Search

Your search keyword '"Pin, Isabelle"' showing total 244 results
Start Over Author "Pin, Isabelle" Search Limiters Peer Reviewed
244 results on '"Pin, Isabelle"'

3. Residential greenspace and lung function decline over 20 years in a prospective cohort: The ECRHS study

Author

Markevych, Iana, Zhao, Tianyu, Fuertes, Elaine, Marcon, Alessandro, Dadvand, Payam, Vienneau, Danielle, Garcia Aymerich, Judith, Nowak, Dennis, de Hoogh, Kees, Jarvis, Deborah, Abramson, Michael J., Accordini, Simone, Amaral, Andre FS, Bentouhami, Hayat, Jacobsen Bertelsen, Randi, Boudier, Anne, Bono, Roberto, Bowatte, Gayan, Casas, Lidia, Dharmage, Shyamali C, Forsberg, Bertil, Gislason, Thorarinn, Gnesi, Marco, Holm, Mathias, Jacquemin, Benedicte, Janson, Christer, Jogi, Rain, Johannessen, Ane, Keidel, Dirk, Leynaert, Benedicte, Maldonado Perez, José Antonio, Marchetti, Pierpaolo, Migliore, Enrica, Martínez-Moratalla, Jesús, Orru, Hans, Pin, Isabelle, Potts, James, Probst-Hensch, Nicole, Ranzi, Andrea, Sánchez-Ramos, José Luis, Siroux, Valerie, Soussan, David, Sunyer, Jordi, Urrutia Landa, Isabel, Villani, Simona, and Heinrich, Joachim

Published
2023
Full Text
View/download PDF

9. Paediatric long term continuous positive airway pressure and noninvasive ventilation in France: A cross-sectional study

Author

Fauroux, Brigitte, Khirani, Sonia, Amaddeo, Alessandro, Massenavette, Bruno, Bierme, Priscille, Taytard, Jessica, Stremler, Nathalie, Baravalle-Einaudi, Melisande, Mazenq, Julie, Ioan, Iulia, Schweitzer, Cyril, Lampin, Marie Emilie, Binoche, Alexandra, Mordacq, Clemence, Bergounioux, Jean, Mbieleu, Blaise, Rubinsztajn, Robert, Sigur, Elodie, Labouret, Geraldine, Genevois, Aline, Becourt, Arnaud, Hullo, Eglantine, Pin, Isabelle, Debelleix, Stéphane, Galodé, François, Bui, Stéphanie, Moreau, Johan, Renoux, Marie Catherine, Matecki, Stefan, Lavadera, Marc Lubrano, Heyman, Rachel, Pomedio, Michael, Le Clainche, Laurence, Bokov, Plamen, Masson, Alexandra, Hangard, Pauline, Menetrey, Celine, Jokic, Mikael, Gachelin, Elsa, Perisson, Caroline, Pervillé, Anne, Fina, Agnes, Giovannini-Chami, Lisa, Fleurence, Emmanuelle, Barzic, Audrey, Breining, Audrey, Ollivier, Morgane, Labbé, Guillaume, Coutier, Laurianne, and Aubertin, Guillaume

Published
2021
Full Text
View/download PDF

10. Factors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort

Author

Abou-Taam, Rola, Le Bourgeois, Muriel, Hadchouel-Duvergé, Alice, Drummond, David, Delacourt, Christophe, Alyanakian, Marie-Alexandra, Chatennoud, Lucienne, Thumerelle, Caroline, Mordacq, Clémence, Badiu-Decleyre, Irina, Bonnel, Cécile, Delbecque, Laure, Beghin, Laurent, Mingardi, Graziella, Tournegros, Caroline, Roditis, Léa, Wanin, Stéphanie, Lebras, Marie Noelle, Debelleix, Stéphane, Siao, Valérie, Servat, Marine, Simon, Guillaume, El Boustany, Patricia, Bosdure, Emmanuelle, Mazenq, Julie, Cabon, Isabelle, Ohlmann, Camille, Vrielynck, Stéphanie, Jubin, Virginie, André Gomez, Sylvie-Anne, Werck Gallois, Marie-Christine, Lezmi, Guillaume, Lejeune, Stéphanie, Pin, Isabelle, Blanchon, Sylvain, Bouazza, Naïm, Jolaine, Valérie, Marguet, Christophe, Houdoin, Véronique, Berger, Patrick, Fayon, Michael, Dubus, Jean-Christophe, Reix, Philippe, Pellan, Mathieu, Brouard, Jacques, Chiron, Raphael, Giovannini-Chami, Lisa, Deschildre, Antoine, and de Blic, Jacques

Published
2021
Full Text
View/download PDF

11. Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status

Author

Nerpin, Elisabet, Ferreira, Diogenes Seraphim, Weyler, Joost, Schlunnsen, Vivi, Jogi, Rain, Raherison Semjen, Chantal, Gislasson, Thorainn, Demoly, Pascal, Heinrich, Joachim, Nowak, Dennis, Corsico, Angelo, Accordini, Simone, Marcon, Alessandro, Squillacioti, Giulia, Olivieri, Mario, Nielsen, Rune, Johannessen, Ane, Gómez Real, Francisco, Garcia -Aymerich, Judith, Urrutia, Isabel, Pereira-Vega, Antonio, Gullón, Jose Antonio, Olin, Anna-Carin, Forsberg, Bertil, Emilsson, Össur Ingi, Pin, Isabelle, Jarvis, Deborah, Janson, Christer, and Malinovschi, Andrei

Published
2021
Full Text
View/download PDF

12. Prenatal Exposure to P[M.sub.2.5] Oxidative Potential and Lung Function in Infants and Preschool-Age Children: A Prospective Study

Author

Marsal, Anouk, Slama, Remy, Lyon-Caen, Sarah, Borlaza, Lucille Joanna S., Jaffrezo, Jean-Luc, Boudier, Anne, Darfeuil, Sophie, Elazzouzi, Rhabira, Gioria, Yoann, Lepeule, Johanna, Chartier, Ryan, Pin, Isabelle, Quentin, Joane, Bayat, Sam, Uzu, Gaelle, and Siroux, Valerie

Subjects
Redox potential -- Health aspects, Preschool children -- Health aspects -- Physiological aspects, Infants -- Health aspects -- Physiological aspects, Pulmonary ventilation -- Health aspects, Pediatric research, Air pollution -- Health aspects, Particles -- Health aspects -- Physiological aspects, Prenatal influences -- Environmental aspects -- Health aspects, Environmental issues, Health
Abstract

Background: Fine particulate matter (P[M.sub.2.5]) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal P[M.sub.2.5] oxidative potential (OP) on lung function in infants and preschool children. Objectives: We estimated the associations of personal exposure to P[M.sub.2.5] and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics. Methods: We used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout ([N.sub.2]MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal P[M.sub.2.5] mass and OP with lung function parameters were estimated using multiple linear regressions. Results: In neonates, an interquartile (IQR) increase in O[P.sup.DTT.sub.v] (0.89 nmol/min/[m.sup.3]) was associated with a decrease in functional residual capacity (FRC) measured by [N.sub.2]MBW [[beta] = -2.26 mL; 95% confidence interval (CI): -4.68, 0.15]. Associations with P[M.sub.2.5] showed similar patterns in comparison with O[P.sup.DTT.sub.v] but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs ([Rrs.sub.7-19]) from AOS tended to be associated with higher O[P.sup.DTT.sub.v] ([beta] = 0.09hPa * s/L; 95% CI: -0.06, 0.24) and O[P.sup.AA.sub.v] (IQR = 1.14nmol/min/[m.sup.3]; [beta] = 0.12hPa * s/L; 95% CI: -0.04, 0.27) but not with P[M.sub.2.5] (IQR = 6.9 [micro]g/[m.sup.3]; [beta] = 0.02hPa * s/L; 95% CI: -0.13, 0.16). Results for FRC and [Rrs.sub.7-19] remained similar in OP models adjusted on P[M.sub.2.5]. Discussion: Prenatal exposure to O[P.sup.DTT.sub.v] was associated with several offspring lung function parameters over time, all related to lung volumes. https://doi.org/10.1289/EHP11155, Introduction Exposure to ambient particulate matter (PM) increases risk of chronic respiratory diseases and triggers asthma and chronic obstructive pulmonary diseases. (1-3) Early life, including pregnancy, is a vulnerable time [...]

Published
2023
Full Text
View/download PDF

13. Phenol and Phthalate Effects on Thyroid Hormone Levels during Pregnancy: Relying on In Vitro Assays and Adverse Outcome Pathways to Inform an Epidemiological Analysis

Author

Nakiwala, Dorothy, Noyes, Pamela D., Faure, Patrice, Chovelon, Benoit, Corne, Christelle, Gauchez, Anne Sophie, Guergour, Dorra, Lyon-Caen, Sarah, Sakhi, Amrit K., Sabaredzovic, Azemira, Thomsen, Cathrine, Pin, Isabelle, Slama, Remy, and Philippat, Claire

Subjects
Thyroid hormones -- Health aspects -- Measurement, Fetal diseases -- Risk factors, Phenols -- Environmental aspects -- Health aspects, Thyroid diseases -- Risk factors -- Complications and side effects, Phthalates -- Environmental aspects -- Health aspects, Pregnant women -- Health aspects, Pediatric research, Environmental issues, Health
Abstract

Background: Studies characterizing associations between phenols, phthalates and thyroid hormones during pregnancy produce inconsistent results. This divergence may be partly attributable to false positives due to multiple comparison testing of large numbers of chemicals, and measurement error as studies rely on small numbers of biospecimens despite high intra-individual variability in urinary chemical metabolite concentrations. Objectives: This study employs a priori chemical filtering and expanded urinary biomonitoring to evaluate associations between phenol/phthalate exposures and serum thyroid hormones assessed during pregnancy. Methods: A two-tiered approach was implemented: a) In vitro high-throughput screening results from the ToxCast/Tox21 database, as informed by a thyroid Adverse Outcome Pathway network, were evaluated to select phenols/phthalates with activity on known and putative molecular initiating events in the thyroid pathway; and b) Adjusted linear regressions were used to study associations between filtered compounds and serum thyroid hormones measured in 437 pregnant women recruited in Grenoble area (France) between 2014 and 2017. Phenol/phthalate metabolites were measured in repeated spot urine sample pools (median: 21 samples/women). Results: The ToxCast/Tox21 screening reduced the chemical set from 16 to 13 and the associated number of statistical comparisons by 19%. Parabens were negatively associated with free triiodothyronine (T3) and the T3/T4 (total thyroxine) ratio. Monobenzyl phthalate was positively associated with total T4 and negatively with the T3/T4 ratio. Effect modification by iodine status was detected for several compounds (among them ZDEHP and mono-n-butyl phthalate) that were associated with some hormones among women with normal iodine levels. Conclusion: For these chemicals, screening for compounds with an increased likelihood for thyroid-related effects and relying on repeated urine samples to assess exposures improved the overall performance of multichemical analyses of thyroid disruption. This approach may improve future evaluations of human data for the thyroid pathway with implication for fetal health and may serve as a model for evaluating other toxicity outcomes. https://doi.org/10.1289/EHP10239, Introduction During pregnancy, euthyroidism is crucial for normal fetal growth and development. (1) Even subtle alterations of thyroid hormone homeostasis can negatively impact the growing fetus and postnatal health. (2) [...]

Published
2022
Full Text
View/download PDF

14. Skewed X-chromosome inactivation drives the proportion of DNAAF6-defective airway motile cilia and variable expressivity in primary ciliary dyskinesia.

Author

Thomas, Lucie, Cuisset, Laurence, Papon, Jean-Francois, Tamalet, Aline, Pin, Isabelle, Taam, Rola Abou, Faucon, Catherine, Montantin, Guy, Tissier, Sylvie, Duquesnoy, Philippe, Moal, Florence Dastot - Le, Copin, Bruno, Carion, Nathalie, Louis, Bruno, Chantot-Bastaraud, Sandra, Siffroi, Jean-Pierre, Mitri, Rana, Coste, André, Escudier, Estelle, and Thouvenin, Guillaume

Abstract

Background Primary ciliary dyskinesia (PCD) is a rare airway disorder caused by defective motile cilia. Only male patients have been reported with pathogenic mutations in X-linked DNAAF6, which result in the absence of ciliary dynein arms, whereas their heterozygous mothers are supposedly healthy. Our objective was to assess the possible clinical and ciliary consequences of X-chromosome inactivation (XCI) in these mothers. Methods XCI patterns of six mothers of male patients with DNAAF6-related PCD were determined by DNA-methylation studies and compared with their clinical phenotype (6/6 mothers), as well as their ciliary phenotype (4/6 mothers), as assessed by immunofluorescence and high-speed videomicroscopy analyses. The mutated X chromosome was tracked to assess the percentage of cells with a normal inactivated DNAAF6 allele. Results The mothers' phenotypes ranged from absence of symptoms to mild/moderate or severe airway phenotypes, closely reflecting their XCI pattern. Analyses of the symptomatic mothers' airway ciliated cells revealed the coexistence of normal cells and cells with immotile cilia lacking dynein arms, whose ratio closely mirrored their XCI pattern. Conclusion This study highlights the importance of searching for heterozygous pathogenic DNAAF6 mutations in all female relatives of male PCD patients with a DNAAF6 defect, as well as in females consulting for mild chronic respiratory symptoms. Our results also demonstrate that about one-third--ranging from 20% to 50%--normal ciliated airway cells sufficed to avoid severe PCD, a result paving the way for gene therapy. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

15. Low serum DHEA-S is associated with impaired lung function in women

Author

Pesce, Giancarlo, Triebner, Kai, van der Plaat, Diana A., Courbon, Dominique, Hustad, Steinar, Sigsgaard, Torben, Nowak, Dennis, Heinrich, Joachim, Anto, Josep M., Dorado-Arenas, Sandra, Martinez-Moratalla, Jesús, Gullon-Blanco, Jose A., Sanchez-Ramos, José L., Raherison, Chantal, Pin, Isabelle, Demoly, Pascal, Gislason, Thorarinn, Torén, Kjell, Forsberg, Bertil, Lindberg, Eva, Zemp, Elisabeth, Jogi, Rain, Probst-Hensch, Nicole, Dharmage, Shyamali C., Jarvis, Debbie, Garcia-Aymerich, Judith, Marcon, Alessandro, Gómez-Real, Francisco, and Leynaert, Bénédicte

Published
2020
Full Text
View/download PDF

16. Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma

Author

Marcon, Alessandro, Marchetti, Pierpaolo, Antó, Josep M., Cazzoletti, Lucia, Cerveri, Isa, Corsico, Angelo, Ferreira, Diogenes Seraphim, Garcia-Aymerich, Judith, Gislason, David, Heinrich, Joachim, Jõgi, Rain, Johannessen, Ane, Leynaert, Bénédicte, Malinovschi, Andrei, Pin, Isabelle, Probst-Hensch, Nicole, Weyler, Joost, Janson, Christer, Jarvis, Deborah, and Accordini, Simone

Published
2020
Full Text
View/download PDF

17. Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts

Author

Burte, Emilie, Leynaert, Bénédicte, Marcon, Alessandro, Bousquet, Jean, Benmerad, Meriem, Bono, Roberto, Carsin, Anne-Elie, de Hoogh, Kees, Forsberg, Bertil, Gormand, Frederic, Heinrich, Joachim, Just, Jocelyne, Nieuwenhuijsen, Mark, Pin, Isabelle, Stempfelet, Morgane, Sunyer, Jordi, Villani, Simona, Künzli, Nino, Siroux, Valérie, Jarvis, Deborah, Nadif, Rachel, and Jacquemin, Bénédicte

Published
2020
Full Text
View/download PDF

18. Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades : the European Community Respiratory Health Survey

Author

Lytras, Theodore, Kogevinas, Manolis, Kromhout, Hans, Carsin, Anne-Elie, Antó, Josep Maria, Bentouhami, Hayat, Weyler, Joost, Heinrich, Joachim, Nowak, Dennis, Urrutia, Isabel, Martínez-Moratalla, Jesús, Gullón, José Antonio, Vega, Antonio Pereira, Semjen, Chantal Raherison, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Villani, Simona, Gíslason, Thorarinn, Svanes, Øistein, Holm, Mathias, Forsberg, Bertil, Norbäck, Dan, Mehta, Amar J, Probst-Hensch, Nicole, Benke, Geza, Jogi, Rain, Torén, Kjell, Sigsgaard, Torben, Schlünssen, Vivi, Olivieri, Mario, Blanc, Paul D, Watkins, John, Bono, Roberto, Buist, A. Sonia, Vermeulen, Roel, Jarvis, Deborah, and Zock, Jan-Paul

Published
2019

19. Non-infectious rhinitis is more strongly associated with early—rather than late—onset of COPD: data from the European Community Respiratory Health Survey (ECRHS)

Author

Bergqvist, Joel, Andersson, Anders, Schiöler, Linus, Olin, Anna-Carin, Murgia, Nicola, Bove, Mogens, Janson, Christer, Abramson, Michael J., Leynaert, Bénédicte, Nowak, Dennis, Franklin, Karl A., PIN, Isabelle, Storaas, Torgeir, Schlünssen, Vivi, Heinrich, Joachim, and Hellgren, Johan

Published
2020
Full Text
View/download PDF

20. Restrictive spirometry pattern is associated with low physical activity levels. A population based international study

Author

Carsin, Anne-Elie, Fuertes, Elaine, Schaffner, Emmanuel, Jarvis, Debbie, Antó, Josep M., Heinrich, Joachim, Bellisario, Valeria, Svanes, Cecilie, Keidel, Dirk, Imboden, Medea, Weyler, Joost, Nowak, Dennis, Martinez-Moratalla, Jesus, Gullón, José-Antonio, Sanchez Ramos, José Luis, Caviezel, Seraina, Beckmeyer-Borowko, Anna, Raherison, Chantal, Pin, Isabelle, Demoly, Pascal, Cerveri, Isa, Accordini, Simone, Gislason, Thorarinn, Toren, Kjell, Forsberg, Bertil, Janson, Christer, Jogi, Rain, Emtner, Margareta, Gómez Real, Francisco, Raza, Wasif, Leynaert, Bénédicte, Pascual, Silvia, Guerra, Stefano, Dharmage, Shyamali C., Probst-Hensch, Nicole, and Garcia-Aymerich, Judith

Published
2019
Full Text
View/download PDF

21. Asthma Medication Ratio Phenotypes in Elderly Women

Author

Chanoine, Sébastien, Pin, Isabelle, Sanchez, Margaux, Temam, Sofia, Pison, Christophe, Le Moual, Nicole, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Fournier, Agnès, Bousquet, Jean, Bedouch, Pierrick, Varraso, Raphaëlle, and Siroux, Valérie

Published
2018
Full Text
View/download PDF

23. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes

Author

Anto, Josep M., Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S., Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N., Lodrup Carlsen, Karin C., Koppelman, Gerard H., Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L., Maier, Dieter, Melén, Erik, Smit, Henriette A., Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M., Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C., Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J., Siroux, Valerie, Tischer, Christina G., Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian

Published
2017
Full Text
View/download PDF

26. Identification of a new locus at 16q12 associated with time to asthma onset

Author

Sarnowski, Chloé, Sugier, Pierre-Emmanuel, Granell, Raquel, Jarvis, Debbie, Dizier, Marie-Hélène, Ege, Markus, Imboden, Medea, Laprise, Catherine, Khusnutdinova, Elza K., Freidin, Maxim B., Cookson, William O.C., Moffatt, Miriam, Lathrop, Mark, Siroux, Valérie, Ogorodova, Ludmila M., Karunas, Alexandra S., James, Alan, Probst-Hensch, Nicole M., von Mutius, Erika, Pin, Isabelle, Kogevinas, Manolis, Henderson, A. John, Demenais, Florence, and Bouzigon, Emmanuelle

Published
2016
Full Text
View/download PDF

28. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis

Author

Aberer, Werner, Adachi, Mitsuru, Agache, Ioana, Akdis, Cezmi, Akdis, Mubeccel, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arshad, S. Hasan, Baiardini, Ilaria, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Bel, Elisabeth H., Ben Kheder, Ali, Bennoor, Kazi S., Benson, Michael, Bernstein, David, Michael, Bewick, Thomas, Bieber, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Buhl, Roland, Burney, Peter, Bush, Andrew, Caballero-Fonseca, Fernando, Caimmi, Davide P., Camargos, Paulo, Camuzat, Thierry, Carlsen, Kai-Hakon, Carr, Warner, Casale, Thomas B., Sarabia, Alfonso Cepeda, Chatzi, Leda, Chen, Yuzhi, Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander, Ciprandi, Georgio, Cirule, Ieva, Correia de Sousa, Jaime, Costa, David, Crooks, George, Custovic, Adnan, Dahlen, Sven-Erik, Darsow, Ulf, De Blay, Frédéric, De Manuel Keenoy, Esteban, Dedeu, Tony, Deleanu, Diana, Denburg, Judah, Didier, Alain, Dinh-Xuan, Anh-Tuan, Dokic, Dejan, Douagui, Habib B., Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, El-Gamal, Yehia, Emuzyte, Regina, Fink-Wagner, Antje, Fiocchi, Alessandro, Forastiere, Francesco, Gamkrelidze, Amiran, Gemicioğlu, Bilun, Gereda, Jose E., Gerth van Wijk, Roy, Gotua, Maia, Grisle, Ineta, Guzmán, M. Antonieta, Haahtela, Tari, Heinrich, Joachim, Hellquist-Dahl, Birthe, Horak, Friedrich, Howarth, Peter H., Humbert, Marc, Hyland, Michael, Ivancevich, Juan-Carlos, Jares, Edgardo J., Johnston, Sebastian L., Jonquet, Olivier, Joos, Guy, Jung, Ki-Suck, Just, Jocelyne, Jutel, Marek, Kaidashev, Igor P., Khaitov, Musa, Kalayci, Omer, Kalyoncu, Fuat, Keith, Paul, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Klimek, Ludger, N'Goran, Bernard Koffi, Kolek, Vitezlav, Koppelman, Gerard H., Kowalski, Marek, Kull, Inger, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Laune, Daniel, Le Thi Tuyet, Lan, Li, Jing, Lieberman, Phillipe, Lipworth, Brian J., Renaud, Louis, Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Majer, Ivan, Makela, Mika, Manning, Peter J., Masjedi, Mohamad R., Maurer, Marcus, Mavale-Manuel, Sandra, Melén, Erik, Melo-Gomes, Elisabete, Mercier, Jacques, Merk, Hans, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Molimard, Mathieu, Momas, Isabelle, Montilla-Santana, Anna, Morais-Almeida, Mario, Mösges, Ralph, Nadif, Rachel, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Niggemann, Bodo, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier-Luigi, Pali-Schöll, Isabella, Palmer, Stephen, Panzner, Petr, Papi, Alberto, Park, Hae-Sim, Pavord, Ian, Pawankar, Ruby, Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Pohl, Wolfgang, Popov, Todor, Postma, Dirkje S., Potter, Paul, Poulsen, Lars K., Rabe, Klaus F., Raciborski, Filip, Pontal, Françoise Radier, Reitamo, Sakari, Repka-Ramirez, Maria-Susana, Robalo-Cordeiro, Carlos, Roberts, Graham, Rodenas, Francisco, Rolland, Christine, Rodriguez, Miguel Roman, Romano, Antonino, Rosado-Pinto, José, Rosario, Nelson A., Rosenwasser, Larry, Rottem, Menachem, Sanchez-Borges, Mario, Sastre-Dominguez, Joaquim, Schmid-Grendelmeier, Peter, Serrano, Eli, Simons, F. Estelle R., Sisul, Juan-Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Rafael, Strandberg, Timo, Sunyer, Jordi, Thijs, Carel, Todo-Bom, Ana-Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., van Hage, Marianne, Vandenplas, Olivier, Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Wagenmann, Martin, Wahn, Ulrich, De Yun, Wang, Williams, Denis, Wright, John, Yawn, Barbara P., Yiallouros, Panayiotis, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Bousquet, Jean, Schünemann, Holger J., Hellings, Peter W., Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bergmann, Karl-Christian, Bosnic-Anticevich, Sinthia, Brozek, Jan, Calderon, Moises, Canonica, G. Walter, Chavannes, Niels H., Cox, Linda, Chrystyn, Henry, Cruz, Alvaro A., Dahl, Ronald, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Phillipe, Dray, Gérard, Fletcher, Monica, Fokkens, Wytske J., Fonseca, Joao, Gonzalez-Diaz, Sandra N., Grouse, Lawrence, Keil, Thomas, Kuna, Piotr, Larenas-Linnemann, Désirée, Lodrup Carlsen, Karin C., Meltzer, Eli O., Mullol, Jaoquim, Muraro, Antonella, Naclerio, Robert N., Palkonen, Susanna, Papadopoulos, Nikolaos G., Passalacqua, Giovanni, Price, David, Ryan, Dermot, Samolinski, Boleslaw, Scadding, Glenis K., Sheikh, Aziz, Spertini, François, Valiulis, Arunas, Valovirta, Erkka, Walker, Samantha, Wickman, Magnus, Yorgancioglu, Arzu, and Zuberbier, Torsten

Published
2016
Full Text
View/download PDF

29. Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study

Author

de Blic, Jacques, Deschildre, Antoine, Lemanac'h, Gaëlle, Bui, Stéphanie, Marguet, Christophe, Lubrano, Marc, Labbé, André, Petit, Isabelle, Faye, Albert, Lorrot, Mathie, Mahdi, Fouad, Dubus, Jean-Christophe, Bosdure, Emmanuelle, Pin, Isabelle, Llerena, Cathy, Derelle, Jocelyne, Schweitzer, Cyril, Epaud, Ralph, Nathan, Nadia, Reix, Philippe, Wanin, Stéphanie, David, Valérie, de Pontbriand, Ulrika, Brouard, Jacques, Bessière, Aude, Douay, Caroline, Dupont, Claire, Petit, Claire, Richard, Jean-Romain, Toneatti, Christine, Vibet, Marie-Anne, Le Bourgeois, Muriel, Ferroni, Agnès, Leruez-Ville, Marianne, Varon, Emmanuelle, Thumerelle, Caroline, Brémont, François, Fayon, Michael J., Delacourt, Christophe, Ligier, Caroline, Watier, Laurence, and Guillemot, Didier

Published
2016
Full Text
View/download PDF

31. Changes in IgE sensitization and total IgE levels over 20 years of follow-up

Author

Amaral, André F.S., Newson, Roger B., Abramson, Michael J., Antó, Josep M., Bono, Roberto, Corsico, Angelo G., de Marco, Roberto, Demoly, Pascal, Forsberg, Bertil, Gislason, Thorarinn, Heinrich, Joachim, Huerta, Ismael, Janson, Christer, Jõgi, Rain, Kim, Jeong-Lim, Maldonado, José, Martinez-Moratalla Rovira, Jesús, Neukirch, Catherine, Nowak, Dennis, Pin, Isabelle, Probst-Hensch, Nicole, Raherison-Semjen, Chantal, Svanes, Cecilie, Urrutia Landa, Isabel, van Ree, Ronald, Versteeg, Serge A., Weyler, Joost, Zock, Jan-Paul, Burney, Peter G.J., and Jarvis, Deborah L.

Published
2016
Full Text
View/download PDF

32. Early-Life Exposure to a Mixture of Phenols and Phthalates in Relation to Child Social Behavior: Applying an Evidence-Based Prioritization to a Cohort with Improved Exposure Assessment.

Author

Mustieles, Vicente, Rolland, Matthieu, Pin, Isabelle, Thomsen, Cathrine, Sakhi, Amrit K., Sabaredzovic, Azemira, Muckle, Gina, Guichardet, Karine, Slama, Rémy, and Philippat, Claire

Subjects
PHENOL analysis, MATERNAL exposure, AIR pollution, MOTHERS, STATISTICS, PHENOLS, HIGH performance liquid chromatography, CONFIDENCE intervals, THIRD trimester of pregnancy, CHILD behavior, HEALTH outcome assessment, REGRESSION analysis, PLASTICIZERS, TRICLOSAN, T-test (Statistics), RESEARCH funding, URINE collection & preservation, COMMUNICATION, QUESTIONNAIRES, MASS spectrometry, STATISTICAL hypothesis testing, SOCIAL skills, SECOND trimester of pregnancy, DATA analysis software, LOGISTIC regression analysis, SENSITIVITY & specificity (Statistics), DATA analysis, METABOLITES, PARENTS, KETONES, PREGNANCY
Abstract

BACKGROUND: Previous studies aiming at relating exposure to phenols and phthalates with child social behavior characterized exposure using one or a few spot urine samples, resulting in substantial exposure misclassification. Moreover, early infancy exposure was rarely studied. OBJECTIVES: We aimed to examine the associations of phthalates and phenols with child social behavior in a cohort with improved exposure assessment and to a priori identify the chemicals supported by a higher weight of evidence. METHODS: Among 406 mother-child pairs from the French Assessment of Air Pollution exposure during Pregnancy and Effect on Health (SEPAGES) cohort, 25 phenols/phthalate metabolites were measured in within-subject pools of repeated urine samples collected at the second and third pregnancy trimesters (∼21 samples/trimester) and at 2 months and 1-year of age (∼7 samples/period). Social behavior was parent-reported at 3 years of age of the child using the Social Responsiveness Scale (SRS). A structured literature review of the animal and human evidence was performed to prioritize the measured phthalates/phenols based on their likelihood to affect social behavior. Both adjusted linear regression and Bayesian Weighted Quantile Sum (BWQS) regression models were fitted. False discovery rate (FDR) correction was applied only to nonprioritized chemicals. RESULTS: Prioritized compounds included bisphenol A, bisphenol S, triclosan (TCS), diethyl-hexyl phthalate (RDEHP), mono-ethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), and mono-benzyl phthalate (MBzP). With the exception of bisphenols, which showed a mixed pattern of positive and negative associations in pregnant mothers and neonates, few prenatal associations were observed. Most associations were observed with prioritized chemicals measured in 1-y-old infants: Each doubling in urinary TCS (β=0.78; 95% CI: 0.00, 1.55) and MEP (β=0.92; 95% CI: -0.11, 1.96) concentrations were associated with worse total SRS scores, whereas MnBP and RDEHP were associated with worse Social Awareness (β=0.25; 95% CI: 0.01, 0.50) and Social Communication (β=0.43; 95% CI: -0.02, 0.89) scores, respectively. BWQS also suggested worse total SRS [Beta 1=1.38; 95% credible interval (CrI): -0.18, 2.97], Social Awareness (Beta 1=0.37; 95% CrI: 0.06, 0.70), and Social Communication (Beta 1=0.91; 95% CrI: 0.31, 1.53) scores per quartile increase in the mixture of prioritized compounds assessed in 1-y-old infants. The few associations observed with nonprioritized chemicals did not remain after FDR correction, with the exception of benzophenone-3 exposure in 1-y-old infants, which was suggestively associated with worse Social Communication scores (corrected 푝=0.07). DISCUSSION: The literature search allowed us to adapt our statistical analysis according to the weight of evidence and create a corpus of experimental and epidemiological knowledge to better interpret our findings. Early infancy appears to be a sensitive exposure window that should be further investigated. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

33. Comparing Mycobacterium massiliense and Mycobacterium abscessus lung infections in cystic fibrosis patients

Author

Roux, Anne-Laure, Catherinot, Emilie, Soismier, Nathalie, Heym, Beate, Bellis, Gil, Lemonnier, Lydie, Chiron, Raphaël, Fauroux, Brigitte, Le Bourgeois, Muriel, Munck, Anne, Pin, Isabelle, Sermet, Isabelle, Gutierrez, Cristina, Véziris, Nicolas, Jarlier, Vincent, Cambau, Emmanuelle, Herrmann, Jean-Louis, Guillemot, Didier, and Gaillard, Jean-Louis

Published
2015
Full Text
View/download PDF

34. Central venous thrombosis and thrombophilia in cystic fibrosis: A prospective study

Author

Munck, Anne, Kheniche, Ahmed, Alberti, Corinne, Hubert, Dominique, Martine, Reynaud-Gaubert, Nove-Josserand, Raphaele, Pin, Isabelle, Bremont, Francois, Chiron, Raphael, Couderc, Laure, Dalphin, Marie Laure, Darviot, Estelle, Delaisi, Bertrand, Dominique, Stéphane, Durieu, Isabelle, Fanton, Annelyse, Fayon, Michael, Gérardin, Michèle, Giniès, Jean-Louis, Giraut, Charlotte, Grenet, Dominique, Guillot, Marcel, Huet, Frédéric, Le bourgeois, Muriel, Murris-Epin, Marlène, Ramel, Sophie, Sardet, Anne, Sermet-Gaudelus, Isabelle, Varaigne, Françoise, Wanin, Stéphanie, Weiss, Laurence, and Hurtaud, Marie-Francoise

Published
2015
Full Text
View/download PDF

35. Toward the Standardization of Mycological Examination of Sputum Samples in Cystic Fibrosis: Results from a French Multicenter Prospective Study

Author

Coron, Noémie, Pihet, Marc, Fréalle, Emilie, Lemeille, Yolande, Pinel, Claudine, Pelloux, Hervé, Gargala, Gilles, Favennec, Loic, Accoceberry, Isabelle, Durand-Joly, Isabelle, Dalle, Frédéric, Huet, Frédéric, Fanton, Annlyse, Boldron, Amale, Loeuille, Guy-André, Domblides, Philippe, Coltey, Bérengère, Pin, Isabelle, Llerena, Catherine, Troussier, Françoise, Person, Christine, Marguet, Christophe, Wizla, Nathalie, Thumerelle, Caroline, Turck, Dominique, Bui, Stéphanie, Fayon, Michael, Duhamel, Alain, Prévotat, Anne, Wallaert, Benoit, Leroy, Sylvie, Bouchara, Jean-Philippe, and Delhaes, Laurence

Published
2017
Full Text
View/download PDF

36. Early delivery following chronic and acute ambient temperature exposure: a comprehensive survival approach.

Author

Hough, Ian, Rolland, Matthieu, Guilbert, Ariane, Seyve, Emie, Heude, Barbara, Slama, Rémy, Lyon-Caen, Sarah, Pin, Isabelle, Chevrier, Cécile, Kloog, Itai, and Lepeule, Johanna

Subjects
PREMATURE labor, WEATHER hazards, TEMPERATE climate, TEMPERATURE, HEALTH policy, HEAT waves (Meteorology)
Abstract

Background Ambient temperature, particularly heat, is increasingly acknowledged as a trigger for preterm delivery but study designs have been limited and results mixed. We aimed to comprehensively evaluate the association between ambient temperature throughout pregnancy and preterm delivery. Methods We estimated daily temperature throughout pregnancy using a cutting-edge spatiotemporal model for 5347 live singleton births from three prospective cohorts in France, 2002–2018. We performed Cox regression (survival analysis) with distributed lags to evaluate time-varying associations with preterm birth simultaneously controlling for exposure during the first 26 weeks and last 30 days of pregnancy. We examined weekly mean, daytime, night-time and variability of temperature, and heatwaves accounting for adaptation to location and season. Results Preterm birth risk was higher following cold (5th vs 50th percentile of mean temperature) 7–9 weeks after conception [relative risk (RR): 1.3, 95% CI: 1.0–1.6 for 2°C vs 11.6°C] and 10–4 days before delivery (RR: 1.6, 95% CI: 1.1–2.1 for 1.2°C vs 12.1°C). Night-time heat (95th vs 50th percentile of minimum temperature; 15.7°C vs 7.4°C) increased risk when exposure occurred within 5 weeks of conception (RR: 2.0, 95% CI: 1.05–3.8) or 20–26 weeks after conception (RR: 2.9, 95% CI: 1.2–6.8). Overall and daytime heat (high mean and maximum temperature) showed consistent effects. We found no clear associations with temperature variability or heatwave indicators, suggesting they may be less relevant for preterm birth. Conclusions In a temperate climate, night-time heat and chronic and acute cold exposures were associated with increased risk of preterm birth. These results suggest night-time heat as a relevant indicator. In the context of rising temperatures and more frequent weather hazards, these results should inform public health policies to reduce the growing burden of preterm births. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

43. Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome

Author

Cheung, Warren A., Shao, Xiaojian, Morin, Andréanne, Siroux, Valérie, Kwan, Tony, Ge, Bing, Aïssi, Dylan, Chen, Lu, Vasquez, Louella, Allum, Fiona, Guénard, Frédéric, Bouzigon, Emmanuelle, Simon, Marie-Michelle, Boulier, Elodie, Redensek, Adriana, Watt, Stephen, Datta, Avik, Clarke, Laura, Flicek, Paul, Mead, Daniel, Paul, Dirk S., Beck, Stephan, Bourque, Guillaume, Lathrop, Mark, Tchernof, André, Vohl, Marie-Claude, Demenais, Florence, Pin, Isabelle, Downes, Kate, Stunnenberg, Hendrick G., Soranzo, Nicole, Pastinen, Tomi, and Grundberg, Elin

Published
2017
Full Text
View/download PDF

45. Genome-wide association analysis identifies six new loci associated with forced vital capacity

Author

Loth, Daan W, Artigas, María Soler, Gharib, Sina A, Wain, Louise V, Franceschini, Nora, Koch, Beate, Pottinger, Tess D, Smith, Albert Vernon, Duan, Qing, Oldmeadow, Chris, Lee, Mi Kyeong, Strachan, David P, James, Alan L, Huffman, Jennifer E, Vitart, Veronique, Ramasamy, Adaikalavan, Wareham, Nicholas J, Kaprio, Jaakko, Wang, Xin-Qun, Trochet, Holly, Kähönen, Mika, Flexeder, Claudia, Albrecht, Eva, Lopez, Lorna M, de Jong, Kim, Thyagarajan, Bharat, Alves, Alexessander Couto, Enroth, Stefan, Omenaas, Ernst, Joshi, Peter K, Fall, Tove, Viñuela, Ana, Launer, Lenore J, Loehr, Laura R, Fornage, Myriam, Li, Guo, Wilk, Jemma B, Tang, Wenbo, Manichaikul, Ani, Lahousse, Lies, Harris, Tamara B, North, Kari E, Rudnicka, Alicja R, Hui, Jennie, Gu, Xiangjun, Lumley, Thomas, Wright, Alan F, Hastie, Nicholas D, Campbell, Susan, Kumar, Rajesh, Pin, Isabelle, Scott, Robert A, Pietiläinen, Kirsi H, Surakka, Ida, Liu, Yongmei, Holliday, Elizabeth G, Schulz, Holger, Heinrich, Joachim, Davies, Gail, Vonk, Judith M, Wojczynski, Mary, Pouta, Anneli, Johansson, Åsa, Wild, Sarah H, Ingelsson, Erik, Rivadeneira, Fernando, Völzke, Henry, Hysi, Pirro G, Eiriksdottir, Gudny, Morrison, Alanna C, Rotter, Jerome I, Gao, Wei, Postma, Dirkje S, White, Wendy B, Rich, Stephen S, Hofman, Albert, Aspelund, Thor, Couper, David, Smith, Lewis J, Psaty, Bruce M, Lohman, Kurt, Burchard, Esteban G, Uitterlinden, André G, Garcia, Melissa, Joubert, Bonnie R, McArdle, Wendy L, Musk, A Bill, Hansel, Nadia, Heckbert, Susan R, Zgaga, Lina, van Meurs, Joyce B J, Navarro, Pau, Rudan, Igor, Oh, Yeon-Mok, Redline, Susan, Jarvis, Deborah L, Zhao, Jing Hua, Rantanen, Taina, O'Connor, George T, Ripatti, Samuli, Scott, Rodney J, Karrasch, Stefan, Grallert, Harald, Gaddis, Nathan C, Starr, John M, Wijmenga, Cisca, Minster, Ryan L, Lederer, David J, Pekkanen, Juha, Gyllensten, Ulf, Campbell, Harry, Morris, Andrew P, Gläser, Sven, Hammond, Christopher J, Burkart, Kristin M, Beilby, John, Kritchevsky, Stephen B, Gudnason, Vilmundur, Hancock, Dana B, Williams, O Dale, Polasek, Ozren, Zemunik, Tatijana, Kolcic, Ivana, Petrini, Marcy F, Wjst, Matthias, Kim, Woo Jin, Porteous, David J, Scotland, Generation, Smith, Blair H, Viljanen, Anne, Heliövaara, Markku, Attia, John R, Sayers, Ian, Hampel, Regina, Gieger, Christian, Deary, Ian J, Boezen, H Marike, Newman, Anne, Jarvelin, Marjo-Riitta, Wilson, James F, Lind, Lars, Stricker, Bruno H, Teumer, Alexander, Spector, Timothy D, Melén, Erik, Peters, Marjolein J, Lange, Leslie A, Barr, R Graham, Bracke, Ken R, Verhamme, Fien M, Sung, Joohon, Hiemstra, Pieter S, Cassano, Patricia A, Sood, Akshay, Hayward, Caroline, Dupuis, Josée, Hall, Ian P, Brusselle, Guy G, Tobin, Martin D, and London, Stephanie J

Published
2014
Full Text
View/download PDF

46. Prenatal Exposure to PM2.5 Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study.

Author

Marsal, Anouk, Slama, Rémy, Lyon-Caen, Sarah, S. Borlaza, Lucille Joanna, Jaffrezo, Jean-Luc, Boudier, Anne, Darfeuil, Sophie, Elazzouzi, Rhabira, Gioria, Yoann, Lepeule, Johanna, Chartier, Ryan, Pin, Isabelle, Quentin, Joane, Bayat, Sam, Uzu, Gaëlle, Siroux, Valérie, and the SEPAGES cohort study group

Subjects
LUNG physiology, PARTICULATE matter, MATERNAL exposure, STATISTICS, CONFIDENCE intervals, MULTIPLE regression analysis, PRENATAL exposure delayed effects, PULMONARY function tests, DESCRIPTIVE statistics, RESEARCH funding, BIOLOGICAL assay, BREATH tests, DATA analysis software, OXIDATION-reduction reaction, LONGITUDINAL method, PREGNANCY
Abstract

BACKGROUND: Fine particulate matter (PM2.5) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children. OBJECTIVES: We estimated the associations of personal exposure to PM2.5  and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics. METHODS: We used data from 356 mother–child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N2MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM2.5  mass and OP with lung function parameters were estimated using multiple linear regressions. RESULTS: In neonates, an interquartile (IQR) increase in OPDTTv (0.89nmol/min/m³) was associated with a decrease in functional residual capacity (FRC) measured by N2MBW  [β = -2.26 mL ; 95% confidence interval (CI): -4.68, 0.15]. Associations with PM2.5  showed similar patterns in comparison with OPDTTv  but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs7-19) from AOS tended to be associated with higher OPDTTv  (β = 0.09hPa×s/L ; 95% CI: -0.06, 0.24) and OPAAv  (IQR = 1.14nmol/min/m³ ; β = 0.12hPa×s/L ; 95% CI: -0.04, 0.27) but not with PM2.5  (IQR = 6.9µg/m³ ; β = 0.02hPa×s/L ; 95% CI: -0.13, 0.16). Results for FRC and Rrs7-19 remained similar in OP models adjusted on PM2.5. DISCUSSION: Prenatal exposure to OPDTTv was associated with several offspring lung function parameters over time, all related to lung volumes. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

48. Pregnancy Exposure to Phenols and Anthropometric Measures in Gestation and at Birth.

Author

Jedynak, Paulina, Rolland, Matthieu, Pin, Isabelle, Thomsen, Cathrine, Sakhi, Amrit K., Sabaredzovic, Azemira, Philippat, Claire, Slama, Rémy, and the SEPAGES study group, and the SEPAGES Study Group

Subjects
MATERNAL exposure, PHENOLS, FETAL development, TRICLOSAN, BIRTH weight
Abstract

Background: Some synthetic phenols alter pathways involved in fetal development. Despite their high within-subject temporal variability, earlier studies relied on spot urine samples to assess pregnancy exposure. In this study, we examined associations between prenatal phenol exposure and fetal growth.Methods: We measured concentrations of two bisphenols, four parabens, benzophenone-3, and triclosan in 478 pregnant women in two weekly pools of 21 samples each, collected at 18 and 34 gestational weeks. We used adjusted linear regressions to study associations between phenol concentrations and growth outcomes assessed twice during pregnancy and at birth.Results: Benzophenone-3 was positively associated with all ultrasound growth parameters in at least one time point, in males but not females. In females, butylparaben was negatively associated with third-trimester abdominal circumference and weight at birth. We observed isolated associations for triclosan (negative) and for methylparaben and bisphenol S (positive) and late pregnancy fetal growth.Conclusions: Our results suggest associations between prenatal exposure to phenols and fetal growth. Benzophenone-3 was the exposure most consistently (positively) associated across all growth parameters. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

49. Neurodevelopment at two years and appropriate schooling at five years in children born very preterm.

Author

Gebus, Maya, Chevallier, Marie, Hatton, Laure‐Anne, Jacquez, Laure, Vilotitch, Antoine, Ego, Anne, Pin, Isabelle, and Debillon, Thierry

Abstract

Aim: This single‐centre French cohort study evaluated the relationship between standardised assessment at 2 years of corrected age and schooling level at 5 years of age in children born at ≤32 weeks' gestational age. Methods: This was a single‐centre retrospective study of children born preterm between 2010 and 2014 included in a follow‐up network. At 5 years of age, the population was divided into 2 groups: (1) 'appropriate schooling', defined as age‐appropriate schooling without support, and (2) 'schooling with support'. At 2 years of corrected age, the developmental quotient (DQ) was calculated using the revised Brunet–Lezine test. Neonatal variables and DQ categories were compared between the 2 groups on univariate and multivariate analyses. Results: DQ was available for 251 of the 270 children included (93%), with a median score of 93.0 (IQR [87.0–100.0]), and 171 children (68%) were in the schooling without support group. On multivariate analysis, DQ ≥100 (n = 67) was the only variable that significantly associated with schooling without support (OR = 13.9; 95% CI: 5.5–35.4) at 5 years of age. Conclusion: This result may be useful for clinicians in their routine practice and for information given to parents in neonatal follow‐up. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results