HC differentiation, but the lineage of Atoh1-positive cells within the cochlear duct remains unclear. To address this issue, we used an inducible Atoh1 Cre⁎PR allele to permanently mark Atoh1-expressing cells at different developmental time points. We found that up to 30% of cells from the Atoh1-lineage develop as SCs, and that the number of Atoh1-positive SCs decreases both spatially and temporally in a pattern consistent with ongoing commitment. Modulation of Notch signaling, necessary for formation of the HC–SC mosaic, changes the percentage of cells from the Atoh1-lineage that develop as either HCs or SCs. The HC–SC ratio is also affected by morphogenesis of the cochlea, as inhibiting the outgrowth of the cochlear duct increases the number of Atoh1-lineage cells that develop as SCs. Our results demonstrate that the Atoh1-lineage is established early in cochlear development, but also show that expression of Atoh1 does not absolutely result in commitment to a HC fate. [Copyright &y& Elsevier]
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- 2013
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8. Unipolar Brush Cells of the Cerebellum Are Produced in the Rhombic Lip and Migrate through Developing White Matter.
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Englund, Chris, Kowalczyk, Tom, Daza, Ray A. M., Dagan, Avner, Lau, Charmaine, Rose, Matthew F., and Hevner, Robert F.
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Unipolar brush cells (UBCs) are glutamatergic interneurons in the cerebellar cortex and dorsal cochlear nucleus. We studied the development of UBCs, using transcription factor Tbr2/Eomes as a marker for UBCs and their progenitors in embryonic and postnatal mouse cerebellum. Tbr2+ UBCs appeared to migrate out of the upper rhombic lip via two cellular streams: a dorsal pathway into developing cerebellar white matter, where the migrating cells dispersed widely before entering the internal granular layer, and a rostral pathway alongthe cerebellar ventricular zonetowardthe brainstem. Ablation ofthe rhombic lipin organotypic slice cultures substantially reduced the production of Tbr2+ UBCs. In coculture experiments, Tbr2+ UBCs migrated from rhombic lip explants directly into the developing white matter of adjacent cerebellar slices. The origin of Tbr2+ UBCs was confirmed by colocalization with β-galactosidase expressed from the Math1 locus, a molecular marker of rhombic lip lineages. Moreover, the production of Tbr2+ UBCs was Math1 dependent, as Tbr2+ UBCs were severely reduced in Math1-null cerebellum. In reeler mutant mice, Tbr2+ UBCs accumulated near the rhombic lip, consistent with impaired migration through developing white matter. Our results suggest that UBCs arise from the rhombic lip and migrate via novel pathways to their final destinations in the cerebellum and dorsal cochlear nucleus. Our findings support a model of cerebellar neurogenesis, in which glutamatergic and GABAergic neurons are produced from separate progenitor pools located mainly in the rhombic lip and the cerebellar ventricular zone, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2006
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9. Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.
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Young, Juan I., Hong, Eugene P., Castle, John C., Crespo-Barreto, Juan, Bowman, Aaron B., Rose, Matthew F., Dongcheul Kang, Richman, Ron, Johnson, Jason M., Bergett, Susan, and Zoghbi, Huda V.
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RETT syndrome , *GENETIC mutation , *RNA splicing , *GENETIC regulation , *METHYLATION , *CARRIER proteins , *INTELLECTUAL disabilities , *GENE expression - Abstract
Rett syndrome (RTT) is a postnatal neurodevelopmental disorder characterized by the loss of acquired motor and language skills, autistic features, and unusual stereotyped movements. RTT is caused by mutations in the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2). Mutations in MECP2 cause a variety of neurodevelopmental disorders including X-linked mental retardation, psychiatric disorders, and some cases of autism. Although MeCP2 was identified as a methylation-dependent transcriptional repressor, transcriptional profiling of RNAs from mice lacking MeCP2 did not reveal significant gene expression changes, suggesting that MeCP2 does not simply function as a global repressor. Changes in expression of a few genes have been observed, but these alterations do not explain the full spectrum of Rett-like phenotypes, raising the possibility that additional MeCP2 functions play a role in pathogenesis. In this study, we show that MeCP2 interacts with the RNA-binding protein V box-binding protein I and regulates splicing of reporter minigenes. Importantly, we found aberrant alternative splicing patterns in a mouse model of RU. Thus, we uncovered a previously uncharacterized function of MeCP2 that involves regulation of splicing, in addition to its role as a transcriptional repressor. [ABSTRACT FROM AUTHOR]
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- 2005
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10. The AXH Domain of Ataxin-1 Mediates Neurodegeneration through Its Interaction with Gfi-1/Senseless Proteins
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Tsuda, Hiroshi, Jafar-Nejad, Hamed, Patel, Akash J., Sun, Yaling, Chen, Hung-Kai, Rose, Matthew F., Venken, Koen J.T., Botas, Juan, Orr, Harry T., Bellen, Hugo J., and Zoghbi, Huda Y.
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NEURODEGENERATION , *AMINO acids , *GLUTAMINE , *DROSOPHILA - Abstract
Summary: Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by an expanded glutamine tract in human Ataxin-1 (hAtx-1). The expansion stabilizes hAtx-1, leading to its accumulation. To understand how stabilized hAtx-1 induces selective neuronal degeneration, we studied Drosophila Atx-1 (dAtx-1), which has a conserved AXH domain but lacks a polyglutamine tract. Overexpression of hAtx-1 in fruit flies produces phenotypes similar to those of dAtx-1 but different from the polyglutamine peptide alone. We show that the Drosophila and mammalian transcription factors Senseless/Gfi-1 interact with Atx-1’s AXH domain. In flies, overexpression of Atx-1 inhibits sensory-organ development by decreasing Senseless protein. Similarly, overexpression of wild-type and glutamine-expanded hAtx-1 reduces Gfi-1 levels in Purkinje cells. Deletion of the AXH domain abolishes the effects of glutamine-expanded hAtx-1 on Senseless/Gfi-1. Interestingly, loss of Gfi-1 mimics SCA1 phenotypes in Purkinje cells. These results indicate that the Atx-1/Gfi-1 interaction contributes to the selective Purkinje cell degeneration in SCA1. [Copyright &y& Elsevier]
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- 2005
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11. The roof plate regulates cerebellar cell-type specification and proliferation.
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Chizhikov, Victor V., Lindgren, Anne G., Currle, D. Spencer, Rose, Matthew F., Monuki, Edwin S., and Millen, Kathleen J.
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RHOMBENCEPHALON , *NEURAL tube , *EMBRYOLOGY , *GENE expression , *CEREBELLUM - Abstract
During embryogenesis, the isthmic organizer, a well-described signaling center at the junction of the mid-hindbrain, establishes the cerebellar territory along the anterior/posterior axis of the neural tube. Mechanisms specifying distinct populations within the early cerebellar anlage are less defined. Using a newly developed gene expression map of the early cerebellar anlage, we demonstrate that secreted signals from the rhombomere 1 roof plate are both necessary and sufficient for specification of the adjacent cerebellar rhombic lip and its derivative fates. Surprisingly, we show that the roof plate is not absolutely required for initial specification of more distal cerebellar cell fates, but rather regulates progenitor proliferation and cell position within the cerebellar anlage. Thus, in addition to the isthmus, the roof plate represents an important signaling center controlling multiple aspects of cerebellar patterning. [ABSTRACT FROM AUTHOR]
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- 2006
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