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Your search keyword '"Natalia Nugaeva"' showing total 9 results
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9 results on '"Natalia Nugaeva"'

1. Plasticity of the injured human spinal cord: insights revealed by spinal cord functional MRI.

Author

David W Cadotte, Rachael Bosma, David Mikulis, Natalia Nugaeva, Karen Smith, Ronald Pokrupa, Omar Islam, Patrick W Stroman, and Michael G Fehlings

Subjects
Medicine, Science
Abstract

IntroductionWhile numerous studies have documented evidence for plasticity of the human brain there is little evidence that the human spinal cord can change after injury. Here, we employ a novel spinal fMRI design where we stimulate normal and abnormal sensory dermatomes in persons with traumatic spinal cord injury and perform a connectivity analysis to understand how spinal networks process information.MethodsSpinal fMRI data was collected at 3 Tesla at two institutions from 38 individuals using the standard SEEP functional MR imaging techniques. Thermal stimulation was applied to four dermatomes in an interleaved timing pattern during each fMRI acquisition. SCI patients were stimulated in dermatomes both above (normal sensation) and below the level of their injury. Sub-group analysis was performed on healthy controls (n = 20), complete SCI (n = 3), incomplete SCI (n = 9) and SCI patients who recovered full function (n = 6).ResultsPatients with chronic incomplete SCI, when stimulated in a dermatome of normal sensation, showed an increased number of active voxels relative to controls (p = 0.025). There was an inverse relationship between the degree of sensory impairment and the number of active voxels in the region of the spinal cord corresponding to that dermatome of abnormal sensation (R(2) = 0.93, pConclusionsIn this work we demonstrate the use of spinal fMRI to investigate changes in spinal processing of somatosensory information in the human spinal cord. We provide evidence for plasticity of the human spinal cord after traumatic injury based on an increase in the average number of active voxels in dermatomes of normal sensation in chronic SCI patients and an increased number of intraspinal connections in incomplete SCI patients relative to healthy controls.

Published
2012
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2. Clinical Outcomes of Adult Fontan-Associated Liver Disease and Combined Heart-Liver Transplantation

Author

Matthew J. Lewis, Leigh C. Reardon, Jamil Aboulhosn, Christiane Haeffele, Sharon Chen, Yuli Kim, Stephanie Fuller, Lisa Forbess, Laith Alshawabkeh, Marcus A. Urey, Wendy M. Book, Fred Rodriguez, Jonathan N. Menachem, Daniel E. Clark, Anne Marie Valente, Matthew Carazo, Alexander Egbe, Heidi M. Connolly, Eric V. Krieger, Jilian Angiulo, Ari Cedars, Jong Ko, Roni M. Jacobsen, Michael G. Earing, Jonathan W. Cramer, Peter Ermis, Christopher Broda, Natalia Nugaeva, Heather Ross, Jordan D. Awerbach, Richard A. Krasuski, and Marlon Rosenbaum

Subjects
Cardiology and Cardiovascular Medicine
Published
2023
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3. Morbidity and Mortality in Adult Fontan Patients After Heart or Combined Heart-Liver Transplantation

Author

Matthew J. Lewis, Leigh C. Reardon, Jamil Aboulhosn, Christiane Haeffele, Sharon Chen, Yuli Kim, Stephanie Fuller, Lisa Forbess, Laith Alshawabkeh, Marcus A. Urey, Wendy M. Book, Fred Rodriguez, Jonathan N. Menachem, Daniel E. Clark, Anne Marie Valente, Matthew Carazo, Alexander Egbe, Heidi M. Connolly, Eric V. Krieger, Jilian Angiulo, Ari Cedars, Jong Ko, Roni M. Jacobsen, Michael G. Earing, Jonathan W. Cramer, Peter Ermis, Christopher Broda, Natalia Nugaeva, Heather Ross, Jordan D. Awerbach, Richard A. Krasuski, and Marlon Rosenbaum

Subjects
Cardiology and Cardiovascular Medicine
Published
2023
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4. MORBIDITY AND MORTALITY IN ADULT FONTAN PATIENTS AFTER HEART OR COMBINED HEART LIVER TRANSPLANT: A REPORT FROM THE FOSTER STUDY

Author

Wendy Book, Alexander C. Egbe, Natalia Nugaeva, Jong Ko, Richard A. Krasuski, Jamil A. Aboulhosn, Christiane Haeffele, Matthew J. Lewis, Michael G. Earing, Jilian Angiulo, Heather Joan Ross, Peter Ermis, Anne Marie Valente, Chris Broda, Leigh Reardon, Jonathan W. Cramer, Ari M. Cedars, Sharon Chen, Roni Jacobson, Eric Krieger, Fred H. Rodriguez, Yuli Y. Kim, Marlon Rosenbaum, and Matthew Carazo

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, surgical procedures, operative, business.industry, Cohort, cardiovascular system, Medicine, cardiovascular diseases, Cardiology and Cardiovascular Medicine, business
Abstract

We examined a retrospective, multicenter cohort of adult Fontan patients referred for heart transplant (HT) to assess the impact of comorbidities and combined heart-liver transplant (CHLT) on mortality. All patients at participating institutions with a history of a Fontan-type palliation referred

Published
2020
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5. MORBIDITY AND MORTALITY IN ADULT FONTAN PATIENTS REFERRED FOR TRANSPLANT: A REPORT FROM THE FOSTER STUDY

Author

Marlon Rosenbaum, Eric Krieger, Jonathan W. Cramer, Alexander C. Egbe, Roni Jacobson, Wendy Book, Jamil A. Aboulhosn, Sharon Chen, Natalia Nugaeva, Jilian Angiulo, Peter Ermis, Christiane Haeffele, Heather Joan Ross, Anne Marie Valente, Chris Broda, Leigh Reardon, Yuli Y. Kim, Matthew J. Lewis, Michael G. Earing, Richard A. Krasuski, Matthew Carazo, Jong Ko, Ari M. Cedars, and Fred H. Rodriguez

Subjects
Pediatrics, medicine.medical_specialty, Management strategy, Adverse outcomes, business.industry, Survivorship curve, medicine, Retrospective cohort study, Cardiology and Cardiovascular Medicine, business, humanities
Abstract

The optimum management strategy of adult Fontan patients referred for heart transplant (HT) remains unknown. We performed a multicenter, retrospective study of patients referred for HT to determine survivorship and risk factors for adverse outcomes. All patients at participating institutions with a

Published
2020
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6. CLINICAL CHARACTERISTICS OF 'FAILING' ADULT FONTAN PATIENTS ACROSS 14 CENTERS: A REPORT FROM THE FOSTER STUDY

Author

Christiane Haeffele, Heather J. Ross, Wendy Book, Alexander C. Egbe, Roni Jacobson, Eric V. Krieger, Jilian Angiulo, Marlon Rosenbaum, Anne Marie Valente, Leigh C. Reardon, Peter R. Ermis, Sharon Chen, Jong Ko, Natalia Nugaeva, Richard A. Krasuski, Ari M. Cedars, Fred H. Rodriguez, Christopher R. Broda, Jamil Aboulhosn, Matthew J. Lewis, Michael G. Earing, Yuli Y. Kim, Matthew Carazo, and Jonathan W. Cramer

Subjects
medicine.medical_specialty, business.industry, Emergency medicine, Medicine, Cardiology and Cardiovascular Medicine, business
Published
2020
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8. An Antibody-Sensitized Microfabricated Cantilever for the Growth Detection of Aspergillus niger Spores.

Author

Natalia Nugaeva, Karin Y. Gfeller, Natalia Backmann, Marcel Düggelin, Hans Peter Lang, Hans-Joachim Güntherodt, and Martin Hegner

Subjects
ASPERGILLUS niger, BACTERIAL spores, BIOSENSORS, ASPERGILLUS
Abstract

We demonstrate a new sensitive biosensor for detection of vital fungal spores of Aspergillus niger. The biosensor is based on silicon microfabricated cantilever arrays operated in dynamic mode. The change in resonance frequency of the sensor is a function of mass binding to the cantilever surface. For specific A. niger spore immobilization on the cantilever, each cantilever was individually coated with anti-Aspergillus niger polyclonal antibodies. We demonstrate the detection of single A. niger spores and their subsequent growth on the functionalized cantilever surface by online measurements of resonance frequency shifts. The new biosensor operating in humid air allows quantitative and qualitative detection of A. niger spores as well as detection of vital, functional spores in situ within ∼4 h. The detection limit of the sensor is 103 CFU mL−1. Mass sensitivity of the cantilever sensor is ∼53 pg Hz−1. [ABSTRACT FROM AUTHOR]

Published
2007
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9. The SCIentinel study - prospective multicenter study to define the spinal cord injury-induced immune depression syndrome (SCI-IDS) - study protocol and interim feasibility data

Author

Ralf Watzlawick, Benedikt Brommer, Wolfgang Ertel, Axel Ekkernkamp, Hans-Dieter Volk, Gertraut Lindemann, Michael G. Fehlings, Claudia Druschel, Marcel A. Kopp, Ramin Raul Ossami Saidy, Peter Vajkoczy, Harald Prüss, Rick C. Hellmann, Armin Curt, Peter Martus, Nadine Unterwalder, Natalia Nugaeva, Guido A. Wanner, Ulrich Dirnagl, Mario Cabraja, Ines Laginha, Andreas Niedeggen, Thomas Liebscher, Christian Meisel, Vieri Failli, Uwe Kölsch, Julius Dengler, Erik Prilipp, Jan M. Schwab, Klaus D. Schaser, Paolo Cinelli, University of Zurich, and Schwab, Jan M

Subjects
Oncology, medicine.medical_specialty, Internationality, Neurology, diagnosis [Spinal Cord Injuries], Databases, Factual, Central nervous system, Clinical Neurology, 610 Medicine & health, Spinal cord injury, Disease, Infections, Study Protocol, Autoimmune Diseases of the Nervous System, Immune system, High-dose methylprednisolone treatment, Internal medicine, medicine, Humans, ddc:610, Longitudinal Studies, Prospective Studies, Lesion height dependency, Spinal Cord Injuries, Neurogenic bladder dysfunction, epidemiology [Spinal Cord Injuries], epidemiology [Autoimmune Diseases of the Nervous System], business.industry, diagnosis [Autoimmune Diseases of the Nervous System], General Medicine, Spinal cord, medicine.disease, 10021 Department of Trauma Surgery, 2728 Neurology (clinical), medicine.anatomical_structure, Anesthesia, Feasibility Studies, 10046 Balgrist University Hospital, Swiss Spinal Cord Injury Center, Neurology (clinical), Neurosurgery, business, Immune paralysis
Abstract

Background Infections are the leading cause of death in the acute phase following spinal cord injury and qualify as independent risk factor for poor neurological outcome (“disease modifying factor”). The enhanced susceptibility for infections is not stringently explained by the increased risk of aspiration in tetraplegic patients, neurogenic bladder dysfunction, or by high-dose methylprednisolone treatment. Experimental and clinical pilot data suggest that spinal cord injury disrupts the balanced interplay between the central nervous system and the immune system. The primary hypothesis is that the Spinal Cord Injury-induced Immune Depression Syndrome (SCI-IDS) is 'neurogenic’ including deactivation of adaptive and innate immunity with decreased HLA-DR expression on monocytes as a key surrogate parameter. Secondary hypotheses are that the Immune Depression Syndrome is i) injury level- and ii) severity-dependent, iii) triggers transient lymphopenia, and iv) causes qualitative functional leukocyte deficits, which may endure the post-acute phase after spinal cord injury. Methods/Design SCIentinel is a prospective, international, multicenter study aiming to recruit about 118 patients with acute spinal cord injury or control patients with acute vertebral fracture without neurological deficits scheduled for spinal surgery. The assessment points are: i)

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