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3. Sialyl α(2→3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers

Author

Oka, Hiroyuki, Onaga, Tomotsune, Koyama, Tetsuo, Guo, Chao-Tan, Suzuki, Yasuo, Esumi, Yasuaki, Hatano, Ken, Terunuma, Daiyo, and Matsuoka, Koji

Subjects
*RESPIRATORY infections, *INFECTION, *RESPIRATORY diseases, *COMMON cold
Abstract

Abstract: An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with sialyl α(2→3) lactose (Neu5Acα(2→3)Galβ(1→4)Glcβ1→) moieties was accomplished. The results of a preliminary study on biological responses against influenza virus hemagglutinin, using the sialyl lactose clusters showed unique biological activities on the basis of the structure–activity relationship according to the carbosilane scaffolds. [Copyright &y& Elsevier]

Published
2008
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