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5 results on '"Philip A, MacCarthy"'

1. Long‐term durability of self‐expanding and balloon‐expandable transcatheter aortic valve prostheses: UK TAVI registry

Author

Noman Ali, David Hildick‐Smith, Jessica Parker, Christopher J. Malkin, Michael S. Cunnington, Shuslim Gurung, Jonathan Mailey, Philip A. MacCarthy, Apurva Bharucha, Stephen J. Brecker, Stephen P. Hoole, Stephen Dorman, Sagar N. Doshi, Andrew Wiper, Mamta H. Buch, Adrian P. Banning, Mark S. Spence, and Daniel J. Blackman

Subjects
Radiology, Nuclear Medicine and imaging, General Medicine, Cardiology and Cardiovascular Medicine
Published
2023
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2. Prior Coronary Artery Bypass Graft Surgery and Outcome After Percutaneous Coronary Intervention: An Observational Study From the Pan‐London Percutaneous Coronary Intervention Registry

Author

Krishnaraj S. Rathod, Anne‐Marie Beirne, Richard Bogle, Sam Firoozi, Pitt Lim, Jonathan Hill, Miles C. Dalby, Ajay K. Jain, Iqbal S. Malik, Anthony Mathur, Sundeep Singh Kalra, Ranil DeSilva, Simon Redwood, Philip A. MacCarthy, Andrew Wragg, Elliot J. Smith, and Daniel A. Jones

Subjects
coronary artery bypass graft surgery, percutaneous coronary intervention, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Limited information exists regarding procedural success and clinical outcomes in patients with previous coronary artery bypass grafting (CABG) undergoing percutaneous coronary intervention (PCI). We sought to compare outcomes in patients undergoing PCI with or without CABG. Methods and Results This was an observational cohort study of 123 780 consecutive PCI procedures from the Pan‐London (UK) PCI registry from 2005 to 2015. The primary end point was all‐cause mortality at a median follow‐up of 3.0 years (interquartile range, 1.2–4.6 years). A total of 12 641(10.2%) patients had a history of previous CABG, of whom 29.3% (n=3703) underwent PCI to native vessels and 70.7% (n=8938) to bypass grafts. There were significant differences in the demographic, clinical, and procedural characteristics of these groups. The risk of mortality during follow‐up was significantly higher in patients with prior CABG (23.2%; P=0.0005) compared with patients with no prior CABG (12.1%) and was seen for patients who underwent either native vessel (20.1%) or bypass graft PCI (24.2%; P

Published
2020
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3. Outcome of 1051 Octogenarian Patients With ST‐Segment Elevation Myocardial Infarction Treated With Primary Percutaneous Coronary Intervention: Observational Cohort From the London Heart Attack Group

Author

Daniel I. Bromage, Daniel A. Jones, Krishnaraj S. Rathod, Claire Grout, M. Bilal Iqbal, Pitt Lim, Ajay Jain, Sundeep S. Kalra, Tom Crake, Zoe Astroulakis, Mick Ozkor, Roby D. Rakhit, Charles J. Knight, Miles C. Dalby, Iqbal S. Malik, Anthony Mathur, Simon Redwood, Philip A. MacCarthy, and Andrew Wragg

Subjects
acute myocardial infarction, aging, cardiovascular disease, complications, elderly, epidemiology, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundST‐segment elevation myocardial infarction is increasingly common in octogenarians, and optimal management in this cohort is uncertain. This study aimed to describe the outcomes of octogenarians with ST‐segment elevation myocardial infarction treated by primary percutaneous coronary intervention. Methods and ResultsWe analyzed 10 249 consecutive patients with ST‐segment elevation myocardial infarction treated with primary percutaneous coronary intervention between 2005 and 2011 at 8 tertiary cardiac centers across London, United Kingdom. The primary end point was all‐cause mortality at a median follow‐up of 3 years. In total, 1051 patients (10.3%) were octogenarians, with an average age of 84.2 years, and the proportion increased over the study period (P=0.04). In‐hospital mortality (7.7% vs 2.4%, P

Published
2016
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4. Oxidative stress and heart failure

Author

Philip A. MacCarthy and Ajay M. Shah

Subjects
Heart Failure, Oxidative Stress, Free Radicals, Humans, Syndrome, General Medicine, Reactive Oxygen Species, Cardiology and Cardiovascular Medicine, Antioxidants, United Kingdom, United States
Published
2003
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5. Nitric oxide enhances the inotropic response to β-adrenergic stimulation in the isolated guinea-pig heart

Author

J.F. Wilson, Bernard Prendergast, Philip A. MacCarthy, and Ajay M. Shah

Subjects
Nitroprusside, Agonist, Inotrope, Chronotropic, medicine.medical_specialty, Physiology, medicine.drug_class, Vasodilator Agents, Guinea Pigs, Stimulation, In Vitro Techniques, Substance P, Nitric Oxide, Nitric oxide, chemistry.chemical_compound, Heart Rate, Dobutamine, Physiology (medical), Internal medicine, Heart rate, medicine, Animals, Cardiac Output, Chemistry, Heart, Adrenergic beta-Agonists, Myocardial Contraction, Endocrinology, Sodium nitroprusside, Cardiology and Cardiovascular Medicine, medicine.drug
Abstract

Nitric oxide (NO) exerts several effects on myocardial contraction, including enhancement of relaxation and diastolic function, modulation of beta-adrenergic inotropic responses, and inotropic effects in the absence of agonist pre-stimulation. Different effects have been observed in different species and preparations, and it is unclear whether they are species- or preparation-specific, or whether they represent a range of responses that can manifest in most mammalian species. We therefore examined the effects of NO on the inotropic response to beta-adrenergic stimulation in the isolated guinea-pig heart, a species in which we have previously shown that NO enhances basal left ventricular (LV) relaxation and modulates the Frank-Starling response. Isolated ejecting hearts were perfused with Krebs buffer at constant placed heart rate (1 microM) indomethacin, 37 degrees C, constant loading conditions), and high fidelity LV pressure was monitored by an apical 2 F Millar catheter. All hearts were initially treated with dobutamine (0.1 microM) and then, once the peak inotropic and chronotropic response had been established, with either (a) no further treatment (n = 6), (b) the NO donor sodium nitroprusside (1 microM, n = 6; 10 microM, n = 6), or (c) the specific agonist for NO release, substance P (0.1 microM, n = 6). Dobutamine (0.1 microM) produced a rapid positive inotropic and chronotropic response, associated with a fall in LV end-diastolic pressure (LVEDP) and a rise in coronary flow. The positive inotropic effect of dobutamine declined over 20-28 minutes, while the chronotropic response persisted over this period. Low dose sodium nitroprusside (1 microM) delayed the decline in the inotropic response to dobutamine and exaggerated the fall in LVEDP. Similar effects were observed with substance P (0.1 microM). In contrast, a higher dose of sodium nitroprusside (10 microM) did not alter the response to dobutamine. These data indicate that "low dose" NO augments the inotropic response to beta-adrenergic stimulation in the isolated ejecting guinea-pig heart, in addition to its previously reported effects on basal LV relaxation in the same preparation.

Published
1998
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