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Abstract Background Several recent studies have demonstrated that naïve raters tend to evaluate individuals with Borderline Personality Disorder (BPD) negatively at zero-acquaintance (i.e., in a ‘first impression’ type situation, where the rater has no knowledge of the individual and no prior interactions with them). Specifically, individuals with BPD were evaluated as less trustworthy, likeable, and cooperative than healthy participants (HCs). Based on previous impression formation studies, we hypothesized that the non-verbal cues positive affect display, negative affect display, and eye contact contribute to negative first impressions of those with BPD. Methods To address this question, we recruited 101 participants that rated the degree of positive affect display, negative affect display, and eye contact in 52 videos of age-and gender-matched BPD and HC participants. We hypothesized that low positive affect display, high negative affect display, and eye contact would mediate the association between group (BPD vs. HC) and ratings of trustworthiness, likeability, and cooperativeness. Results Ratings for positive affect display were significantly lower and those for negative affect display significantly higher for BPD versus HC targets, whereas eye contact did not differ significantly between groups. In multiple mediation models, positive affect display significantly mediated the association between group and trustworthiness/likeability, whereas negative affect display only mediated the association between group and likeability. None of the individual cues was a significant mediator of the association between group and cooperation. Conclusions We emphasize therapeutic possibilities to improve positive affect display –and thus overall first impressions– to increase the chances of forming social bonds for BPD individuals.

Most decision-making models describing individual differences in heuristics and biases tasks build on the assumption that reasoners produce a first incorrect answer in a quick, automatic way which they may or may not override later and that the advantage of high capacity reasoners arises from this late correction mechanism. To investigate this assumption, we developed a mouse-tracking analysis technique to capture individuals’ first answers and subsequent thinking dynamics. Across two denominator neglect task experiments, we observed that individuals initially move the mouse cursor towards the correct answer option in a substantial number of cases suggesting that reasoners may not always produce an incorrect answer first. Furthermore, we observed that, compared to low capacity reasoners, high capacity individuals revise their first answer more frequently if it is incorrect and make fewer changes if it is correct. However, we did not find evidence that high capacity individuals produce correct initial answers more frequently. Consistent with the predictions of previous decision-making models, these results suggest that in the denominator neglect task the capacity-normativity relationship arises after the initial response is formulated. The present work demonstrates how the analysis of mouse trajectories can be utilized to investigate individual differences in decision-making and help us better apprehend the dynamics of thinking behind decision biases.

Judgments and decisions can rely on rules to integrate cue information or on the retrieval of similar exemplars from memory. Research on exemplar-based processes in judgment has discovered several task variables influencing the dominant mode of processing. This research often aggregates data across participants or classifies them as using either exemplar-based or cue-based processing. It has been argued for theoretical and empirical reasons that both kinds of processes might operate together or in parallel. Hence, a classification of strategies may be a severe oversimplification that also sacrifices statistical power to detect task effects. We present a simple measurement tool combining both processing modes. The simple model contains a mixture parameter quantifying the relative contribution of both kinds of processes in a judgment and decision task. In three experiments, we validate the measurement model by demonstrating that instructions and task variables affect the mixture parameter in predictable ways, both in memory-based and screen-based judgments.

Judgments and decisions can rely on rules to integrate cue information or on the retrieval of similar exemplars from memory. Research on exemplar-based processes in judgment has discovered several task variables influencing the dominant mode of processing. This research often aggregates data across participants or classifies them as using either exemplar-based or cue-based processing. It has been argued for theoretical and empirical reasons that both kinds of processes might operate together or in parallel. Hence, a classification of strategies may be a severe oversimplification that also sacrifices statistical power to detect task effects. We present a simple measurement tool combining both processing modes. The simple model contains a mixture parameter quantifying the relative contribution of both kinds of processes in a judgment and decision task. In three experiments, we validate the measurement model by demonstrating that instructions and task variables affect the mixture parameter in predictable ways, both in memory-based and screen-based judgments.

Myrseth and Wollbrant (2015) offer an alternative theoretical explanation for our finding that defection entails more cognitive conflict than cooperation (Kieslich & Hilbig, 2014). Although we completely agree that different theoretical explanations for a result are possible, we maintain that the theoretical approach we tested (Rand et al., 2014) is parsimonious and falsifiable, excluding certain plausible results a priori. By comparison, the alternative framework proposed by Myrseth and Wollbrant requires several debatable assumptions to account for our findings, rendering it the more complex theory. Besides, their framework as a whole could have accounted for any possible finding in our experiment, making it impossible to falsify it with our data. We thus conclude that the notion by Rand et al.—that there is a spontaneous disposition to cooperate—has more empirical content while requiring fewer assumptions.

Myrseth and Wollbrant (2015) offer an alternative theoretical explanation for our finding that defection entails more cognitive conflict than cooperation (Kieslich and Hilbig, 2014). Although we completely agree that different theoretical explanations for a result are possible, we maintain that the theoretical approach we tested (Rand et al., 2014) is parsimonious and falsifiable, excluding certain plausible results a priori. By comparison, the alternative framework proposed by Myrseth and Wollbrant requires several debatable assumptions to account for our findings, rendering it the more complex theory. Besides, their framework as a whole could have accounted for any possible finding in our experiment, making it impossible to falsify it with our data. We thus conclude that the notion by Rand et al.---that there is a spontaneous disposition to cooperate---has more empirical content while requiring fewer assumptions.

Recently, it has been suggested that people are spontaneously inclined to cooperate in social dilemmas, whereas defection requires effortful deliberation. From this assumption, we derive that defection should entail more cognitive conflict than cooperation. To test this hypothesis, the current study presents a first application of the response dynamics paradigm (i.e., mouse-tracking) to social dilemmas. In a fully incentivized lab experiment, mouse movements were tracked while participants played simple two-person social dilemma games with two options (cooperation and defection). Building on previous research, curvature of mouse movements was taken as an indicator of cognitive conflict. In line with the hypothesis of less cognitive conflict in cooperation, response trajectories were more curved (towards the non-chosen option) when individuals defected than when they cooperated. In other words, the cooperative option exerted more “pull” on mouse movements in case of defection than the non-cooperative option (defection) did in case of cooperation. This effect was robust across different types of social dilemmas and occurred even in the prisoner’s dilemma, where defection was predominant on the choice level. Additionally, the effect was stronger for dispositional cooperators as measured by the Honesty-Humility factor of the HEXACO personality model. As such, variation in the effect across individuals could be accounted for through cooperativeness.

Recently, it has been suggested that people are spontaneously inclined to cooperate in social dilemmas, whereas defection requires effortful deliberation. From this assumption, we derive that defection should entail more cognitive conflict than cooperation. To test this hypothesis, the current study presents a first application of the response dynamics paradigm (i.e., mouse-tracking) to social dilemmas. In a fully incentivized lab experiment, mouse movements were tracked while participants played simple two-person social dilemma games with two options (cooperation and defection). Building on previous research, curvature of mouse movements was taken as an indicator of cognitive conflict. In line with the hypothesis of less cognitive conflict in cooperation, response trajectories were more curved (towards the non-chosen option) when individuals defected than when they cooperated. In other words, the cooperative option exerted more ``pull'' on mouse movements in case of defection than the non-cooperative option (defection) did in case of cooperation. This effect was robust across different types of social dilemmas and occurred even in the prisoner's dilemma, where defection was predominant on the choice level. Additionally, the effect was stronger for dispositional cooperators as measured by the Honesty-Humility factor of the HEXACO personality model. As such, variation in the effect across individuals could be accounted for through cooperativeness.

Individuals with Borderline Personality Disorder (BPD) or Social Anxiety Disorder (SAD) suffer from substantial interpersonal dysfunction and have difficulties establishing social bonds. A tendency to form negative first impressions of others could contribute to this by way of reducing approach behavior. We tested whether women with BPD or SAD would show negative impression formation compared to healthy women (HCs). We employed the Thin Slices paradigm and showed videos of 52 authentic target participants to 32 women with BPD, 29 women with SAD, and 37 HCs. We asked participants to evaluate whether different positive or negative adjectives described targets and expected BPD raters to provide the most negative ratings, followed by SAD and HC. BPD and SAD raters both agreed with negative adjectives more often than HCs (e.g., 'Yes, the person is greedy'), and BPD raters rejected positive adjectives more often (e.g., 'No, the person is not humble.'). However, BPD and SAD raters did not differ significantly from each other. Additionally, we used the novel process tracing method mouse-tracking to assess the cognitive conflict (via trajectory deviations) raters experienced during decision-making. We hypothesized that HCs would experience more conflict when making unfavorable (versus favorable) evaluations and that this pattern would flip in BPD and SAD. We quantified cognitive conflict via maximum absolute deviations (MADs) of the mouse-trajectories. As hypothesized, HCs showed more conflict when rejecting versus agreeing with positive adjectives. The pattern did not flip in BPD and SAD but was substantially reduced, such that BPD and SAD showed similar levels of conflict when rejecting and agreeing with positive adjectives. Contrary to the hypothesis for BPD and SAD, all three groups experienced substantial conflict when agreeing with negative adjectives. We discuss therapeutic implications of the combined choice and mouse-tracking results.

To correlate histopathologic findings from biopsy specimens with their corresponding location within enhancing areas, non-enhancing areas and necrotic areas on contrast enhanced T1-weighted MRI scans (cT1).In 37 patients with newly diagnosed glioblastoma who underwent stereotactic biopsy, we obtained a correlation of 561 1mm3 biopsy specimens with their corresponding position on the intraoperative cT1 image at 1.5 Tesla. Biopsy points were categorized as enhancing (CE), non-enhancing (NE) or necrotic (NEC) on cT1 and tissue samples were categorized as "viable tumor cells", "blood" or "necrotic tissue (with or without cellular component)". Cell counting was done semi-automatically.NE had the highest content of tissue categorized as viable tumor cells (89% vs. 60% in CE and 30% NEC, respectively). Besides, the average cell density for NE (3764 ± 2893 cells/mm2) was comparable to CE (3506 ± 3116 cells/mm2), while NEC had a lower cell density with 2713 ± 3239 cells/mm2. If necrotic parts and bleeds were excluded, cell density in biopsies categorized as "viable tumor tissue" decreased from the center of the tumor (NEC, 5804 ± 3480 cells/mm2) to CE (4495 ± 3209 cells/mm2) and NE (4130 ± 2817 cells/mm2).The appearance of a glioblastoma on a cT1 image (circular enhancement, central necrosis, peritumoral edema) does not correspond to its diffuse histopathological composition. Cell density is elevated in both CE and NE parts. Hence, our study suggests that NE contains considerable amounts of infiltrative tumor with a high cellularity which might be considered in resection planning.

BACKGROUND:Many studies have assessed emotion recognition in patients with Borderline Personality Disorder and considerable evidence has been accumulated on patients' ability to categorize emotions. In contrast, their ability to detect emotions has been investigated sparsely. The only two studies that assessed emotion detection abilities found contradictory evidence on patients' ability to detect angry faces. METHODS:To clarify whether patients with Borderline Personality Disorder show enhanced detection of angry faces, we conducted three experiments: a laboratory study (n = 53) with a clinical sample and two highly powered web studies that measured Borderline features (n1 = 342, n2 = 220). Participants in all studies completed a visual search paradigm, and the reaction times for the detection of angry vs. happy faces were measured. RESULTS:Consistently, data spoke against enhanced detection of angry faces in the Borderline groups, indicated by non-significant group (Borderline vs. healthy control) × target (angry vs. happy) interactions, despite highly satisfactory statistical power to detect even small effects. CONCLUSIONS:In contrast to emotion categorization, emotion detection appears to be intact in patients with Borderline Personality Disorder and individuals high in Borderline features. The importance of distinguishing between these two processes in future studies is discussed.

Several studies have analyzed a correlation between the apparent diffusion coefficient (ADC) derived from diffusion-weighted MRI and the tumor cellularity of corresponding histopathological specimens in brain tumors with inconclusive findings. Here, we compared a large dataset of ADC and cellularity values of stereotactic biopsies of glioblastoma patients using a new postprocessing approach including trajectory analysis and automatic nuclei counting.Thirty-seven patients with newly diagnosed glioblastomas were enrolled in this study. ADC maps were acquired preoperatively at 3T and coregistered to the intraoperative MRI that contained the coordinates of the biopsy trajectory. 561 biopsy specimens were obtained; corresponding cellularity was calculated by semi-automatic nuclei counting and correlated to the respective preoperative ADC values along the stereotactic biopsy trajectory which included areas of T1-contrast-enhancement and necrosis.There was a weak to moderate inverse correlation between ADC and cellularity in glioblastomas that varied depending on the approach towards statistical analysis: for mean values per patient, Spearman's ρ = -0.48 (p = 0.002), for all trajectory values in one joint analysis Spearman's ρ = -0.32 (p < 0.001). The inverse correlation was additionally verified by a linear mixed model.Our data confirms a previously reported inverse correlation between ADC and tumor cellularity. However, the correlation in the current article is weaker than the pooled correlation of comparable previous studies. Hence, besides cell density, other factors, such as necrosis and edema might influence ADC values in glioblastomas.

Due to its sensitivity to deoxyhemoglobin, susceptibility weighted imaging (SWI) enables the visualization of deep medullary veins (DMV) in patients with acute stroke, which are difficult to depict under physiological circumstances. This study assesses the asymmetric appearance of prominent DMV as an independent predictor for stroke severity and outcome.SWI of 86 patients with acute middle cerebral artery (MCA) stroke were included. A scoring system from 0 (no visible DMV) to 3 (very prominent DMV) was applied for both hemispheres separately. A difference of scores between ipsi- and contralateral side was defined as asymmetric (AMV+). Occurrence of AMV+ was correlated with the National Institute of Health Stroke Scale (NIHSS) Score on admission and discharge, as well as the modified Rankin Scale (mRS) at discharge. Ordinal regression analysis was used to evaluate NIHSS and mRS as predictors of stroke severity, clinical course of disease and outcome.55 patients displayed AMV+ while 31 did not show an asymmetry (AMV-). Median NIHSS on admission was 17 (11-21) in the AMV+ group and 9 (5-15) in the AMV- group (p = 0.001). On discharge median NIHSS was 11 (5-20) for AMV+ and 5 (2-14) for AMV- (p = 0.005). The median mRS at discharge was 4 (3-5) in the AMV+ group and 3 (1-4) in AMV- (p = 0.001). Odds ratio was 3.19 (95% CI: 1.24-8.21) for AMV+ to achieve a higher mRS than AMV- (p = 0.016).The asymmetric appearance of DMV on SWI is a fast and easily evaluable parameter for the prediction of stroke severity and can be used as an additional imaging parameter in patients with acute MCA stroke.