160 results on '"Osborne, Timothy F"'
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2. Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
3. Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease
4. SREBP signaling is essential for effective B cell responses
5. SCAP deficiency facilitates obesity and insulin resistance through shifting adipose tissue macrophage polarization
6. Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus
7. MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis
8. Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum
9. SREBP-1a–stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1
10. Spatiotemporal dynamics of SETD5-containing NCoR–HDAC3 complex determines enhancer activation for adipogenesis
11. Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue
12. Lipid balance must be just right to prevent development of severe liver damage
13. T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways
14. Distinct subpopulations of human subcutaneous adipose tissue precursor cells revealed by single-cell RNA sequencing.
15. Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance
16. Transcriptional Control of Subcutaneous Adipose Tissue by the Transcription Factor CTCF Modulates Heterogeneity in Fat Distribution in Women.
17. An Atlas of Promoter Chromatin Modifications and HiChIP Regulatory Interactions in Human Subcutaneous Adipose-Derived Stem Cells.
18. Carbon dioxide regulates cholesterol levels through SREBP2.
19. Nutrient Regulation of Gene Expression by the Sterol Regulatory Element Binding Proteins: Increased Recruitment of Gene-Specific Coregulatory Factors and Selective Hyperacetylation of Histone H3 in vivo
20. Specificity in Cholesterol Regulation of Gene Expression by Coevolution of Sterol Regulatory DNA Element and Its Binding Protein
21. Sterol Regulation of Acetyl Coenzyme A Carboxylase: A Mechanism for Coordinate Control of Cellular Lipid
22. SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation
23. Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: primary outcomes
24. An SREBP-Responsive microRNA Operon Contributes to a Regulatory Loop for Intracellular Lipid Homeostasis
25. SREBPs: metabolic integrators in physiology and metabolism
26. A feed-forward loop amplifies nutritional regulation of PNPLA3
27. Genome-Wide Analysis of SREBP-1 Binding in Mouse Liver Chromatin Reveals a Preference for Promoter Proximal Binding to a New Motif
28. COUP-TFII Acts Downstream of Wnt/β-Catenin Signal to Silence PPARγ Gene Expression and Repress Adipogenesis
29. Genome-wide Localization of SREBP-2 in Hepatic Chromatin Predicts a Role in Autophagy
30. Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein-1a
31. Domains of Transcription Factor Sp1 Required for Synergistic Activation with Sterol Regulatory Element Binding Protein 1 of Low Density Lipoprotein Receptor Promoter
32. Multiple Genes Encode Nuclear Factor 1-Like Proteins that Bind to the Promoter for 3-hydroxy-3-methylglutaryl-coenzyme A Reductase
33. Mapping a Eukaryotic Promoter: A DNA Sequence Required for in vivo Expression of Adenovirus Pre-Early Functions
34. SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice
35. Parasympathetic response in chick myocytes and mouse heart is controlled by SREBP
36. Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells
37. Genome-wide analysis of FoxO1 binding in hepatic chromatin: Potential involvement of FoxO1 in linking retinoid signaling to hepatic gluconeogenesis
38. CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin
39. Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1
40. Regulation of steroid 5-α reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin
41. Two uniquely arranged thyroid hormone response elements in the far upstream 5′ flanking region confer direct thyroid hormone regulation to the murine cholesterol 7α hydroxylase gene
42. Selective Association of Sterol Regulatory Element-binding Protein Isoforms with Target Promoters in Vivo
43. DNA Methylation as a Marker of Body Shape in Premenopausal Women.
44. Ubiquitination‐dependent and ‐independent repression of target genes by SETDB1 reveal a context‐dependent role for its methyltransferase activity during adipogenesis.
45. Genome-wide analysis of hepatic LRH-1 reveals a promoter binding preference and suggests a role in regulating genes of lipid metabolism in concert with FXR
46. Related membrane domains in proteins of sterol sensing and cell signaling provide a glimpse of treasures still buried within the dynamic realm of intracellular metabolic regulation
47. Fat Distribution in Women Is Associated With Depot-Specific Transcriptomic Signatures and Chromatin Structure.
48. Inflammation triggers liver X receptor-dependent lipogenesis.
49. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been
50. SREBP-1a-stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1.
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