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42. Virtual Speech System Based on Sensing Technology and Teaching Management in Universities

Author

Niu Yan

Subjects
compressed sensing technology, interactive 3d speech, frequency domain parameter compression, speech coding, speech feature extraction, 97c70, Mathematics, QA1-939
Abstract

In this paper, digital speech is compressed using discrete Fourier transform, discrete cosine transform, and improved discrete cosine transform, and compressed sensing technology is proposed. Based on the compressed sensing technology, the frequency domain parameter compression algorithm and the speech coding and decoding algorithm are designed, and the interactive 3D virtual speech system design is completed through the pre-processing of the speech system, the extraction of speech features and the design of speech control commands. The virtual voice system designed in this paper is introduced in the teaching management mode of colleges and universities, and the main functions of the system include four major sections: notification management, online Q&A, virtual voice system interaction, and teaching resource management. The virtual voice system built using sensing technology is simulated and tested, and the practical application effect of the system is studied through empirical analysis. The experimental results show that the amplitude of the sound recorded by the compression sensor in the voice sensing experiment is more concentrated, the range is concentrated between [-0.025,0.025], and the detected voice is smaller and more effective than the amplitude recorded by the cell phone. Students were mainly satisfied and very satisfied with the four system functions designed in this paper, and in terms of the online Q&A function, only one student expressed great dissatisfaction and the total number of satisfied people was 119, and the students were highly satisfied with the teaching management of the system designed in this study.

Published
2024
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44. A chimeric influenza virus vaccine expressing fusion protein epitopes induces protection from human metapneumovirus challenge in mice

Author

Tian Chongyu, Lei Guanglin, Sun Fang, Deng Zhuoya, Yang Hao, Li Cong, Li Xinyu, He Wei, Tan Lingyun, Niu Yan, and Yang Penghui

Subjects
influenza virus, RG technology, HMPV, fusion protein, HMPV vaccine, Microbiology, QR1-502
Abstract

Human metapneumovirus (HMPV) is a common virus associated with acute respiratory distress syndrome in pediatric patients. There are no HMPV vaccines or therapeutics that have been approved for prevention or treatment. In this study, we constructed a novel recombinant influenza virus carrying partial HMPV fusion protein (HMPV-F), termed rFLU-HMPV/F-NS, utilizing reverse genetics, which contained (HMPV-F) in the background of NS segments of influenza virus A/PuertoRico/8/34(PR8). The morphological characteristics of rFLU-HMPV/F-NS were consistent with the wild-type flu virus. Additionally, immunofluorescence results showed that fusion proteins in the chimeric rFLU-HMPV/F-NS could work well, and the virus could be stably passaged in SPF chicken embryos. Furthermore, intranasal immunization with rFLU-HMPV/F-NS in BALB/c mice induced robust humoral, mucosal and Th1-type dominant cellular immune responses in vivo. More importantly, we discovered that rFLU-HMPV/F-NS afforded significant protective efficacy against the wild-type HMPV and influenza virus challenge, with significantly attenuated pathological changes and reduced viral titers in the lung tissues of immunized mice. Collectively, these findings demonstrated that chimeric recombinant rFLU-HMPV/F-NS as a promising HMPV candidate vaccine has potentials for the development of HMPV vaccine.

Published
2023
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