1. Estimated treatment responses in metastatic colorectal carcinoma based on longitudinal carcinoembryonic antigen series
- Author
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B Nørgaard-Pedersen, Jesper Carl, N Brunsgaard, and M Kjaer
- Subjects
Adult ,Male ,Oncology ,medicine.medical_specialty ,Colorectal cancer ,Clinical Biochemistry ,Leucovorin ,Alpha interferon ,Interferon alpha-2 ,Carcinoembryonic antigen ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Carcinoma ,Humans ,Prospective Studies ,Neoplasm Metastasis ,Prospective cohort study ,Interferon alfa ,Aged ,biology ,Epithelioma ,business.industry ,Interferon-alpha ,General Medicine ,Middle Aged ,medicine.disease ,Recombinant Proteins ,Carcinoembryonic Antigen ,Fluorouracil ,biology.protein ,Female ,Colorectal Neoplasms ,business ,medicine.drug - Abstract
Carl J, Brunsgaard N, Kjaer M, Norgaard-Pedersen B. Estimated treatment responses in metastatic colorectal carcinoma based on longitudinal carcinoembryonic antigen series. Scand J Clin Lab Invest 1993; 53: 829-834.Patients presenting with advanced or metastatic colorectal carcinoma were randomized to treatment with either 5-Fluoro-Uracil + leucovorin or 5-Fluoro-Uracil + interferon α-2-a. Longitudinal series of Carcino-embryonic-antigen were obtained and analyzed with a dynamic model in seven of 16 patients had CEA levels above lOngml−1. Clinical evaluation based on X-ray, ultrasound and CT-scans showed a partial response to the given treatment in three of the seven patients. The dynamic model consistinly estimated the maximal accumulated cell kill (approximately three logs) in the patients experiencing a clinical response. The remaining four patients with CEA levels above lOngml−1 showed some reduction in CEA as a consequence of the treatment cycles, although no clinical response could be established. No...
- Published
- 1993
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