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Aim: To investigate the diagnostic role of the 18F-FDG PET in the detection of residual tumour in Hodgkin disease. Material and methods: In the last decade in Hodgkin disease patients following the primary therapy CT investigation revealed residual disease in 73 cases. 18F-FDG PET investigations were performed for restaging in all of these patients. Results: 18F-FDG PET revealed active disease in 28 patients. Twenty-one of these patients had activity sings. In 5 of the patients complete remission was found after second-line therapy, and progressive disease was diagnosed in 16 cases. The other 7 patients did not have other activity signs, all of these patient are in stabile state. 18F-FDG PET was negative in 45 patients. In 2 of these cases recurrent disease was diagnosed in the first year. The other 43 patients did not showed activity signs. Conclusion: Negative 18F-FDG PET result is a good prognostic sign in Hodgkin disease patients for the disease free survival after the first-line therapy. Positive 18F-FDG PET finding with other activity signs indicates second-line therapy. Other investigations are required to clarify the cause of the relative high rate of 18F-FDG positive cases, in whom second line therapy was unnecessary. [ABSTRACT FROM AUTHOR]