Search

For decades, conventional amour shield is mainly oriented on metallic materials which are today well-known. Since the use of non conventional threats as IEDs, performances of those protections are required to be upgraded. The expected improvements that manufacturers are looking for are mainly oriented to the weight reduction which is the key parameter to reduce the fuel consumption, increase the payload, and offer more manoeuvrability to vehicles [1]. However, the difficulty is to reduce as cautiously as possible the total mass of the protection solution while ensuring the safety of the vehicle. One of the possible solutions is to use new combinations of materials, able to be more efficient against new threats and lighter than the traditional steel armour. It is in this context that the combination between some well-known ballistic alloys and textile composite material appear as a high potential solution for armour plated protection. Indeed, used as a backing, textile composite material present some interesting properties such as a very low density compared with steel and good behaviour in term of ballistic efficiency. This study proposes to test and compare the behaviour and efficiency of three different textile composite backings.

In today's scenario, numerous studies have shown a great interest on 3D woven structures like 3D warp interlock fabric as a fibre reinforcement for composite material to provide a better impact than 2D laminated fabrics with unlinked structures in the thickness. The impact energy absorption capacity depends on different and independent parameters, including the shape and speed of the projectile, the type of fibrous structure (geometry), the type and nature of the threads (raw material, linear density, and twisting value), and the type of impregnation of the composite material. As part of our research work on hard impact protection solutions, the interest of textile composite structures, in particular those integrating 3D warp interlock fabrics, has been revealed. Based on the result, protection solutions with such fabric structure revealed larger dynamic deformation capacity for absorbing the impact energy as compared with not only a ceramic material facing a 12.7 mm ammunition (mass 43 g) at 610 m/s but also those solutions made with metallic materials facing a FSP (diameter 20 mm, mass 54 g) at 630 m/s and 1600 m/s. For each of these different threats, a specific type of composite material has to be used. These composite material solutions are mainly defined to respond to the appropriate mode of impact behaviour. [ABSTRACT FROM AUTHOR]

Pulmonary autograft reinforcement to prevent dilatation and subsequent neo-aortic valve regurgitation was reported. However, the late functional outcome of the native pulmonary valve inside a rigid Dacron conduit requires to be documented. We aimed to assess the results of modified Ross procedure associated with autograft reinforcement reimplantation technique. Outcomes of 61 consecutive patients who underwent Ross procedure with reinforcement between 2009 and 2021 were analyzed. Majority of cases has presented with mono or bicuspid aortic valve (n = 52; 85%), predominant aortic valve regurgitation (n = 47; 77%) and dilatation (> 30 mm) of the ascending aorta (n = 33; 54%). Forty-seven patients (77%) had prior aortic valve procedure including 38 surgical repair (62%) and 9 balloon dilatation (15%). Pulmonary autograft was reimplanted in a Dacron conduit of a median diameter = 25.6 mm (ranges: 20–30) using Tirone David's valve sparing aortic root replacement technique. No death occurred. Median age at procedure was 16.8 years (range: 6–38). Two patients (3%) required early neo-Aortic root revision, one other was reoperated later on resulting in neo-aortic valve replacement in 3 (4.9% IC 95% [0.34%; 12.7%]) because of respectively infective endocarditis, left ventricular false aneurysm and leaflet perforation. Six patients required right ventricular outflow conduit replacement including one percutaneous replacement. At mean 66 ± 50.5 months postoperatively, the survival rate with freedom from reintervention was 83% [71.9; 93.5] and the deterioration of the initial neo-Aortic valve function (regurgitation or stenosis) was not observed (Fig. 1). Autograft reinforcement by means of reimplantation technique allowed to extend the indications for Ross procedure to all patients requiring Aortic valve replacement and prevented neo-Aortic root dilatation. Failures were early and rare, and late controls confirmed the stability of the neo-aortic valve function in follow-up. [ABSTRACT FROM AUTHOR]

Dilatation of the pulmonary autograft resulting in aortic valve regurgitation represents a common issue following Ross procedure with root replacement, in particular when performed beyond childhood. We present our early experience with modified Ross procedure associated with autograft reinforcement using reimplantation technique. Records of 59 consecutive patients who underwent Ross procedure with reinforcement between 2009 and 2021were analysed. Pulmonary autograft was reimplanted in a Dacron conduit of a median diameter = 26 mm (range: 20–30) using Tirone David's technique of valve sparing aortic root replacement (VSRR). Median age was 17 years (range: 6–38). Majority of cases has presented with mono or bicuspid aortic valve (n = 50; 85%), predominant aortic valve regurgitation (n = 38; 64%) and dilatation (> 30 mm) of the ascending aorta (n = 32; 54%). Forty-six (78%) had at least one prior aortic valve procedure. No death occurred. Three patients required early procedure-related reoperation 8 others were reoperated on later resulting in 3 neo-aortic valve replacement all-over (5%). The mean duration of follow-up was 46 ± 12 months. Neither more than mild autograft regurgitation nor stenosis was observed. Mean diameters of the autograft annulus and sinotubular junction were respectively 24.8 ± 2.6 mm and 25.3 ± 2.1 mm at discharge and 25.3 ± 2.1 mm and 25.4 ± 2.7 mm at the last visit (P = 0.06 and 0.08). Autograft reinforcement by means of reimplantation technique prevented neo-aortic root dilatation and allowed to extend the indications for Ross procedure to patients for whom the conventional Ross technique was qualified to be unsuitable. Early failure was rare (5%) and mid-term outcomes confirmed the stability of the neo-aortic valve function in follow-up. [ABSTRACT FROM AUTHOR]

A honeybee colony, part of an apiary of nine, showed abnormalities in brood pattern and was thus presented for study. A classic veterinary medicine approach has allowed the diagnosis of a severe case of sacbrood virus (SBV) confirmed by a high viral load in affected larvae. SBV is known to infect larvae of the honeybee (Apis mellifera), resulting in failure to pupate and ultimately death of infected larvae. Several contributing factors combined, among them the parasite Varroa destructor, have been identified in this particular affected colony to explain the clinical outbreak of the disease whereas, in the majority of cases, infected colonies remain asymptomatic. As no specific cure of honeybee viruses is available, the management of these contributing factors is essential, including feeding of colonies and control of the Varroa parasite. After implementation of management solutions, the colony rapidly recovered in six weeks, but did not recommence honey production and remained at higher risk of a winter collapse. An earlier control management would have been more effective: regular visits of the colonies by the beekeepers should be the rule in order to detect abnormalities and also to detect and eliminate as early as possible the combination of factors that contribute to the proliferation of the virus. [ABSTRACT FROM AUTHOR]

Cardiac ultrasound has remained the primary tool for diagnostic and surgical decision-making for congenital heart disease (CHD). With recent developments in fusion imaging especially between CT and 3D echocardiography, previously described in percutaneous tricuspid annuloplasty and left atrial appendage closure, we obtain more information from combined images. Our aim is to study the feasibility and the added preoperative input and educational value of CT/3D-US fusion in prospective cohort of CHD patients more specifically in double outlet right ventricle, where a biventricular repair approach may need delicate preoperative analysis in order to achieve the best result. We prospectively included 25 patients (median age: 5 years) with mild to complex CHD, who underwent cardiac CT and 3D transthoracic echocardiography as part of their pre-operative or follow-up evaluation at our centre. We included three complete atrioventricular canal, three transposition of the great arteries, two congenitally corrected transposition of the great arteries with VSD and pulmonary stenosis, seven double outlet right ventricle, three truncus arteriosus, two tetralogy of Fallot, three Sinus Venosus ASD, one multiple VSD and one congenitally abnormal aortic valve. Time for completing fusion process and the quality of fusion between CT and 3D-US were noted. Educational value was evaluated by fellows. Fusion was successful in all patients with median fusion quality scored 4/5. The median time to complete the fusion process was 735 seconds [628–1163] regardless of the cardiopathy complexity. Landmarks were significantly modified in complex congenital heart disease. Educational value was scored by fellows (C: No-Little value; B: Intermediate value; A: Major value) (Fig. 1). Using Fusion modatily is feasible for everyone with little knowledge. The simultaneous visualization of intracardiac structures with fusion helps better understand anatomical relations of atrioventricular valves with outlets and helps young fellows in pediatric cardiology better visualize intracardiac repair and familiarize with congenital heart disease. Fusion technique can be routinely applied to patients regardless of their age and weight. [ABSTRACT FROM AUTHOR]

The article discusses a study which investigated the prevalence of infectious agents in honey bees in western France. Topics covered include the drastic decline in the pollinating insect population, the use of polymerase chain reaction (PCR) methods in quantifying sample contents and the high prevalence of infectious agents found in terms of colonies and of apiaries. Also mentioned is the assessment of the survival of the colonies after the wintering season.

The purpose of this study was to compare levels of gross motor (GM) and fine motor (FM) development in young children with autism spectrum disorder (ASD), and to compare their levels ofGMand FM development with children with developmental delay (DD) without ASD. Thirty-eight children (ASD group: n = 19; DD group: n = 19) between 21 and 41 months of age were assessed using the Peabody Developmental Motor Scales, Second Edition (PDMS-2). Using PDMS-2 classifications as well as differences between standard scores, each child was placed in one of three motor profiles based on the child's relative levels of GM and FM skills (GM = FM,GM>FM, and GM

This pilot study investigated the feasibility of using functional magnetic resonance imaging (fMRI) as a physiological marker of brain plasticity before and after an intensive body-weight-supported treadmill training (BWSTT) program in children with cerebral palsy (CP). Six ambulatory children (four males, two females; mean age 10y 6mo, age range 6-14y) with spastic CP (four hemiplegia, two asymmetric diplegia, all Gross Motor Function Classification System Level I) received BWSTT twice daily for 2 weeks. All children tolerated therapy; only one therapy session was aborted due to fatigue. With training, over ground mean walking speed increased from 1.47 to 1.66m/s (p=0.035). There was no change in distance walked for 6 minutes (pre-: 451m; post-: 458m;p 0.851). In three children, reliable fMRIs were taken of cortical activation pre- and post-intervention. Post-intervention increases in cortical activation during ankle dorsiflexion were observed in all three children. This study demonstrates that children with CP between 6 and 14 years of age can tolerate intensive locomotor training and, with appropriate modifications, can complete an fMRI series. This study supports further studies designed to investigate training-dependent plasticity in children with CP. [ABSTRACT FROM AUTHOR]

Polydnaviruses are unique because of their obligatory association with thousands of parasitoid wasp species from the braconid and ichneumonid families of hymenopterans. PDVs are injected into the parasitized hosts and are essential for parasitism success. However, polydnaviruses are also unique because of their genome composed of multiple dsDNA segments. Cytological evidence has recently confirmed the results of genetic and molecular analyses indicating that PDV segments were integrated in the wasp genome. Moreover a phylogenetic study performed using the age of available fossils to calibrate the molecular clock indicated that the polydnaviruses harboured by braconid wasps have resided within the wasp genome for approximately 70 million years. In the absence of horizontal transmission, the evolution of the PDV genomes has been driven exclusively by the reproductive success they have offered the wasps. The consequences of this particular selection pressure can be observed in the gene content of certain PDV genomes from which increasing sequence data are available. Molecular mechanisms already identified could be involved in the acquisition and loss of genes by the PDV genomes and lead us to speculate on the definition of the virus genome. [Copyright &y& Elsevier]

A major sensory processing disorder that may exist in infants and young children is increased vulnerability to sensory input, or sensory defensiveness. The Sensory Rating Scale for Infants and Young Children (SRS) was developed as a parent report measure that can be used to identify and quantify sensory responsiveness, including sensory defensive behaviors, in the birth to 3-year-old population. The SRS was administered to the parents of 120 normal children to provide data on internal consistency and intrarater and interrater reliability of the tool. Correlation coefficients and percentages of agreement for clinically important information were found to be high. The SRS appears useful as a clinical tool to assess sensory responsiveness in children. [ABSTRACT FROM AUTHOR]

Cotesia congregata is a parasitoid wasp that injects its eggs in the host caterpillar Manduca sexta. In this host-parasite interaction, successful parasitism is ensured by a third partner: a bracovirus. The relationship between parasitic wasps and bracoviruses constitutes one of the few known mutualisms between viruses and eukaryotes. The C. congregata bracovirus (CcBV) is injected at the same time as the wasp eggs in the host hemolymph. Expression of viral genes alters the caterpillar's immune defense responses and developmental program, resulting in the creation of a favorable environment for the survival and emergence of adult parasitoid wasps. Here, we describe the characterization of a CcBV multigene family which is highly expressed during parasitism and which encodes three proteins with homology to members of the cystatin superfamily. Cystatins are tightly binding, reversible inhibitors of cysteine proteases. Other cysteine protease inhibitors have been described for lepidopteran viruses; however, this is the first description of the presence of cystatins in a viral genome. The expression and purification of a recombinant form of one of the CcBV cystatins, cystatin 1, revealed that this viral cystatin is functional having potent inhibitory activity towards the cysteine proteases papain, human cathepsins L and B and Sarcophaga cathepsin B in assays in vitro. CcBV cystatins are, therefore, likely to play a role in host caterpillar physiological deregulation by inhibiting host target proteases in the course of the host-parasite interaction. [ABSTRACT FROM AUTHOR]