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7. BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation

Author

Sartori, Maxime, Mendes, Tiago, Desai, Shruti, Lasorsa, Alessia, Herledan, Adrien, Malmanche, Nicolas, Mäkinen, Petra, Marttinen, Mikael, Malki, Idir, Chapuis, Julien, Flaig, Amandine, Vreulx, Anaïs-Camille, Ciancia, Marion, Amouyel, Philippe, Leroux, Florence, Déprez, Benoit, Cantrelle, François-Xavier, Maréchal, Damien, Pradier, Laurent, Hiltunen, Mikko, Landrieu, Isabelle, Kilinc, Devrim, Herault, Yann, Laporte, Jocelyn, and Lambert, Jean-Charles

Published
2019
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16. Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors.

Author

Despres, Clément, Di, Jing, Cantrelle, François-Xavier, Li, Zizheng, Huvent, Isabelle, Chambraud, Béatrice, Zhao, Jing, Chen, Jianle, Chen, Shiguo, Lippens, Guy, Zhang, Fuming, Linhardt, Robert, Wang, Chunyu, Klärner, Frank-Gerrit, Schrader, Thomas, Landrieu, Isabelle, Bitan, Gal, and Smet-Nocca, Caroline

Published
2019
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17. Waitlist Outcomes in Candidates With Rare Causes of Heart Failure After Implementation of the 2018 French Heart Allocation Scheme.

Author

Legeai, Camille, Coutance, Guillaume, Cantrelle, Christelle, Jasseron, Carine, Para, Marylou, Sebbag, Laurent, Battistella, Pascal, Kerbaul, François, and Dorent, Richard

Abstract

BACKGROUND: In 2018, an algorithm-based allocation system for heart transplantation (HT) was implemented in France. Its effect on access to HT of patients with rare causes of heart failure (HF) has not been assessed. METHODS: In this national study, including adults listed for HT between 2018 and 2020, we analyzed waitlist and posttransplant outcomes of candidates with rare causes of HF (restrictive cardiomyopathy [RCM], hypertrophic cardiomyopathy, and congenital heart disease). The primary end point was death on the waitlist or delisting for clinical deterioration. Secondary end points included access to HT and posttransplant mortality. The cumulative incidence of waitlist mortality estimated with competing risk analysis and incidence of transplantation were compared between diagnosis groups. The association of HF cause with outcomes was determined by Fine-Gray or Cox models. RESULTS: Overall, 1604 candidates were listed for HT. At 1 year postlisting, 175 patients met the primary end point and 1040 underwent HT. Candidates listed for rare causes of HF significantly differed in baseline characteristics and had more frequent score exceptions compared with other cardiomyopathies (31.3%, 32.0%, 36.4%, and 16.7% for patients with hypertrophic cardiomyopathy, RCM, congenital heart disease, and other cardiomyopathies). The cumulative incidence of death on the waitlist and probability of HT were similar between diagnosis groups (P =0.17 and 0.40, respectively). The adjusted risk of death or delisting for clinical deterioration did not significantly differ between candidates with rare and common causes of HF (subdistribution hazard ratio (HR): hypertrophic cardiomyopathy, 0.51 [95% CI, 0.19–1.38]; P =0.18; RCM, 1.04 [95% CI, 0.42–2.58]; P =0.94; congenital heart disease, 1.82 [95% CI, 0.78–4.26]; P =0.17). Similarly, the access to HT did not significantly differ between causes of HF (hypertrophic cardiomyopathy: HR, 1.18 [95% CI, 0.92–1.51]; P =0.19; RCM: HR, 1.19 [95% CI, 0.90–1.58]; P =0.23; congenital heart disease: HR, 0.76 [95% CI, 0.53–1.09]; P =0.14). RCM was an independent risk factor for 1-year posttransplant mortality (HR, 2.12 [95% CI, 1.06–4.24]; P =0.03). CONCLUSIONS: Our study shows equitable waitlist outcomes among HT candidates whatever the indication for transplantation with the new French allocation scheme. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A.

Author

Badillo, Aurelie, Receveur-Brechot, Véronique, Sarrazin, Stéphane, Cantrelle, François-Xavier, Delolme, Frédéric, Fogeron, Marie-Laure, Molle, Jennifer, Montserret, Roland, Bockmann, Anja, Bartenschlager, Ralf, Lohmann, Volker, Lippens, Guy, Ricard-Blum, Sylvie, Hanoulle, Xavier, and Penin, François

Published
2017
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26. F2‐06‐01: MAJOR DIFFERENCES BETWEEN THE SELF‐ASSEMBLY, SEEDING BEHAVIOR, AND INTERACTION WITH MODULATORS OF HEPARIN‐INDUCED VERSUS IN‐VITRO PHOSPHORYLATED TAU.

Author

Bitan, Gal, Despres, Clément, Di, Jing, Cantrelle, François-Xavier, Li, Zizheng, Huvent, Isabelle, Chambraud, Beatrice, Zhao, Jing, Chen, Jianle, Chen, Shiguo, Lippens, Guy, Zhang, Fuming, Linhardt, Robert, Wang, Chunyu, Klärner, Frank-Gerrit, Schrader, Thomas, Landrieu, Isabelle, and Smet-Nocca, Caroline

Published
2019
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27. Breast Feeding, Mortality in Childhood and Fertility in a Rural Zone of Senegal

Author

H. Leridon and P. Cantrelle

Subjects
education.field_of_study, History, business.industry, media_common.quotation_subject, Total fertility rate, Population, Fertility, Infant mortality, Birth rate, Child mortality, Medicine, Rural area, education, business, Breast feeding, media_common, Demography
Abstract

The data analysed in the present study were collected in the course of a demographic survey conducted at repeated intervals in the Sine-Saloum region of Senegal. 1 This study was financed by a grant from the 'Fond d'aide et de coopération' of France, from 1963-65, and by the WHO Section for Research on Human Reproduction from 1966-67. The study was conducted by ORSTOM in collaboration with the Statistical Service of Senegal. The data used in this paper were analysed at INED. Only the data concerning the Sine (Niakhar) area are analysed here.

Published
1971
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28. Factors contributing to geographic disparities in access to heart transplantation in France.

Author

Cantrelle, C., Dorent, R., Savoye, E., Tuppin, P., Lebreton, G., Legeai, C., and Bastien, O.

Abstract

Context Transplantation represents the ultimate option for patients with advanced heart failure refractory to other treatments. We aimed to assess the between-center disparities in access to heart transplantation 1-year after listing in France by adjusting for candidate and center factors identified to be significantly associated with access to heart transplantation. Materials and methods Adults ( n = 2,347) registered on the French national waiting list between January 1, 2010 and December 31, 2014 in the 23 transplant centers were included. The association of candidate and transplant center characteristics with access to transplantation was assessed with mixed-effects Cox models. Results Within 1-year of listing, 65% of candidates underwent transplantation. Candidates blood type O and A, sensitization and body mass index ≥ 30 kg/m 2 were independently associated with lower access to transplantation, while female gender, heart failure severity and high serum bilirubin level were independently associated with greater access to transplantation. Center factors associated with access to transplantation were heart procurement rate in the geographic area, proportion of high-urgency candidates among listed patients and donor heart offer decline rate. Access to transplantation between-center variability increased by 5% after adjustment for candidate factors and decreased by 57% after adjustment for center factors. However, after adjustment for candidate and center factors, 5 centers were still outside of normal variability. Conclusion Regional disparities in access to heart transplantation were largely driven by center factors. These findings will be taken into consideration in the future French heart allocation system with priority statuses defined according to objective candidate characteristics rather than medical management and with extending nationwide graft sharing to candidates without priority. [ABSTRACT FROM AUTHOR]

Published
2018
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