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Insulin resistance (IR) develops in obese children because of low vitamin levels and increased pro-inflammatory cytokine levels. This study aimed to analyze the relation between vitamin D, insulin resistance, tumor necrosis factor-alpha and interleukin 6 (IL-6) levels at admission and after weight loss. This study included 84 obese and 28 healthy pubertal children. Patient group was divided into four: IR positive and negative; weight loss (WL) positive and negative. Baseline and follow-up (6th month) values of serum 25-hydroxyvitamin D and other parameters were evaluated. The prevalence of serum vitamin D deficiency and insufficiency were 3.6% and 21.4% in the control group, 15.2% and 10.9% and 7.9% and 15.8% in the obese insulin positive and negative group; respectively. There was no relationship between vitamin D and IRand IL-6 levels, whereas cytokine levels were lower in obese children. As WL increased, vitamin D level and IR improved. No significant difference was found between vitamin D levels of obese and control subjects. In obese children with weight loss, an insignificant increase was observed in vitamin D, cytokines, quantitative insulin sensitivity check index values and an insignificant decrease was noted in homeostatic model assessment for IR value. Further longitudinal studies with larger patient series with greater WL are warranted.

ABSTRACT Objective To determine whether first-voided urinary LH (FV-ULH) – level measurement can adequately assess pubertal suppression as much as standard tests can. Subjects and methods The study group included patients with central precocious puberty and rapidly progressing early puberty who received up to 3 – 4 doses of GnRHa therapy monthly and did not have adequate hormonal suppression after GnRH stimulation (90-minute LH level > 4 IU/L). Design: All of the participants underwent an LHRH test just after admission to the study. According to the stimulated peak LH levels, the patients were divided into 2 groups and followed until the end of the first year of treatment. The concordance between FV-ULH and stimulated LH levels was assessed. Results The FV-ULH levels in patients with inadequate hormonal suppression were significantly high compared to patients with adequate hormonal suppression. FV-ULH levels were very strongly correlated with stimulated LH levels (r = 0.91). Its correlation with basal LH levels was significant (r = 0.65). However, this positive correlation was modestly weakened after the first year of treatment. The cutoff value for FV-ULH of 1.01 mIU/mL had the highest sensitivity (92.3%) and specificity (100%). Conclusion FV-ULH levels, using more reliable and sensitive assay methods, can be used to monitor the adequacy of GnRHa therapy.

Objective:A close diabetes team-patient relationship is required for establishing satisfactory metabolic control. The purpose of this study was to investigate the effect of a telehealth system on diabetes control.Methods:The study was carried out between June 2015 and January 2016 at the Gazi University Faculty of Medicine, Pediatric Endocrinology Department. The telehealth system was developed by the diabetes team. The demographic characteristics, frequency of use and hemoglobin A1c (HbA1c) changes of type 1 diabetic (T1DM) patients using this communication network were analysed.Results:Eighty two patients [43 (52.4%) females, mean (±standard deviation) age 10.89±4 years] used the telehealth system. Fourteen (17.1%) of the cases were on pump therapy and 59 (72.0%) were counting carbohydrates. The individuals with diabetes or their families preferred WhatsApp communication. Whatsapp provided a means for instant messaging in most instances (57.3%), contact with diabetes education nurse (32.9%) and consultation with the diabetes team about insulin doses and blood glucose regulation (42.7%). HbA1c values after six months were significantly lower in patients/parents calling frequently (p

Abstract  Hungry bone syndrome (HBS), i.e., persistent hypocalcemia and hypophosphatemia as a result of extensive remineralization, is rarely encountered in children after parathyroid surgery. Herein, we report a 12-year-old girl who was diagnosed to have an ectopic parathyroid adenoma, and HBS was observed in the postsurgical follow-up. The diagnosis and the risk factors are discussed in the light of the literature. [ABSTRACT FROM AUTHOR]