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Nicola Farina,1,2,* Giovanni Benanti,1,2,* Giacomo De Luca,1,2 Anna Palmisano,2,3 Giovanni Peretto,4 Sara Tomassetti,5 Veronica Giorgione,6 Ornella Forma,7 Antonio Esposito,2,3 Silvio Danese,2,8 Lorenzo Dagna,1,2 Marco Matucci-Cerinic,1,9 Corrado Campochiaro1,2 1Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Milan, Italy; 2School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; 3Unit of Clinical and Experimental Radiology, IRCCS San Raffaele Hospital, Milan, Italy; 4Unit of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Hospital, Milan, Italy; 5Department of Experimental and Clinical Medicine, Careggi University Hospital, Florence, Italy; 6Molecular and Clinical Sciences Research Institute, Fetal Medicine Unit, Department of Obstetrics and Gynaecology, St. George’s University Hospitals NHS Foundation Trust, London, UK; 7Vulnology Nursing Service, IRCCS San Raffaele Scientific Institute, Milan, Italy; 8Unit of Gastroenterology and Endoscopy, IRCCS San Raffaele Hospital, Milan, Italy; 9Department of Experimental and Clinical Medicine, University of Florence and Division of Rheumatology AOUC, Florence, Italy*These authors contributed equally to this workCorrespondence: Corrado Campochiaro, Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Via Olgettina 60, Milan, 20132, Italy, Tel +39 0226437060, Fax +39 0226433729, Email campochiaro.corrado@hsr.itAbstract: Systemic sclerosis (SSc) is a rare connective tissue disease characterised by immune dysfunction, vascular damage and fibrosis affecting the skin and multiple internal organs. The clinical spectrum of SSc is wide and its manifestations may lead to severe morbidity and mortality, in addition to a great impact on patients’ quality of life. Due to the multifaceted clinical manifestations of SSc, its management requires a combined expertise of different medical specialists to guarantee an adequate disease control and prevent organ complications. Multi-disciplinary teams (MDT), which are composed by physicians and other specialized health professionals, represent therefore a key element for the comprehensive management of SSc patients. Moreover, MTD can improve communication and patients’ empowerment while the presence of dedicated nurses can help patients to ask questions about their condition. The scope of this narrative review is to analyse the available evidences regarding the role of MDT in the management of SSc patients, and how this holistic approach may improve different disease domains and the overall prognosis. MDT regarding the cardiovascular and lung complication are the more represented in literature, given the great impact in prognosis. Nonetheless, MDT have been shown to be fundamental also in other disease domains as they can intercept early manifestations, thus stratifying patients based on the individual risks in order to personalize patients’ follow-up. MDTs may also minimize the treatment delay, enabling fast-track specialist referral. On the other hand, there are few trials specifically studying MDT in SSc and several authors have highlight the lack of standardization.Keywords: systemic sclerosis, scleroderma, multidisciplinary team, shared management

Cardiac laminopathies, associated with mutations in the LMNA gene, encompass a wide spectrum of clinical manifestations, involving electrical and mechanical alterations of cardiomyocytes. Thus, dilated cardiomyopathy, bradyarrhythmias and atrial or ventricular tachyarrhythmias may occur in a number of combined phenotypes. Nowadays, some attempt has been made to identify clinical predictors for the most life-threatening complications of LMNA-associated heart disease, i.e. sudden cardiac death and end-stage heart failure. The goal of this manuscript is to combine the most recent evidences in an updated review to show the state-of-the-art of such a complex disease group. This is supposed to be the starting point to collect more data and design new ad hoc studies to identify clinically useful predictors to stratify risk in mutation carriers, including probands and their asymptomatic relatives. [ABSTRACT FROM AUTHOR]

Cardiac laminopathies, associated with mutations in the LMNA gene, encompass a wide spectrum of clinical manifestations, involving electrical and mechanical alterations of cardiomyocytes. Thus, dilated cardiomyopathy, bradyarrhythmias and atrial or ventricular tachyarrhythmias may occur in a number of combined phenotypes. Nowadays, some attempt has been made to identify clinical predictors for the most life-threatening complications of LMNA-associated heart disease, i.e. sudden cardiac death and end-stage heart failure. The goal of this manuscript is to combine the most recent evidences in an updated review to show the state-of-the-art of such a complex disease group. This is supposed to be the starting point to collect more data and design new ad hoc studies to identify clinically useful predictors to stratify risk in mutation carriers, including probands and their asymptomatic relatives. [ABSTRACT FROM AUTHOR]

A 43-year-old man was admitted to our hospital for sustained ventricular tachycardia refractory to both electric and pharmacological cardioversion, while on prednisone (25 mg daily) plus mycophenolate mofetil therapy for misdiagnosed systemic lupus erythematosus. His past medical history was consistent with primary antiphospholipid syndrome (APS) with triple positivity for antiphospholipid antibody profile, for which he was on oral anticoagulant therapy with warfarin and hydroxychloroquine. Other reports have highlighted the presence and the clinical relevance of a specific APS cardiomyopathy in patients with normal coronary arteries and non-inflammatory microvascular disease demonstrated on EMB ([5], [6]). [Extracted from the article]

The article presents a case study of a 43-year-old woman suffering from acute lymphocytic virus-negative myocarditis with limited cutaneous systemic sclerosis. She was admitted to the emergency department of the hospital with lower limb oedema and fatigue. Cardiac magnetic resonance (CMR) revealed T2-hyperintensity and delayed gadolinium enhancement (DGE) areas, that indicated subacute myocarditis.

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Poster: Physics track: Radiobiological and predictive modelling, and radiomics PO-1572: Use of intravoxel incoherent motion (IVIM) MRI for predicting dysphagia in oropharyngeal carcinoma M. Maddalo, L. Altabella, L. Pegurri, A. Guerini, G. Peretto, A. Alghisi, O. Turla, A. Guaineri, G. Costantino, L. Spiazzi, L. Costa, C. Mozzetti, N. Pasinetti, M. Buglione. [Extracted from the article]

Poster: Clinical track: Haematology PO-0917: Radiotherapy-based approach for the treatment of solitary plasmacytoma A. Alghisi, P. Borghetti, M. Maddalo, A.M. Roccaro, A. Tucci, S.M. Magrini, A. Lo Casto, M.L. Bonù, D. Tomasini, A. Baiguini, G. Peretto, M. Buglione, L. Triggiani. [Extracted from the article]