Search

La présente étude propose d’analyser les caractéristiques spatio-temporelles de la voix de patients francophones présentant une immobilité laryngée suite à une opération de la glande thyroïde. Il s’agit ici d’évaluer les conséquences de l’immobilité laryngée sur le timing des articulateurs, à l’aide d’un corpus de logatomes (ou de séquences VCV). Notre investigation, bien qu’acoustique, entend analyser, le Voice Onset Time les différents indices articulatori-acoustiques qui peuvent être observés à partir d’un signal acoustique continu, et ainsi remonter aux configurations articulatoires (Abry et al., 1985). Une attention particulière sera donc accordée aux différentes perturbations temporelles qu’une immobilité laryngée peut provoquer sur la voix des patients, grâce à l’étude de la réorganisation temporelles des paramètres retenus. Notre étude se veut longitudinale puisque la voix des patients est enregistrée lors de différentes phases post-opératoires (post-opératoire 2, 3 et 4), ce qui devrait nous permettre de mettre au jour, non seulement les perturbations provoquées par l’immobilité laryngée, mais également les réajustements que les patients pourraient mettre en place au cours du temps et de leur rééducation orthophonique. Seul l’intervalle du VOT pour les occlusives sonores a été modifié. Pour les occlusives voisées, la transition CV implique uniquement un changement d’un état obstrué de conduit vocal à un état suffisamment dégagé de celui-ci pour permettre l’apparition d’une structure formantique claire et stable. En revanche, pour les occlusives non voisées, cette transition CV exige, outre le changement d’état du conduit vocal, une modification de la configuration de la glotte d’une position ouverte pour la consonne non voisée à une position fermée pour la voyelle subséquente. En conséquence, en raison de difficultés de maintien de vibrations laryngées, le VOT, qui est un indice de voisement, est alors généralement plus long pour les occlusives voisées que celles produites par les locuteurs contrôles. La durée du VOT de Klatt (1975) des occlusives voisées des patients reste toutefois quantitativement distincte des occlusives non voisées. En conséquence, la durée de la tenue consonantique des patients se voit également allongée dans les phases d’enregistrement précoces.

ABSTRACT This article deals with the preparation of novel co-oligoethers constituted with 1,3-propanediol (PDO) and isosorbide units and, prepared according to two different melt processes, without any solvent in the presence of acid catalyst: co-etherification of PDO and isosorbide (process A) and, trans-etherification between polytrimethylene ether glycol (PTEG) and isosorbide (process B). Complementary analytical methods: D and 2D 1H NMR and gas chromatography analysis, coupled with FID and MS-MALDI-TOF mass spectrometry, were performed to precisely define the microstructure of the final products. In particular, one can observe that two mechanisms involve during the reaction: etherification and trans-etherification where isosorbide reacts decreasing the molar mass of polymers chains. This led to oligomers having isosorbide units at each extremity and little inner isosorbide units. Computational calculations have been performed in parallel, and the data well duplicate the experimental results. Finally, it was shown that these new telechelic oligoethers have higher compatibility to water and higher Tg level and thermal stability than PTEG homopolymer. Therefore, such oligomers can be considered as new intermediates for designing new surfactants and/or new copolymers. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2178-2189 [ABSTRACT FROM AUTHOR]

Vacuum-ultraviolet (VUV) high-resolution absorption spectroscopy is a unique tool for the study of gas-phase atomic and molecular electronic structure. To date, it has been performed by using lasers or synchrotron radiation-based grating spectrometers, but none of these techniques can offer simultaneous high resolution, wavelength accuracy and broad tunability. The only technique combining these three important features is Fourier-transform spectroscopy, but this is limited to the mid-UV range (down to 140 nm; ref. 1) because of a lack of beamsplitters. Here, we present a new instrument based on a wavefront-division scanning interferometer, applied for the first time to the VUV range. This instrument, coupled to the DESIRS beamline at synchrotron SOLEIL, covers a broad range of wavelengths (typically 7%, adjustable in the 250-40 nm range), a resolving power of ∼1 × 106, an extrinsic absolute wavelength accuracy of 1 × 10−7 and a high signal-to-noise ratio. [ABSTRACT FROM AUTHOR]

To investigate the expression and significance of proteasomes reactivator REG gamma (γ) in breast cancer. First, we showed the expression of REGγ in breast cancer, metastatic lymph nodes and normal breast tissues. Meanwhile, we also analyzed the relationship between REGγ and estrogen receptor (ER), CerBb-2, lymph nodes metastasis and clinical stage of breast cancer. REGγ expression was determined by immunohistochemical staining and western blot. Secondly, we detected the expression of REGγ and REGγ-mRNA in human breast cancer cell lines (MDA-MB-231, MCF-7) and human breast ductal epithelial cell line (HBL-100) by western blot and real-time PCR. Finally, in order to identify effect of REGγ on breast cancer cell cycle and proliferation, we constructed recombinant plasmid of PcDNA3.1-REGγ and designed siRNA for REGγ in vitro. Cell cycle was assayed by flow cytometer (FCM), proliferation was measured by methyl thiazolyl tetrazolium (MTT). The results demonstrated abnormal high expression of REGγ in breast cancer and its metastatic lymph nodes. REGγ expression was related to breast cancer and its status of ER, CerBb-2 and lymph nodes metastasis. REGγ is one of the potential markers in breast cancer. REGγ could facilitate the growth of breast cancer cells. [ABSTRACT FROM AUTHOR]

ence of hormonal receptors (HR) expression is a predictive factor of high pathologic complete response (pCR) rate after neo-adjuvant chemotherapy. However, HR-positive tumors are less chemosensitive. In the present study, we evaluated the predictive value of estrogen (ER) and progesterone (PgR) semi-quantitative expression in patients with HR-positive tumors treated uniformly with antracycline-based neoadjuvant chemotherapy without hormonal treatment. Value of HR expression as a predictive factor was then evaluated in a multivariate analysis with tumor grade, Ki67 index and HER2 expression. From January 2000 and December 2006, 177 patients with HR-positive breast ductal invasive carcinoma ≥2 cm in its largest diameter were treated with six cycles of an anthracycline-based neo-adjuvant chemotherapy. Tumor grade, ER, PgR, HER2 status and Ki67 index were determined on microbiopsy performed before chemotherapy. A semi-quantitative evaluation of ER and PgR expression by IHC was performed using the Barnes'score. pCR rate was significantly different ( P < 0.001) according to the ER expression score. pCR rate was 28% for low score, 9% for medium score and 3% for high score. On the contrary, pCR rate was not significantly different ( P = 0.49) according to the PgR expression score. In the multivariate analysis, ER expression score ( P = 0.0002) and Ki67 index ( P = 0.02) were the only predictive factors of response for HR-positive tumors. pCR after anthracycline-based chemotherapy is significantly correlated with the ER expression score. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Otolaryngology -- Head & Neck Surgery is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

The presence of a metastatic papillary carcinoma in the neck is presumptive evidence of a primary thyroid neoplasm since neck metastases of other primary tumors are uncommon. Immunohistochemical studies may be required to diagnose these metastases. We report 2 cases in which an unrelated tumor mimicked a thyroid malignancy. Both patients had been referred for evaluation of enlarged lymph neck nodes without any other symptoms. In both cases, a lymph node biopsy identified a metastatic papillary adenocarcinoma that was believed to be consistent with a thyroid primary. Thyroidectomy was not performed in either case. Further investigations led to the diagnosis of other primary tumors that were unrelated to the thyroid; the unrelated primaries were an ovarian serous tumor in one patient and a papillary renal cell carcinoma in the other. [ABSTRACT FROM AUTHOR]