168 results on '"Peat, Thomas S."'
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2. Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer
3. Enhancing PET Degrading Enzymes: A Combinatory Approach.
4. Enhancing the Imine Reductase Activity of a Promiscuous Glucose Dehydrogenase for Scalable Manufacturing of a Chiral Neprilysin Inhibitor Precursor.
5. Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins
6. Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices
7. Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity
8. HBO1 is required for the maintenance of leukaemia stem cells
9. Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects
10. Characterization of novel mevalonate kinases from the tardigrade Ramazzottius varieornatus and the psychrophilic archaeon Methanococcoides burtonii.
11. Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects
12. Cryo-EM structure of the active, G.sub.s-protein complexed, human CGRP receptor
13. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth
14. Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?
15. Crystal Structure of an Indole-3-Acetic Acid Amido Synthetase from Grapevine Involved in Auxin Homeostasis
16. An Efficient High-Throughput Screening Method for MYST Family Acetyltransferases, a New Class of Epigenetic Drug Targets
17. Interrogating HIV integrase for compounds that bind- a SAMPL challenge
18. Molecular characterization of cyanobacterial short‐chain prenyltransferases and discovery of a novel GGPP phosphatase.
19. Practical Aspects of the SAMPL Challenge: Providing an Extensive Experimental Data Set for the Modeling Community
20. The DINGO dataset: a comprehensive set of data for the SAMPL challenge
21. Over the rainbow: structural characterization of the chromoproteins gfasPurple, amilCP, spisPink and eforRed.
22. Cyanuric acid hydrolase: evolutionary innovation by structural concatenation
23. Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation
24. Haloalkane dehalogenases: structure of a Rhodococcus enzyme
25. Novel Escherichia coli umuD' mutants: structure-function insights into SOS mutagenesis
26. Structure of the UmuD' protein and its regulation in response to DNA damage
27. Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase
28. The X‐ray crystal structure of the N‐terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin‐remodelling protein.
29. Crystal structures of human ENPP1 in apo and bound forms.
30. Azidothymidine "Clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase–Telomerase Dual-Hybrid Inhibitors.
31. Chapter Four - Bacterial catabolism of s-triazine herbicides: biochemistry, evolution and application.
32. Structural Basis for the Allosteric Regulation of the SbtA Bicarbonate Transporter by the PII-like Protein, SbtB, from Cyanobium sp. PCC7001.
33. Fragment screening for a protein-protein interaction inhibitor to WDR5.
34. The evolving story of AtzT, a periplasmic binding protein.
35. Structures of the transcriptional regulator BgaR, a lactose sensor.
36. A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP.
37. Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor.
38. Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841.
39. 8‐Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.
40. Structural characterization of a novel monotreme‐specific protein with antimicrobial activity from the milk of the platypus.
41. Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction.
42. Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay Between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis.
43. Identification of a New Zinc Binding Chemotype by Fragment Screening.
44. T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein.
45. High-Resolution X-Ray Structures of Two Functionally Distinct Members of the Cyclic Amide Hydrolase Family of Toblerone Fold Enzymes.
46. The nanoscience behind the art of in-meso crystallization of membrane proteins.
47. Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC.
48. X-ray crystal structure of a malonate-semialdehyde dehydrogenase from Pseudomonas sp. strain AAC.
49. CASP11 statistics and the prediction center evaluation system.
50. A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC.
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