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23. Daily fat intake is associated with basolateral amygdala response to high-calorie food cues and appetite for high-calorie food.

Author

Nakamura, Yuko and Koike, Shinsuke

Subjects
*AMYGDALOID body, *FUNCTIONAL magnetic resonance imaging, *FAT, *LOW calorie foods, *STRUCTURAL equation modeling
Abstract

Animal studies have indicated that fat intake mediates amygdala activation, which in turn promotes fat intake, while amygdala activation increases the preference for fat and leads to increased fat intake. However, the association among fat intake, amygdala activation, and appetite for high-calorie foods in humans remains unclear. Thus, to examine this association, we conducted a functional magnetic resonance imaging (fMRI) experiment. Fifty healthy-weight adults (18 females; mean age: 22.9 ± 3.02 years) were included. Participants were shown images of high-calorie and low-calorie foods and were instructed to rate their desire to eat the food items during fMRI. All participants provided information on their daily fat intake using a self-reported questionnaire. Associations among fat intake, the desire to eat high-calorie or low-calorie food items, and amygdala responses to food items were examined. The basolateral amygdala (BLA) response was positively associated with fat intake ([x, y, z] = [24, −6, −16], z = 3.91, pFWE-corrected = 0.007) and the desire to eat high-calorie food items ([26, −4, −16], z = 3.75, pFWE-corrected = 0.010). Structural equation modeling showed that the desire for high-calorie food items was predicted by BLA response to high-calorie food items (p = 0.013, β = 3.176), and BLA response was predicted by fat intake (p < 0.001, β = 0.026). Fat intake influences BLA response to high-fat food, which in turn increases the desire to eat palatable high-fat food. This may lead to additional fat intake and increase the risk of weight gain. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Development of Philadelphia chromosome-negative acute myeloid leukemia with IDH2 and NPM1 mutations in a patient with chronic myeloid leukemia who showed a major molecular response to tyrosine kinase inhibitor therapy

Author

Nakamura, Fumi, Arai, Honoka, Nannya, Yasuhito, Ichikawa, Motoshi, Furuichi, Shiho, Nagasawa, Fusako, Takahashi, Wataru, Handa, Tomoyuki, Nakamura, Yuko, Tanaka, Hiroko, Nakamura, Yuka, Sasaki, Ko, Miyano, Satoru, Ogawa, Seishi, and Mitani, Kinuko

Published
2021
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29. Breakfast Frequency and Smoking Initiation in University Students: A Retrospective Cohort Study.

Author

Mori, Rika, Yamamoto, Ryohei, Shinzawa, Maki, Otsuki, Naoko, Matsumura, Yuichiro, Nakamura, Yuko, Li, Qinyan, Sakaguchi, Yusuke, Matsui, Isao, Mizui, Masayuki, Shinomiya, Haruki, Ishibashi, Chisaki, Nakanishi, Kaori, Kanayama, Daisuke, and Nagatomo, Izumi

Abstract

Smoking causes various health problems. Limited studies have reported a clinical effect of skipping breakfast on smoking initiation among adolescents. This retrospective cohort study aimed to assess the dose-dependent association between skipping breakfast and smoking initiation in university students. This study included 17,493 male and 8880 female students aged 18−22 years at a national university in Japan. The association between breakfast frequency (eating every day and skipping occasionally, often, and usually) and smoking initiation was evaluated using Cox proportional hazards models adjusted for clinically relevant factors. Smoking initiation was observed in 2027 (11.6%) male and 197 (2.2%) female students over the median observational period of 3.0 and 3.1 years. Skipping breakfast was significantly associated with smoking initiation in a dose-dependent fashion in male students (the adjusted hazard ratios [95% confidence interval] of eating breakfast every day and skipping occasionally, often, and usually: 1.00 [reference], 1.30 [1.15, 1.46], 1.47 [1.21, 1.79], and 1.77 [1.40, 2.25], respectively). Female students skipping breakfast occasionally and often were more vulnerable to smoking initiation than those who ate breakfast every day (1.00 [reference], 1.86 [1.24, 2.78], 2.97 [1.66, 5.32], and 1.76 [0.55, 5.64], respectively). Breakfast frequency may be useful to identify university students at risk of smoking initiation who need improvement in their health literacy. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons

Author

Berland, Chloé, Montalban, Enrica, Perrin, Elodie, Di Miceli, Mathieu, Nakamura, Yuko, Martinat, Maud, Sullivan, Mary, Davis, Xue S., Shenasa, Mohammad Ali, Martin, Claire, Tolu, Stefania, Marti, Fabio, Caille, Stephanie, Castel, Julien, Perez, Sylvie, Salinas, Casper Gravesen, Morel, Chloé, Hecksher-Sørensen, Jacob, Cador, Martine, Fioramonti, Xavier, Tschöp, Matthias H., Layé, Sophie, Venance, Laurent, Faure, Philippe, Hnasko, Thomas S., Small, Dana M., Gangarossa, Giuseppe, and Luquet, Serge H.

Published
2020
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47. Lifestyle factors associated with a rapid decline in the estimated glomerular filtration rate over two years in older adults with type 2 diabetes–Evidence from a large national database in Japan.

Author

Li, Yaya, Fujii, Makoto, Ohno, Yuko, Ikeda, Asuka, Godai, Kayo, Nakamura, Yuko, Akagi, Yuya, Yabe, Daisuke, Tsushita, Kazuyo, Kashihara, Naoki, Kamide, Kei, and Kabayama, Mai

Subjects
GLOMERULAR filtration rate, OLDER people, DATABASES, DIABETIC nephropathies, NATIONAL health insurance, BLOOD pressure, SYSTOLIC blood pressure
Abstract

Background: The present study investigated lifestyle risk factors from metabolic syndrome-related lifestyles for a rapid decline in the estimated glomerular filtration rate (eGFR) among adults aged 40–74 years with treated and untreated type 2 diabetes. Methods and results: This study analyzed data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan, encompassing the period from fiscal year (FY) 2017 to FY2020. We established FY2018 as our baseline year. The subjects of this study were adults aged 40–74 in FY2018(baseline) who had type 2 diabetes and underwent specific health checkups in FY2020. We excluded adults with a medical record of kidney dialysis between FY2017 and FY2018, records of suspected type 1 diabetes between FY2017 and FY2020, or a baseline eGFR >85 mL/min/1.73 m2 or missing eGFR data as of FY2020. Eventually we analyzed 573,860 individuals. The outcome variable was a rapid decline in eGFR (≥30%) during the follow-up. Exposure lifestyle factors included skipping breakfast, late-night dinners, regular smoking, a high alcohol intake, non-refreshing sleep, and a lack of habitual exercise. Logistic regression models were stratified by age (40–59 and 60–74 years) and baseline eGFR levels (60–85, 30–59, and <30 mL/min/1.73 m2). Covariates included sex, a history of heart disease, a history of stroke, a history of renal failure, anemia, low-density lipoprotein, systolic blood pressure, hemoglobin A1C, body mass index, antidiabetic medications, antihypertension drugs, lipid-lowering drugs, the oral adsorbent Kremezin, non-steroidal anti-inflammatory drugs, and drugs for the treatment of renal anemia. A rapid decline in eGFR was detected in approximately 1.3% of participants (7,683 cases). In the baseline eGFR >30 subgroups (60–85 or 30–59 mL/min/1.73 m2), skipping breakfast and regular smoking were associated with a rapid decline in eGFR in both age groups, while a lack of habitual exercise and late-night dinners in the 60–74 age group and non-refreshing sleep in the 40–59 age group were identified as risk factors. Additionally, skipping breakfast was a risk factor for a rapid decline in eGFR in the 60–74 age group regardless of baseline eGFR levels. In the baseline eGFR <30 mL/min/1.73 m2 subgroup, skipping breakfast and non-refreshed sleep were risk factors for a rapid decline in eGFR. Conclusions: We found specific lifestyle risk factors were associated with a rapid eGFR decline among people with type 2 diabetes from a nationwide database in Japan. The associations varied by baseline eGFR level, age, and sex. Lifestyle modifications may effectively prevent the aggravation of diabetic kidney disease. [ABSTRACT FROM AUTHOR]

Published
2023
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