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2. Successful Thrombectomy Improves Functional Outcome in Tandem Occlusions with a Large Ischemic Core

Author

Lapergue, Bertrand, Wang, Adrien, Consoli, Arturo, Coskun, Oguzhan, Maria, Federico Di, Pizzuto, Silvia, Sgreccia, Alessandro, Benoit, Charline, Gorza, Lucas, Weisenburger-Lile, David, Jabeur, Waliyde, Maia, Tchikviladze, Evrard, Serge, Rodesch, Georges, Blanc, Raphaël, Obadia, Michael, Desilles, Jean-Philippe, Piotin, Michel, Seners, Pierre, Smajda, Stanislas, Escalard, Simon, Maier, Benjamin, Sabben, Candice, Redjem, Hocine, Mikaelmazhigi, Adwan, Grace, Delvoye, François, Raaisi, Amira Al, Boisseau, William, Eker, Omer, Cho, Tae-Hee, Derex, Laurent, Fontaine, Julia, Mechtouff, Laura, Nighoghossian, Norbert, Ong, Elodie, Rascle, Lucie, Riva, Roberto, Turjman, Françis, Laubacher, Morgane, Beyragued, Mehdi, Berthezene, Yves, Hermier, Marc, Roxanna, Ameli, Bani-Sadr, Alexandre, Filip, Andrea, Cappucci, Matteo, Bourcier, Romain, Duport, Benjamin Daumas, Alexandre, Pierre Louis, Lenoble, Cédric, Hubertdesal, Gaalon, Solène De, Guillon, Benoît, Preterre, Cécile, Tessier, Guillaume, Lionnet, Arthur, Gory, Benjamin, Humbertjean-Selton, Lisa, Anxionnat, René, Derelle, Anne-Laure, Liao, Liang, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Mione, Gioia, Lacour, Jean-Christophe, Douarinou, Marian, Micard, Emilien, Chen, Bailiang, Audibert, Gérard, Masson, Agnès, Alb, Lionel, Beaumont, Marine, Tabarna, Adriana, Voicu, Marcela, Barthel, Grégoire, Podar, Iona, Brezeanu, Madalina, Reitter, Marie, Zhu, François, Marnat, Gaultier, Liegey, Jean-Sébastien, Briau, Pierre, Papillon, Lisa, Sibon, Igor, Barreau, Xavier, Papaxanthos, Jean, Berge, Jérome, Debruxelles, Sabrina, Olindo, Stephane, Poli, Mathilde, Renou, Pauline, Sagnier, Sharmila, Tourdias, Thomas, Courret, Thomas, Lucas, Ludovic, Milnerowicz, Malgorzata, Dargazanli, Cyril, Costalat, Vincent, Mourand, Isabelle, Arquizan, Caroline, Corti, Lucas, Adrien, Schiphorst, Ter, Federico, Cagnazzo, Derraz, Imad, Mahmoudi, Mehdi, Lefevre, Pierre-Henri, Gascou, Grégory, Spelle, Laurent, Caroff, Jildaz, Denier, Christian, Chalumeau, Vanessa, Mihalea, Cristian, Nicolaslegris, Ozanne, Augustin, Ikka, Leon, Chassin, Olivier, Gallas, Sophie, Venditti, Laura, Marianasarov, Cortese, Jonathan, Ferre, Jean-Christophe, Vannier, Stephane, Ronziere, Thomas, Veronica Lassalle, Maria, Gauvrit, Jean-Yves, Tracol, Clément, Boustia, Abdelghani Fakhreddine, Malrain, Cécile, Beaufreton, Edouard, Lapotre, Thibault, Alias, Quentin, Hissier, Julien, Guillen, Maud, Eugene, François, Chivot, Cyril, Courselle, Audrey, Ouin, Elisa, Lamy, Chantal, Delaforge, Kevin, Fernandez, Manuel, Vial, Jérémie, Laferte, Quentin, Desdoit, Xavier, Timsit, Serge, Jourdain, Aurore, Gentric, Jean-Christophe, Ognard, Julien, Viakhireva, Irina, Coris, Jordan, Prud'hon, Sabine, Merrien, François-Mathias, Marechal, Denis, Bruguet, Marie, Rousseau, Pierre Yves, Goas, Philippe, Boulanger, Marion, Touze, Emmanuel, Vivien, Denis, Barbier, Charlotte, Schneckenburger, Romain, Salaris, Fabrizio, Cogez, Julien, Guettier, Sophie, Porte, Estelle La, Bouchart, Jean, Mounayer, Charbel, Rouchaud, Aymeric, Saleme, Suzana, Forestier, Géraud, Clarencon, Frédéric, Rosso, Charlotte, Leder, Sara, Baronnet, Flore, Crozier, Sophie, Leger, Anne, Premat, Kevin, Eimad, Shotar, Lenck, Stéphanie, Sourour, Nader, Bottin, Laure, Ghazanfari, Sam, Yger, Marion, Alamowitch, Sonia, Delorme, Stephen, Wittwer, Aymeric, Vassilev, Christine, Naggara, Olivier, Turc, Guillaume, Hassen, Wagih Ben, Kerleroux, Basile, Trystram, Denis, Rodriguez-Regent, Christine, Ozkul-Wermester, Ozlem, Papagiannaki, Chrysanthi, Massardier, Evelyne, Triquenot, Aude, Lefebvre, Margaux, Burel, Julien, Viguier, Alain, Cognard, Christophe, Januel, Anne Christine, Albucher, Jean-François, Calviere, Lionel, Olivot, Jean-Marc, Darcourt, Jean, Raposo, Nicolas, Bonneville, Fabrice, Bellanger, Guillaume, Fontaine, Louis, Tall, Philippe, Thalamas, Claire, Geerearts, Thomas, Grepon, Antoine Faurie, Bourdain, Frédéric, Bernady, Patricia, Ballan, Guillaume, Bannier, Stéphanie, Ellie, Emmanuel, Flabeau, Olivier, Potenza, Julia, Soulages, Antoine, Lagoarde-Segot, Laurent, Cailliez, Hélène, Veunac, Louis, Higue, David, Lebras, Anthony, Adam, Sarah, Pegat, Benoit, Guen, Arnaud Le, Chedeville, François, Jouan, Jérémy, Demasles, Stéphanie, Richter, Johann Sebastian, Thierry Barroso, Bruno, Dahan, Camille, Gonnet, Alexis, Hubrecht, Régis, Lepine, Zoé, Castagnet, Hélène, Marasescu, Raluca, Heck, Olivier, Cuisenier, Pauline, Detante, Olivier, Wiki, Isabelle Favre, Bonaz, Clémentine, Garambois, Katia, Legris, Loic, Kastler, Adrian, Boubagra, Kamel, Berthet, Corentin, Charara, Stéphane, Wolff, Valérie, Pop, Raoul, Quenardelle, Véronique, Lauer, Valérie, Pierre-Paul, Irène, Roxanagheoca, Trzeciak, Malwina, Moulin, Solène, Tuan, Hua Vi, Pagano, Paolo, Doucet, Alexandre, Gelmini, Christophe, Manceau, Pierrefrançois, Paiusan, Laurentiu, Serre, Isabelle, Soize, Sébastien, Phuong Nguyen, Thi Ngoc, Sahnoun, Maher, Caucheteux, Nathalie, Ferrier, Anna, Zerroug, Abderrahim, Moreno, Ricardo, Chabert, Emmanuel, Lteif, Elie, Paulineparis, Bourgois, Nathalie, Raquin, Marie, Pasco-Papon, Anne, Girot, Jean Baptiste, Lecluse, Alderic, Godard, Sophie, L'allinec, Vincent, Janot, Kevin, Bibi, Richard, Gaudron, Marie, Bretonniere, Arnaud, Annan, Mariam, Ifergan, Héloïse, Boulouis, Grégoire, Pasi, Marco, Debiais, Séverine, Molinier, Elisabeth, Wietrich, Anthony, Ruche, Valérie, Lavandier, Karine, Bejot, Yannick, Lemogne, Brivale, Ricolfi, Fédéric, Baptiste, Laura, Thouant, Pierre, Duloquin, Gaulthier, Olivier Comby, Pierre, Charbonnier, Guillaume, Bonnet, Louise, Raybaud, Nicolas, Bouamra, Benjamin, Moulin, Thierry, Biondi, Alessandra, Finitsis, Stephanos, and Mazighi, Mikael

Published
2023
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3. Safety and efficacy of prophylactic levetiracetam for prevention of epileptic seizures in the acute phase of intracerebral haemorrhage (PEACH): a randomised, double-blind, placebo-controlled, phase 3 trial

Author

Peter-Derex, Laure, Philippeau, Frédéric, Garnier, Pierre, André-Obadia, Nathalie, Boulogne, Sébastien, Catenoix, Hélène, Convers, Philippe, Mazzola, Laure, Gouttard, Michel, Esteban, Maud, Fontaine, Julia, Mechtouff, Laura, Ong, Elodie, Cho, Tae-Hee, Nighoghossian, Norbert, Perreton, Nathalie, Termoz, Anne, Haesebaert, Julie, Schott, Anne-Marie, Rabilloud, Muriel, Pivot, Christine, Dhelens, Carole, Filip, Andrea, Berthezène, Yves, Rheims, Sylvain, Boutitie, Florent, and Derex, Laurent

Published
2022
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4. More Than 50 Percent Reduction in LDL Cholesterol in Patients With Target LDL <70 mg/dL After a Stroke

Author

Amarenco, Pierre, Lavallée, Philippa C., Kim, Jong S., Labreuche, Julien, Charles, Hugo, Giroud, Maurice, Lee, Byung-Chul, Mahagne, Marie-Hélène, Meseguer, Elena, Nighoghossian, Norbert, Steg, Philippe Gabriel, Vicaut, Éric, Bruckert, Eric, Kim, Jong S, Touboul, Pierre-Jean, Leys, Didier, Béjot, Yannick, Pico, Fernando, Touzé, Emmanuel, Ducrocq, Gregory, Abtan, Jérémy, Varenne, Olivier, Touboul, Pierre-Jean, Kemmel, Agnes, Syana, Fausta, Ledra, Manele, Nagasara, Tharani, Ledjeroud, Mervette, Samia, Bahous, Hadia, Hafirassou, Hazare, Benyoub, Jaghouni, Ikrame El, Yelles, Nessima, Zemouri, Sofia, Ladjeroud, Mervette, Kerai, Salim, In, YunJeong, Hobeanu, Cristina, Guidoux, Celine, Cabrejo, Lucie, Lapergue, Bertrand, Sabben, Candice, Gonzalez-Valcarcel, Jaime, Rigual, Ricardo, Sirimarco, Gaia, Martin-Bechet, Anna, Viedma, Elena, Avram, Ioan, Samson, Yves, Rosso, Charlotte, Crozier, Sophie, Leder, Sara, Léger, Anne, Deltour, Sandrine, Mutlu, Gurkan, Yger, Marion, Zavanone, Chiara, Baronnet, Flore, Pires, Christine, Lapergue, Bertrand, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Bourdain, Frédéric, Lopez, Delphine, Pico, Fernando, de la Tour, Laetitia Bayon, Chadenat, Marie-Laure, Duong, Duc Long, Genty, Solène, Hirel, Catherine, Mutlu, Gurkan, Nifle, Chantal, Servan, Jérôme, Stanciu, Daniela, Sudacevschi, Veronica, Tir, Mélissa, Troussière, Anne-Cécile, Yeung, Jennifer, Zeghoudi, Anne-Céline, Tidafi-Bayou, Ikram, Lachaud, Sylvain, Cho, Tae-Hee, Mechtouff, Laura, Ritzenthaller, Thomas, Derex, Laurent, Albanesi, Carlo, Ong, Elodie, Benoit, Amandine, Berhoune, Nadia, Felix, Sandra, Esteban-Mader, Maud, Sibon, Igor, Kazadi, Annabelle, Rouanet, François, Renou, Pauline, Debruxelles, Sabrina, Poli, Mathilde, Sagnier, Sharmila, Mas, Jean-Louis, Domigo, Valérie, Lamy, Catherine, Bodiguel, Eric, Grimaud, Jérôme, Bohotin, Valentin, Obadia, Michael, Sabben, Candice, Morvan, Erwan, Rodier, Gilles, Vadot, Wilfried, Hénon, Hilde, Cordonnier, Charlotte, Dumont, Frédéric, Bodenant, Marie, Lucas, Christian, Moulin, Solène, Dequatre, Nelly, Alamowitch, Sonia, Muresan, Jean-Paul, Drouet, Thomas, Gallea, Magalie, Dalloz, Marie-Amélie, Delorme, Stephen, Yger, Marion, Béjot, Yannick, Loisel, Philippe, Bonnin, Carine, Bernigal, Virginie, Osseby, Guy Victor, Hervieu-BègueMarsac, Marie, Garnier, Pierre, Accassat, Sandrine, Epinat, Magali, Varvat, Jérôme, Marinescu, Doïna, Triquenot-Bagan, Aude, Ozkul- Wermester, Ozlem, Philippeau, Frédéric, Olaru, Angel, Vieillart, Anne, Lannuzel, Annie, Demoly, Alice, Wolff, Valérie, Diaconu, Mihaela, Bataillard, Marc, Montoro, Francisco Macian, Faugeras, Frédéric, Gimenez, Laeticia, Abdallah-Lebeau, Françoise, Timsit, Serge, Viakhireva-Dovganyuk, Irina, Tirel-Badets, Anne, Merrien, François-Mathias, Goas, Philippe, Rouhart, François, Jourdain, Aurore, Guillon, Benoit, Hérissson, Fanny, Sevin-Allouet, Mathieu, Nasr, Nathalie, Olivot, Jean-Marc, Lecluse, Alderic, Marc, Guillaume, Touzé, Emmanuel, de la Sayette, Vincent, Apoil, Marion, Lin, Li, Cogez, Julien, Guettier, Sophie, Godefroy, Olivier, Lamy, Chantal, Bugnicourt, Jean-Marc, Taurin, Grégory, Mérienne, Marc, Gere, Julien, Chessak, Anne-Marie, Habet, Tarik, Ferrier, Anna, Bourgois, Nathalie, Minier, Dominique, Caillier-Minier, Marie, Contégal- Callier, Fabienne, Vion, Philippe, Vaschalde, Yvan, Amrani, Mohammed El, Emilie, Zuber, Mathieu, Bruandet, Marie, Join- Lambert, Claire, Garcia, Pierre-Yves, Serre, Isabelle, Faucheux, Jean-Marc, Radji, Fatia, Leca-Radu, Elena, Debroucker, Thomas, Cumurcuc, Rodica, Cakmak, Serkan, Peysson, Stéphane, Ellie, Emmanuel, Bernady, Patricia, Moulin, Thierry, Montiel, Paola, Revenco, Eugeniu, Decavel, Pierre, Medeiros, Elisabeth, Bouveret, Myriam, Louchart, Pierre, Vaduva, Claudia, Couvreur, Grégory, Sartori, Eric, Carpentier, Alnajar, Levasseur, Michèle, Louchart, Pierre, Faucheux, Jean-Marc, Neau, Philippe, Vandamme, Xavier, Meresse, Isabelle, Stantescu, Bataillard, Marc, Ozsancak, Canan, Beauvais, Katell, Auzou, Pascal, Amevigbe, Joséphine, Vuillemet, Francis, Dugay-Arentz, Marie-Hélène, Carelli, Gabriela, Martinez, Mikel, Maillet-Vioud, Marcel, Escaillas, Jean-Pierre, Chapuis, Stéphane, Tardy, Jean, Manchon, Eric, Varnet, Olivier, Kim, Yong-Jae, Chang, Yoonkyung, Song, Tae-Jin, Kim, Jong Sung, Han, Jung-Hoon, Noh, Kyung Chul, Lee, Eun-Jae, Kang, Dong-Wha, Kwon, Sun Uck, Kwon, Boseoung, Park, Seongho, Lee, Dongwhane, Kwon, Hyuk Sung, Jeong, Daeun, Lee, MinHwan, Kim, Joonggoo, Lee, Hanbin, Nam, Hyo Jung, Lee, Sang Hun, Kim, Bum Joon, Cha, Jae-kwan, Kim, DaeHyun, Kim, Rae Young, Sohn, Sang Wuk, Shim, Dong-Hyun, Lee, Hyungjin, Nah, Hyun-Wook, Sung, Sang Min, Lee, Kyung Bok, Yoon Lee, Jeong, Yoon, Jee Eun, Kim, Eung-Gyu, Seo, Jung Hwa, Kim, Yong-Won, Hwang, Yangha, Park, Man Seok, Kim, Joon-Tae, Choi, Kang-Ho, Nam, Hyo Suk, Heo, Ji Hoe, Kim, Young Dae, Hwang, In Gun, Park, Hyung Jong, Kim, Kyoung Sub, Baek, Jang Hyun, Song, Dong Beom, Yoo, Joon Sang, Park, Jong-Moo, Kwon, Ohyun, Lee, Woong-Woo, Lee, Jung-Ju, Kang, Kyusik, Kim, Byung Kun, Lim, Jae-Sung, Oh, Mi Sun, Yu, Kyung-Ho, Hong, Bora, Jang, Mihoon, Jang, Seyoung, Jin, Jung Eun, Kim, Jei, Jeong, Hye Seon, Hong, Keun Sik, Park, Hong Kyun, Cho, Yong Jin, Bang, Oh Young, Seo, Woo-Keun, and Chung, Jongwon

Published
2023
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6. Endovascular Therapy or Medical Management Alone for Isolated Posterior Cerebral Artery Occlusion: A Multicenter Study

Author

Sabben, Candice, Charbonneau, Frédérique, Delvoye, François, Strambo, Davide, Heldner, Mirjam R., Ong, Elodie, Ter Schiphorst, Adrien, Henon, Hilde, Ben Hassen, Wagih, Agasse-Lafont, Thomas, Legris, Loïc, Sibon, Igor, Wolff, Valérie, Sablot, Denis, Elhorany, Mahmoud, Preterre, Cécile, Nehme, Nour, Soize, Sébastien, Weisenburger-Lile, David, Triquenot-Bagan, Aude, Mione, Gioia, Aignatoaie, Andreea, Papassin, Jérémie, Poll, Roxana, Béjot, Yannick, Carrera, Emmanuel, Garnier, Pierre, Michel, Patrik, Saliou, Guillaume, Mordasini, Pasquale, Berthezene, Yves, Costalat, Vincent, Bricout, Nicolas, Albers, Gregory W., Mazighi, Mikael, Turc, Guillaume, Seners, Pierre, Antonenko, Kateryna, Arquizan, Caroline, Benammar, Lynda, Boutet, Claire, Clarençon, Frédéric, Comby, Pierre-Olivier, Desal, Hubert, Detante, Olivier, Eugene, François, Gerardin, Emmanuel, Gory, Benjamin, Kremer, Stéphane, Ledure, Sylvain, Krug, Mathieu, Lapergue, Bertrand, Niclot, Philippe, Magni, Christophe, Obadia, Michael, Ozsancak, Canan, Pico, Fernando, Pilgram-Pastor, Sara, Pop, Raoul, Richard, Sébastien, Rosso, Charlotte, Savatovsky, Julien, Moulin, Solène, Tracol, Clément, and Zbinden, Martin

Published
2023
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7. Effect of the COVID-19 pandemic on acute stroke reperfusion therapy: data from the Lyon Stroke Center Network

Author

Plumereau, Cécile, Cho, Tae-Hee, Buisson, Marielle, Amaz, Camille, Cappucci, Matteo, Derex, Laurent, Ong, Elodie, Fontaine, Julia, Rascle, Lucie, Riva, Roberto, Schiavo, David, Benhamed, Axel, Douplat, Marion, Bony, Thomas, Tazarourte, Karim, Tuttle, Célia, Eker, Omer Faruk, Berthezène, Yves, Ovize, Michel, Nighoghossian, Norbert, and Mechtouff, Laura

Published
2021
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9. Collateral circulation assessment within the 4.5 h time window in patients with and without DWI/FLAIR MRI mismatch

Author

Berthezène, Yves, Eker, Omer, Makris, Nikolaos, Bettan, Maxime, Mansuy, Adeline, Chabrol, Aurélie, Mikkelsenm, Irene K., Hermier, Marc, Mechtouff, Laura, Ong, Elodie, Derex, Laurent, Berner, Lise-Prune, Ameli, Roxana, Pedraza, Salvador, Thomalla, Gotz, Østergaard, Leif, Baron, Jean-Claude, Cho, Tae-Hee, and Nighoghossian, Norbert

Published
2018
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11. In vivo targeting and multimodal imaging of cerebral amyloid-β aggregates using hybrid GdF3 nanoparticles.

Author

Lerouge, Frédéric, Ong, Elodie, Rositi, Hugo, Mpambani, Francis, Berner, Lise-Prune, Bolbos, Radu, Olivier, Cécile, Peyrin, Françoise, Apputukan, Vinu K, Monnereau, Cyrille, Andraud, Chantal, Chaput, Frederic, Berthezène, Yves, Braun, Bettina, Jucker, Mathias, Åslund, Andreas KO, Nyström, Sofie, Hammarström, Per, R Nilsson, K Peter, and Lindgren, Mikael

Abstract

Aim: To propose a new multimodal imaging agent targeting amyloid-β (Aβ) plaques in Alzheimer's disease. Materials & methods: A new generation of hybrid contrast agents, based on gadolinium fluoride nanoparticles grafted with a pentameric luminescent-conjugated polythiophene, was designed, extensively characterized and evaluated in animal models of Alzheimer's disease through MRI, two-photon microscopy and synchrotron x-ray phase-contrast imaging. Results & conclusion: Two different grafting densities of luminescent-conjugated polythiophene were achieved while preserving colloidal stability and fluorescent properties, and without affecting biodistribution. In vivo brain uptake was dependent on the blood–brain barrier status. Nevertheless, multimodal imaging showed successful Aβ targeting in both transgenic mice and Aβ fibril-injected rats. The design and study of a new contrast agent targeting amyloid-β (Aβ) plaques in Alzheimer's disease (AD) is proposed. Aβ plaques are the earliest pathological sign of AD, silently appearing in the brain decades before the symptoms of the disease are manifested. While current detection of Aβ plaques is based on nuclear medicine (a technique using a radioactive agent), a different kind of contrast agent is here evaluated in animal models of AD. The contrast agent consists of a nanoparticle made of gadolinium and fluorine ions (core), and decorated with a molecule previously shown to bind to Aβ plaques (grafting). The core is detectable with MRI and x-ray imaging, while the grafting molecule is detectable with fluorescence imaging, thus allowing different imaging methods to be combined to study the pathology. In this work, the structure, stability and properties of the contrast agent have been verified in vitro (in tubes and on brain sections). Then the ability of the contrast agent to bind to Aβ plaques and provide a detectable signal in MRI, x-ray or fluorescence imaging has been demonstrated in vivo (in rodent models of AD). This interdisciplinary research establishes the proof of concept that this new class of versatile agent contrast can be used to target pathological processes in the brain. New multimodal contrast agent developed at University of Lyon: a functionalized gadolinium-based nanoparticle shows successful targeting of amyloid-β fibrils and in vivo detection with two-photon microscopy and MRI in animal models of Alzheimer's disease. [ABSTRACT FROM AUTHOR]

Published
2022
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13. A lower admission level of interleukin-6 is associated with first-pass effect in ischemic stroke patients.

Author

Mechtouff, Laura, Bochaton, Thomas, Paccalet, Alexandre, Da Silva, Claire Crola, Buisson, Marielle, Amaz, Camille, Derex, Laurent, Ong, Elodie, Berthezene, Yves, Dufay, Nathalie, Ovize, Michel, Mewton, Nathan, Tae-Hee Cho, Nighoghossian, Norbert, and Eker, Omer F.

Subjects
INTERLEUKINS, BIOMARKERS, C-reactive protein, CONFIDENCE intervals, ISCHEMIC stroke, INFLAMMATION, MULTIVARIATE analysis, PATIENTS, MAGNETIC resonance imaging, HOSPITAL admission & discharge, VEIN surgery, TREATMENT effectiveness, THROMBECTOMY, ENZYME-linked immunosorbent assay, STROKE patients, DESCRIPTIVE statistics, LOGISTIC regression analysis, ODDS ratio
Abstract

Background First-pass effect (FPE) defined as a complete or near-complete reperfusion achieved after a single thrombectomy pass is predictive of favorable outcome in acute ischemic stroke (AIS) patients. We aimed to assess whether admission levels of inflammatory markers are associated with FPE. Methods HIBISCUS-STROKE (CoHort of Patients to Identify Biological and Imaging markerS of CardiovascUlar Outcomes in Stroke) includes AIS patients with large vessel occlusion treated with mechanical thrombectomy following brain MRI. C-reactive protein, interleukin (IL)-6, IL-8, IL-10, monocyte chemoattractant protein-1, soluble tumor necrosis factor receptor I, soluble form suppression of tumorigenicity 2, matrix metalloproteinase-9 (MMP-9), soluble P-selectin, and vascular cellular adhesion molecule-1 were measured in admission sera using an ELISA assay. FPE was defined as a complete or near-complete reperfusion (thrombolysis in cerebral infarction scale (TICI) 2c or 3) after the first pass. A multivariate logistic regression analysis was performed to assess independent factors associated with FPE. Results A total of 151 patients were included. Among them, 43 (28.5%) patients had FPE. FPE was associated with low admission levels of IL-6, MMP-9, and platelet count, an older age, lack of hypertension, lack of tandem occlusion, a shorter thrombus length, and a reduced procedural time. Following multivariate analysis, a low admission level of IL-6 was associated with FPE (OR 0.66, 95% CI 0.46 to 0.94). Optimal cut-off of IL-6 level for distinguishing FPE from non-FPE was 3.0 pg/mL (sensitivity 92.3%, specificity 42.3%). Conclusion A lower admission level of IL-6 is associated with FPE. [ABSTRACT FROM AUTHOR]

Published
2022
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14. Does the Brush-Sign Reflect Collateral Status and DWI-ASPECTS in Large Vessel Occlusion?

Author

Rascle, Lucie, Bani Sadr, Alexandre, Amaz, Camille, Mewton, Nathan, Buisson, Marielle, Hermier, Marc, Ong, Elodie, Fontaine, Julia, Derex, Laurent, Berthezène, Yves, Eker, Omer Faruk, Cho, Tae-Hee, Nighoghossian, Norbert, and Mechtouff, Laura

Subjects
DIGITAL subtraction angiography, INTERNAL carotid artery, ISCHEMIC stroke, CEREBRAL arteries
Abstract

Introduction: The relevance of the brush-sign remained poorly documented in large vessel occlusion (LVO). We aimed to assess the relationship between the brush-sign and collateral status and its potential impact on baseline diffusion-weighted imaging–Alberta Stroke Program Early Computed Tomography Score (DWI-ASPECTS) in acute ischemic stroke (AIS) patients eligible to mechanical thrombectomy (MT). Methods: Consecutive patients admitted in the Lyon Stroke Center with anterior circulation AIS due to intracranial internal carotid artery (ICA) and/or M1 or M2 segment of the middle cerebral artery (MCA) occlusion eligible for MT were included. The brush-sign was assessed on T2-gradient-echo MRI. Collateral status was assessed on digital subtraction angiography according to the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) score. Results: In this study, 504 patients were included, among which 171 (33.9%) patients had a brush-sign. Patients with a brush-sign more frequently had a poor collateral status [72 (42.1%) vs. 103 (30.9%); p = 0.017]. In univariable analysis, a DWI-ASPECTS < 7 was associated with a brush sign. Following multivariable analysis, the brush-sign no longer affected DWI-ASPECTS < 7 while the latter remained associated with younger age [odds ratio (OR) 0.97, 95% CI.96–0.99], male sex (OR 1.79, 95% CI 1.08–2.99), a higher National Institutes of Health Stroke Scale (NIHSS) score (OR 1.16, 95% CI 1.1–1.21), a poor collateral status (OR 9.35, 95% CI 5.59-16.02), MCA segment (OR 2.54, 95% CI 1.25–5.38), and intracranial ICA (OR 3.01, 95% CI 1.16–8) occlusion. Conclusions and Relevance: The brush-sign may be a marker of poor collateral status but did not independently predict a lower DWI-ASPECTS. Clinical Trial Registration: ClinicalTrials.gov, identifier: NCT04620642. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Temporal trends in reperfusion therapy for patients with acute ischemic stroke.

Author

El Khoury, Carlos, Aboa-Eboule, Corine, Fraticelli, Laurie, Claustre, Clément, Bischoff, Magali, Blanc-Lasserre, Karine, Buisson, Marielle, Cakmak, Serkan, Tee-hi Cho, Ferroud-Plattet, Bruno, Guerrier, Olivier, Philippeau, Frédéric, Serre, Patrice, Mechtouff, Laura, Nighoghossian, Norbert, Ruzteroltz, Thierry, Vallet, Anne-Evelyne, Ong, Elodie, and Derex, Laurent

Published
2022
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21. Clinical Imaging of Choroid Plexus in Health and in Brain Disorders: A Mini-Review.

Author

Hubert, Violaine, Chauveau, Fabien, Dumot, Chloé, Ong, Elodie, Berner, Lise-Prune, Canet-Soulas, Emmanuelle, Ghersi-Egea, Jean-François, and Wiart, Marlène

Subjects
CHOROID plexus, BRAIN diseases, NEURAL development, BIOLOGICAL tags, IRON oxide nanoparticles
Abstract

The choroid plexuses (ChPs) perform indispensable functions for the development, maintenance and functioning of the brain. Although they have gained considerable interest in the last years, their involvement in brain disorders is still largely unknown, notably because their deep location inside the brain hampers non-invasive investigations. Imaging tools have become instrumental to the diagnosis and pathophysiological study of neurological and neuropsychiatric diseases. This review summarizes the knowledge that has been gathered from the clinical imaging of ChPs in health and brain disorders not related to ChP pathologies. Results are discussed in the light of pre-clinical imaging studies. As seen in this review, to date, most clinical imaging studies of ChPs have used disease-free human subjects to demonstrate the value of different imaging biomarkers (ChP size, perfusion/permeability, glucose metabolism, inflammation), sometimes combined with the study of normal aging. Although very few studies have actually tested the value of ChP imaging biomarkers in patients with brain disorders, these pioneer studies identified ChP changes that are promising data for a better understanding and follow-up of diseases such as schizophrenia, epilepsy and Alzheimer's disease. Imaging of immune cell trafficking at the ChPs has remained limited to pre-clinical studies so far but has the potential to be translated in patients for example using MRI coupled with the injection of iron oxide nanoparticles. Future investigations should aim at confirming and extending these findings and at developing translational molecular imaging tools for bridging the gap between basic molecular and cellular neuroscience and clinical research. [ABSTRACT FROM AUTHOR]

Published
2019
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22. Impact of the Thrombectomy Trials on the Management and Outcome of Large Vessel Stroke: Data From the Lyon Stroke Center.

Author

Viannay, Louis, Haesebaert, Julie, Florin, Fannie, Riva, Roberto, Mechtouff, Laura, Gory, Benjamin, Ong, Elodie, Labeyrie, Paul-Emile, Derex, Laurent, Hermier, Marc, Chamard, Leila, Berner, Lise-Prune, Ameli, Roxana, Berthezène, Yves, Turjman, Francis, Nighoghossian, Norbert, and Cho, Tae-Hee

Subjects
STROKE patients, CLINICAL trials, BLOOD coagulation disorders
Abstract

Introduction: Randomized trials (RT) have recently validated the superiority of thrombectomy over standard medical care, including intravenous thrombolysis (IVT). However, data on their impact on routine clinical care remains scarce. Methods: Using a prospective observational registry, we assessed: (1) the clinical and radiological characteristics of all consecutive patients treated with thrombectomy; (2) the outcome of all patients with M1 occlusion (treated with thrombectomy or IVT alone). Two periods were compared: before (2013–2014) and after (2015–2016) the publication of RT. Results: Endovascular procedures significantly increased between the two periods (N = 82 vs. 314, p < 0.0001). In 2015–2016, patients were older (median [IQR]: 69 [57-80]; vs. 66 [53-74]; p = 0.008), had shorter door-to-clot times (69 [47-95]; vs. 110 [83-155]; p < 0.0001) resulting in a trend toward shorter delay from symptom onset to reperfusion (232 [185-300]; vs. 250 [200-339]; p = 0.1), with higher rates of reperfusion (71 vs. 48%; p = 0.0001). Conversely, no significant differences in baseline NIHSS scores, ASPECTS, delay to IVT or intracranial hemorrhage were found. In 2015–2016, patients with M1 occlusion were treated with thrombectomy more often than in 2013–2014 (87 vs. 32%, respectively; p < 0.0001), with a significant improvement in clinical outcome (shift analysis, lower modified Rankin scale scores: OR = 1.68; 95% CI: 1.10–2.57; p = 0.017). Conclusion: Following the publication of RT, thrombectomy was rapidly implemented with significant improvements in intrahospital delay and reperfusion rates. Treatment with thrombectomy increased with better clinical outcomes in patients with M1 occlusion. [ABSTRACT FROM AUTHOR]

Published
2018
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23. Effect of Cyclosporine on Lesion Growth and Infarct Size Within the White and Gray Matter.

Author

Ong, Elodie, Mewton, Nathan, Bouvier, Julien, Chauveau, Fabien, Ritzenthaler, Thomas, Mechtouff, Laura, Derex, Laurent, Buisson, Marielle, Berthezène, Yves, Ovize, Michel, Nighoghossian, Norbert, and Tae-Hee Cho

Subjects
CYCLOSPORINE, GRAY matter (Nerve tissue), ISCHEMIA
Abstract

Background: In a recent trial, cyclosporine A (CsA) failed to reduce infarct size in acute stroke patients treated with intravenous thrombolysis. White matter (WM) and gray matter (GM) may have distinct vulnerability to ischemia and response to therapy. Using final infarct size and lesion growth as endpoints, our objectives were to (1) investigate any tissue-specific effect of CsA and (2) compare WM and GM response to thrombolysis. Materials and methods: We analyzed 84 patients from the randomized and placebocontrolled CsA-Stroke trial, who underwent MRI both on admission and at 1 month. Lesion growth was defined voxel-wise as infarcted tissue at 1 month with no visible lesion on baseline diffusion-weighted imaging. After automatic segmentation of GM/WM, final infarct size and lesion growth were compared within the GM and WM. Results: Occlusion level was distal (>M1) in 51% of cases. No significant difference in GM/WM proportions was observed within final infarcts between treatment groups (P = 0.21). Infarct size within the GM or WM was similar between the CsA and control groups [GM: 9.2 (2.4; 22.8) with CsA vs 8.9 (3.7; 28.4) mL with placebo, P = 0.74; WM: 9.9 (4.7; 25.4) with CsA vs 14.1 (5.6; 34.1) mL with placebo, P = 0.26]. There was no significant effect of CsA on lesion growth in either the GM or WM. Pooling all patients, a trend for increased relative lesion growth in WM compared to GM was observed [49.0% (14.7; 185.7) vs 43.1% (15.4; 117.1), respectively; P = 0.12]. Conclusion: No differential effect of CsA was observed between WM and GM. Pooling all patients, a trend toward greater lesion growth in WM was observed. [ABSTRACT FROM AUTHOR]

Published
2017
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24. MRI Profile and Collateral Status in Patients with a Transient Ischemic Attack and an Intracranial Artery Occlusion.

Author

Ong, Elodie, Derex, Laurent, Mechtouff, Laura, Cho, Tae Hee, Nighoghossian, Norbert, Chamard, Leila, Eker, Omer, Berthezene, Yves, and Buisson, Marielle

Subjects
*COLLATERAL circulation, *BLOOD circulation, *INTRACRANIAL aneurysms, *CEREBROVASCULAR disease, *INTRACRANIAL arterial diseases
Abstract

Background and Purpose: Transient ischemic attack may rarely reveal an intracranial artery occlusion. We analyzed acute magnetic resonance imaging (MRI) patterns and early outcome after reperfusion therapy in these cases.Method: Clinical and imaging data were taken retrospectively from our comprehensive stroke center registry. Two MRI patterns were determined. Pattern A: full mismatch with negative diffusion-weighted imaging (DWI) and perfusion defect. Pattern B: large mismatch with positive DWI and perfusion defect. MRI-derived collateral flow maps were automatically generated from the raw of dynamic susceptibility contrast MRI. Patients were treated either by recombinant tissue plasminogen activator (rtPA) alone or in combination with mechanical thrombectomy.Results: From October 1, 2010 to May 15, 2016, 1,019 patients were admitted and treated by t-PA within 4.5 hours of stroke onset of them; 14 had a transient ischemic attack (TIA) within the 6 hours preceding MRI. Perfusion imaging was performed in 11 patients. An arterial occlusion was found in all of them, 11 patients had a distal anterior circulation occlusion, whereas 3 patients (21%) had a proximal occlusion. According to MRI, 6 patients showed pattern A, whereas 5 patients had pattern B. Good collaterals were observed in 10 patients (6 patients with grade 3 and 4 patients with grade 4), whereas 1 patient had poor collaterals (grade 2). The day 1 National Institutes of Health Stroke Scale median was 0. Modified Rankin Scale median at 3 months was 0.Conclusion: TIAs may reveal acute intracranial artery occlusion. Acute MRI may able to assist in therapeutic decision. [ABSTRACT FROM AUTHOR]

Published
2019
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25. Cyclosporine A, a Potential Therapy of Ischemic Reperfusion Injury. A Common History for Heart and Brain.

Author

Nighoghossian, Norbert, Ovize, Michel, Mewton, Nathan, Ong, Elodie, and Cho, Tae-Hee

Subjects
CYCLOSPORINE, TREATMENT of reperfusion injuries, IMMUNOSUPPRESSIVE agents
Abstract

Background: Ischemic stroke (IS) and acute myocardial infarction require emergency reperfusion tissue in order to improve functional outcome. Intra-arterial thrombectomy recently showed very encouraging improvement in IS patients' outcome. However, endovascular methods enhancing reperfusion may expose patients to increase in ischemic reperfusion injury. Experimental evidence indicates that brain ischemic reperfusion injury may be attenuated by ischemic pre- and post-conditioning. The opening of mitochondrial permeability transition pore plays a critical role in the onset of reperfusion damage. This mechanism can be inhibited by immunosuppressive drugs like cyclosporine A (CsA). Summary: In this review, we present existing experimental and clinical data suggesting that conditioning interventions may prevent brain ischemic reperfusion injury and future challenge for neuroprotection by CsA in acute IS. Key Messages: The concept of conditioning has been recently investigated clinically but to a lesser extent in the realm of IS. Recent experimental and phase II clinical research has suggested potential neuroprotective properties of cyclosporine; however, further larger clinical trials are needed to demonstrate that CsA improves clinical outcome in acute IS patients. [ABSTRACT FROM AUTHOR]

Published
2016
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26. Outcomes of stent retriever thrombectomy in basilar artery occlusion: an observational study and systematic review.

Author

Gory, Benjamin, Eldesouky, Islam, Sivan-Hoffmann, Rotem, Rabilloud, Murielle, Ong, Elodie, Riva, Roberto, Nicolae Gherasim, Dorin, Turjman, Alexis, Nighoghossian, Norbert, Turjman, Francis, and Gherasim, Dorin Nicolae

Subjects
ARTERIAL occlusions, ETIOLOGY of stroke, STROKE-related mortality, STROKE treatment, META-analysis, CEREBRAL infarction, THERAPEUTICS, DISEASE risk factors
Abstract

Background: Basilar artery occlusion (BAO) remains one of the most devastating subtypes of stroke with high mortality and poor outcome. Early recanalisation is the most powerful predictor of favourable outcome in patients with stroke, and may be improved with mechanical thrombectomy using stent retriever devices. However, the benefit in functional outcome and safety of stent retrievers are not yet well known. The aim of this study was to assess efficacy and safety profiles of stent retriever thrombectomy in BAO patients with stroke.Methods: We analysed data retrospectively from our consecutive clinical series and conducted a systematic review and meta-analysis of all previous studies of stent retriever thrombectomy in BAO patients with stroke between November 2010 and April 2014.Results: From March 2010 to March 2013, 22 patients with acute BAO were treated with a Solitaire stent retriever in our series. Favourable outcome was significantly associated with younger age and distal BAO. The literature search identified 15 previous studies involving a total of 312 subjects. In the meta-analysis, including our series data, the recanalisation rate (Thrombolysis In Cerebral Infarction (TICI) score ≥ 2b) reached 81% (95% CI 73% to 87%). The rate of symptomatic intracranial haemorrhage was 4% (95% CI 2% to 8%), favourable outcome (modified Rankin Scale (mRS) ≤ 2 at 3 months) was found in 42% (95% CI 36% to 48%) and mortality rate was 30% (95% CI 25% to 36%).Conclusions: Stent retriever thrombectomy is a safe treatment modality for patients with stroke presenting with BAO. Although the stent retrievers showed a good recanalisation rate, there are currently no randomised clinical trials to assess its clinical efficacy in comparison with the reference treatment. [ABSTRACT FROM AUTHOR]

Published
2016
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31. MRI coupled with clinically-applicable iron oxide nanoparticles reveals choroid plexus involvement in a murine model of neuroinflammation.

Author

Hubert, Violaine, Dumot, Chloé, Ong, Elodie, Amaz, Camille, Canet-Soulas, Emmanuelle, Chauveau, Fabien, and Wiart, Marlène

Abstract

Choroid plexus (ChPs) are involved in the early inflammatory response that occurs in many brain disorders. However, the activation of immune cells within the ChPs in response to neuroinflammation is still largely unexplored in-vivo. There is therefore a crucial need for developing imaging tool that would allow the non-invasive monitoring of ChP involvement in these diseases. Magnetic resonance imaging (MRI) coupled with superparamagnetic particles of iron oxide (SPIO) is a minimally invasive technique allowing to track phagocytic cells in inflammatory diseases. Our aim was to investigate the potential of ultrasmall SPIO (USPIO)-enhanced MRI to monitor ChP involvement in-vivo in a mouse model of neuroinflammation obtained by intraperitoneal administration of lipopolysaccharide. Using high resolution MRI, we identified marked USPIO-related signal drops in the ChPs of animals with neuroinflammation compared to controls. We confirmed these results quantitatively using a 4-points grading system. Ex-vivo analysis confirmed USPIO accumulation within the ChP stroma and their uptake by immune cells. We validated the translational potential of our approach using the clinically-applicable USPIO Ferumoxytol. MR imaging of USPIO accumulation within the ChPs may serve as an imaging biomarker to study ChP involvement in neuroinflammatory disorders that could be applied in a straightforward way in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2019
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33. Inflammatory profile and white matter hyperintensity burden in acute ischemic stroke patients.

Author

Rascle, Lucie, Nighoghossian, Norbert, Cho, Tae-Hee, Bochaton, Thomas, Paccalet, Alexandre, Crola Da Silva, Claire, Buisson, Marielle, Amaz, Camille, Fontaine, Julia, Ong, Elodie, Derex, Laurent, Berthezene, Yves, Eker, Omer Faruk, Mewton, Nathan, Ovize, Michel, and Mechtouff, Laura

Subjects
*STROKE patients, *WHITE matter (Nerve tissue), *ISCHEMIC stroke, *CEREBRAL small vessel diseases
Abstract

Inflammation is involved in small vessel disease (SVD). We aim to clarify whether inflammation related to white matter hyperintensities (WMH), a key component of SVD, may affect the inflammatory response in acute ischemic stroke (AIS) patients. For this, we sequentially measured 10 circulating inflammatory markers and assessed WMH burden on admission MRI in AIS patients treated with thrombectomy. Of 149 patients, 57 (38.3%) had a high WMH burden (Fazekas≥3). A high WMH burden was associated with 4 markers levels but this association did not remain following multivariable analyses. WMH burden is not associated with a specific inflammatory profile in AIS. [Display omitted] • 57 (38.3%) patients had a high white matter hyperintensity (WMH) burden (Fazekas≥3). • Univariable analysis showed an association between 4 markers levels and WMH burden. • None of these associations remained following multivariable analysis. [ABSTRACT FROM AUTHOR]

Published
2022
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