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This paper presents the behaviour and design procedure of bolted connections which tend to be sensitive to block shear failure. The finite element method is employed to examine the block shear failure. The research-oriented finite element method (RFEM) model is validated with the results of experimental tests. The validated model is used to verify the component-based FEM (CBFEM) model, which combines the analysis of internal forces by the finite element method and design of plates, bolts and welds by the component method (CM). The CBFEM model is verified by an analytical solution based on existing formulas. The method is developed for the design of generally loaded complicated joints, where the distribution of internal forces is complex. The resistance of the steel plates is controlled by limiting the plastic strain of plates and the strength of connectors, e.g., welds, bolts and anchor bolts. The design of plates at a post-critical stage is available to allow local buckling of slender plates. The prediction of the initial stiffness and the deformation capacity is included natively. Finally, a sensitivity study is prepared. The studied parameters include gusset plate thickness and pitch distance.

Nicorandil, a balanced vasodilator, is used in the second-line therapy of angina pectoris. In this study, we aimed to illuminate the effects of nicorandil on inflammation, apoptosis, and atherosclerotic plaque progression. Twenty-five LDL-R -/- mice were fed a high-fat diet for 14 weeks. After 6 weeks mice were randomly allocated to treatment with nicorandil (10 mg/kg/day) or tap water. Nicorandil treatment led to a more stable plaque phenotype, displaying an increased thickness of the fibrous cap (p = 0.014), a significant reduction in cholesterol clefts (p = 0.045), and enhanced smooth muscle cell content (p = 0.009). In endothelial cells nicorandil did not reduce the induction of adhesion molecules or proinflammatory cytokines. In H2O2 challenged endothelial cells, pretreatment with nicorandil significantly reduced the percentage of late apoptotic/necrotic cells (p = 0.016) and the ratio of apoptotic to living cells (p = 0.036). Atherosclerotic lesions of animals treated with nicorandil exhibited a significantly decreased content of cleaved caspase-3 (p = 0.034), lower numbers of apoptotic nuclei (p = 0.040), and reduced 8-oxogunanine staining (p = 0.039), demonstrating a stabilizing effect of nicorandil in established atherosclerotic lesions. We suggest that nicorandil has a positive effect on atherosclerotic plaque stabilization by reducing apoptosis.