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Objective: There is no evidence about the effects of personal traits on physical health, mental health and health-related quality of life (HRQOL) in healthcare workers in Vietnam, particularly during the COVID-19 pandemic. This study aimed to measure associations between the personality of healthcare workers (HCWs) in Vietnam and their physical health, mental health and health-related quality of life (HRQOL). Methods: A multi-centre cross-sectional study was conducted on 245 HCWs in Hanoi, Vietnam, during the COVID-19 pandemic. The Eysenck Personality Inventory (EPI) was used to measure HCWs’ personality. Physical Health Questionnaire-14 (PHQ-14), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder – 7 (GAD7) and EuroQOL-5 Dimensions-5 Levels (EQ-5D-5 L) instruments were used to measure physical health, mental health and HRQOL. Multivariate Tobit regression models were used. Results: The mean EPI Extraversion and Neuroticism scores were 8.75/24 (SD=5.66) and 8.69/24 (SD=6.30). The Extraversion score was negatively associated with PHQ14 respiratory infection (Coef.= - 0.13, 95 %CI=-0.24; -0.02) and GAD7 score (Coef. = -0.22, 95 %CI= - 0.40; -0.04). The Neuroticism score was positively correlated with PHQ14 gastrointestinal issue score, PHQ14 headache score, PHQ14 respiratory infection score, PHQ14 sleep disruption score, PQH14 total score, PHQ9 score, GAD7 score and fear of COVID-19 score, while negatively correlated with EQ-5D index (Coef. = -0.006, 95 %CI= -0.010; -0.002). Conclusion: This study indicated that personality had potential roles in impacting the physical and mental well-being of HCWs in Vietnam during the COVID-19 pandemic. Interventions to implement mindfulness practices, enhance overall well-being, and foster group dynamics among HCWs should be warranted..

BackgroundThis study aimed to measure the preferences for mental health support among health professionals, their willingness to support the mental health of colleagues and associated factors.MethodA descriptive cross-sectional study was performed from August to October 2022 within five hospitals located in Hanoi, Vietnam. A total of 244 health professionals participated in the study. Data on socio-economic status, health and COVID-19-related characteristics, Depression Anxiety Stress Scale (DASS-21); and preferences for mental health support services were collected by using a structured self-reported questionnaire. Multivariate logistic regression models were utilized to identify associated factors with the demand for mental support services.Results13.9%, 17.1% and 8.6% reported having at least mild depression, anxiety and stress, respectively. There 13.9% did not seek any mental health support during the COVID-19 pandemic. The most common support included talking with friends (52.9%), family (50.8%), colleagues (47.6%) and using social networks/Internet (43.5%). There 31.1% had been aware of mental health services, but only 18.0% used this service at least once. Regarding preferences, 47.3% had a demand for mental support services, and the most preferred service was providing coping skills (25.9%), followed by skills to support others against mental problems (22.2%). Major sources of support included psychiatrists (34.4%), colleagues (29.1%) and family (27.9%). The main preferred channels for support included telephone/mobile phone (35.7%) and Internet (20.9%). Only 12.3% were willing to provide mental support for colleagues during the pandemic. Age, education, perceived mental health status, ever seeking any mental service, and DASS-21 depression score were associated with demand for mental support services.ConclusionThis study found a lack of awareness of mental health services for health professionals, as well as moderate levels of demand for this service in this population. Raising awareness and developing tailored mental health support services are important to enhancing the mental well-being of health professionals in Vietnam to prepare for the next pandemic.

ABSTRACT: Objective: This study described the rate of suicidal ideation in lung cancer patients and identify associated factors. Method: A cross-sectional study was conducted from August 2021 to October 2022 at the Nuclear Medicine and Oncology Center – Bach Mai Hospital, Hanoi, Vietnam. A total of 256 patients completed the survey. The Columbia Suicide Severity Rating Scale (C-SSRS) was used to measure suicidal ideation. The Hospital Anxiety and Depression Scale (HADS) was utilized to evaluate depression and anxiety. Socio-demographic characteristics, clinical features and pain severity were also measured. Multivariate logistic regression was used to identify factors associated with suicidal ideation. Results: There was 8.2% having suicidal ideation. Among patients with suicidal ideation, the mean score of intensity subscale was 13.33 ± 4.98, and mean scores on intensity scale items were as follows: frequency (mean=2.86 ± 1.32). duration (mean=2.29 ± 1.15), controllability (mean=2.67 ± 1.28), deterrents (mean=2.48 ± 1.21), and reason for ideation (mean=3,05 ± 1,63). Being female (OR=3.36, 95%CI=1.35-8.37), having severxe pain (OR=5.91, 95%CI=1.65-21.18), having depression (OR=10.36, 95%CI=3.93-27.39) and having anxiety (OR=7.81, 95%CI=3.05-20.01) were positively associated with the likelihood of having suicidal ideation among lung cancer patients. Conclusion: Findings revealed the high prevalence of suicidal ideation among individuals diagnosed with lung cancer in Vietnam. Notably, this trend was more pronounced among female patients, those with severe pain, and individuals experiencing mental disorders such as depression and anxiety. Practitioners ought to prioritize the screening and intervention processes for lung cancer patients with a high risk of suicidal tendencies.

Talaromyces sp. DC2 is an endophytic fungus that was isolated from the stem of Catharanthus roseus (L.) G. Don in Hanoi, Vietnam and is capable of producing vinca alkaloids. This study utilizes the PacBio Sequel technology to completely sequence the whole genome of Talaromyces sp. DC2The genome study revealed that DC2 contains a total of 34.58 Mb spanned by 156 contigs, with a GC content of 46.5%. The identification and prediction of functional protein-coding genes, tRNA, and rRNA were comprehensively predicted and highly annotated using various BLAST databases, including non-redundant (Nr) protein sequence, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Clusters of Orthologous Groups (COG), and Carbohydrate-Active Enzymes (CAZy) databases. The genome of DC2 has a total of 149, 227, 65, 153, 53, and 6 genes responsible for cellulose, hemicellulose, lignin, pectin, chitin, starch, and inulin degradation, respectively. The Antibiotics and Secondary Metabolites Analysis Shell (AntiSMASH) analyses revealed that strain DC2 possesses 20 biosynthetic gene clusters responsible for producing secondary metabolites. The strain DC2 has also been found to harbor the DDC gene encoding aromatic L-amino acid decarboxylase enzyme. Conclusively, this study has provided a comprehensive understanding of the processes involved in secondary metabolites and the ability of the Talaromyces sp. DC2 strain to degrade plant cell walls.

Acinic cell carcinoma (ACC) is a rare malignant tumor of the salivary glands that accounts for 6%-10% of all salivary gland malignancies. It has a propensity to considerably recur, metastasize to the lung or cervical lymph nodes. In addition, ACC can potentially be fatal. The parotid gland is where ACC most frequently begins. The purpose of this paper was to describe an unusual case of parotid gland ACC in a 58-year-old Vietnamese adult female. Before surgery, a fine-needle aspiration biopsy revealed the existence of tumor cells with acinar differentiation. Following that, she underwent successful surgery without complications. The existence of ACC was verified by the postoperative final histologic results.

Adenoid cystic carcinoma (ACC) is a slowly progressing malignant tumor of the salivary glands that mostly affects minor salivary glands. ACC of parotid gland is exceptionally rare. In this article, we aimed to provide a case report of parotid gland ACC in a 55-year-old female that was misdiagnosed as benign mixed tumor. The patient was successfully treated by surgery without any complications. We recommend that ACC of parotid gland should be considered in differential diagnosis of benign mixed tumor since there still existed overlapped imaging characteristics.

The set of equivalence classes of cobounded actions of a group G$G$ on different hyperbolic metric spaces carries a natural partial order. Following Abbott–Balasubramanya–Osin, the group G$G$ is H$\mathcal {H}$‐accessible if the resulting poset has a largest element. In this paper, we prove that every nongeometric 3‐manifold has a finite cover with H$\mathcal {H}$‐inaccessible fundamental group and give conditions under which the fundamental group of the original manifold is H$\mathcal {H}$‐inaccessible. We also prove that every Croke–Kleiner admissible group (a class of graphs of groups that generalizes fundamental groups of three‐dimensional graph manifolds) has a finite index subgroup that is H$\mathcal {H}$‐inaccessible. [ABSTRACT FROM AUTHOR]

We show that if 퐺 is an admissible group acting geometrically on a CAT ⁡ (0) space 푋, then 퐺 is a hierarchically hyperbolic space and its 휅-Morse boundary (∂ κ G , ν) is a model for the Poisson boundary of (G , μ) , where 휈 is the hitting measure associated to the random walk driven by 휇. [ABSTRACT FROM AUTHOR]

Talaromyces sp. DC2 is an endophytic fungus that was isolated from the stem of Catharanthus roseus (L.) G. Don in Hanoi, Vietnam and is capable of producing vinca alkaloids. This study utilizes the PacBio Sequel technology to completely sequence the whole genome of Talaromyces sp. DC2The genome study revealed that DC2 contains a total of 34.58 Mb spanned by 156 contigs, with a GC content of 46.5%. The identification and prediction of functional protein-coding genes, tRNA, and rRNA were comprehensively predicted and highly annotated using various BLAST databases, including non-redundant (Nr) protein sequence, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Clusters of Orthologous Groups (COG), and Carbohydrate-Active Enzymes (CAZy) databases. The genome of DC2 has a total of 149, 227, 65, 153, 53, and 6 genes responsible for cellulose, hemicellulose, lignin, pectin, chitin, starch, and inulin degradation, respectively. The Antibiotics and Secondary Metabolites Analysis Shell (AntiSMASH) analyses revealed that strain DC2 possesses 20 biosynthetic gene clusters responsible for producing secondary metabolites. The strain DC2 has also been found to harbor the DDC gene encoding aromatic L-amino acid decarboxylase enzyme. Conclusively, this study has provided a comprehensive understanding of the processes involved in secondary metabolites and the ability of the Talaromyces sp. DC2 strain to degrade plant cell walls. [ABSTRACT FROM AUTHOR]

Objective. To evaluate brachial-ankle pulse wave velocity (baPWV) in patients with rheumatoid arthritis (RA); and find out the relationship between baPWV and risk factors, disease-related factors, some echocardiographic indicators. Methods. A cross-sectional study was conducted on 47 patients with RA who were admitted to the Hue University Hospital Department of Cardiology. A control group that included 34 patients without RA who agreed to participate in the investigation was enrolled. Results. The average baPWV of the RA group was 1736.6±436.8 cm/s and was higher than that of the control group (1275.8±224.2 cm/s), p<0.001. There were moderate correlations between baPWV and the SCORE index (r=0.583, p<0.001). With the same risk factors such as age, gender, obesity, hypertension, and smoking, the baPWV of the RA group was higher than the control group. There were moderate correlations between baPWV and velocity A (r=0.562, p<0.001), E/e’ ratio (r=0.394, p=0.006), E/A ratio (r= -0.449, p=0.002), septal e’(r = -0.488, p<0.001), lateral e’(r= -0.397, p= 0.006). Conclusion. RA is associated with increased arterial stiffness compared to subjects without RA. [ABSTRACT FROM AUTHOR]

In this paper, we give a condition under which strong quasiconvexity in a finitely generated group is preserved under amalgams and HNN extension. [ABSTRACT FROM AUTHOR]

Emotional intelligence (EI), intrinsic learning motivation (IM), and willingness to communicate (WTC) are among the factors that influence students' success in foreign language learning (FLL). However, the research concerning the association between these three factors is limited, especially those dealing with the EI subcomponents. In addition, there has been no report on the link between EI, IM, and WTC of the students learning Japanese and Korean as foreign languages. Therefore, this study investigated the relationships of EI of FLL university students with IM and with WTC. At the same time, it explored the potential of EI subcomponents to serve as predictors for IM and WTC. Using descriptive statistics, Pearson product-moment correlation, and stepwise regression, this study analyzed questionnaire responses from 78 FLL undergraduates. The results indicated that the students' EI positively correlated with their IM and WTC, and one of four EI subcomponents predicted IM and WTC. Meanwhile, the one-way ANOVA test indicated that no significant difference existed within groups of students learning English, Japanese, and Korean as foreign languages. These results suggested several meaningful implications. [ABSTRACT FROM AUTHOR]

We have developed a microfluidic tool to measure the diffusion coefficient D of solutes in an aqueous solution by following the temporal relaxation of an initially steep concentration gradient in a microchannel. Our chip exploits multilayer soft lithography and the opening of a pneumatic microvalve to trigger the interdiffusion of pure water and the solution initially separated in the channel by the valve, the so-called free interface diffusion technique. Another microvalve at a distance from the diffusion zone closes the channel and thus suppresses convection. Using this chip, we have measured diffusion coefficients of solutes in water with a broad size range, from small molecules to polymers and colloids, with values in the range D ∈ [ 10 − 13 – 10 − 9 ] m2/s. The same experiments but with added colloidal tracers also revealed diffusio-phoresis and diffusio-osmosis phenomena due to the presence of the solute concentration gradient. We nevertheless show that these interfacial-driven transport phenomena do not affect the measurements of the solute diffusion coefficients in the explored concentration range. [ABSTRACT FROM AUTHOR]

Great efforts to advance the diagnosis and treatment of hypertension for controlling hypertension have been made; however, the rates of uncontrolled blood pressure are still high. This study explored the rate of uncontrolled hypertension in patients with hypertension managed in an urban hospital of Vietnam and identified associated factors. A cross-sectional survey was performed from August to October 2019 among hypertensive patients at an urban hospital in Hanoi, Vietnam. Blood pressure was evaluated at the time of medical examination. Demographic, clinical, and behavioral characteristics were also collected. Multivariate logistic regression was used to identify the factors related to uncontrolled hypertension. Among 220 patients, the rate of uncontrolled hypertension was 40.5%. Females had a lower likelihood of having uncontrolled hypertension compared to males (adjusted OR = 0.33; 95% CI = 0.11–0.98). Higher duration of diseases (adjusted OR = 1.07; 95% CI = 1.01–1.14) and higher body mass index (adjusted OR = 1.23; 95% CI = 1.05–1.45) were positively associated with uncontrolled hypertension. Patients who carried supplies needed for self-care, cut down on stress, exercised regularly, and stopped/cut down on smoking were also less likely to develop uncontrolled hypertension. This study reveals that uncontrolled hypertension was common among hypertensive patients in Vietnam. Improving self-care capacity and encouraging healthy behaviors are critically important to control blood pressure, particularly among patients who were males and had high disease duration and body mass index. [ABSTRACT FROM AUTHOR]

In this paper, we compute the subgroup distortion of all finitely generated subgroups of all finitely generated 3-manifold groups, and the subgroup distortion in this case can only be linear, quadratic, exponential and double exponential. It turns out that the subgroup distortion of a subgroup of a 3-manifold group is closely related to the separability of this subgroup. [ABSTRACT FROM AUTHOR]

We report the fabrication of permeable membranes for microfluidic dialysis applications in poly(dimethylsiloxane) (PDMS) channels. A maskless UV projection device was used to photo-pattern long hydrogel membranes (mm–cm) with a spatial resolution of a few microns in PDMS chips integrating also micro-valves. We show in particular that multi-layer soft lithography allows one to deplete oxygen from the PDMS walls using a nitrogen gas flow and therefore makes possible in situ UV-induced polymerization of hydrogels. We also report a simple surface modification of the PDMS channels leading to strongly anchored hydrogel membranes that can withstand trans-membrane pressure drops up to 1 bar without leakages. We then measured the Darcy permeability of these membranes and estimated their cut-off by measuring the kinetics of diffusion of macromolecules of different sizes through the membrane. Finally, we illustrate the opportunities offered by such microfluidic chips for dialysis applications by observing in real time the crystallization of a model protein in a chamber of a few nanoliters. [ABSTRACT FROM AUTHOR]

In this paper, we study the manifold structure and the relative hyperbolic structure of right-angled Coxeter groups with planar nerves. We then apply our results to the quasi-isometry problem for this class of right-angled Coxeter groups. [ABSTRACT FROM AUTHOR]

Triglyceride is the main lipid class in nature, found as droplets in both living systems and man-made products (such as manufactured foods and drugs). Characterizing triglyceride droplets in situ in these systems is complex due to many environmental interactions. To answer basic research questions about droplet formation, structuration, stability, or degradation, microfluidic strategies were developed, allowing well-controlled droplets to be formed, manipulated, and studied. In this review, these strategies are described, starting with the presentation of droplet production devices, with applications essentially related to microencapsulation and delivery, then detailing methods to monitor droplet degradation in situ and in real time, finishing with microfluidic platforms allowing the investigation of many aspects of biological lipid droplets simultaneously. • Microfluidic devices enable controlled triglyceride droplets generation and study. • Specific droplet structures and microencapsulation/protection systems can be produced. • Real-time droplet monitoring can be performed directly on the microfluidic chips. • Advanced analyses of lipid droplets can be done in situ with lab on chip platforms. [ABSTRACT FROM AUTHOR]

We show there exists a closed graph manifold N and infinitely many non-separable, horizontal surfaces { S n ↬ N } n ∈ ℕ such that there does not exist a quasi-isometry π 1 (N) → π 1 (N) taking π 1 (S n) to π 1 (S m) within a finite Hausdorff distance when n ≠ m. [ABSTRACT FROM AUTHOR]

Vehicle routing is a class of combinatorial optimization problems arising in the industry of transportation and logistics. The goal of these problems is to compute an optimal route plan for a set of vehicles for serving transport requests of customers. There are many variants of the vehicle routing problems: routing for delivering goods, routing for demand responsive transport (taxi, school bus, ...). Each problem might have different constraints, objectives. In this paper, we introduce a Constraint-Based Local Search (CBLS) framework for general offline and online vehicle routing problems. We extend existing neighborhood structures in the literature by proposing new neighborhoods to facilitate the resolution of different class of vehicle routing problems in a unified platform. A novel feature of the framework is the available APIs for online vehicle routing problems where requests arrive online during the execution of the computed route plan. Experimental results on three vehicle routing problems (the min-max capacitated vehicle routing problem, the multi-vehicle covering tour problem, and the online people-andparcel share-a-ride taxis problem) show the modelling flexibility, genericity, extensibility and efficiency of the proposed framework. [ABSTRACT FROM AUTHOR]

Conversion of CO 2 into valuable fuel or chemical feedstock is important to sustainable technological development. Hydrogenation of CO 2 to methanol, preferably under a relatively low temperature and moderate pressure, is attractive. In this study, a combined (CO 2 + CO) hydrogenation process is proposed as an alternative two-stage route for methanol production. Cu-based hybrid catalysts supported on alumina nanoparticle clusters were developed for promoting methanol production. The results show an increase of ≈ 3.2 times in methanol space-time yield (STY MeOH) at 220 °C by incorporating CO to the CO 2 hydrogenation process, and the maximum STY MeOH , 6.1 mmolg cat -1h-1, was achievable under a low-temperature (220 °C), moderate high-pressure operation (30 bar). The work demonstrates a rational design of hybrid nanostructured material to achieve superior catalytic performance in the combined (CO 2 + CO) hydrogenation. The mechanistic understanding gives insights into the interfacial catalysis by Cu-ZnO hybrid nanostructured materials for methanol production. [Display omitted] • An alternative two-stage route for CO 2 hydrogenation to methanol is proposed. • Cu-ZnO nanoparticles decorated on Al 2 O 3 nanoparticle cluster as catalyst. • High activity under low temperature (≦ 220 °C) and moderate pressure (30 bar). • Methanol yield increased by 3.2 × via the combined (CO 2 + CO) hydrogenation route. • Achieved high selectivity (> 80%) and high methanol yield (6.1 mmolgcat-1 h-1). [ABSTRACT FROM AUTHOR]

Abstract: Background: With the aging population and improved cancer care, the number of cancer survivors is steadily increasing. Planning for their care requires an understanding of the impact of cancer and chronic conditions on quality of life. We sought to determine chronic conditions and health status in older cancer survivors compared to controls. Methods: In this retrospective cross-sectional study, we used survey data from 18,133 cancer survivors and 94,407 controls age 65 and older who participated in the Behavioral Risk Factor Surveillance System 2009 telephonic survey. Our main measures were chronic conditions (cardiovascular disease, hypertension, diabetes mellitus, high cholesterol, and arthritis) and poor health status (poor or fair self-rated health). Results: Cancer survivors were older, more likely white, had higher education, and slightly more likely to have a healthcare provider and higher levels of emotional support. More survivors reported having 2 or more chronic conditions compared to controls (67.5% vs. 64.5%, respectively). Health status was lower for survivors, and was significantly different by racial/ethnic group. In a multivariable model for health status, having 2 or more chronic conditions was more strongly associated with poorer health status than cancer survivorship. Conclusions: Cancer survivors had slightly higher numbers of chronic conditions and poorer health status than controls. However, chronic conditions were more strongly associated with poor health status than cancer. Monitoring for recurrence and second cancers is important in cancer survivors, but chronic conditions also need to be given priority due to their substantial impact on health status. [Copyright &y& Elsevier]

(1) Background: The present study measures the fear of COVID-19 among hospital healthcare workers and identifies several factors associated with increasing fear of COVID-19. (2) Methods: A cross-sectional, hospital-based survey was conducted on healthcare workforce recruited from the National Hospital of Tropical Diseases from 1 October 2021 and 20 October 2021. We selected the participants who have been directly involved in diagnosing, treating, or providing nursing care to patients with COVID-19. The primary data was collected via sending the invitation directly to the participants, utilizing structured self-completed questionnaires. The seven-item fear of COVID-19 scale was used to measure the data. The responses of 208 hospital healthcare workers were included in the final analysis. (3) Results: Total score of COVID-19 fear was 19.62 (SD = 5.22). The COVID-19 fear score of 7 items ranged from 2.38 (SD = 0.83) to 3.21 (SD = 0.96). The lowest and highest scores were the item 'My hands become clammy when I think about Corona' and the item 'I am most afraid of corona' was the highest, respectively. Linear regression of the COVID-19 fear showed that the factors positively correlated with the fear of COVID-19 among hospital healthcare workers were: being influenced by the community (p = 0.001), feeling at very high risk of COVID-19 (p = 0.03), and experiencing traumatic stress with an academic event (p = 0.042). (4) Conclusions: Although these findings merit further elaboration, these preliminary findings suggest relatively great fear of the COVID-19 pandemic among Vietnamese hospital healthcare workers and that social and personal connections are necessary for maintaining the mental wellbeing. [ABSTRACT FROM AUTHOR]

The goal of this study was to develop an algorithm for detecting epilepsy cases in managed care organizations (MCOs). A data set of potential epilepsy cases was constructed from an MCO's administrative data system for all health plan members continuously enrolled in the MCO for at least 1 year within the study period of July 1, 1996 through June 30, 1998. Epilepsy status was determined using medical record review for a sample of 617 cases. The best algorithm for detecting epilepsy cases was developed by examining combinations of diagnosis, diagnostic procedures, and medication use. The best algorithm derived in the exploratory phase was then applied to a new set of data from the same MCO covering the period of July 1, 1998 through June 30, 2000. A stratified sample based on ethnicity and age was drawn from the preliminary algorithm-identified epilepsy cases and non-cases. Medical record review was completed for 644 cases to determine the accuracy of the algorithm. Data from both phases were combined to permit refinement of logistic regression models and to provide more stable estimates of the parameters. The best model used diagnoses and antiepileptic drugs as predictors and had a positive predictive value of 84% (sensitivity 82%, specificity 94%). The best model correctly classified 90% of the cases. A stable algorithm that can be used to identify epilepsy patients within MCOs was developed. Implications for use of the algorithm in other health care settings are discussed. [ABSTRACT FROM AUTHOR]

• Aerosol-based synthesis of Mg-Al-O composite nanocatalyst for biodiesel production. • Surface area of MgO nanocatalyst increased via hybridization with Al 2 O 3. • A maximum of 3.4× in yield by using Mg-Al-O composite nanocatalyst. • Strong basic site and catalytic activity increased by hybridization MgO with Al 2 O 3. • Sufficient high operation stability and chemical stability in cyclic test. A facile, aerosol-based controlled synthesis of porous Mg-Al-O composite nanoparticle is demonstrated for developing solid base catalysts with high performance for transesterification of soybean oil to biodiesel. Pore size, crystallite size and chemical composition of the Mg-Al-O composite nanoparticle are tunable by design. A significantly higher surface area (by 1.8 times) and a smaller pore size (i.e., decreased by 20%) of the Mg-Al-O composite particle achieved by using the aerosol-based synthesis than the conventional method. Hybridization with Al 2 O 3 remarkably increased surface area of the MgO particle by decreasing pore size using homogenous Al precursor or increasing pore volume via choosing heterogeneous Al precursor. The fatty acid methyl esters (FAME) yield catalyzed by Mg-Al-O composite particle was significantly higher in comparison to the results without catalysts (i.e., a maximum of 3.4×). The FAME yield was proportional to methanol-to-oil molar ratio, and the highest yield was identified at Mg/Al = 4, in accordance to the highest number of strong basic site quantified via a CO 2 -based temperature-programmed desorption study. Operation stability (i.e., FAME yield declined by <4%) and chemical stability (i.e., mass leaching <0.06% of total catalyst mass) were sufficiently high for the synthesized porous Mg-Al-O composite nanoparticle based on the 3-cycle test. The work establishes a prototype study of developing porous Mg-Al-O composite nanostructure by applying a gas-phase evaporation-induced self-assembly to achieve high activity and operation stability. The study also shows promise to further enhance strong basicity and corresponding catalytic activity through mechanistic understanding of the designed composite nanocatalyst. [ABSTRACT FROM AUTHOR]