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28 results on '"Nakanishi, Kazuya"'

1. A New Rule for Terminating Resuscitation of Out-of-Hospital Cardiac Arrest Patients in Japan: A Prospective Study

Author

Inokuchi, Sadaki, Masui, Yoshihiro, Miura, Kunihisa, Tsutsumi, Haruhiko, Takuma, Kiyotsugu, Atsushi, Ishihara, Nakano, Minoru, Tanaka, Hiroshi, Ikegami, Keiichi, Arai, Takao, Yaguchi, Arino, Kitamura, Nobuya, Oda, Shigeto, Kobayashi, Kenji, Suda, Takayuki, Ono, Kazuyuki, Morimura, Naoto, Furuya, Ryosuke, Koido, Yuichi, Iwase, Fumiaki, Nagao, Ken, Kanesaka, Shigeru, Okada, Yasusei, Unemoto, Kyoko, Sadahiro, Tomohito, Iyanaga, Masayuki, Muraoka, Asaki, Hayashi, Munehiro, Ishimatsu, Shinichi, Miyake, Yasufumi, Yokokawa, Hideo, Koyama, Yasuaki, Tsuchiya, Asuka, Kashiyama, Tetsuya, Hayashi, Munetaka, Oshima, Kiyohiro, Kiyota, Kazuya, Hamabe, Yuichi, Yokota, Hiroyuki, Hori, Shingo, Inaba, Shin, Sakamoto, Tetsuya, Harada, Naoshige, Kimura, Akio, Kanai, Masayuki, Otomo, Yasuhiro, Sugita, Manabu, Kinoshita, Kosaku, Sakurai, Takatoshi, Kitano, Mitsuhide, Matsuda, Kiyoshi, Tanaka, Kotaro, Yoshihara, Katsunori, Yoh, Kikuo, Suzuki, Junichi, Toyoda, Hiroshi, Mashiko, Kunihiro, Shimizu, Naoki, Muguruma, Takashi, Shimada, Tadanaga, Kobe, Yoshiro, Shoko, Tomohisa, Nakanishi, Kazuya, Shiga, Takashi, Yamamoto, Takefumi, Sekine, Kazuhiko, and Izuka, Shinichi

Published
2017
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11. Brorin is required for neurogenesis, gliogenesis, and commissural axon guidance in the zebrafish forebrain.

Author

Miyake, Ayumi, Mekata, Yoko, Fujibayashi, Hidenori, Nakanishi, Kazuya, Konishi, Morichika, and Itoh, Nobuyuki

Subjects
DEVELOPMENTAL neurobiology, BONE morphogenetic proteins, AXONS, PROSENCEPHALON physiology, LABORATORY zebrafish
Abstract

Bmps regulate numerous neural functions with their regulators. We previously identified Brorin, a neural-specific secreted antagonist of Bmp signaling, in humans, mice, and zebrafish. Mouse Brorin has two cysteine-rich domains containing 10 cysteine residues in its core region, and these are located in similar positions to those in the cysteine-rich domains of Chordin family members, which are secreted Bmp antagonists. Zebrafish Brorin had two cysteine-rich domains with high similarity to those of mouse Brorin. We herein examined zebrafish brorin in order to elucidate its in vivo actions. Zebrafish brorin was predominantly expressed in developing neural tissues. The overexpression of brorin led to the inactivation of Bmp signaling. On the other hand, the knockdown of brorin resulted in the activation of Bmp signaling and brorin morphants exhibited defective development of the ventral domain in the forebrain. Furthermore, the knockdown of brorin inhibited the generation of γ–aminobutyric acid (GABA)ergic interneurons and oligodendrocytes and promoted the generation of astrocytes in the forebrain. In addition, brorin was required for axon guidance in the forebrain. The present results suggest that Brorin is a secreted Bmp antagonist predominantly expressed in developing neural tissues and that it plays multiple roles in the development of the zebrafish forebrain. [ABSTRACT FROM AUTHOR]

Published
2017
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12. Mechanical Cardiopulmonary Resuscitation and Hospital Survival Among Adult Patients With Nontraumatic Out‐of‐Hospital Cardiac Arrest Attending the Emergency Department: A Prospective, Multicenter, Observational Study in Japan (SOS‐KANTO [Survey of Survivors after Out‐of‐Hospital Cardiac Arrest in Kanto Area] 2012 Study)

Author

Hayashida, Kei, Tagami, Takashi, Fukuda, Tatsuma, Suzuki, Masaru, Yonemoto, Naohiro, Kondo, Yutaka, Ogasawara, Tomoko, Sakurai, Atsushi, Tahara, Yoshio, Nagao, Ken, Yaguchi, Arino, Morimura, Naoto, Kitamura, Nobuya, Nomura, Tomohisa, Shimizu, Naoki, Akashi, Akiko, Inokuchi, Sadaki, Masui, Yoshihiro, Miura, Kunihisa, Tsutsumi, Haruhiko, Takuma, Kiyotsugu, Atsushi, Ishihara, Nakano, Tanaka, Hiroshi, Ikegami, Keiichi, Arai, Takao, Oda, Shigeto, Kobayashi, Kenji, Suda, Takayuki, Ono, Kazuyuki, Furuya, Ryosuke, Koido, Yuichi, Iwase, Fumiaki, Kanesaka, Shigeru, Okada, Yasusei, Unemoto, Kyoko, Sadahiro, Tomohito, Iyanaga, Masayuki, Muraoka, Asaki, Hayashi, Munehiro, Miyake, Yasufumi, Yokokawa, Hideo, Koyama, Yasuaki, Tsuchiya, Asuka, Kashiyama, Tetsuya, Hayashi, Munetaka, Oshima, Kiyohiro, Kiyota, Kazuya, Hamabe, Yuichi, Yokota, Hiroyuki, Hori, Shingo, Inaba, Shin, Sakamoto, Tetsuya, Harada, Naoshige, Kimura, Akio, Kanai, Masayuki, Otomo, Yasuhiro, Sugita, Manabu, Kinoshita, Kosaku, Sakurai, Takatoshi, Kitano, Mitsuhide, Matsuda, Kiyoshi, Tanaka, Kotaro, Yoshihara, Katsunori, Yoh, Kikuo, Suzuki, Junichi, Toyoda, Hiroshi, Mashiko, Kunihiro, Muguruma, Takashi, Shimada, Tadanaga, Kobe, Yoshiro, Shoko, Tomohisa, Nakanishi, Kazuya, Shiga, Takashi, Yamamoto, Takefumi, Sekine, Kazuhiko, and Izuka, Shinichi

Subjects
cardiopulmonary resuscitation, emergency department, mechanical chest compression device, Cardiopulmonary Resuscitation and Emergency Cardiac Care
Abstract

Background: Mechanical cardiopulmonary resuscitation (mCPR) for patients with out‐of‐hospital cardiac arrest attending the emergency department has become more widespread in Japan. The objective of this study is to determine the association between the mCPR in the emergency department and clinical outcomes. Methods and Results: In a prospective, multicenter, observational study, adult patients with out‐of‐hospital cardiac arrest with sustained circulatory arrest on hospital arrival were identified. The primary outcome was survival to hospital discharge. The secondary outcomes included a return of spontaneous circulation and successful hospital admission. Multivariate analyses adjusted for potential confounders and within‐institution clustering effects using a generalized estimation equation were used to analyze the association of the mCPR with outcomes. Between January 1, 2012 and March 31, 2013, 6537 patients with out‐of‐hospital cardiac arrest were eligible; this included 5619 patients (86.0%) in the manual CPR group and 918 patients (14.0%) in the mCPR group. Of those patients, 28.1% (1801/6419) showed return of spontaneous circulation in the emergency department, 20.4% (1175/5754) had hospital admission, 2.6% (168/6504) survived to hospital discharge, and 1.2% (75/6419) showed a favorable neurological outcome at 1 month after admission. Multivariate analyses revealed that mCPR was associated with a decreased likelihood of survival to hospital discharge (adjusted odds ratio, 0.40; 95% confidence interval, 0.20–0.78; P=0.005), return of spontaneous circulation (adjusted odds ratio, 0.71; 95% confidence interval, 0.53–0.94; P=0.018), and hospital admission (adjusted odds ratio, 0.57; 95% confidence interval, 0.40–0.80; P=0.001). Conclusions: After accounting for potential confounders, the mCPR in the emergency department was associated with decreased likelihoods of good clinical outcomes after adult nontraumatic out‐of‐hospital cardiac arrest. Further studies are needed to clarify circumstances in which mCPR may benefit these patients.

Published
2017
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17. The Change in Renal Replacement Therapy on Acute Renal Failure in a General Intensive Care Unit in a University Hospital and its Clinical Efficacy: A Japanese Experience.

Author

Hirayama, Yoh, Hirasawa, Hiroyuki, Oda, Shigeto, Shiga, Hidetoshi, Nakanishi, Kazuya, Matsuda, Kenichi, Nakamura, Masataka, Hirano, Takeshi, Moriguchi, Takeshi, Watanabe, Eizo, Nitta, Masakazu, Abe, Ryuzo, and Nakada, Takaaki

Subjects
KIDNEY transplantation, ACUTE kidney failure, INTENSIVE care units, UNIVERSITY hospitals, HEMODYNAMICS
Abstract

Discusses the change in renal replacement therapy on acute renal failure (ARF) in an intensive care unit in a university hospital in Japan. Effects of blood purification on hemodynamics and renal function; Investigation on the pathophysiology and treatment of ARF; Efficacy of the blood purification techniques in the treatment of ARF.

Published
2003
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24. A successful salvage therapy with daptomycin and linezolid for right-sided infective endocarditis and septic pulmonary embolism caused by methicillin-resistant Staphylococcus aureus.

Author

Yazaki, Megumi, Oami, Takehiko, Nakanishi, Kazuya, Hase, Ryota, and Watanabe, Hiroyuki

Subjects
*METHICILLIN-resistant staphylococcus aureus, *TREATMENT of endocarditis, *PULMONARY embolism, *SALVAGE therapy, *FEMALES, *DISEASES
Abstract

Although vancomycin administration is recommended for the treatment of infective endocarditis (IE) caused by methicillin-resistant Staphylococcus aureus (MRSA), it is unclear whether an alternative agent, daptomycin, can be used to treat IE with pulmonary complications. A 26-year-old female who had undergone surgical repair of a ventricular septal defect as an early teenager presented with fever, headache, and vomiting. She was admitted to our hospital and diagnosed with right-sided IE with septic pulmonary embolism caused by MRSA. Vancomycin, rifampicin, and gentamicin were administered; however, exacerbation of drug eruption due to the antimicrobial agents on the 11th day led us to switch from vancomycin and rifampicin to daptomycin. Furthermore, we included linezolid to treat lung abscesses that accompanied the septic pulmonary embolism. We confirmed negative blood cultures on the 18th day. On the same day, a patch closure for the ventricular septal defect and tricuspid valve replacement were performed. She was discharged on the 65th day with an uneventful postoperative course. This experience suggests that daptomycin and linezolid are effective salvage therapies for right-sided IE caused by MRSA and accompanied by pulmonary complications. [ABSTRACT FROM AUTHOR]

Published
2018
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25. Acute celiac artery compression syndrome with superior mesenteric artery stenosis and aortic stenosis: A rare but life-threatening complication after adult spinal deformity surgery.

Author

Kotani, Toshiaki, Sakuma, Tsuyoshi, Iijima, Yasushi, Sato, Shinichi, Nakanishi, Kazuya, Ueda, Takuya, Hara, Takeshi, Nakayama, Keita, Sunami, Takahiro, Asada, Tomoyuki, Akazawa, Tsutomu, Kishida, Shunji, Sasaki, Yu, Inage, Kazuhide, Shiga, Yasuhiro, Minami, Shohei, and Ohtori, Seiji

Subjects
*SUPERIOR mesenteric artery syndrome, *CELIAC artery, *ARTERIAL stenosis, *AORTIC stenosis, *SPINAL surgery, *SPINE abnormalities, *CRUSH syndrome
Published
2023
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28. Efficacy of Micafungin Sodium on Fungal Infection in Critical Care.

Author

Tateishi, Yoshihisa, Hirasawa, Hiroyuki, Oda, Shigeto, Nakanishi, Kazuya, Kitamura, Shinya, and Aikawa, Naoki

Subjects
*ANTIFUNGAL agents, *MYCOSES, *CRITICALLY ill, *CANDIDA albicans
Abstract

The clinical effects and tolerability of micafungin sodium in daily practice for the treatment of fungal infection in critically ill patients were evaluated in an open-labeled, non-comparative, observational study. All patients admitted to intensive care units (ICUs) of 3 hospitals in Chiba prefecture between June 2003 and March 2005, who were treated with micafungin because of known or suspected fungal infection, were included in the study. A total of 34 patients received micafungin and 29 cases of them were subjected to analysis. Fungal infections were classified as "proven" in 3 patients (10.3%) and "possible" in 26 (89.7%). Candida was detected in 16 patients, most of them were Candida albicans and 4 cases were non-albicans Candida. Clinical effects of micafungin were "cured" and "improved" in 20 patients (77%), "failure" in 6 (23%), and "undetermined" in 3 cases. Adverse events were reported in 10 patients, but there was no significant event. In conclusion, micafungin was effective in 77% of proven or suspected fungal infections in critically ill patients admitted to the ICU. The drug was well tolerated and discontinuation of its treatment due to adverse events was not experienced during the study period. [ABSTRACT FROM AUTHOR]

Published
2006
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