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Improving the capabilities of online condition monitoring systems, able to detect arising of catastrophic wear on cutting tools, has been an important target to be pursued for the metal cutting industry. Currently, different systems have been proposed, moved by the rising need of part quality improvements and production cost control. Despite this, cutter wear development, being related to several process variables and conditions, is still really difficult to be predicted accurately. This paper presents a detection wear method based on the time-domain analysis of vibro-acoustic signals. Specifically, cutter wear monitoring, using sound signals of a milling process, was performed at a laboratory level in a well-isolated working room. Sound signals were recorded at fixed main machining parameters, i.e., cutting speed, feed rate and depth of cut. The tests were carried out starting with a new set of inserts with significant wear conditions for the investigated process configuration. Results showed a consistent overlapping between the beginning of the catastrophic wear and an evident increment in the trend of the root mean square of the monitored acoustic signal, showing the potential of the methodology in detecting a suitable time to stop the milling process and to change the worn-out cutters. [ABSTRACT FROM AUTHOR]

Brain injuries resulting from spinal cord injuries, strokes, or cerebral palsy are among the traumas most capable of compromising the motor activities of human limbs, hence the necessity for the development of exoskeletons dedicated to the rehabilitation of these organs. This review examines the landscape of actuators essential for the design of cutting-edge upper-limb rehabilitation exoskeletal structures. Beyond merely surveying the current types of actuators available, the paper aims to provide guidelines for selecting actuators that fit optimally with the objectives of upper-limb rehabilitation. The description starts with a brief discussion on the biomechanics of the upper limbs, focusing on the kinematics of pivotal joints (wrist, elbow, shoulder). Subsequently, the existing actuators are systematically reviewed, offering detailed insights into their primary features, operational principles, strengths, weaknesses, and noteworthy applications within the realm of rehabilitation robotics. After the discussion about the actuators, the paper advances by furnishing valuable guidelines for actuators' selection tailored for upper limb rehabilitation. These guidelines discuss crucial factors, such as the forces required and the natural Range Of Motions (ROMs) of upper limb joints. Finally, the manuscript serves as a valuable resource for researchers, engineers, and practitioners involved in the development of innovative upper-limb rehabilitation devices. [ABSTRACT FROM AUTHOR]

Major depressive disorder (MDD) increases the risk of type 2 diabetes (T2D) by 60% in untreated patients, and hypercortisolism is common in MDD as well as in some patients with T2D. Patients with MDD, despite hypercortisolism, show inappropriately normal levels of corticotropin-releasing hormone (CRH) and plasma adrenocorticotropin (ACTH) in the cerebrospinal fluid, which might implicate impaired negative feedback. Also, a positive feedback loop of the CRH–norepinephrine (NE)–CRH system may be involved in the hypercortisolism of MDD and T2D. Dysfunctional CRH receptor 1 (CRHR1) and CRH receptor 2 (CRHR2), both of which are involved in glucose regulation, may explain hypercortisolism in MDD and T2D, at least in a subgroup of patients. CRHR1 increases glucose-stimulated insulin secretion. Dysfunctional CRHR1 variants can cause hypercortisolism, leading to serotonin dysfunction and depression, which can contribute to hyperglycemia, insulin resistance, and increased visceral fat, all of which are characteristics of T2D. CRHR2 is implicated in glucose homeostasis through the regulation of insulin secretion and gastrointestinal functions, and it stimulates insulin sensitivity at the muscular level. A few studies show a correlation of the CRHR2 gene with depressive disorders. Based on our own research, we have found a linkage and association (i.e., linkage disequilibrium [LD]) of the genes CRHR1 and CRHR2 with MDD and T2D in families with T2D. The correlation of CRHR1 and CRHR2 with MDD appears stronger than that with T2D, and per our hypothesis, MDD may precede the onset of T2D. According to the findings of our analysis, CRHR1 and CRHR2 variants could modify the response to prolonged chronic stress and contribute to high levels of cortisol, increasing the risk of developing MDD, T2D, and the comorbidity MDD-T2D. We report here the potential links of the CRH system, NE, and their roles in MDD and T2D. [ABSTRACT FROM AUTHOR]

For the monitoring of large landslides, total stations equipped with an Electronic Distance Meter (EDM) are widely used. To obtain the atmospheric parameters, required along the line of sight of every measure, the data collected by a weather station close to the instrument are usually adopted. Even after these corrections, the results obtained in the monitoring of areas with complex topography don't reach the accuracies theoretically attainable by the high-end instruments. The article proposes a method for removing the errors due to the influence of microclimate on the measurements obtained by a high-end EDM, in order to get the maximum accuracy obtainable from such instruments. The method is based on an atmospheric model, set up by using the climatic data and a digital terrain model (DTM) of the landslide area. The methodology has been applied to a landslide in southern Italy. Over 38,000 distances, acquired for each monitored point, were used. The results demonstrate the effectiveness of the method: the standard deviations of the distances after their correction, show a reduction, ranging from 20% to 50%, with respect to the most diffused procedures; furthermore, the obtained accuracy equals the one declared by the manufacturer of the instrument for measurements in optimal conditions. [ABSTRACT FROM AUTHOR]

An integrated sensor for the measurement and monitoring of position and inclination, characterized by low cost, small size and low weight, has been designed, realized and calibrated at the Geomatics Lab of the University of Calabria. The design of the prototype, devoted to the monitoring of landslides and structures, was aiming at realizing a fully automated monitoring instrument, able to send the data acquired periodically or upon request by a control center through a bidirectional transmission protocol. The sensor can be released with different accuracy and range of measurement, by choosing bubble vials with different characteristics. The instrument is provided with a computer, which can be programmed so as to independently perform the processing of the data collected by a single sensor or a by a sensor network, and to transmit, consequently, alert signals if the thresholds determined by the monitoring center are exceeded. The bidirectional transmission also allows the users to vary the set of the monitoring parameters (time of acquisition, duration of satellite acquisitions, thresholds for the observed data). In the paper, hardware and software of the sensor are described, along with the calibration, the results of laboratory tests and of the first in field acquisitions. [ABSTRACT FROM AUTHOR]

All machining processes involve vibrations generated by structural sources such as a machine's moving parts or by the interaction between cutting tools and work-pieces. Relative vibrations between the work-pieces and the cutting tool are the most relevant from the point of view of the regenerative chatter phenomenon. In fact, these vibrations can lead to a chip yregeneration effect, which results in unwanted consequences, rapidly degenerating towards a very poor quality of surface finishing or, in case of severe chatter conditions, to machine-tool or work-piece damage. In the past decades, two different approaches for chatter avoidance were proposed by the scientific community, and they are commonly referred to as Out-of-Process (OuP) and in-Process (iP) solutions. The OuP solutions are off-line approaches, which allow to properly set the working parameters before machining starts. Ip solutions are on-line techniques, which allow to dynamically change the working parameters during machining by using single or multiple sensors. By monitoring the machining process, iP algorithms try to keep the machining process in stable working conditions while keeping high productivity levels. This study dealt with a novel iP chatter-detection strategy based on the Power Spectral Density (PSD) analysis and on the Wavelet Packet Decomposition (WPD) of different sensor signals. The preliminary results demonstrate the stability and feasibility of proposed indicators for chatter detection in industrial application. [ABSTRACT FROM AUTHOR]

Assessing passenger cars' dynamic performance is a critical aspect for car industries, due to its impact on the overall vehicle safety evaluation and the subjective nature of the involved handling and comfort metrics. Accordingly, ISO standards, such as ISO 4138 and ISO 3888, define several specific driving tests to assess vehicle dynamics performance objectively. Consequently, proper evaluation of the dynamic behaviour requires measuring several physical quantities, including accelerations, speed, and linear and angular displacements obtained after instrumenting a vehicle with multiple sensors. This experimental activity is highly demanding in terms of hardware costs, and it is also significantly time-consuming. Several approaches can be considered for reducing vehicle development time. In particular, simulation software can be exploited to predict the approximate behaviour of a vehicle using virtual scenarios. Moreover, motion platforms and detail-scalable numerical vehicle models are widely implemented for the purpose. This paper focuses on a customized simulation environment developed in C++, which exploits the advantages of object-oriented programming. The presented framework strives to perform concurrent simulations of vehicles with different characteristics such as mass, tyres, engine, suspension, and transmission systems. Within the proposed simulation framework, we adopted a hierarchical and modular representation. Vehicles are modelled by a 14 degree-of-freedom (DOF) full-vehicle model, capable of capturing the dynamics and complemented by a set of scalable-detail models for the remaining sub-systems such as tyre, engine, and steering system. Furthermore, this paper proposes the usage of autonomous virtual drivers for a more objective evaluation of vehicle dynamic performances. Moreover, to further evaluate our simulator architecture's efficiency and assess the achieved level of concurrency, we designed a benchmark able to analyse the scaling of the performances with respect to the number of different vehicles during the same simulation. Finally, the paper reports the proposed simulation environment's scalability resulting from a set of different and varying driving scenarios. [ABSTRACT FROM AUTHOR]