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2 results on '"Poling, Lara"'

1. Discovery and Verification of Extracellular miRNA Biomarkers for Non-invasive Prediction of Pre-eclampsia in Asymptomatic Women

Author

Boggess, Kim A., Saade, George R., Sullivan, Scott A., Markenson, Glenn R., Iams, Jay D., Coonrod, Dean V., Pereira, Leonardo M., Esplin, M. Sean, Cousins, Larry M., Lam, Garrett K., Hoffman, Matthew K., Srinivasan, Srimeenakshi, Treacy, Ryan, Herrero, Tiffany, Olsen, Richelle, Leonardo, Trevor R., Zhang, Xuan, DeHoff, Peter, To, Cuong, Poling, Lara G., Fernando, Aileen, Leon-Garcia, Sandra, Knepper, Katharine, Tran, Vy, Meads, Morgan, Tasarz, Jennifer, Vuppala, Aishwarya, Park, Soojin, Laurent, Clara D., Bui, Tony, Cheah, Pike See, Tabitha Overcash, Rachael, Ramos, Gladys A., Roeder, Hilary, Ghiran, Ionita, Parast, Mana, Breakefield, Xandra O., Lueth, Amir J., Rust, Sharon R., Dufford, Max T., Fox, Angela C., Hickok, Durlin E., Burchard, Julja, Boniface, J. Jay, and Laurent, Louise C.

Published
2020
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2. Discovery and verification of extracellular microRNA biomarkers for diagnostic and prognostic assessment of preeclampsia at triage.

Author

Morey, Robert, Poling, Lara, Srinivasan, Srimeenakshi, Martinez-King, Carolina, Anyikam, Adanna, Zhang-Rutledge, Kathy, Cuong To, Hakim, Abbas, Mochizuki, Marina, Verma, Kajal, Mason, Antoinette, Tran, Vy, Meads, Morgan, Lamale-Smith, Leah, Roeder, Hilary, Mariko Horii, Ramos, Gladys A., DeHoff, Peter, Parast, Mana M., and Pantham, Priyadarshini

Abstract

We report on the identification of extracellular miRNA (ex-miRNA) biomarkers for early diagnosis and prognosis of preeclampsia (PE). Small RNA sequencing of maternal serum prospectively collected from participants undergoing evaluation for suspected PE revealed distinct patterns of ex-miRNA expression among different categories of hypertensive disorders in pregnancy. Applying an iterative machine learning method identified three bivariate miRNA biomarkers (miR-522-3p/miR-4732-5p, miR-516a-5p/miR-144-3p, and miR-27b-3p/let-7b-5p) that, when applied serially, distinguished between PE cases of different severity and differentiated cases from controls with a sensitivity of 93%, specificity of 79%, positive predictive value (PPV) of 55%, and negative predictive value (NPV) of 89%. In a small independent validation cohort, these ex-miRNA biomarkers had a sensitivity of 91% and specificity of 57%. Combining these ex-miRNA biomarkers with the established sFlt1:PlGF protein biomarker ratio performed better than either set of biomarkers alone (sensitivity of 89.4%, specificity of 91.3%, PPV of 95.5%, and NPV of 80.8%). [ABSTRACT FROM AUTHOR]

Published
2023
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