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Your search keyword '"Riswan, Soedarsono"' showing total 25 results
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25 results on '"Riswan, Soedarsono"'

1. Soils on exposed Sunda Shelf shaped biogeographic patterns in the equatorial forests of Southeast Asia

Author

Slik, J. W. Ferry, Aiba, Shin-Ichiro, Bastian, Meredith, Brearley, Francis Q., Cannon, Charles H., Eichhorn, Karl A. O., Fredriksson, Gabriella, Kartawinata, Kuswata, Laumonier, Yves, Mansor, Asyraf, Marjokorpi, Antti, Meijaard, Erik, Morley, Robert J., Nagamasu, Hidetoshi, Nilus, Reuben, Nurtjahya, Eddy, Payne, John, Permana, Andrea, Poulsen, Axel D., Raes, Niels, Riswan, Soedarsono, van Schaik, Carel P., Sheil, Douglas, Sidiyasa, Kade, Suzuki, Eizi, van Valkenburg, Johan L. C. H., Webb, Campbell O., Wich, Serge, Yoneda, Tsuyoshi, Zakaria, Rahmad, and Zweifel, Nicole

Published
2011

15. Silvestrol and episilvestrol, potential anticancer rocaglate derivatives from Aglaia silvestris

Author

Bang Yeon Hwang, Heebyung Chai, Bao-Ning Su, Qiuwen Mi, Afriastini, Johar J., Kardono, Leonardus B. S., Riswan, Soedarsono, Santarsiero, Bernard D., Mesecar, Andrew D., Wild, Robert, Fairchild, Craig R, Vite, Gregory D., Rose, William C., Fransworth, Norman R., Cordell, Geoffrey A., Pezzuto, John M., Swanson, Steven M., and Kinghorn, Douglas A.

Subjects
Chemical bonds -- Analysis, Cancer -- Research, Biological sciences, Chemistry
Abstract

The fruits and twigs of Aglaia silvestris are used to isolate two cytotoxic rocaglate derivatives possessing an unusual dioxanyloxy unit, silvestrol and episilvestrol, by bioassay-guided fractionation monitored with a human oral epidermoid carcinoma cell line.

Published
2004

16. Isolation and characterization of aromatase inhibitors from Brassaiopsis glomerulata (Araliaceae).

Author

Balunas, Marcy J., Su, Bin, Riswan, Soedarsono, Fong, Harry H.S., Brueggemeier, Robert W., Pezzuto, John M., and Kinghorn, A. Douglas

Subjects
CYTOCHROME P-450, OXIDOREDUCTASES, ENZYMES, ALDOSE reductase, AROMATASE, CARBONYL reductase, CHOLESTEROL hydroxylase
Abstract

Abstract: The hexane- and ethyl acetate-soluble extracts of the leaves of Brassaiopsis glomerulata (Blume) Regel (Araliaceae), collected in Indonesia, were found to inhibit aromatase, the rate-limiting enzyme in the production of estrogens from androgens, in both enzyme- and cell-based aromatase inhibition (AI) assays. Bioassay-guided fractionation led to the isolation of six known compounds of the steroid and triterpenoid classes (1–6) from the hexane extract, of which 6β-hydroxystimasta-4-en-3-one (5), was moderately active in the cell-based AI assay. Fractionation of the ethyl acetate extract afforded seven pure isolates (7–13) of the modified peptide, fatty acid, monoterpenoid, and benzenoid types, including six known compounds and the new natural product, N-benzoyl-l-phenylalanine methyl ester (9). The absolute stereochemistry of 9 and the other two peptides, 7 and 8, was determined by Marfey’s analysis. Linoleic acid (10) was found to be active in the enzyme-based AI assay, while 9 and (−)-dehydrololiolide (12) showed activity in the cell-based AI assay. [Copyright &y& Elsevier]

Published
2009
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22. Bioactivity-guided isolation of cytotoxic sesquiterpenes of Rolandra fruticosa

Author

Pan, Li, Lantvit, Daniel D., Riswan, Soedarsono, Kardono, Leonardus B.S., Chai, Hee-Byung, Carcache de Blanco, Esperanza J., Farnsworth, Norman R., Soejarto, Djaja Doel, Swanson, Steven M., and Kinghorn, A. Douglas

Subjects
*ASTERACEAE, *SESQUITERPENES, *ANTINEOPLASTIC agents, *CANCER cells, *CELL lines, *COLON cancer, *MOLECULAR structure, *SPECTRUM analysis
Abstract

Abstract: Cytotoxicity-guided fractionation of a methanol extract of the leaves and twigs of Rolandra fruticosa using the HT-29 human colon cancer cell line led to the isolation of seven sesquiterpene lactones, including the hitherto unknown isorolandrolide, 13-methoxyisorolandrolide (1), and bourbonenolide, 2α,13-diacetoxy-4α-hydroxy-8α-isobutyroyloxybourbonen-12,6α-olide (2), as well as five known compounds, 13-acetoxyrolandrolide (3), 8-desacyl-13-acetoxyrolandrolide-8-O-tiglate (4), 2-epi-glaucolide E (5), 2α,13-diacetoxy-4α-hydroxy-8α-methacryloyloxybourbonen-12,6α-olide (6), and 2α,13-diacetoxy-4α-hydroxy-8α-tigloyloxybourbonen-12,6α-olide (7). The structures of the two sesquiterpenes were elucidated on the basis of spectroscopic methods. All isolates were evaluated for their cytotoxicity using the HT-29 cell line, and only 13-acetoxyrolandrolide (3) was found to possess a potent inhibitory effect against this cell line. Compounds 3, 5 and 6 were also tested in a NF-κB (p65) inhibition assay, and 3 was assessed in an in vivo hollow fiber assay. [Copyright &y& Elsevier]

Published
2010
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23. Edulisones A and B, two epimeric benzo[b]oxepine derivatives from the bark of Aglaia edulis

Author

Kim, Soyoung, Su, Bao-Ning, Riswan, Soedarsono, Kardono, Leonardus B.S., Afriastini, Johar J., Gallucci, Judith C., Chai, Heebyung, Farnsworth, Norman R., Cordell, Geoffrey A., Swanson, Steven M., and Kinghorn, A. Douglas

Subjects
*OPTICAL polarization, *PYRROLIDINE, *CHEMISTRY, *OPTICAL diffraction, *HYDROLYSIS
Abstract

Abstract: Two benzo[b]oxepine derivatives, edulisones A ( 1 ) and B ( 2 ), were isolated from the bark of Aglaia edulis, collected in Indonesia. The relative stereochemistry of 1 was determined by single-crystal X-ray diffraction analysis. Treatment of compounds 1 and 2 with lithium hydroxide produced the same hydrolysis products, 1a and 1b , as a result of cleavage of the pyrrolidine ring to an alkylated amide mixture in each case, which demonstrated that these substances are epimeric at their 2-aminopyrrolidine moiety. [Copyright &y& Elsevier]

Published
2005
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24. Dioxadispiroketal compounds and a potential acyclic precursor from Amomum aculeatum

Author

Salim, Angela A., Su, Bao-Ning, Chai, Hee-Byung, Riswan, Soedarsono, Kardono, Leonardus B.S., Ruskandi, Agus, Farnsworth, Norman R., Swanson, Steven M., and Douglas Kinghorn, A.

Subjects
*ORGANIC cyclic compounds, *ZINGIBERACEAE, *ORGANIC oxides, *ORGANIC chemistry
Abstract

Abstract: Four new compounds having an unusual 1,7-dioxadispiro[5.1.5.2]-12-ene-11-one tricyclic ring system (1–4), their potential precursor, 5R-hydroxy-1-(4-hydroxyphenyl)-eicosan-3-one (5), and two known compounds, aculeatins A (6) and B (7), have been isolated from Amomum aculeatum. All compounds were characterized by spectroscopic methods and the configurations were established by 2D NOE correlations. Compounds 1–4, 6, and 7 showed cytotoxic activity against several human cancer cell lines. [Copyright &y& Elsevier]

Published
2007
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25. Rotational isomerism of a resveratrol tetramer, shoreaketone, in Shorea uliginosa

Author

Ito, Tetsuro, Furusawa, Miyuki, Iliya, Ibrahim, Tanaka, Toshiyuki, Nakaya, Ken-ichi, Sawa, Ryuichi, Kubota, Yumiko, Takahashi, Yoshikazu, Riswan, Soedarsono, and Iinuma, Munekazu

Subjects
*ISOMERISM, *TETRAMERS (Oligomers), *SHOREA, *DIPEROCARPACEAE
Abstract

Abstract: A new resveratrol tetramer, shoreaketone, was isolated from the stem bark of Shorea uliginosa (Dipterocarpaceae). The structure and the relative configuration were confirmed on the basis of 1D- and 2D-NMR spectral data. The structure has a novel framework of fused heptacyclic ring system including an α,β-unsaturated carbonyl group. In NMR spectra, shoreaketone is observed as two different conformers due to rotational isomerism. [Copyright &y& Elsevier]

Published
2005
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