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The indiscriminate use of water resources has led to ecological, public health, social and economical problems. Many diseases that could be extinct still persist because of the lack of a proper sanitation policy. Therefore, due to the problems caused by the discharges of wastewater, the current importance given to environmental issues and the importance of drinking water for the population, it is necessary to monitor its quality, especially in areas such as the industrial district of a city. In order to check the quality of water in the industrial region of Bauru, where a sewage treatment plant (STP) will soon be constructed, the present study aimed at monitoring and comparing the analyzes of water from the streams “Água Comprida”, “Vargem Limpa”, “Ribeirão Vargem Limpa” and Bauru River between the center and the industrial district of the city of Bauru. This region has major companies, including chemical ones that somehow contribute, through their effluents to increase the pollution of these water bodies. For this comparative analysis, we conducted a quantitative and qualitative study in partnership with the Bauru Department of Water and Sewerage (DAE) in the Wastewater Laboratory. Through the analysis of the water quality it was possible to evaluate the quality of water that will soon be treated by the sewage treatment plant, thus informing the public about the serious problems that persist in the region and how an industrial district affects the water quality of a city.