196 results on '"Pang, Zengchang"'
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2. The metabolic signature of blood lipids: a causal inference study using twins
- Author
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Wang, Yutong, Liu, Shunkai, Cao, Weihua, Lv, Jun, Yu, Canqing, Huang, Tao, Sun, Dianjianyi, Liao, Chunxiao, Pang, Yuanjie, Pang, Zengchang, Yu, Min, Wang, Hua, Wu, Xianping, Liu, Yu, Gao, Wenjing, and Li, Liming
- Published
- 2024
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3. One-size-fits-all versus risk-category-based screening interval strategies for cardiovascular disease prevention in Chinese adults: a prospective cohort study
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Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Barnard, Maxim, Bennett, Derrick, Belbasis, Lazaros, Boxall, Ruth, Chan, Ka Hung, Chen, Yiping, Clarke, Charlotte, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fry, Hannah, Gilbert, Simon, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Lam, Hubert, Lin, Kuang, Liu, James, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozarickij, Alfred, Rahmati, Maryanm, Ryder, Paul, Said, Saredo, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Wang, Baihan, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Xia, Qingmei, Liu, Chao, Pei, Pei, Sun, Dianjianyi, Yu, Canqing, Pan, Lang, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Duan, Haiping, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Sun, Wei, Yan, Shichun, Cui, Xiaoming, Wang, Chi, Wu, Zhenyuan, Li, Yanjie, Kang, Quan, Luo, Huiming, Ou, Tingting, Zheng, Xiangyang, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Fang Liu, Jian Su., Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Lin, Mei, Lu, Zhenzhen, Zhou, Lifang, Xie, Changping, Lan, Jian, Zhu, Tingping, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Chang, Xiaoyu, Yuan, Mingqiang, Wu, Xia, Jiang, Wei, Liu, Jiaqiu, Sun, Qiang, Chen, Faqing, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Kang, Kai, Feng, Shixian, Tian, Huizi, Fan, Lei, Li, XiaoLin, Sun, Huarong, He, Pan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Zhang, Xiaoyi, Cao, Yuan, Xie, Kaixu, Chen, Lingli, Shen, Dun, Li, Xiaojun, Jin, Donghui, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Xin, Zhang, Hao, Chen, Jianwei, Peng, Yuan, Zhang, Libo, Qu, Chan, Sun, Zhijia, Ma, Yu, and Pang, Yuanjie
- Published
- 2024
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4. Association between health insurance cost-sharing and choice of hospital tier for cardiovascular diseases in China: a prospective cohort study
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Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Li, Liming, Wang, Chen, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Barnard, Maxim, Bennett, Derrick, Boxall, Ruth, Chan, Kahung, Chen, Yiping, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fry, Hannah, Gilbert, Simon, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Lam, Hubert, Lin, Kuang, Liu, James, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozaricki, Alfred, Ryder, Paul, Said, Saredo, Schmidt, Dan, Stevens, Becky, Turnbull, Iain, Wang, Baihan, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Xia, Qingmei, Liu, Chao, Pei, Pei, Sun, Dianjianyi, Yu, Canqing, Chen, Naying, Liu, Duo, Tang, Zhenzhu, Chen, Ningyu, Jiang, Qilian, Lan, Jian, Li, Mingqiang, Liu, Yun, Meng, Fanwen, Meng, Jinhuai, Pan, Rong, Qin, Yulu, Wang, Ping, Wang, Sisi, Wei, Liuping, Zhou, Liyuan, Dong, Caixia, Ge, Pengfei, Ren, Xiaolan, Li, Zhongxiao, Mao, Enke, Wang, Tao, Zhang, Hui, Zhang, Xi, Chen, Jinyan, Hu, Ximin, Wang, Xiaohuan, Guo, Zhendong, Li, Huimei, Li, Yilei, Weng, Min, Wu, Shukuan, Yan, Shichun, Zou, Mingyuan, Zhou, Xue, Guo, Ziyan, Kang, Quan, Li, Yanjie, Yu, Bo, Xu, Qinai, Chang, Liang, Fan, Lei, Feng, Shixian, Zhang, Ding, Zhou, Gang, Gao, Yulian, He, Tianyou, He, Pan, Hu, Chen, Sun, Huarong, Zhang, Xukui, Chen, Biyun, Fu, Zhongxi, Huang, Yuelong, Liu, Huilin, Xu, Qiaohua, Yin, Li, Long, Huajun, Xu, Xin, Zhang, Hao, Zhang, Libo, Su, Jian, Tao, Ran, Wu, Ming, Yang, Jie, Zhou, Jinyi, Zhou, Yonglin, Hu, Yihe, Hua, Yujie, Jin, Jianrong, Liu, Fang, Liu, Jingchao, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Jun, Cheng, Liang, Du, Ranran, Gao, Ruqin, Li, Feifei, Li, Shanpeng, Liu, Yongmei, Ning, Feng, Pang, Zengchang, Sun, Xiaohui, Tian, Xiaocao, Wang, Shaojie, Zhai, Yaoming, Zhang, Hua, Hou, Wei, Lv, Silu, Wang, Junzheng, Chen, Xiaofang, Wu, Xianping, Zhang, Ningmei, Chang, Xiaoyu, Li, Jianguo, Liu, Jiaqiu, Luo, Guojin, Sun, Qiang, Zhong, Xunfu, Gong, Weiwei, Hu, Ruying, Wang, Hao, Wang, Meng, Yu, Min, Chen, Lingli, Gu, Qijun, Pan, Dongxia, Wang, Chunmei, Xie, Kaixu, Zhang, Xiaoyi, Chen, Hongyuan, Liu, Liyang, Gou, Haiyan, Wang, Xun, Ding, Jing, Zhang, Ning, Mao, Yueshi, Zhou, Shanshan, Jin, Lirong, Cheng, Xin, Lu, Yun, Chen, Li, Hao, Zilong, Xing, Xiaona, Wang, Lei, Ju, Naixin, Mao, Yiting, Li, Shuya, Du, Peng, Wang, Deren, Sun, Xiaojia, You, Shihao, Wang, Weizhi, Zhu, Yanmei, Li, Xiaojiu, Dong, Yi, Levy, Muriel, Buckell, John, Wu, Nina, Yip, Winnie, and Mihaylova, Borislava
- Published
- 2024
- Full Text
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5. Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults
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Phelps, Nowell H, Singleton, Rosie K, Zhou, Bin, Heap, Rachel A, Mishra, Anu, Bennett, James E, Paciorek, Christopher J, Lhoste, Victor PF, Carrillo-Larco, Rodrigo M, Stevens, Gretchen A, Rodriguez-Martinez, Andrea, Bixby, Honor, Bentham, James, Di Cesare, Mariachiara, Danaei, Goodarz, Rayner, Archie W, Barradas-Pires, Ana, Cowan, Melanie J, Savin, Stefan, Riley, Leanne M, Aguilar-Salinas, Carlos A, Baker, Jennifer L, Barkat, Amina, Bhutta, Zulfiqar A, Branca, Francesco, Caixeta, Roberta B, Cuschieri, Sarah, Farzadfar, Farshad, Ganapathy, Shubash, Ikeda, Nayu, Iotova, Violeta, Kengne, Andre P, Khang, Young-Ho, Laxmaiah, Avula, Lin, Hsien-Ho, Ma, Jun, Mbanya, Jean Claude N, Miranda, J Jaime, Pradeepa, Rajendra, Rodríguez-Artalejo, Fernando, Sorić, Maroje, Turley, Maria, Wang, Limin, Webster-Kerr, Karen, Aarestrup, Julie, Abarca-Gómez, Leandra, Abbasi-Kangevari, Mohsen, Abdeen, Ziad A, Abdrakhmanova, Shynar, Abdul Ghaffar, Suhaila, Abdul Rahim, Hanan F, Abdurrahmonova, Zulfiya, Abu-Rmeileh, Niveen M, Abubakar Garba, Jamila, Acosta-Cazares, Benjamin, Adam, Ishag, Adamczyk, Marzena, Adams, Robert J, Adu-Afarwuah, Seth, Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agbor, Valirie N, Agdeppa, Imelda A, Aghazadeh-Attari, Javad, Ågren, Åsa, Aguenaou, Hassan, Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmadi, Nastaran, Ahmed, Imran, Ahmed, Soheir H, Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M, Al-Hinai, Halima, Al-Lahou, Badreya, Al-Lawati, Jawad A, Al-Raddadi, Rajaa, Al Asfoor, Deena, Al Hourani, Huda M, Al Qaoud, Nawal M, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Aldwairji, Maryam A, Alexius, Sylvia, Ali, Mohamed M, Alieva, Anna V, Alkandari, Abdullah, Alkerwi, Ala'a, Alkhatib, Buthaina M, Allin, Kristine, Alomary, Shaker A, Alomirah, Husam F, Alshangiti, Arwa M, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N, Amiano Etxezarreta, Pilar, Amoah, John, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A, Androutsos, Odysseas, Ängquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Anufrieva, Elena, Aounallah-Skhiri, Hajer, Araújo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E, Arlappa, Nimmathota, Aryal, Krishna K, Assefa, Nega, Aspelund, Thor, Assah, Felix K, Assembekov, Batyrbek, Assunção, Maria Cecília F, Aung, May Soe, Aurélio de Valois, Correia Júnior Marco, Auvinen, Juha, Avdičová, Mária, Avi, Shina, Azad, Kishwar, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Babu, Bontha V, Bacopoulou, Flora, Bæksgaard Jørgensen, Maja, Baharudin, Azli, Bahijri, Suhad, Bajramovic, Izet, Bakacs, Marta, Balakrishna, Nagalla, Balanova, Yulia, Bamoshmoosh, Mohamed, Banach, Maciej, Banegas, José R, Baran, Joanna, Baran, Rafał, Barbagallo, Carlo M, Barbosa Filho, Valter, Barceló, Alberto, Baretić, Maja, Barnoya, Joaquin, Barrera, Lena, Barreto, Marta, Barros, Aluisio JD, Barros, Mauro Virgílio Gomes, Bartosiewicz, Anna, Basit, Abdul, Bastos, Joao Luiz, Bata, Iqbal, Batieha, Anwar M, Batista, Aline P, Batista, Rosangela L, Battakova, Zhamilya, Baur, Louise A, Bayauli, Pascal M, Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedek, Theodora, Benedics, Judith, Benet, Mikhail, Benitez Rolandi, Gilda Estela, Benzeval, Michaela, Bere, Elling, Berger, Nicolas, Bergh, Ingunn Holden, Berhane, Yemane, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Berrios Carrasola, Ximena, Bettiol, Heloísa, Beutel, Manfred E, Beybey, Augustin F, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K, Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Biasch, Katia, Bika Lele, Elysée Claude, Bikbov, Mukharram M, Bista, Bihungum, Bjelica, Dusko J, Bjerregaard, Anne A, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B, Björkelund, Cecilia, Bloch, Katia V, Blokstra, Anneke, Blychfeld Magnazu, Moran, Bo, Simona, Bobak, Martin, Boddy, Lynne M, Boehm, Bernhard O, Boer, Jolanda MA, Boggia, Jose G, Bogova, Elena, Boissonnet, Carlos P, Bojesen, Stig E, Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Botomba, Steve, Bourne, Rupert RA, Bovet, Pascal, Boymatova, Khadichamo, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn CE, Braithwaite, Tasanee, Brajkovich, Imperia, Breckenkamp, Juergen, Breda, João, Brenner, Hermann, Brewster, Lizzy M, Brian, Garry R, Briceño, Yajaira, Brinduse, Lacramioara, Bringolf-Isler, Bettina, Brito, Miguel, Brophy, Sinead, Brug, Johannes, Bruno, Graziella, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de León, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, José, Can, Günay, Cândido, Ana Paula c, Cañete, Felicia, Capanzana, Mario V, Čapková, Naděžda, Capuano, Eduardo, Capuano, Rocco, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C, Carlsson, Axel C, Carmuega, Esteban, Carvalho, Joana, Casajús, José A, Casanueva, Felipe F, Casas, Maribel, Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A, Chamnan, Parinya, Chamukuttan, Snehalatha, Chan, Angelique, Chan, Queenie, Charchar, Fadi J, Charles, Marie-Aline, Chaturvedi, Himanshu K, Chaturvedi, Nish, Che Abdul Rahim, Norsyamlina, Chee, Miao Li, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Long-Sheng, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheng, Yiling J, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chinapaw, Mai JM, Chinnock, Anne, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Chirlaque, María-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G, Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Cirillo, Massimo, Claessens, Frank, Clare, Philip, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Cojocaru, Cosmin R, Colorado-Yohar, Sandra, Compañ-Gabucio, Laura-María, Concin, Hans, Confortin, Susana C, Cooper, Cyrus, Coppinger, Tara C, Corpeleijn, Eva, Cortés, Lilia Yadira, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L, Crampin, Amelia C, Cross, Amanda J, Crujeiras, Ana B, Cruz, Juan J, Csányi, Tamás, Csilla, Semánová, Cucu, Alexandra M, Cui, Liufu, Cureau, Felipe V, Czenczek-Lewandowska, Ewelina, D'Arrigo, Graziella, d'Orsi, Eleonora, da Silva, Alanna G, Dacica, Liliana, Dahm, Christina C, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T, Dankner, Rachel, Dantoft, Thomas M, Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, de Assis Guedes de Vasconcelos, Francisco, de Assis, Maria Alice Altenburg, De Backer, Guy, De Bacquer, Dirk, De Bacquer, Jaco, de Bont, Jeroen, De Curtis, Amalia, de Fragas Hinnig, Patrícia, de Gaetano, Giovanni, De Henauw, Stefaan, De Miguel-Etayo, Pilar, De Neve, Jan-Walter, Duarte de Oliveira, Paula, De Ridder, David, De Ridder, Karin, de Rooij, Susanne R, de Sá, Ana Carolina MGN, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D, DeGennaro, Vincent Jr, Delisle, Hélène, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Dereń, Katarzyna, Deschamps, Valérie, Devrishov, Ruslan D, Dhimal, Meghnath, Di Castelnuovo, Augusto, Dias-da-Costa, Juvenal Soares, Díaz-Sánchez, María Elena, Diaz, Alejandro, Díaz Fernández, Pedro, Díez Ripollés, María Pilar, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha TP, Dobson, Annette J, Dominguez, Liria, Donati, Maria Benedetta, Donfrancesco, Chiara, Dong, Guanghui, Dong, Yanhui, Donoso, Silvana P, Döring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Dörr, Marcus, Doua, Kouamelan, Dragano, Nico, Drygas, Wojciech, Du, Shufa, Duan, Jia Li, Duante, Charmaine A, Duboz, Priscilla, Duleva, Vesselka L, Dulskiene, Virginija, Dumith, Samuel C, Dushpanova, Anar, Dwyer, Terence, Dyussupova, Azhar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Ebrahimi, Narges, Echeverría, Guadalupe, Eddie, Ricky, Eftekhar, Ebrahim, Efthymiou, Vasiliki, Egbagbe, Eruke E, Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ammari, Laila, El Ati, Jalila, Eldemire-Shearer, Denise, Elliott, Paul, Enang, Ofem, Endevelt, Ronit, Engle-Stone, Reina, Erasmus, Rajiv T, Erem, Cihangir, Ergor, Gul, Eriksen, Louise, Eriksson, Johan G, Escobedo-de la Peña, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Evans, Roger G, Faeh, David, Fagherazzi, Guy, Fakhradiyev, Ildar, Fakhretdinova, Albina A, Fall, Caroline H, Faramarzi, Elnaz, Farjam, Mojtaba, Farrugia Sant'Angelo, Victoria, Farzi, Yosef, Fattahi, Mohammad Reza, Fawwad, Asher, Fawzi, Wafaie W, Felix-Redondo, Francisco J, Ferguson, Trevor S, Fernandes, Romulo A, Fernández-Bergés, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Gerson, Ferrari, Marika, Ferrario, Marco M, Ferreccio, Catterina, Ferreira, Haroldo S, Ferrer, Eldridge, Ferrieres, Jean, Figueiró, Thamara Hubler, Fijalkowska, Anna, Fink, Günther, Fisberg, Mauro, Fischer, Krista, Foo, Leng Huat, Forsner, Maria, Fottrell, Edward F, Fouad, Heba M, Francis, Damian K, Franco, Maria do Carmo, Fras, Zlatko, Fraser, Brooklyn, Frontera, Guillermo, Fuchs, Flavio D, Fuchs, Sandra C, Fujiati, Isti I, Fujita, Yuki, Fumihiko, Matsuda, Furdela, Viktoriya, Furusawa, Takuro, Gabriela, Stefan Adela, Gaciong, Zbigniew, Gafencu, Mihai, Galán Cuesta, Manuel, Galbarczyk, Andrzej, Galcheva, Sonya V, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Gao, Pei, Garcia-de-la-Hera, Manoli, García Mérida, María José, García Solano, Marta, Gareta, Dickman, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gaya, Adroaldo Cesar Araujo, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M, George, Ronnie, Gerdts, Eva, Ghaderi, Ebrahim, Ghamari, Seyyed-Hadi, Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Gialluisi, Alessandro, Giampaoli, Simona, Gianfagna, Francesco, Gieger, Christian, Gill, Tiffany K, Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Glushkova, Natalya, Godara, Ramesh, Godos, Justyna, Gogen, Sibel, Goldberg, Marcel, Goltzman, David, Gómez, Georgina, Gómez Gómez, Jesús Humberto, Gomez, Luis F, Gómez, Santiago F, Gomula, Aleksandra, Gonçalves Cordeiro da Silva, Bruna, Gonçalves, Helen, Gonçalves, Mauer, González-Alvarez, Ana D, Gonzalez-Chica, David A, González-Gil, Esther M, Gonzalez-Gross, Marcela, González-Leon, Margot, González-Rivas, Juan P, González-Villalpando, Clicerio, González-Villalpando, María-Elena, Gonzalez, Angel R, Gottrand, Frederic, Graça, Antonio Pedro, Grafnetter, Dušan, Grajda, Aneta, Grammatikopoulou, Maria G, Gregg, Edward W, Gregor, Ronald D, Gregório, Maria João, Grøholt, Else Karin, Grøntved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Guajardo, Viviana, Gualdi-Russo, Emanuela, Guallar-Castillón, Pilar, Gualtieri, Andrea, Gudmundsson, Elias F, Gudnason, Vilmundur, Guerchet, Maëlenn, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L, Gujral, Unjali P, Gulliford, Martin C, Gunnlaugsdottir, Johanna, Gunter, Marc J, Guo, Xiu-Hua, Guo, Yin, Gupta, Prakash C, Gupta, Rajeev, Gureje, Oye, Gurinović, Mirjana A, Gutiérrez González, Enrique, Gutierrez, Laura, Gutzwiller, Felix, Gwee, Xinyi, Ha, Seongjun, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A, Haghshenas, Rosa, Hakimi, Hamid, Halkjær, Jytte, Hambleton, Ian R, Hamzeh, Behrooz, Hanekom, Willem A, Hange, Dominique, Hanif, Abu AM, Hantunen, Sari, Hao, Jie, Hardman, Carla Menêses, Hardy, Louise, Hari Kumar, Rachakulla, Harmer Lassen, Tina, Harooni, Javad, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, Hayes, Alison J, He, Jiang, He, Yuan, He, Yuna, Heidinger-Felső, Regina, Heier, Margit, Heinen, Mirjam, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Hernandez Cadena, Leticia, Herrala, Sauli, Herrera-Cuenca, Marianella, Herrera, Victor M, Herter-Aeberli, Isabelle, Herzig, Karl-Heinz, Heshmat, Ramin, Heude, Barbara, Hill, Allan G, Ho, Sai Yin, Ho, Suzanne C, Hobbs, Michael, Höfelmann, Doroteia A, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hoogendijk, Emiel, Hopman, Wilma M, Horimoto, Andrea RVR, Hormiga, Claudia M, Horta, Bernardo L, Houti, Leila, Howitt, Christina, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Huerta, José María, Huhtaniemi, Ilpo Tapani, Huiart, Laetitia, Huidumac Petrescu, Constanta, Husseini, Abdullatif, Huu, Chinh Nguyen, Huybrechts, Inge, Hwalla, Nahla, Hyska, Jolanda, Iacoviello, Licia, Iakupova, Ellina M, Ibarluzea, Jesús, Ibrahim, Mohsen M, Ibrahim Wong, Norazizah, Igland, Jannicke, Ijoma, Chinwuba, Ikram, M Arfan, Iñiguez, Carmen, Irazola, Vilma E, Ishida, Takafumi, Isiguzo, Godsent C, Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Islek, Duygu, Ittermann, Till, Ivanova-Pandourska, Ivaila Y, Iwasaki, Masanori, Jääskeläinen, Tuija, Jackson, Rod T, Jacobs, Jeremy M, Jadoul, Michel, Jafar, Tazeen, Jallow, Bakary, James, Kenneth, Jamil, Kazi M, Jamrozik, Konrad, Jan, Nataša, Jansson, Anna, Janszky, Imre, Janus, Edward, Jarani, Juel, Jarnig, Gerald, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelaković, Ana, Jelaković, Bojan, Jennings, Garry, Jiang, Chao Qiang, Jimenez, Ramon O, Jöckel, Karl-Heinz, Joffres, Michel, Jokelainen, Jari J, Jonas, Jost B, Jonnagaddala, Jitendra, Jøran Kjerpeseth, Lars, Jørgensen, Torben, Joshi, Pradeep, Joshi, Rohina, Josipović, Josipa, Joukar, Farahnaz, Jóźwiak, Jacek J, Judge, Debra S, Juolevi, Anne, Jurak, Gregor, Jurca Simina, Iulia, Juresa, Vesna, Kaaks, Rudolf, Kaducu, Felix O, Kadvan, Agnes L, Kafatos, Anthony, Kaj, Mónika, Kajantie, Eero O, Kakutia, Natia, Kállayová, Daniela, Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kameli, Yves, Kanala, Kodanda R, Kannan, Srinivasan, Kapantais, Efthymios, Karaglani, Eva, Karakosta, Argyro, Kårhus, Line L, Karki, Khem B, Karlsson, Omat, Kassi Anicet, Adoubi, Katchunga, Philippe B, Katibeh, 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Maciej, Topbas, Murat, Topór-Mądry, Roman, Torheim, Liv Elin, Tornaritis, Michael J, Torrent, Maties, Torres-Collado, Laura, Toselli, Stefania, Touloumi, Giota, Traissac, Pierre, Tran, Thi Tuyet-Hanh, Tremblay, Mark S, Triantafyllou, Areti, Trichopoulos, Dimitrios, Trichopoulou, Antonia, Trinh, Oanh TH, Trivedi, Atul, Tshepo, Lechaba, Tsigga, Maria, Tsintavis, Panagiotis, Tsugane, Shoichiro, Tuitele, John, Tuliakova, Azaliia M, Tulloch-Reid, Marshall K, Tullu, Fikru, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Twig, Gilad, Tynelius, Per, Tzala, Evangelia, Tzotzas, Themistoklis, Tzourio, Christophe, Udoji, Nwannedimma, Ueda, Peter, Ugel, Eunice, Ukoli, Flora AM, Ulmer, Hanno, Unal, Belgin, Usupova, Zhamyila, Uusitalo, Hannu MT, Uysal, Nalan, Vaitkeviciute, Justina, Valdivia, Gonzalo, Vale, Susana, Valvi, Damaskini, van Dam, Rob M, van den Born, Bert-Jan, Van der Heyden, Johan, van der Schouw, Yvonne T, Van Herck, Koen, Van Lippevelde, Wendy, Van Minh, Hoang, Van Schoor, Natasja M, van Valkengoed, Irene GM, Vanderschueren, Dirk, Vanuzzo, Diego, Varbo, Anette, Varela-Moreiras, Gregorio, Vargas, Luz Nayibe, Varona-Pérez, Patricia, Vasan, Senthil K, Vasques, Daniel G, Vatasescu, Radu, Vega, Tomas, Veidebaum, Toomas, Velasquez-Melendez, Gustavo, Velika, Biruta, Verloigne, Maïté, Veronesi, Giovanni, Verschuren, WM Monique, Victora, Cesar G, Viegi, Giovanni, Viet, Lucie, Vik, Frøydis N, Vilar, Monica, Villalpando, Salvador, Vioque, Jesus, Viriyautsahakul, Napaphan, Virtanen, Jyrki K, Visser, Marjolein, Visvikis-Siest, Sophie, Viswanathan, Bharathi, Vladulescu, Mihaela, Vlasoff, Tiina, Vocanec, Dorja, Vollenweider, Peter, Völzke, Henry, Vourli, Georgia, Voutilainen, Ari, Vrijheid, Martine, Vrijkotte, Tanja GM, Vuletić, Silvije, Wade, Alisha N, Waldhör, Thomas, Walton, Janette, Wambiya, Elvis OA, Wan Bebakar, Wan Mohamad, Wan Mohamud, Wan Nazaimoon, Wanderley Júnior, Rildo de Souza, Wang, Chongjian, Wang, Huijun, Wang, Ming-Dong, Wang, Ningli, Wang, Qian, Wang, Xiangjun, Wang, Ya Xing, Wang, Ying-Wei, Wannamethee, S Goya, Wareham, Nicholas, Wartha, Olivia, Weber, Adelheid, Wedderkopp, Niels, Weghuber, Daniel, Wei, Wenbin, Weres, Aneta, Werner, Bo, Westbury, Leo D, Whincup, Peter H, Wichstrøm, Lars, Wickramasinghe, Kremlin, Widhalm, Kurt, Widyahening, Indah S, Więcek, Andrzej, Wild, Philipp S, Wilks, Rainford J, Willeit, Johann, Willeit, Peter, Williams, Julianne, Wilsgaard, Tom, Wirth, James P, Wojtyniak, Bogdan, Woldeyohannes, Meseret, Wolf, Kathrin, Wong-McClure, Roy A, Wong, Andrew, Wong, Emily B, Wong, Jyh Eiin, Wong, Tien Yin, Woo, Jean, Woodward, Mark, Wu, Frederick C, Wu, Hon-Yen, Wu, Jianfeng, Wu, Li Juan, Wu, Shouling, Wyszyńska, Justyna, Xu, Haiquan, Xu, Liang, Yaacob, Nor Azwany, Yamborisut, Uruwan, Yan, Li, Yan, Weili, Yang, Ling, Yang, Xiaoguang, Yang, Yang, Yardim, Nazan, Yasuharu, Tabara, Yépez García, Martha, Yiallouros, Panayiotis K, Yngve, Agneta, Yoosefi, Moein, Yoshihara, Akihiro, Yotov, Yoto, You, Qi Sheng, You, San-Lin, Younger-Coleman, Novie O, Yu, Yu-Ling, Yu, Yunjiang, Yusof, Safiah Md, Yusoff, Ahmad Faudzi, Zaccagni, Luciana, Zafiropulos, Vassilis, Zainuddin, Ahmad A, Zakavi, Seyed Rasoul, Zamani, Farhad, Zambon, Sabina, Zampelas, Antonis, Zamrazilová, Hana, Zapata, Maria Elisa, Zargar, Abdul Hamid, Zaw, Ko Ko, Zayed, Ayman A, Zdrojewski, Tomasz, Żegleń, Magdalena, Zejglicova, Kristyna, Zeljkovic Vrkic, Tajana, Zeng, Yi, Zentai, Andrea, Zhang, Bing, Zhang, Luxia, Zhang, Zhen-Yu, Zhao, Dong, Zhao, Ming-Hui, Zhao, Wenhua, Zhecheva, Yanitsa V, Zhen, Shiqi, Zheng, Wei, Zheng, Yingfeng, Zholdin, Bekbolat, Zhou, Maigeng, Zhu, Dan, Zimmet, Paul, Zins, Marie, Zitt, Emanuel, Zocalo, Yanina, Zoghlami, Nada, Zuñiga Cisneros, Julio, Zuziak, Monika, and Ezzati, Majid
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- 2024
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6. Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population
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Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walter, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Burgess, Sue, Chan, Ka Hung, Chang, Yumei, Chen, Yiping, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fairhurst-Hunter, Zammy, Fry, Hannah, Hill, Mike, Holmes, Michael, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Kerosi, Rene, Lin, Kuang, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozarickij, Alfred, Ryder, Paul, Said, Saredo, Schmidt, Dan, Sherliker, Paul, Stevens, Becky, Turnbull, Iain, Walters, Robin, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Yu, Canqing, Xia, Qingmei, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Duan, Haiping, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Sun, Wei, Yan, Shichun, Cui, Xiaoming, Wang, Chi, Wu, Zhenyuan, Li, Yanjie, Kang, Quan, Luo, Huiming, Ou, Tingting, Zheng, Xiangyang, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Lin, Mei, Lu, Zhenzhen, Zhou, Lifang, Xie, Changping, Lan, Jian, Zhu, Tingping, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Chang, Xiaoyu, Yuan, Mingqiang, Wu, Xia, Jiang, Wei, Liu, Jiaqiu, Sun, Qiang, Chen, Faqing, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, zhang, Xi, Kang, Kai, Feng, Shixian, Tian, Huizi, Fan, Lei, Li, XiaoLin, Sun, Huarong, He, Pan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Zhang, Xiaoyi, Cao, Yuan, Xie, Kaixu, Chen, Lingli, Shen, Dun, Li, Xiaojun, Jin, Donghui, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Xin, Zhang, Hao, Chen, Jianwei, Peng, Yuan, Zhang, Libo, Qu, Chan, Zhu, Yunqing, Zhuang, Zhenhuang, Sun, Dianjianyi, Millwood, Iona Y., and Walters, Robin G.
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- 2024
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7. Association of seafood consumption with cardiovascular disease among adults in Qingdao, China
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Yan, Hongxuan, Sun, Xiaohui, Wu, Yili, Ge, Bing, Wang, Weijing, Liu, Xiao, Pan, Chi, Ning, Feng, Pang, Zengchang, and Zhang, Dongfeng
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- 2024
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8. A wide landscape of morbidity and mortality risk associated with marital status in 0.5 million Chinese men and women: a prospective cohort study
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Chen, Junshi, Chen (PI, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li (PI, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Burgess, Sue, Chan, Ka Hung, Chang, Yumei, Chen, Yiping, Chen, Zhengming, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fairhurst-Hunter, Zammy, Fry, Hannah, Hill, Mike, Holmes, Michael, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Kerosi, Rene, Lin, Kuang, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozarickij, Alfred, Ryder, Paul, Said, Saredo, Schmidt, Dan, Sherliker, Paul, Stevens, Becky, Turnbull, Iain, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Yu, Canqing, Xia, Qingmei, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Duan, Haiping, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Sun, Wei, Yan, Shichun, Cui, Xiaoming, Wang, Chi, Wu, Zhenyuan, Li, Yanjie, Kang, Quan, Luo, Huiming, Ou, Tingting, Zheng, Xiangyang, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Lin, Mei, Lu, Zhenzhen, Zhou, Lifang, Xie, Changping, Lan, Jian, Zhu, Tingping, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Chang, Xiaoyu, Yuan, Mingqiang, Wu, Xia, Jiang, Wei, Liu, Jiaqiu, Sun, Qiang, Chen, Faqing, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, zhang, Xi, Kang, Kai, Feng, Shixian, Tian, Huizi, Fan, Lei, Li, XiaoLin, Sun, Huarong, He, Pan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Zhang, Xiaoyi, Cao, Yuan, Xie, Kaixu, Chen, Lingli, Shen, Dun, Li, Xiaojun, Jin, Donghui, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Xin, Zhang, Hao, Chen, Jianwei, Peng, Yuan, Zhang, Libo, Qu, Chan, Xiao, Meng, Li, Aolin, Wang, Yueqing, Pang, Yuanjie, Li, Liming, and Sun, Dianjianyi
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- 2024
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9. Long-Term Exposure to Fine Particulate Matter and Incidence of Esophageal Cancer: A Prospective Study of 0.5 Million Chinese Adults
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Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Peto, Richard, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Burgess, Sue, Chan, Ka Hung, Chang, Yumei, Chen, Yiping, Clarke, Johnathan, Du, Huaidong, Mohamed, Ahmed Edris, Fairhurst-Hunter, Zammy, Fry, Hannah, Gilbert, Simon, Hacker, Alex, Hill, Mike, Holmes, Michael, Im, Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Kerosi, Rene, Lin, Kuang, Mazidi, Mohsen, Millwood, Iona, Morris, Sam, Nie, Qunhua, Pozarickij, Alfred, Ryder, Paul, Said, Saredo, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Han, Xiao, Hou, Can, Lv, Jun, Pei, Pei, Liu, Chao, Yu, Canqing, Xia, Qingmei, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Duan, Haiping, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Sun, Wei, Yan, Shichun, Cui, Xiaoming, Wang, Chi, Wu, Zhenyuan, Li, Yanjie, Kang, Quan, Luo, Huiming, Ou, Tingting, Zheng, Xiangyang, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Lin, Mei, Lu, Zhenzhen, Zhou, Lifang, Xie, Changping, Lan, Jian, Zhu, Tingping, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Chang, Xiaoyu, Yuan, Mingqiang, Wu, Xia, Jiang, Wei, Liu, Jiaqiu, Sun, Qiang, Chen, Faqing, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Kang, Kai, Feng, Shixian, Tian, Huizi, Fan, Lei, Li, XiaoLin, Sun, Huarong, He, Pan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Zhang, Xiaoyi, Cao, Yuan, Xie, Kaixu, Chen, Lingli, Shen, Dun, Li, Xiaojun, Jin, Donghui, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Xin, Zhang, Hao, Chen, Jianwei, Peng, Yuan, Zhang, Libo, Qu, Chan, Sun, Dong, Liu, Cong, Zhu, Yunqing, Sun, Dianjianyi, Pang, Yuanjie, Meng, Xia, Liu, Yang, and Kan, Haidong
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- 2023
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10. Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study
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Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Burgess, Sushila, Chan, Peter Ka Hung, Chen, Yiping, Chen, Zhengming, Clarke, Johnathan, Clarke, Robert, Du, Huaidong, Mohamed, Ahmed Edris, Fry, Hannah, Gilbert, Simon, Hill, Mike, Im, Becky Pek Kei, Iona, Andri, Kakkoura, Maria, Kartsonaki, Christiana, Lam, Hubert, Lin, Kuang, Mazidi, Mohsen, Millwood, Iona Y, Morris, Sam, Nie, Qunhua, Pozarickij, Alfred, Ryder, Paul, Said, Saredo, Schmidt, Dan, Sherliker, Paul, Stevens, Rebecca, Turnbull, Iain, Walters, Robin, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Guo, Yu, Han, Xiao, Hou, Can, Xia, Qingmei, Liu, Chao, Lv, Jun, Pei, Pei, Yu, Canqing, Chen, Junshi, Collins, Rory, Li, Liming, Wang, Chen, Peto, Richard, Chen, Naying, Liu, Duo, Tang, Zhenzhu, Chen, Ningyu, Jiang, Qilian, Lan, Jian, Li, Mingqiang, Liu, Yun, Meng, Fanwen, Meng, Jinhuai, Pan, Rong, Qin, Yulu, Wang, Ping, Wang, Sisi, Wei, Liuping, Zhou, Liyuan, Dong, Caixia, Ge, Pengfei, Ren, Xiaolan, Li, Zhongxiao, Mao, Enke, Wang, Tao, Zhang, Hui, Zhang, Xi, Chen, Jinyan, Hu, Ximin, Wang, Xiaohuan, Guo, Zhendong, Li, Huimei, Li, Yilei, Weng, Min, Wu, Shukuan, Yan, Shichun, Zou, Mingyuan, Zhou, Xue, Guo, Ziyan, Kang, Quan, Li, Yanjie, Yu, Bo, Xu, Qinai, Chang, Liang, Fan, Lei, Feng, Shixian, Zhang, Ding, Zhou, Gang, Gao, Yulian, He, Tianyou, He, Pan, Hu, Chen, Sun, Huarong, Zhang, Xukui, Chen, Biyun, Fu, Zhongxi, Huang, Yuelong, Liu, Huilin, Xu, Qiaohua, Yin, Li, Long, Huajun, Xu, Xin, Zhang, Hao, Zhang, Libo, Su, Jian, Tao, Ran, Wu, Ming, Yang, Jie, Zhou, Jinyi, Zhou, Yonglin, Hu, Yihe, Hua, Yujie, Jin, Jianrong, Liu, Fang, Liu, Jingchao, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Jun, Cheng, Liang, Du, Ranran, Gao, Ruqin, Li, Feifei, Li, Shanpeng, Liu, Yongmei, Ning, Feng, Pang, Zengchang, Sun, Xiaohui, Tian, Xiaocao, Wang, Shaojie, Zhai, Yaoming, Zhang, Hua, Hou, Wei, Lv, Silu, Wang, Junzheng, Chen, Xiaofang, Wu, Xianping, Zhang, Ningmei, Zhou, Weiwei, Li, Jianguo, Liu, Jiaqiu, Luo, Guojin, Sun, Qiang, Zhong, Xunfu, Gong, Weiwei, Hu, Ruying, Wang, Hao, Wang, Meng, Yu, Min, Chen, Lingli, Gu, Qijun, Pan, Dongxia, Wang, Chunmei, Xie, Kaixu, Zhang, Xiaoyi, Chan, Ka Hung, and Xiao, Dan
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- 2022
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11. Association between dairy consumption and ischemic heart disease among Chinese adults: a prospective study in Qingdao
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Song, Jiahui, Pan, Chi, Li, Feifei, Guo, Yu, Pei, Pei, Tian, Xiaocao, Wang, Shaojie, Gao, Ruqin, Pang, Zengchang, Chen, Zhengming, and Li, Liming
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- 2022
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12. Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts
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Silventoinen, Karri, Piirtola, Maarit, Jelenkovic, Aline, Sund, Reijo, Tarnoki, Adam D., Tarnoki, David L., Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Honda, Chika, Inui, Fujio, Tomizawa, Rie, Watanabe, Mikio, Sakai, Norio, Gatz, Margaret, Butler, David A., Lee, Jooyeon, Lee, Soo Ji, Sung, Joohon, Franz, Carol E., Kremen, William S., Lyons, Michael J., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Tynelius, Per, Rasmussen, Finn, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Brandt, Ingunn, Nilsen, Thomas S., Harris, Jennifer R., Tyler, Jessica, Hopper, John L., Magnusson, Patrik K. E., Pedersen, Nancy L., Dahl Aslan, Anna K., Ordoñana, Juan R., Sánchez-Romera, Juan F., Colodro-Conde, Lucia, Rebato, Esther, Zhang, Dongfeng, Pang, Zengchang, Tan, Qihua, Silberg, Judy L., Maes, Hermine H., Boomsma, Dorret I., Sørensen, Thorkild I. A., Korhonen, Tellervo, and Kaprio, Jaakko
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- 2022
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13. Temporal associations between leukocytes DNA methylation and blood lipids: a longitudinal study
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Wu, Zhiyu, Chen, Lu, Hong, Xuanming, Si, Jiahui, Cao, Weihua, Yu, Canqing, Huang, Tao, Sun, Dianjianyi, Liao, Chunxiao, Pang, Yuanjie, Pang, Zengchang, Cong, Liming, Wang, Hua, Wu, Xianping, Liu, Yu, Guo, Yu, Chen, Zhengming, Lv, Jun, Gao, Wenjing, and Li, Liming
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- 2022
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14. Overweight and risk of type 2 diabetes: A prospective Chinese twin study
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Xi, Yu'e, Gao, Wenjing, Zheng, Ke, Lv, Jun, Yu, Canqing, Wang, Shengfeng, Huang, Tao, Sun, Dianjianyi, Liao, Chunxiao, Pang, Yuanjie, Pang, Zengchang, Yu, Min, Wang, Hua, Wu, Xianping, Dong, Zhong, Wu, Fan, Jiang, Guohong, Wang, Xiaojie, Liu, Yu, Deng, Jian, Lu, Lin, Cao, Weihua, and Li, Liming
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- 2022
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15. Educational attainment of same-sex and opposite-sex dizygotic twins: An individual-level pooled study of 19 twin cohorts
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Silventoinen, Karri, Bogl, Leonie H., Jelenkovic, Aline, Vuoksimaa, Eero, Latvala, Antti, Li, Weilong, Tan, Qihua, Zhang, Dongfeng, Pang, Zengchang, Ordoñana, Juan R., Sánchez-Romera, Juan F., Colodro-Conde, Lucia, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E.M., Rebato, Esther, Corley, Robin P., Huibregtse, Brooke M., Hopper, John L., Tyler, Jessica, Duncan, Glen E., Buchwald, Dedra, Silberg, Judy L., Maes, Hermine H., Kandler, Christian, Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Nelson, Tracy L., Whitfield, Keith E., Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Heikkilä, Kauko, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J.F., Magnusson, Patrik K.E., Pedersen, Nancy L., Dahl Aslan, Anna K., Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Siribaddana, Sisira H., Rose, Richard J., Sørensen, Thorkild I.A., Boomsma, Dorret I., and Kaprio, Jaakko
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- 2021
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16. Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study.
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Miao, Ke, Hong, Xuanming, Cao, Weihua, Lv, Jun, Yu, Canqing, Huang, Tao, Sun, Dianjianyi, Liao, Chunxiao, Pang, Yuanjie, Hu, Runhua, Pang, Zengchang, Yu, Min, Wang, Hua, Wu, Xianping, Liu, Yu, Gao, Wenjing, and Li, Liming
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TYPE 2 diabetes ,TWIN studies ,EPIGENETICS ,HYPERGLYCEMIA ,BLOOD sugar ,LONGITUDINAL method ,GLYCOSYLATED hemoglobin - Abstract
Epigenetic clocks based on DNA methylation have been known as biomarkers of aging, including principal component (PC) clocks representing the degree of aging and DunedinPACE representing the pace of aging. Prior studies have shown the associations between epigenetic aging and T2DM, but the results vary by epigenetic age metrics and people. This study explored the associations between epigenetic age metrics and T2DM or glycemic traits, based on 1070 twins (535 twin pairs) from the Chinese National Twin Registry. It also explored the temporal relationships of epigenetic age metrics and glycemic traits in 314 twins (157 twin pairs) who participated in baseline and follow‐up visits after a mean of 4.6 years. DNA methylation data were used to calculate epigenetic age metrics, including PCGrimAge acceleration (PCGrimAA), PCPhenoAge acceleration (PCPhenoAA), DunedinPACE, and the longitudinal change rate of PCGrimAge/PCPhenoAge. Mixed‐effects and cross‐lagged modelling assessed the cross‐sectional and temporal relationships between epigenetic age metrics and T2DM or glycemic traits, respectively. In the cross‐sectional analysis, positive associations were identified between DunedinPACE and glycemic traits, as well as between PCPhenoAA and fasting plasma glucose, which may be not confounded by shared genetic factors. Cross‐lagged models revealed that glycemic traits (fasting plasma glucose, HbA1c, and TyG index) preceded DunedinPACE increases, and TyG index preceded PCGrimAA increases. Glycemic traits are positively associated with epigenetic age metrics, especially DunedinPACE. Glycemic traits preceded the increases in DunedinPACE and PCGrimAA. Lowering the levels of glycemic traits may reduce DunedinPACE and PCGrimAA, thereby mitigating age‐related comorbidities. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Mortality and recurrent vascular events after first incident stroke: a 9-year community-based study of 0·5 million Chinese adults
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Chen, Yiping, Wright, Neil, Guo, Yu, Turnbull, Iain, Kartsonaki, Christiana, Yang, Ling, Bian, Zheng, Pei, Pei, Pan, Dongxia, Zhang, Yidan, Qin, Haiqiang, Wang, Yilong, Lv, Jun, Liu, Ming, Hao, Zilong, Wang, Yongjun, Yu, Canqing, Peto, Richard, Collins, Rory, Li, Liming, Clarke, Robert, Chen, Zhengming, Chen, Junshi, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Bragg, Fiona, Chang, Yumei, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Kerosi, Rene, Lancaster, Garry, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sohoni, Rajani, Wang, Jenny, Wang, Lin, Yang, Xiaoming, Han, Xiao, Hou, Can, Jing, Biao, Liu, Chao, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, and Qiu, Zhe
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- 2020
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18. Cooking fuels and risk of all-cause and cardiopulmonary mortality in urban China: a prospective cohort study
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Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Boxall, Ruth, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Hill, Mike, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Kurmi, Om, Lancaster, Garry, Lewington, Sarah, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Bian, Zheng, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Tan, Yunlong, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Yu, Kuai, Qiu, Gaokun, Wang, Chaolong, Pan, An, Liang, Liming, Hu, Frank B, and Wu, Tangchun
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- 2020
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19. Cigarette Smoking and Secondhand Smoke Exposure Before and After a Tobacco-Free Olympic Policy Period : Qingdao, China
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Zhao, Jing, Li, Xiaojing, Stewart, Susan LeRoy, Gao, Weiguo, Qi, Fei, Zhang, Lei, Pang, Zengchang, Qiao, Qing, Ning, Feng, and Tong, Elisa
- Published
- 2019
20. Adiposity and risk of ischaemic and haemorrhagic stroke in 0·5 million Chinese men and women: a prospective cohort study
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Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Bragg, Fiona, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kurmi, Om, Lewington, Sarah, Lancaster, Garry, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Bian, Zheng, Chen, Ge, Han, Xiao, Hou, Can, Pei, Pei, Qu, Shuzhen, Tan, Yunlong, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Lv, Silu, Wang, Junzheng, Hou, Wei, Yin, Jiyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Mu, Huaiyi, Xu, Qinai, Dou, Meiling, Ren, Jiaojiao, Wang, Shanqing, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Zheng, Xiangyang, Li, Yilei, Li, Huimei, Wang, Yanjun, Wu, Ming, Zhou, Jinyi, Tao, Ran, Yang, Jie, Ni, Chuanming, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Zhang, Weiyuan, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Guan, Hairong, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Tang, Xuefeng, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Lv, Qiannan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixue, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Huang, Yuelong, Chen, Biyun, Yin, Li, Jin, Donghui, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Xiong, Youping, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Parish, Sarah, Holmes, Michael V, Lacey, Ben, Liu, Fang, Zhang, Zengzhi, and Walters, Robin G
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- 2018
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21. Age-specific association between blood pressure and vascular and non-vascular chronic diseases in 0·5 million adults in China: a prospective cohort study
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Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Bragg, Fiona, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kurmi, Om, Lewington, Sarah, Lancaster, Garry, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Bian, Zheng, Chen, Ge, Han, Xiao, Hou, Can, Pei, Pei, Qu, Shuzhen, Tan, Yunlong, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Lv, Silu, Wang, Junzheng, Hou, Wei, Yin, Jiyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Mu, Huaiyi, Xu, Qinai, Dou, Meiling, Ren, Jiaojiao, Wang, Shanqing, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Zheng, Xiangyang, Li, Yilei, Li, Huimei, Wang, Yanjun, Wu, Ming, Zhou, Jinyi, Tao, Ran, Yang, Jie, Ni, Chuanming, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Zhang, Weiyuan, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Guan, Hairong, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Tang, Xuefeng, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Lv, Qiannan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixue, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Huang, Yuelong, Chen, Biyun, Yin, Li, Jin, Donghui, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Xiong, Youping, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Lacey, Ben, Kong, Xiang Ling, and Walters, Robin G
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- 2018
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22. Smoking and smoking cessation in relation to risk of diabetes in Chinese men and women: a 9-year prospective study of 0·5 million people
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Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Bragg, Fiona, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Kartsonaki, Christiana, Kerosi, Rene, Lancaster, Garry, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Bian, Zheng, Chen, Ge, Han, Xiao, Hou, Can, Pei, Pei, Qu, Shuzhen, Tan, Yunlong, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Lv, Silu, Wang, Junzheng, Hou, Wei, Yin, Jiyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Mu, Huaiyi, Xu, Qinai, Dou, Meiling, Ren, Jiaojiao, Wang, Shanqing, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Zheng, Xiangyang, Li, Yilei, Li, Huimei, Wang, Yanjun, Wu, Ming, Zhou, Jinyi, Tao, Ran, Yang, Jie, Ni, Chuanming, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Zhang, Weiyuan, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Guan, Hairong, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Tang, Xuefeng, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Lv, Qiannan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixue, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Huang, Yuelong, Chen, Biyun, Yin, Li, Jin, Donghui, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Xiong, Youping, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Liu, Xin, and Wang, Kang
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- 2018
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23. Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education
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Jelenkovic, Aline, Sund, Reijo, Yokoyama, Yoshie, Latvala, Antti, Sugawara, Masumi, Tanaka, Mami, Matsumoto, Satoko, Freitas, Duarte L., Maia, José Antonio, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Saudino, Kimberly J., Cutler, Tessa L., Hopper, John L., Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrik K. E., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Nelson, Tracy L., Whitfield, Keith E., Sung, Joohon, Kim, Jina, Lee, Jooyeon, Lee, Sooji, Llewellyn, Clare H., Fisher, Abigail, Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Baker, Laura A., Tuvblad, Catherine, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas S., Harden, K. Paige, Tucker-Drob, Elliot M., Franz, Carol E., Kremen, William S., Lyons, Michael J., Lichtenstein, Paul, Bartels, Meike, Beijsterveldt, Catharina E. M. van, Willemsen, Gonneke, Öncel, Sevgi Y., Aliev, Fazil, Jeong, Hoe-Uk, Hur, Yoon-Mi, Turkheimer, Eric, Boomsma, Dorret I., Sørensen, Thorkild I. A., Kaprio, Jaakko, and Silventoinen, Karri
- Published
- 2020
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24. Association of psychological distress and DNA methylation: A 5‐year longitudinal population‐based twin study.
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Hong, Xuanming, Miao, Ke, Cao, Weihua, Lv, Jun, Yu, Canqing, Huang, Tao, Sun, Dianjianyi, Liao, Chunxiao, Pang, Yuanjie, Hu, Runhua, Pang, Zengchang, Yu, Min, Wang, Hua, Wu, Xianping, Liu, Yu, Gao, Wenjing, and Li, Liming
- Subjects
DNA methylation ,PSYCHOLOGICAL distress ,TWIN studies ,FALSE discovery rate ,FALSE memory syndrome - Abstract
Aim: To identify the psychological distress (PD)–associated 5′‐cytosine‐phosphate‐guanine‐3′ sites (CpGs), and investigate the temporal relationship between dynamic changes in DNA methylation (DNAm) and PD. Methods: This study included 1084 twins from the Chinese National Twin Register (CNTR). The CNTR conducted epidemiological investigations and blood withdrawal twice in 2013 and 2018. These included twins were used to perform epigenome‐wide association studies (EWASs) and to validate the previously reported PD‐associated CpGs selected from previous EWASs in PubMed, Embase, and the EWAS catalog. Next, a cross‐lagged study was performed to examine the temporality between changes in DNAm and PD in 308 twins who completed both 2013 and 2018 surveys. Results: The EWAS analysis of our study identified 25 CpGs. In the validation analysis, 741 CpGs from 29 previous EWASs on PD were selected for validation, and 101 CpGs were validated to be significant at a false discovery rate <0.05. The cross‐lagged analysis found a unidirectional path from PD to DNAm at 14 CpGs, while no sites showed significance from DNAm to PD. Conclusions: This study identified and validated PD‐related CpGs in a Chinese twin population, and suggested that PD may be the cause of changes in DNAm over time. The findings provide new insights into the molecular mechanisms underlying PD pathophysiology. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Association between fruit, vegetable, seafood, and dairy intake and a reduction in the prevalence of type 2 diabetes in Qingdao, China
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Liang, Jiwei, Zhang, Yanlei, Xue, Aili, Sun, Jianping, Song, Xin, Xue, Bai, Ji, Fuling, Gao, Weiguo, He, Liang, Pang, Zengchang, Qiao, Qing, and Ning, Feng
- Published
- 2017
26. Association of famine exposure during early life with the risk of type 2 diabetes in adulthood: a meta-analysis
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Liu, Li, Wang, Weijing, Sun, Jianping, and Pang, Zengchang
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- 2018
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27. Gender differences in the association of hypertension with gamma–glutamyltransferase and alanine aminotransferase levels in Chinese adults in Qingdao, China
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Ren, Jie, Sun, Jianping, Ning, Feng, Pang, Zengchang, Qie, Liangyi, and Qiao, Qing
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- 2015
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28. Minimal improvement in coronary artery disease risk prediction in Chinese population using polygenic risk scores: evidence from the China Kadoorie Biobank.
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Yang, Songchun, Sun, Dong, Sun, Zhijia, Yu, Canqing, Guo, Yu, Si, Jiahui, Sun, Dianjianyi, Pang, Yuanjie, Pei, Pei, Yang, Ling, Millwood, Iona Y., Walters, Robin G., Chen, Yiping, Du, Huaidong, Pang, Zengchang, Schmidt, Dan, Stevens, Rebecca, Clarke, Robert, Chen, Junshi, and Chen, Zhengming
- Published
- 2023
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29. A genome-wide association study of cognitive function in Chinese adult twins
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Xu, Chunsheng, Zhang, Dongfeng, Wu, Yili, Tian, Xiaocao, Pang, Zengchang, Li, Shuxia, and Tan, Qihua
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- 2017
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30. The impact of new screen-detected and previously known type 2 diabetes on health-related quality of life: a population-based study in Qingdao, China
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Zhang, Yanlei, Sun, Jianping, Pang, Zengchang, Wang, Xiaoyong, Gao, Weiguo, Ning, Feng, Ren, Jie, Kapur, Anil, Sintonen, Harri, and Qiao, Qing
- Published
- 2014
31. Genetic and environmental influences on cardiovascular risk factors and cognitive function: A Chinese twin aging study
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Xu, Chunsheng, Tian, Xiaocao, Sun, Jianping, Wu, Yili, Zhang, Dongfeng, Pang, Zengchang, Li, Shuxia, Petersen, Inge, Mengel‐From, Jonas, Christiansen, Lene, Christensen, Kaare, and Tan, Qihua
- Published
- 2018
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32. Heritability of the Effective Connectivity in the Resting-State Default Mode Network
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Xu, Junhai, Yin, Xuntao, Ge, Haitao, Han, Yan, Pang, Zengchang, Liu, Baolin, Liu, Shuwei, and Friston, Karl
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- 2017
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33. Genetic and Environmental Influences on Blood Pressure and Serum Lipids Across Age-Groups.
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Miao, Ke, Wang, Yutong, Cao, Weihua, Lv, Jun, Yu, Canqing, Huang, Tao, Sun, Dianjianyi, Liao, Chunxiao, Pang, Yuanjie, Hu, Runhua, Pang, Zengchang, Yu, Min, Wang, Hua, Wu, Xianping, Liu, Yu, Gao, Wenjing, and Li, Liming
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BLOOD lipids ,DIASTOLIC blood pressure ,HDL cholesterol ,SYSTOLIC blood pressure ,LDL cholesterol ,BLOOD pressure - Abstract
Aging plays a crucial role in the mechanisms of the impacts of genetic and environmental factors on blood pressure and serum lipids. However, to our knowledge, how the influence of genetic and environmental factors on the correlation between blood pressure and serum lipids changes with age remains to be determined. In this study, data from the Chinese National Twin Registry (CNTR) were used. Resting blood pressure, including systolic and diastolic blood pressure (SBP and DBP), and fasting serum lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TGs) were measured in 2378 participants (1189 twin pairs). Univariate and bivariate structural equation models examined the genetic and environmental influences on blood pressure and serum lipids among three age groups. All phenotypes showed moderate to high heritability (0.37–0.59) and moderate unique environmental variance (0.30–0.44). The heritability of all phenotypes showed a decreasing trend with age. Among all phenotypes, SBP and DBP showed a significant monotonic decreasing trend. For phenotype-phenotype pairs, the phenotypic correlation (Rph) of each pair ranged from −0.04 to 0.23, and the additive genetic correlation (Ra) ranged from 0.00 to 0.36. For TC&SBP, TC&DBP, TG&SBP and TGs&DBP, both the Rph and Ra declined with age, and the Ra difference between the young group and the older adult group is statistically significant (p <.05). The unique environmental correlation (Re) of each pair did not follow any pattern with age and remained relatively stable with age. In summary, we observed that the heritability of blood pressure was affected by age. Moreover, blood pressure and serum lipids shared common genetic backgrounds, and age had an impact on the phenotypic correlation and genetic correlations. [ABSTRACT FROM AUTHOR]
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- 2023
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34. Depression, anxiety, and prevalent diabetes in the Chinese population: Findings from the China Kadoorie Biobank of 0.5 million people
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Mezuk, Briana, Chen, Yiping, Yu, Canqing, Guo, Yu, Bian, Zheng, Collins, Rory, Chen, Junshi, Pang, Zengchang, Wang, Huijun, Peto, Richard, Que, Xiangsan, Zhang, Hui, Tan, Zhongwen, Kendler, Kenneth S., Li, Liming, and Chen, Zhengming
- Published
- 2013
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35. Evaluation of two screening methods for undiagnosed diabetes in China: An cost-effectiveness study
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Zhang, Yanlei, Sun, Jianping, Pang, Zengchang, Gao, Weiguo, Sintonen, Harri, Kapur, Anil, and Qiao, Qing
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- 2013
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36. Joint Effect of Family History of Diabetes with Obesity on Prevalence of Type 2 Diabetes Mellitus Among Chinese and Finnish Men and Women
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Ning, Feng, Pang, Zengchang, Laatikainen, Tiina, Gao, Weiguo, Wang, Shaojie, Zhang, Lei, Tuomilehto, Jaakko, and Qiao, Qing
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- 2013
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37. The Qingdao twin registry: A status update
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Duan, Haiping, Ning, Feng, Zhang, Dongfeng, Wang, Shaojie, Zhang, Dong, Tan, Qihua, Tian, Xiaocao, and Pang, Zengchang
- Published
- 2013
38. Heritability and whole genome linkage of pulse pressure in Chinese twin pairs
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Jiang, Wenjie, Zhang, Dongfeng, Pang, Zengchang, Li, Shuxia, Duan, Haiping, Wang, Shaojie, and Tan, Qihua
- Published
- 2012
39. The genetic correlation between cigarette smoking and alcohol drinking among Chinese adult male twins: An ordinal bivariate genetic analysis
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Zhang, Ting, Gao, Wenjing, Cao, Weihua, Zhan, Siyan, Lv, Jun, Pang, Zengchang, Wang, Shaojie, Chen, Rongfu, Hu, Yonghua, and Li, Liming
- Published
- 2012
40. The Prospective Associations of Egg Consumption with the Risk of Total Cerebrovascular Disease Morbidity among Chinese Adults.
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Pan, Chi, Sun, Xiaohui, Song, Jiahui, Yu, Canqing, Guo, Yu, Wang, Shaojie, Gao, Ruqin, Ning, Feng, Pang, Zengchang, Chen, Zhengming, and Li, Liming
- Abstract
Background: Studies investigating the relationship between egg consumption and the risk of cerebrovascular disease (CED) have yielded inconsistent results. This study evaluated the association between egg consumption and the risk of CED among Chinese adults. Methods: Data were obtained from China Kadoorie Biobank, Qingdao. A computerised questionnaire was used to collect information regarding egg consumption frequency. CED events were tracked through linkage with the Disease Surveillance Point System and the new national health insurance databases. Cox proportional hazards regression analyses were used to evaluate associations between egg consumption and CED risk controlling for potential confounders. Results: After a median follow-up of 9.2 years, 865 and 1083 CED events among men and women, respectively, were documented. More than 50% of participants consumed eggs daily with an average age of 52.0 (10.4) years at baseline. No association between egg consumption and CED were identified in the whole cohort and women. However, a 28% lower risk of CED was observed in those who consumed eggs at a higher frequency (HR = 0.72, 95% CI: 0.55–0.95) and a significant trend for the association (p for trend = 0.012) in a multivariable model in men. Conclusion: Higher frequency of egg consumption was associated with a lower risk of total CED events among men but not women in Chinese adults. The beneficial effect on women warrants further investigations. [ABSTRACT FROM AUTHOR]
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- 2023
- Full Text
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41. Family history, waist circumference and risk of ischemic stroke: A prospective cohort study among Chinese adults.
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Liu, Lei, Xue, Xiaojia, Zhang, Hua, Tian, Xiaocao, Chen, Yunhui, Guo, Yu, Pei, Pei, Wang, Shaojie, Duan, Haiping, Gao, Ruqin, Pang, Zengchang, Chen, Zhengming, and Li, Liming
- Abstract
The associations between genetic factors and waist circumference (WC) with stroke risk have been evaluated in Western studies. However, evidence of this association has rarely been reported in the Chinese population. This study aimed to evaluate the association between WC and family history of stroke (FHS) with ischemic stroke (IS) risk among Chinese adults and to further explore the potential interaction of these associations. The China Kadoorie Biobank (CKB) study recruited 35,508 participants aged 30–79 years from the Qingdao urban area during 2004–2008. A total of 33,355 participants were included in study. Cox regression analysis was used to estimate the multivariable-adjusted hazard ratios (HR) and 95% confidence intervals (CI) for the independent and interactional associations between FHS and WC and IS risk. Participants with FHS had a 29% (HR = 1.29, 95% CI: 1.12–1.50) higher IS risk than those without FHS. Participants with excessive WC (85 cm for males and 80 cm for females) had a 78% (HR = 1.78, 95% CI: 1.51–2.10) higher IS risk than those with normal WC. The combined effect of FHS and excessive WC on IS was statistically significant (HR = 2.29, 95% CI: 1.84–2.86). The present study further found statistically significant multiplicative interactions of FHS and WC with IS risk (P interaction < 0.001). The present study indicated that FHS and WC were significantly associated with an increased risk of IS. The association between FHS and IS was associated with excessive WC. • A large prospective cohort study in China. • The relationship between FHS with IS risk increases with number of family members. • A tendency towards an S-shaped curve of WC with IS risk. • FHS and WC have a multiplicative but no additive interaction with IS risk. • FHS and WC with IS risk were pronounced among people aged 30–60 years than >60 years. [ABSTRACT FROM AUTHOR]
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- 2023
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42. Multidimensional Assessment of Health Status in a Dependent Sample: An Exploratory Analysis for Adult Twins in China
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Ning, Yan, Gu, Danan, Hu, Yonghua, Ji, Wenyan, Pang, Zengchang, and Wang, Shaojie
- Published
- 2010
43. Genetic and Environmental Influences on Obesity-Related Phenotypes in Chinese Twins Reared Apart and Together
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Zhou, Bin, Gao, Wenjing, Lv, Jun, Yu, Canqing, Wang, Shengfeng, Liao, Chunxiao, Pang, Zengchang, Cong, Liming, Dong, Zhong, Wu, Fan, Wang, Hua, Wu, Xianping, Jiang, Guohong, Wang, Xiaojie, Wang, Binyou, Cao, Weihua, and Li, Liming
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- 2015
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44. Heritability of Smoking, Alcohol Use, and Psychological Characteristics Among Adolescent Twins in Qingdao, China
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Unger, Jennifer B., Lessov-Schlaggar, Christina N., Pang, Zengchang, Guo, Qian, Ning, Feng, Gallaher, Peggy, Lee, Liming, Conti, David, and Johnson, C.Anderson
- Published
- 2011
45. Environmental tobacco use and indicators of metabolic syndrome in Chinese adults
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Xie, Bin, Palmer, Paula H., Pang, Zengchang, Sun, Ping, Duan, Haiping, and Johnson, C. Anderson
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- 2010
46. Fresh vegetable intake and prevalence of diabetes in a Chinese population in Qingdao
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Zhou, Xianghai, Pang, Zengchang, Gao, Weiguo, Wang, Shaojie, Zhang, Lei, Ning, Feng, Xue, Bai, Chen, Xiaorong, and Qiao, Qing
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- 2011
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47. Association Between DNA Methylation and Blood Pressure: A 5-Year Longitudinal Twin Study.
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Hong, Xuanming, Miao, Ke, Cao, Weihua, Lv, Jun, Yu, Canqing, Huang, Tao, Sun, Dianjianyi, Liao, Chunxiao, Pang, Yuanjie, Pang, Zengchang, Yu, Min, Wang, Hua, Wu, Xianping, Liu, Yu, Gao, Wenjing, and Li, Liming
- Abstract
Background: Previous EWASs (Epigenome-Wide Association Studies) have reported hundreds of blood pressure (BP) associated 5'-cytosine-phosphate-guanine-3' (CpG) sites. However, their results were inconsistent. Longitudinal observations on the temporal relationship between DNA methylation and BP are lacking.Methods: A candidate CpG site association study for BP was conducted on 1072 twins in the Chinese National Twin Registry. PubMed and EMBASE were searched for candidate CpG sites. Cross-lagged models were used to assess the temporal relationship between BP and DNA methylation in 308 twins who completed 2 surveys in 2013 and 2018. Then, the significant cross-lagged associations were validated by adopting the Inference About Causation From Examination of Familial Confounding approach. Finally, to evaluate the cumulative effects of DNA methylation on the progression of hypertension, we established methylation risk scores based on BP-associated CpG sites and performed Markov multistate models.Results: 16 and 20 CpG sites were validated to be associated with systolic BP and diastolic BP, respectively. In the cross-lagged analysis, we detected that methylation of 2 CpG sites could predict subsequent systolic BP, and systolic BP predicted methylation at another 3 CpG sites. For diastolic BP, methylation at 3 CpG sites had significant cross-lagged effects for predicting diastolic BP levels, while the prediction from the opposite direction was observed at one site. Among these, 3 associations were validated in the Inference About Causation From Examination of Familial Confounding analysis. Using the Markov multistate model, we observed that methylation risk scores were associated with the development of hypertension.Conclusions: Our findings suggest the significance of DNA methylation in the development of hypertension. [ABSTRACT FROM AUTHOR]- Published
- 2023
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48. Cardiometabolic Traits in Adult Twins: Heritability and BMI Impact with Age.
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Hong, Xuanming, Wu, Zhiyu, Cao, Weihua, Lv, Jun, Yu, Canqing, Huang, Tao, Sun, Dianjianyi, Liao, Chunxiao, Pang, Yuanjie, Pang, Zengchang, Cong, Liming, Wang, Hua, Wu, Xianping, Liu, Yu, Gao, Wenjing, and Li, Liming
- Abstract
Background: The prevalence of obesity and cardiometabolic diseases continues to rise globally and obesity is a significant risk factor for cardiometabolic diseases. However, to our knowledge, evidence of the relative roles of genes and the environment underlying obesity and cardiometabolic disease traits and the correlations between them are still lacking, as is how they change with age. Method: Data were obtained from the Chinese National Twin Registry (CNTR). A total of 1421 twin pairs were included. Univariate structural equation models (SEMs) were performed to evaluate the heritability of BMI and cardiometabolic traits, which included blood hemoglobin A1c (HbA1c), fasting blood glucose (FBG), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). Bivariate SEMs were used to assess the genetic/environmental correlations between them. The study population was divided into three groups for analysis: ≤50, 51–60, and >60 years old to assess the changes in heritability and genetic/environmental correlations with ageing. Results: Univariate SEMs showed a high heritability of BMI (72%) and cardiometabolic traits, which ranged from 30% (HbA1c) to 69% (HDL-C). With age increasing, the heritability of all phenotypes has different degrees of declining trends. Among these, BMI, SBP, and DBP presented significant monotonous declining trends. The bivariate SEMs indicated that BMI correlated with all cardiometabolic traits. The genetic correlations were estimated to range from 0.14 (BMI and LDL-C) to 0.39 (BMI and DBP), while the environmental correlations ranged from 0.13 (BMI and TC/LDL-C) to 0.31 (BMI and TG). The genetic contributions underlying the correlations between BMI and SBP and DBP, TC, TG, and HDL-C showed a progressive decrease as age groups increased. In contrast, environmental correlations displayed a significant increasing trend for HbA1c, SBP, and DBP. Conclusions: The findings suggest that genetic and environmental factors have essential effects on BMI and all cardiometabolic traits. However, as age groups increased, genetic influences presented varying degrees of decrement for BMI and most cardiometabolic traits, suggesting the increasing importance of environments. Genetic factors played a consistently larger role than environmental factors in the phenotypic correlations between BMI and cardiometabolic traits. Nevertheless, the relative magnitudes of genetic and environmental factors may change over time. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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49. Exploring the Genetic Association between Obesity and Serum Lipid Levels Using Bivariate Methods.
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Ke, Ji, Gao, Wenjing, Wang, Biqi, Cao, Weihua, Lv, Jun, Yu, Canqing, Huang, Tao, Sun, Dianjianyi, Liao, Chunxiao, Pang, Yuanjie, Pang, Zengchang, Cong, Liming, Wang, Hua, Wu, Xianping, Liu, Yu, and Li, Liming
- Subjects
BLOOD lipids ,HDL cholesterol ,LDL cholesterol ,STRUCTURAL equation modeling ,GENETIC correlations ,HIGH density lipoproteins - Abstract
It is crucial to understand the genetic mechanisms and biological pathways underlying the relationship between obesity and serum lipid levels. Structural equation models (SEMs) were constructed to calculate heritability for body mass index (BMI), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and the genetic connections between BMI and the four classes of lipids using 1197 pairs of twins from the Chinese National Twin Registry (CNTR). Bivariate genomewide association studies (GWAS) were performed to identify genetic variants associated with BMI and lipids using the records of 457 individuals, and the results were further validated in 289 individuals. The genetic background affecting BMI may differ by gender, and the heritability of males and females was 71% (95% CI [.66,.75]) and 39% (95% CI [.15,.71]) respectively. BMI was positively correlated with TC, TG and LDL-C in phenotypic and genetic correlation, while negatively correlated with HDL-C. There were gender differences in the correlation between BMI and lipids. Bivariate GWAS analysis and validation stage found 7 genes (LOC105378740 , LINC02506 , CSMD1 , MELK , FAM81A , ERAL1 and MIR144) that were possibly related to BMI and lipid levels. The significant biological pathways were the regulation of cholesterol reverse transport and the regulation of high-density lipoprotein particle clearance (p <.001). BMI and blood lipid levels were affected by genetic factors, and they were genetically correlated. There might be gender differences in their genetic correlation. Bivariate GWAS analysis found MIR144 gene and its related biological pathways may influence obesity and lipid levels. [ABSTRACT FROM AUTHOR]
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- 2022
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50. Longitudinal Association of DNA Methylation With Type 2 Diabetes and Glycemic Traits: A 5-Year Cross-Lagged Twin Study.
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Hong, Xuanming, Wu, Zhiyu, Cao, Weihua, Lv, Jun, Yu, Canqing, Huang, Tao, Sun, Dianjianyi, Liao, Chunxiao, Pang, Yuanjie, Pang, Zengchang, Cong, Liming, Wang, Hua, Wu, Xianping, Liu, Yu, Gao, Wenjing, and Li, Liming
- Subjects
CROSS-sectional method ,EVALUATION research ,RESEARCH funding ,DNA ,DNA methylation ,BLOOD sugar ,GENES ,TYPE 2 diabetes ,RESEARCH ,RESEARCH methodology ,COMPARATIVE studies - Abstract
Investigators of previous cross-sectional epigenome-wide association studies (EWAS) in adults have reported hundreds of 5'-cytosine-phosphate-guanine-3' (CpG) sites associated with type 2 diabetes mellitus (T2DM) and glycemic traits. However, the results from EWAS have been inconsistent, and longitudinal observations of these associations are scarce. Furthermore, few studies have investigated whether DNA methylation (DNAm) could be modified by smoking, drinking, and glycemic traits, which have broad impacts on genome-wide DNAm and result in altering the risk of T2DM. Twin studies provide a valuable tool for epigenetic studies, as twins are naturally matched for genetic information. In this study, we conducted a systematic literature search in PubMed and Embase for EWAS, and 214, 33, and 117 candidate CpG sites were selected for T2DM, HbA1c, and fasting blood glucose (FBG). Based on 1,070 twins from the Chinese National Twin Registry, 67, 17, and 16 CpG sites from previous studies were validated for T2DM, HbA1c, and FBG. Longitudinal review and blood sampling for phenotypic information and DNAm were conducted twice in 2013 and 2018 for 308 twins. A cross-lagged analysis was performed to examine the temporal relationship between DNAm and T2DM or glycemic traits in the longitudinal data. A total of 11 significant paths from T2DM to subsequent DNAm and 15 paths from DNAm to subsequent T2DM were detected, suggesting both directions of associations. For glycemic traits, we detected 17 cross-lagged associations from baseline glycemic traits to subsequent DNAm, and none were from the other cross-lagged direction, indicating that CpG sites may be the consequences, not the causes, of glycemic traits. Finally, a longitudinal mediation analysis was performed to explore the mediation effects of DNAm on the associations of smoking, drinking, and glycemic traits with T2DM. No significant mediations of DNAm in the associations linking smoking and drinking with T2DM were found. In contrast, our study suggested a potential role of DNAm of cg19693031, cg00574958, and cg04816311 in mediating the effect of altered glycemic traits on T2DM. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
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