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It may take years for the immune system to react to intestinal worms because worm antigens that would stimulate the immune system are only released when the worms die. This explains why drug treatment hastens the development of immunity by killing massive numbers of worms.

Author(s): Tinker Ready [1] On a sunny morning in May, a small group of students at the Uphams Corner Charter School in Boston tape two posters on to a whiteboard. [...]

Author(s): Tinker Ready [1] Harvard University hematologist Thomas Stossel has discovered a coveted method for freezing platelets that could revolutionize transfusion therapy. Stossel is seeking an industry partner and stands [...]

Author(s): Tinker Ready [1] It has been a bad week for academic scientists involved in industry-sponsored research. Two new studies suggest that the relationship between academia and industry is not [...]

Author(s): Tinker Ready [1] John Niederhuber, the new director of the US National Cancer Institute (NCI), says politics has no role at the institute. That may be the case now, [...]

Author(s): Tinker Ready [1] Instances when a reviewer steals an idea from a grant or paper under review are hard to trace--and even harder to quantify. In a study published [...]

Author(s): Tinker Ready [1] A new vaccine for high blood pressure has sparked a debate on the long-term safety of the approach. Vaccines for hypertension would solve one of the [...]

Author(s): Tinker Ready [1] Agency official's departure is a troubling sign, observers warn. The US Food and Drug Administration (FDA)'s refusal to endorse the controversial 'morning-after' pill signals a troubling [...]

Author(s): Tinker Ready [1] Whistleblower accuses researchers of misusing NIH funds. Researchers at Cornell University in New York are under investigation for allegedly enrolling inappropriate participants in research studies and [...]

Author(s): Tinker Ready [1] Researchers say the NIH is staggering grant reviews in order to save money. Infectious disease researchers are irate over a decision by the US National Institutes [...]

Author(s): Tinker Ready [1] The Bush administration's influence on the CDC is too restrictive, experts warn. Just as a new European agency steps into the battle against infectious diseases, its [...]

Author(s): Tinker Ready [1] Sweeping new rules designed to curb conflicts of interest at the US National Institutes of Health (NIH) have been met with both approval and anger. The [...]

Author(s): Tinker Ready [1] How does a female life scientist lead a campus full of male engineers? Susan Hockfield rises to the challenge with equal parts caution and confidence. The [...]

Author(s): Tinker Ready [1] Stem cell scientists have a message for those who propose ethically friendly methods to alter human embryos: come on down and give it a shot. "The [...]

Author(s): Tinker Ready [1] When the US National Institutes of Health (NIH) closed a pioneering prion research lab last month, the timing seemed a bit off. British researchers had just [...]

Author(s): Tinker Ready [1] Most stem cell researchers are accustomed to their work being greeted with controversy. But Lola Reid's work is so contentious even those in the field call [...]

Author(s): Tinker Ready [1] Researchers who agree to 'author' ghostwritten papers or conduct industry-sponsored clinical trials may find themselves in legal hot water now that courts worldwide are questioning the [...]

Author(s): Tinker Ready [1] Community groups protesting the proliferation of biodefense 'hot labs' conjure up scenarios of lax security, accidental infections and dangerous microbes escaping into the neighborhood to bolster [...]

Author(s): Tinker Ready [1] Statins do more than prevent heart attacks--that much is clear. But scientists are just beginning to unravel the drugs' panoply of effects.[illus. 1] In the decade [...]

Author(s): Tinker Ready [1] Two days after The Wall Street Journal published his 1 March column supporting stem cell research, Michigan State University researcher Jose Cibelli was still screening calls [...]

Author(s): Tinker Ready [1] Animal studies are under way, human trial protocols are taking shape and drug makers are on alert. All the international health community needs now is a [...]

Author(s): Tinker Ready [1] US soldiers are battling with the federal government over the military's anthrax vaccination scheme. After a flurry of rulings and counter-rulings over whether the vaccine can [...]

Author(s): Tinker Ready [1] Duke University researchers have been asked to review their use of patented research technologies and use alternative approaches wherever possible. An ongoing legal battle between the [...]

Author(s): Tinker Ready [1] Grants technical assistants (GTAs) are the unseen shepherds of grant applications at the US National Institutes of Health (NIH): they track and file paperwork, schedule meetings, [...]

Author(s): Tinker Ready [1] The ambitious US National Institutes of Health (NIH) Roadmap for Medical Research arrived in October to glowing press reports and enthusiastic endorsements from top scientists. But [...]

Author(s): Tinker Ready [1] The US National Institutes of Health (NIH) is quietly formulating a policy that will limit therapeutic HIV/AIDS trials to those countries that provide follow-up treatment to [...]

Author(s): Tinker Ready [1] HIV vaccine researchers have known for years that VaxGen's AIDSVAX, and others like it, have little chance of inducing antibodies that can neutralize HIV. Some have [...]

Author(s): Tinker Ready [1] Plans by a US company to bring back silicone breast implants have rekindled bias accusations against National Cancer Institute researcher Louise Brinton, who heads the institute's [...]

Author(s): Tinker Ready [1] If not finished, then academia's love affair with industry-sponsored trials in the United States is certainly cooling. According to CenterWatch, the independent clinical trials monitor, academic [...]

Within days of the vote to ban somatic-cell nuclear transfer (SCNT) being defeated, Senator Sam Brownback tried another tack, proposing instead to ban patents on SCNT-derived material. Many believe the [...]

Author(s): Tinker Ready [1] Last month, the United States National Institutes of Health (NIH) posted its long-awaited online embryonic stem (ES) cell registry (see http://escr.nih.gov/). It comprises the addresses and [...]

Author(s): Tinker Ready [1] As Nature Medicine went to press, the number of people in the United States who had tested positive for exposure to anthrax had risen to 10--one [...]

Author(s): Tinker Ready [1] In the latest complaint of clinical-trial misconduct, 30 families have filed a lawsuit against the world's largest pharmaceutical company, Pfizer, alleging unethical treatment of children involved [...]

Author(s): Tinker Ready [1] Since the death of Jesse Gelsinger in 1999 in a gene therapy trial, Nature Medicine has reported on the creation of several new oversight groups designed [...]

Author(s): Tinker Ready [1] Protein biologist Susan Lindquist has been appointed the first woman director of the Whitehead Institute for Biomedical Research. Hers is the third appointment of a woman [...]

Author(s): Tinker Ready [1] Johns Hopkins has become the latest in a line of American universities forced to suspend clinical trials because of its failure to comply with federal oversight [...]

Author(s): Tinker Ready Like any good soap opera character, Viki Carpenter has survived a stroke, a brain aneurysm, a gunshot wound, a kidney donation, child sex abuse and multiple personality [...]

Author(s): Tinker Ready [1] Gene therapy researchers in the US expressed their unhappiness last month with what they see as "excessive government oversight" of their field of research. Meeting at [...]

Author(s): Tinker Ready [1] A big boost in National Institutes of Health (NIH) funding in the face of budget freezes and cutbacks at other American research agencies has some scientists [...]

Author(s): Tinker Ready [1] Last month, more than 100 Harvard doctors, economists and public health specialists released a multi-year, multi-billion dollar plan to deliver AIDS drugs to the world's poor. [...]

Author(s): Tinker Ready [1] Unable to pass legislation banning human cloning, the United States is equally undecided about which way to move regarding research into embryonic stem (ES) cells. Although [...]

Author(s): Tinker Ready [1] The fortunes of two controversial gene therapy researchers shifted in late January--one for the worse and one for the better. James Wilson was further sidelined in [...]