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We report a patient who has maintained a regular menstrual cycle despite undergoing cystectomy and chemotherapy for contralateral recurrence of ovarian immature teratoma with gliomatosis peritonei. We initially performed a fertility-sparing right salpingo-oophorectomy, omentectomy and peritoneal biopsy for immature teratoma with gliomatosis peritonei, with adjuvant chemotherapy; we performed a left ovarian cystectomy and peritoneal biopsy for mature cystic teratoma with gliomatosis peritonei 16 months after the first surgery, a fertility-sparing left ovarian cystectomy and peritoneal biopsy for contralateral recurrence of ovarian immature teratoma with gliomatosis peritonei 60 months after the first surgery, and a left ovarian cystectomy and peritoneal and external iliac lymph node biopsy for endometrial cyst with gliomatosis peritonei 71 months after first surgery. The peritoneal gliomatosis lesions gradually decreased through the 4 surgeries over 8 years. The patient has maintained a regular menstrual cycle and currently shows no evidence of disease. [ABSTRACT FROM AUTHOR]

The reported success rate of uterine artery embolization (UAE) for obstetrical hemorrhage is more than 90%. We experienced a case of failed UAE for postpartum hemorrhage, although an embolic particle was found pathologically in the uterine vessels without coagulation. A 42-year-old woman (gravida 7, para 2) with placenta previa had genital bleeding at 35 weeks of gestation, and cesarean section was performed. We immediately added UAE aiming to reduce massive bleeding after the cesarean section, successful embolization of the bilateral uterine arteries and internal iliac arteries were confirmed by angiography regardless the vital sign was recovered with an appropriate amount of transfusion; the massive bleeding recurred after 1 hour of UAE. Hysterectomy was performed and pathological findings of the uterus showed that there was no coagulation in the vessels, which was supposed to be observed by the effect of gelatin sponge. In addition, despite the fact that no coagulation was found, only one gelatin sponge was found in 16 slices of the uterine wall specimens. We speculate that thrombotic materials were caught in vasoconstricted vessels triggered by hypovolemic shock due to acute blood loss, and then the gelatin sponge could be washed out after recovering to normalized circulation status leading to recurrent massive hemorrhage. [ABSTRACT FROM AUTHOR]

We present a case of cervical varix and low-lying placenta. A cesarean section was performed because of the risk of bleeding with vaginal delivery; hemostasis was achieved using z sutures at the bleeding points. After delivery, the cervical varix decreased dramatically in size. It is important to recognize the clinical features and available treatments for cervical varix. [ABSTRACT FROM AUTHOR]

Objective With progression of gynecologic cancer, patients experience a dramatic body fat loss. A tumor-produced lipid mobilizing factor (LMF) characterized by the ability to stimulate lipolysis via stimulation of adenylate cyclase (AC) have been reported to elevate in both serum and urine of cancer cachectic patients. In this study the ability of LMF to interact with the β3adrenoreceptor (β3AR) has been studied Methods LMF was purified from urine of cancer cachectic patients. Effects of a b3AR antagonist SR59230A (SR) on lipolysis in murine adipocytes and stimulation of AC in murine adipocyte plasma membranes (PM) by LMF were determined. Cyclic AMP production was determined in CHOK1 cells transfected with human β3AR (CHOK1 β3). For affinity binding study, LMF was labeled with [sup 125]I and the binding to crude PM from CHOK1 β3 cells was determined Results Induction of lipolysis and stimulation of AC by LMF were attenuated by low concentrations (10sup -7]-10sup -5] M) of SR. LMF (250 nM) produced comparable increases in intracellular cyclic AMP in CHOK1 β3 cells to that obtained with isoprenaline (1 nM). In both cases cyclic AMP production was attenuated by SR. A non-linear regression analysis showed a high affinity binding site with a Kd value 78±45nM and a Bmax value 282 ± lfmole/mgprotein comparable with that of other β3AR agonists Conclusion LMF induces lipolysis through biding to β3AR. [ABSTRACT FROM AUTHOR]