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Your search keyword '"Orkin, S H"' showing total 9 results
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9 results on '"Orkin, S H"'

4. Epigenetic memory in induced pluripotent stem cells

Author

Kim, K., Doi, A., Wen, B., Ng, K., Zhao, R., Cahan, P., Kim, J., Aryee, M. J., Ji, H., Ehrlich, L. I. R., Yabuuchi, A., Takeuchi, A., Cunniff, K. C., Hongguang, H., Mckinney-Freeman, S., Naveiras, O., Yoon, T. J., Irizarry, R. A., Jung, N., Seita, J., Hanna, J., Murakami, P., Jaenisch, R., Weissleder, R., Orkin, S. H., Weissman, I. L., Feinberg, A. P., and Daley, G. Q.

Published
2010
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7. The Transcriptional Network Controlling Pluripotency in ES Cells.

Author

ORKIN, S. H., WANG, J., KIM, J., CHU, J., RAO, S., THEUNISSEN, T. W., SHEN, X., and LEVASSEUR, D. N.

Subjects
*GENETIC transcription, *EMBRYONIC stem cells, *STEM cells, *LABORATORY mice, *GENES
Abstract

The article focuses on the construction of a transcriptional network controlling pluripotency in embryonic stem (ES) cells that is said to form the basis for further studies of directed differentiation and lineage reprogramming. A discussion of how the transcriptional network controlling pluripotency in mouse ES cells is defined through combined proteomic and genomic approaches is offered. The construction of protein interaction network surrounding Nanog and core and reprogramming factor gene targets is also mentioned.

Published
2008
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8. Diversification of haematopoietic stem cells to specific lineages.

Author

Orkin, Stuart H. and Orkin, S H

Subjects
*STEM cells, *HEMATOPOIESIS, *BLOOD cells, *BONE marrow, *CELL differentiation, *HEMATOPOIETIC stem cells, *LEUKEMIA
Abstract

Diverse types of blood cell (lineages) are produced from rare haematopoietic stem cells that reside in the bone marrow. This process, known as haematopoiesis, provides a valuable model for examining how genetic programs are established and executed in vertebrates, and also how homeostasis of blood formation is altered in leukaemias. So, how does an apparently small group of critical lineage-restricted nuclear regulatory factors specify the diversity of haematopoietic cells? Recent findings not only indicate how this may be achieved but also show the extraordinary plasticity of tissue stem cells in vivo. [ABSTRACT FROM AUTHOR]

Published
2000
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