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3. NEUROPSYCHOLOGY

Author

K. K. Boman, L. Hornquist, J. Rickardsson, B. Lannering, G. Gustafsson, N. Pitchford, E. Davis, D. Walker, D. H. Hoang, A. Pagnier, E. Cousin, K. Guichardet, I. Schiff, F. Dubois-Teklali, A. Krainik, M. B. Lazar, K. Resnik, I. T. Olsson, S. Perrin, I. B. Burtscher, J. Lundgren, A. Kahn, A. Johanson, J. Korzeniewska, B. Dembowska-Baginska, M. Perek-Polnik, K. Walsh, A. Gioia, E. Wells, R. Packer, E. D. de Speville, C. Dufour, S. Bolle, K. Giraudat, A. Longaud, V. Kieffer, J. Grill, S. Puget, D. Valteau-Couanet, L. Hetz-Pannier, M. Noulhiane, D. Chieffo, G. Tamburrini, M. Caldarelli, C. Di Rocco, K. Margelisch, M. Studer, M. Steinlin, K. Leibundgut, T. Heinks, A. Longaud-Vales, M. Chevignard, S. Pujet, C. Sainte-Rose, G. Dellatolas, L. Kahalley, D. Grosshans, A. Paulino, M. D. Ris, M. Chintagumpala, F. Okcu, B. Moore, H. Stancel, C. Minard, D. Guffey, A. Mahajan, B. Herrington, J. Raiker, E. Manning, J. Criddle, C. Karlson, W. Guerry, J. Finlay, S. Sands, C. Dockstader, J. Skocic, E. Bouffet, S. Laughlin, U. Tabori, D. Mabbott, I. Moxon-Emre, N. Scantlebury, M. D. Taylor, D. Malkin, N. Law, T. Kumabe, J. Leonard, J. Rubin, S. Jung, S.-K. Kim, N. Gupta, W. Weiss, C. Faria, R. Vibhakar, B. Spiegler, L. Janzen, F. Liu, L. Decker, J. Lemiere, T. Vercruysse, M. Haers, K. Vandenabeele, S. Geuens, S. Jacobs, S. Van Gool, L. Riggs, J. Piscione, B. Timmons, T. Cunningham, U. Bartels, M. Chakravarty, N. Laperriere, J. Pipitone, D. Strother, J. Hukin, C. Fryer, D. McConnell, D. E. Secco, S. Cappelletti, S. Gentile, A. Cacchione, F. Del Bufalo, S. Staccioli, A. Spagnoli, R. Messina, A. Carai, C. E. Marras, A. Mastronuzzi, T. Brinkman, G. Armstrong, C. Kimberg, A. Gajjar, D. K. Srivastava, L. Robison, M. Hudson, K. Krull, K. Hardy, S. Hostetter, E. Hwang, U. Leiss, A. Bemmer, T. Pletschko, J. Grafeneder, A. Schwarzinger, P. Deimann, I. Slavc, P. Batchelder, G. Wilkening, T. Hankinson, N. Foreman, and M. Handler

Subjects
Cancer Research, Pediatrics, medicine.medical_specialty, business.industry, Working memory, Psychological intervention, Neuropsychology, Cognition, Disease, Abstracts, Oncology, Quality of life, medicine, Neurology (clinical), Verbal memory, business, Psychiatry, Neurocognitive
Abstract

Survivors of brain tumors are faced with a high risk for a wide range of cognitive problems and learning difficulties. These problems are caused by the lesion itself and its surgical removal as well as by the treatments to follow (chemo- and/or radiation therapy). A few recent studies have indicated that children with brain tumors (BT) might exhibit cognitive problems already at diagnosis, i.e. before the start of any medical treatment. The aim of the present study was to investigate the "baseline" neuropsychological profile in children with BT in comparison to children with an oncological diagnosis not involving the central nervous system (CNS). 20 children with BT and 27 children with an oncological disease without involvement of the CNS (age range: 6.1 to 16.9 years) were evaluated with an extensive battery of neuropsychological tests tailored to the patient's age. Furthermore, the child and its parents completed self-report questionnaires about emotional functioning and quality of life. In both groups, tests were administered before any therapeutic intervention such as surgery, chemotherapy or irradiation. Groups were comparable regarding age, gender and social economic status. Compared to the CG, patients with BTs performed significantly worse in tests of working memory, verbal memory and attention. In contrast the areas of perceptual reasoning, processing speed and verbal comprehension were preserved at this time. Younger children with BT were especially disadvantaged. Compared to aged matched children with malignancies not involving the CNS and older BT patients the young BT patients showed deficits in attention, working memory and verbal memory measures. Our results highlight the need for cognitive assessments and interventions early in the treatment process in order to minimize or even prevent academic difficulties as patients return to school.

Published
2014
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4. EPENDYMOMA

Author

L. M. Hoffman, A. M. Donson, I. Nakachi, A. M. Griesinger, D. K. Birks, V. Amani, M. S. Hemenway, A. K. Liu, M. Wang, T. C. Hankinson, M. H. Handler, N. K. Foreman, M. Zakrzewska, K. Zakrzewski, W. Fendler, L. Stefanczyk, P. P. Liberski, M. Massimino, L. Gandola, P. Ferroli, L. Valentini, V. Biassoni, M. L. Garre, I. Sardi, L. Genitori, C. Giussani, L. Massimi, D. Bertin, A. Mussano, E. Viscardi, P. Modena, A. Mastronuzzi, S. Barra, G. Scarzello, G. Cinalli, P. Peretta, F. Giangaspero, L. Boschetti, E. Schiavello, G. Calareso, M. Antonelli, E. Pecori, F. Di Meco, R. Migliorati, A. Taborelli, H. Witt, M. Sill, K. Wani, S. C. Mack, D. Capper, K. Pajtler, S. Lambert, T. Tzaridis, T. Milde, P. A. Northcott, A. E. Kulozik, O. Witt, V. P. Collins, D. W. Ellison, M. D. Taylor, M. Kool, D. T. W. Jones, A. Korshunov, A. Ken, S. M. Pfister, K. Makino, H. Nakamura, J.-i. Kuroda, J.-i. Kuratsu, H. Toledano, Y. Margolin, A. Ohali, S. Michowiz, P. Johann, U. Tabori, E. Walker, C. Hawkins, M. Taylor, I. Yaniv, S. Avigad, L. Hoffman, S. R. Plimpton, N. V. Stence, R. Vibhakar, A. Lourdusamy, R. Rahman, J. Ward, H. Rogers, R. Grundy, C. Punchihewa, R. Lee, T. Lin, W. Orisme, J. Dalton, E. Aronica, A. Smith, A. Gajjar, A. Onar, S. Pounds, R. Tatevossian, T. Merchant, D. Ellison, M. Parker, K. Mohankumar, R. Weinlich, T. Phoenix, R. Thiruvenkatam, E. White, K. Gupta, F. Boop, L. Ding, E. Mardis, R. Wilson, J. Downing, R. Gilbertson, D. Speed, T. Gould, t. I. E. Consortium, A. Griesinger, A. Donson, D. Birks, N. Ohe, H. Yano, N. Nakayama, T. Iwama, K. Wright, T. Hassall, D. C. Bowers, J. Crawford, A. Bendel, P. G. Fisher, P. Klimo, G. Armstrong, I. Qaddoumi, G. Robinson, C. Wetmore, A. Broniscer, R. Chapman, C. Mayne, H. Duane, J.-P. Kilday, B. Coyle, A. Graul-Conroy, W. Hartsell, T. Bragg, S. Goldman, S. Rebsamen, D. Puccetti, S. Salamat, N. J. Patel, A. Gomi, H. Oguma, T. Hayase, Y. Kawahara, M. Yagi, A. Morimoto, C. Wilbur, C. Dunham, D. Mabbott, A.-S. Carret, L. Lafay-Cousin, P. D. McNeely, D. Eisenstat, B. Wilson, D. Johnston, J. Hukin, M. Mynarek, R. D. Kortmann, P. Kaatsch, T. Pietsch, B. Timmermann, G. Fleischhack, M. Benesch, C. Friedrich, A. O. von Bueren, N. U. Gerber, K. Muller, S. Tippelt, M. Warmuth-Metz, S. Rutkowski, K. von Hoff, M. K. Murugesan, H. Poppleton, S. Currle, T. Kranenburg, C. Eden, N. Boulos, J. Dapper, Y. Patel, B. Freeman, A. Shelat, C. Stewart, R. Guy, J. Adamski, A. Huang, U. Bartels, V. Ramaswamy, R. Krishnatry, N. Laperriere, E. Bouffet, A. Araki, M. Chocholous, J. Gojo, C. Dorfer, T. Czech, K. Dieckmann, I. Slavc, C. Haberler, E. Doerner, A. z. Muehlen, R. Kortmann, A. von Buehren, H. Ottensmeier, A. Resch, R. Kwiecien, A. Faldum, J. Kuehl, D. Sabnis, L. Storer, L. Simmonds, S. Blackburn, J. Lowe, I. Kerr, I. Wohlers, T. Goschzik, V. Dreschmann, D. Denkhaus, S. Rahmann, L. Klein-Hitpass, M. J. L. Iglesias, F. G. Riet, F. D. Dhermain, S. Canale, C. Dufour, C. S. Rose, S. Puget, J. Grill, S. Bolle, J. Parkes, A. Davidson, A. Figaji, K. Pillay, T. Kilborn, L. Padayachy, M. Hendricks, A. Van Eyssen, E. Piccinin, E. Lorenzetto, M. Brenca, K. Aldape, Y.-J. Cho, W. Weiss, J. Phillips, N. Jabado, J. Mora, X. Fan, S. Jung, J. Y. Lee, K. Zitterbart, P. French, J. M. Kros, P. Hauser, C. Faria, and S. Pfister

Subjects
Abstracts, Cancer Research, Tumor grade, Oncology, Expression pattern, business.industry, microRNA, Cancer research, Medicine, Neurology (clinical), business
Published
2014
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5. MEDICAL RADIATION THERAPIES

Author

I. Ahmed, A. Biswas, S. Krishnamurthy, P. Julka, G. Rath, M. Back, D. Huang, C. Gzell, J. Chen, M. Kastelan, P. Gaur, H. Wheeler, S. N. Badiyan, C. G. Robinson, J. R. Simpson, D. D. Tran, K. M. Rich, J. L. Dowling, M. R. Chicoine, E. C. Leuthardt, A. H. Kim, J. Huang, S. R. Michaelsen, I. J. Christensen, K. Grunnet, M.-T. Stockhausen, H. Broholm, M. Kosteljanetz, H. S. Poulsen, M. Tieu, E. Lovblom, M. Macnamara, W. Mason, D. Rodin, E. Tai, K. Ubhi, N. Laperriere, B.-A. Millar, C. Menard, B. Perkins, C. Chung, J. Clarke, A. Molinaro, J. Phillips, N. Butowski, S. Chang, A. Perry, J. Costello, A. DeSilva, J. Rabbitt, M. Prados, A. L. Cohen, C. Anker, D. Shrieve, B. Hall, K. Salzman, R. Jensen, H. Colman, O. Farber, U. Weinberg, Y. Palti, B. Fisher, H. Chen, D. Macdonald, G. Lesser, S. Coons, D. Brachman, S. Ryu, M. Werner-Wasik, J.-P. Bahary, A. Chakravarti, M. Mehta, T. Gupta, V. Nair, S. Epari, J. Godasastri, A. Moiyadi, P. Shetty, S. Juvekar, R. Jalali, U. Herrlinger, N. Schafer, J. Steinbach, A. Weyerbrock, P. Hau, R. Goldbrunner, R. Kohnen, H. Urbach, W. Stummer, M. Glas, C. Houillier, H. Ghesquieres, C. Chabrot, C. Soussain, G. Ahle, S. Choquet, P. Faurie, J.-O. Bay, J. Vargaftig, C. Gaultier, E. Nicolas-Virelizier, K. Hoang-Xuan, O. Iskanderani, F. Izar, A. Benouaich-Amiel, T. Filleron, E. Moyal, C. Iweha, S. Jain, E. Melian, A. Sethi, K. Albain, D. Shafer, B. Emami, X.-T. Kong, S. Green, E. Filka, R. Green, W. Yong, P. Nghiemphu, T. Cloughesy, A. Lai, S. Mallick, S. Roy, S. Purkait, S. Gupta, P. K. Julka, G. K. Rath, C. Marosi, J. Thaler, C. Ay, A. Kaider, E.-M. Reitter, J. Haselbock, M. Preusser, B. Flechl, C. Zielinski, I. Pabinger, S.-I. Miyatake, M. Furuse, T. Miyata, E. Yoritsune, S. Kawabata, T. Kuroiwa, Y. Muragaki, T. Maruyama, H. Iseki, J. Akimoto, S. Ikuta, M. Nitta, K. Maebayashi, T. Saito, Y. Okada, S. Kaneko, A. Matsumura, K. Karasawa, Y. Nakazato, T. Kayama, L. B. Nabors, K. L. Fink, T. Mikkelsen, D. Grujicic, R. Tarnawski, D.-H. Nam, M. Mazurkiewicz, M. Salacz, L. Ashby, L. Thurzo, V. Zagonel, R. Depenni, J. R. Perry, J. Henslee-Downey, M. Picard, D. A. Reardon, N. Nambudiri, L. Nayak, D. LaFrankie, P. Wen, D. Ney, J. Carlson, D. Damek, P. Blatchford, L. Gaspar, B. Kavanagh, A. Waziri, K. Lillehei, K. Reddy, C. Chen, I. Rashed, K. Barton, D. Anderson, V. Prabhu, R. Rusch, M. Belongia, M. Maheshwari, S. Firat, D. Schiff, A. Desjardins, M. Glantz, M. Chamberlain, W. Shapiro, S. Gopal, K. Judy, S. Patel, A. Mahapatra, J. Shan, D. Gupta, K. Shih, J. A. Bacha, D. Brown, W. J. Garner, A. Steino, R. Schwart, S. Kanekal, M. Li, L. Lopez, H. A. Burris, C. Soderberg-Naucler, A. Rahbar, G. Stragliotto, A. J. Song, A. M. S. Kumar, E. S. Murphy, T. Tekautz, J. H. Suh, V. Recinos, S. T. Chao, J. Spoor, K. Korami, J. Kloezeman, R. Balvers, C. Dirven, M. Lamfers, S. Leenstra, A. Sumrall, D. Haggstrom, A. Crimaldi, J. Symanowski, P. Giglio, A. Asher, S. Burri, G. Sunkersett, Z. Khatib, C. M. Prajapati, E. E. Magalona, M. Mariano, I. M. Sih, R. Torcuator, W. Taal, H. Oosterkamp, A. Walenkamp, L. Beerenpoot, M. Hanse, J. Buter, A. Honkoop, D. Boerman, F. de Vos, R. Jansen, F. van der Berkmortel, D. Brandsma, R. Enting, J. Kros, J. Bromberg, I. van Heuvel, M. Smits, R. van der Holt, R. Vernhout, M. van den Bent, W. Wick, C. Suarez, J. Rodon, P. Forsyth, I. Gueorguieva, A. Cleverly, T. Burkholder, D. Desaiah, M. Lahn, L. Zach, D. Guez, D. Last, D. Daniels, O. Nissim, Y. Grober, C. Hoffmann, D. Nass, A. Talianski, R. Spiegelmann, Z. Cohen, and Y. Mardor

Subjects
Abstracts, Cancer Research, medicine.medical_specialty, Text mining, Oncology, business.industry, Medicine, Medical physics, Neurology (clinical), business, Medical radiation
Published
2013
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6. RADIATION THERAPY

Author

M. K. Behera, A. Sharma, S. Dutta, S. Sharma, P. K. Julka, G. K. Rath, W. J. Kil, C. Ko, A. Kaushal, K. Warran, H. Ning, K. Camphausen, D. Smart, T. Z. Vern-Gross, K. P. McMullen, L. D. Case, J. D. Bourland, T. L. Ellis, J. A. Lawrence, S. B. Tatter, E. G. Shaw, J. J. Urbanic, M. D. Chan, R. L. Jensen, D. C. Shrieve, P. Mohindra, H. I. Robins, W. A. Tome, S. P. Howard, C. Chen, D. Damek, L. E. Gaspar, D. Ney, A. Waziri, K. Lillehei, B. D. Kavanagh, C.-C. Wang, S. Floyd, C.-H. Chang, P. Warnke, C.-C. Chio, E. Kasper, A. Mahadevan, E. Wong, S. Jeyapalan, A. Mahajan, D. Grosshans, M. F. McAleer, P. D. Brown, M. Chintagumpala, T. Vats, V. Puduvalli, T. Yock, M. Schulder, Y. Herschmann, M. Ghaly, J. Knisely, A. Kapur, P. Goetz, S. Lwu, J. Ebinu, M. Arayee, E. Monsalves, N. Laperriere, C. Menard, M. Bernstein, G. Zadeh, A. G. Loganathan, N. Alphonse, A. M. Peiffer, A. Johnson, P. A. Saconn, M. T. Munley, M. Aryaee, C. Lowe, J. DeGroot, G. Mark, R. Ruda, E. Trevisan, U. Magliola, L. Bertero, C. Bosa, U. Ricardi, R. Soffietti, P. Rajappa, K. Margetis, A. G. Wernicke, D. L. Sherr, E. Lavi, R. L. Fine, T. Schwartz, S. C. Pannullo, N. Laack, M. Blanchard, J. Buckner, J. Glass, D. W. Andrews, M. Werner-Wasik, J. Evans, Y. R. Lawrence, W. Shi, I. Strauss, B. W. Corn, D. Matceyevsky, S. Alani, E. Gez, N. Shtraus, A. A. Kanner, M. Spasic, W. Choy, D. Nagasawa, I. Yang, M. Noel, E. Woolf, R. Smith, P. Castillo-Rojas, S. Sorenson, K. Smith, A. C. Scheck, S. J. Han, M. C. Oh, M. E. Sughrue, M. J. Rutkowski, D. Aranda, I. J. Barani, A. T. Parsa, K. J. Redmond, A. Horska, O. Ishaq, E. Ford, T. McNutt, S. Batra, L. Kleinberg, M. Wharam, M. Mahone, S. Terezakis, S. Ryu, J. Rock, B. Movsas, T. Mikkelsen, M. Rosenblum, D. Sabsevitz, J. A. Bovi, P. Leo, P. LaViolette, S. Rand, W. Mueller, A. Phillips, R. Venkatramani, A. Olch, J. Grimm, T. Davidson, R. Brown, G. Dhall, J. Finlay, and K. Wong

Subjects
Abstracts, Cancer Research, Oncology, Neurology (clinical)
Published
2011
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7. Primary CNS lymphoma with intraocular involvement: International PCNSL Collaborative Group Report

Author

A. J. Hall, Tracy T. Batchelor, Edward A. Neuwelt, David Schiff, A. J. M. Ferreri, Fabio M. Iwamoto, Francesc Graus, Tamara Shenkier, N. Laperriere, Ulrich Herrlinger, Jean-Yves Blay, Jeffrey J. Raizer, Nancy D. Doolittle, Lauren E. Abrey, Tali Siegal, Antonio Omuro, Kristoph Jahnke, Eckhard Thiel, James L. Rubenstein, Colin A. McCannel, and Sean Grimm

Subjects
Adult, Male, medicine.medical_specialty, Internationality, Adolescent, Lymphoma, genetic structures, medicine.medical_treatment, Vitrectomy, Central Nervous System Neoplasms, hemic and lymphatic diseases, Internal medicine, Biopsy, Humans, Medicine, Progression-free survival, Cooperative Behavior, Aged, Retrospective Studies, Aged, 80 and over, medicine.diagnostic_test, business.industry, Eye Neoplasms, Research, Brain biopsy, Retrospective cohort study, Articles, Middle Aged, medicine.disease, eye diseases, Surgery, Survival Rate, Radiation therapy, Female, sense organs, Neurology (clinical), Intraocular lymphoma, business, Follow-Up Studies
Abstract

Objective: To describe the demographics, diagnostic details, therapeutic management, and outcome in patients with primary CNS lymphoma (PCNSL) with ocular involvement. Methods: A retrospective study of 221 patients was assembled from 16 centers in seven countries. Only HIV-negative, immunocompetent patients with brain and ocular lymphoma were included; none had systemic lymphoma. Results: Median age at diagnosis was 60. Fifty-seven percent were women. Median Eastern Cooperative Oncology Group performance status was 2. Ocular disturbance and behavioral/cognitive changes were the most common presenting symptoms. Diagnosis of lymphoma was made by brain biopsy (147), vitrectomy (65), or CSF cytology (11). Diagnosis of intraocular lymphoma was made by vitrectomy/choroidal/retinal biopsy (90) or clinical ophthalmic examination (141). CSF cytology was positive in 23%. Treatment information was available for 176 patients. A total of 102 received dedicated ocular therapy (ocular radiotherapy 79, intravitreal methotrexate 22, and both 1) in addition to treatment for their brain lymphoma. Sixty-nine percent progressed at a median of 13 months; sites of progression included brain 52%, eyes 19%, brain and eyes 12%, and systemic 2%. Patients treated with local ocular therapy did not have a statistically significant decreased risk of failing in the eyes ( p = 0.7). Median progression free survival and overall survival for the entire cohort were 18 and 31 months. Conclusion: This is the largest reported series of primary CNS lymphoma (PCNSL) with intraocular involvement. Progression free and overall survival was similar to that reported with PCNSL. Dedicated ocular therapy improved disease control but did not affect overall survival.

Published
2008
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8. Primary intraocular lymphoma: an International Primary Central Nervous System Lymphoma Collaborative Group Report

Author

A. J. M. Ferreri, David Schiff, Kristoph Jahnke, A. J. Hall, Jose S. Pulido, Antonio Omuro, Ulrich Herrlinger, Jean-Yves Blay, Tracy T. Batchelor, Eckhard Thiel, Marc C. Chamberlain, Tamara Shenkier, N. Laperriere, Nancy D. Doolittle, Edward A. Neuwelt, Tali Siegal, Lauren E. Abrey, and Sean Grimm

Subjects
Adult, Male, medicine.medical_specialty, Consensus, medicine.medical_treatment, Risk Assessment, Central Nervous System Neoplasms, Central nervous system disease, Blurred vision, HIV Seronegativity, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Aged, Neoplasm Staging, Retrospective Studies, Aged, 80 and over, business.industry, Eye Neoplasms, Lymphoma, Non-Hodgkin, Primary central nervous system lymphoma, Retrospective cohort study, Hematology, Middle Aged, Prognosis, medicine.disease, Combined Modality Therapy, Survival Analysis, Chemotherapy regimen, Surgery, Lymphoma, Radiation therapy, Treatment Outcome, Oncology, Female, Radiotherapy, Adjuvant, Intraocular lymphoma, Neoplasm Recurrence, Local, medicine.symptom, business
Abstract

Background: Primary intraocular lymphoma (PIOL) is an uncommon subset of primary central nervous system lymphoma. Because it is rare and difficult to diagnose, the natural history and optimal management are unknown. Patients and methods: A retrospective study of 83 HIV negative, immunocompetent PIOL patients was assembled from 16 centers in seven countries. Results: Median age at diagnosis was 65. Median ECOG performance status was 0. Presenting symptoms included blurred vision, decreased visual acuity, and floaters. Median time to diagnosis was 6 months. Diagnosis was made by vitrectomy (74), choroidal/retinal biopsy (6) and ophthalmic exam (3). Eleven percent had positive CSF cytology. Initial treatment was categorized as focal in 23 (intra-ocular methotrexate, ocular radiotherapy) or extensive in 53 (systemic chemotherapy, whole brain radiotherapy). Six received none; details are unknown in one. Forty-seven relapsed: brain 47%, eyes 30%, brain and eyes 15%, and systemic 8%. Median time to relapse was 19 months. Focal therapy alone did not increase risk of brain relapse. Median progression free (PFS) and overall survival (OS) were 29.6 and 58 months, respectively, and unaffected by treatment type. Conclusion: Treatment type did not affect relapse pattern, median PFS or OS. Focal therapy may minimize treatment toxicity without compromising disease control.

Published
2007
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9. Lowering the doses of mifepristone and gemeprost for early abortion: a randomised controlled trial

Author

Alexandre Peregoudov, C Jun-Kang, A Calder, László Kovács, C Sikazwe, P.F.A. Van Look, N. Laperriere, A. A. Templeton, H. von Hertzen, Mohamed M. Ali, E Noonan, Marc Bygdeman, David A. Grimes, S Li-Juan, R.N.V. Prasad, G Kavkasidze, P.C. Ho, Alenka Pretnar-Darovec, M Gomez-Alzugaray, and G. I. Dhall

Subjects
medicine.medical_specialty, Randomized controlled trial, business.industry, Obstetrics, law, Gemeprost, medicine, Early abortion, Obstetrics and Gynecology, Mifepristone, business, medicine.drug, law.invention
Published
2001
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10. Radiotherapy and Marfan syndrome: a report of two cases

Author

N. Laperriere, Robert G. Bristow, and M. Finlay

Subjects
Male, musculoskeletal diseases, Marfan syndrome, congenital, hereditary, and neonatal diseases and abnormalities, Pathology, medicine.medical_specialty, Adolescent, Fibrillin-1, medicine.medical_treatment, Connective tissue, macromolecular substances, Fibrillins, Marfan Syndrome, Transforming Growth Factor beta, Fibrosis, Humans, Medicine, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, skin and connective tissue diseases, Gene knockout, Aged, Regulation of gene expression, Brain Neoplasms, business.industry, Microfilament Proteins, Prostatic Neoplasms, Glioma, medicine.disease, Radiation Pneumonitis, Radiation therapy, medicine.anatomical_structure, Oncology, Toxicity, Female, business, Transforming growth factor
Abstract

Marfan syndrome (MFS) is a heritable disorder of the connective tissue which has been linked to mutations in the FBN ( fibrillin-1 ) gene. Murine knockouts of the FBN gene show increased interstitial fibrosis and TGF-β (tumor growth factor-beta) gene activation. Abnormal TGF-β expression has previously been linked to radiation-induced fibrosis, suggesting a possible link between MFS and increased late effects following radiotherapy. Herein we report two cases in which MFS patients treated with radical radiotherapy without undue acute or late radiotherapy toxicity suggesting that radiotherapy should not be withheld from MFS patients. MFS patients may provide a unique clinico-translational setting to test associations between FBN mutations, TGF-β activation and the risk of tissue fibrosis.

Published
2005
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11. Fulminant blastomycosis with blastomycotic infection of a cerebral glioma

Author

R. Perrin, N. Laperriere, and V. Jay

Subjects
Pathology, medicine.medical_specialty, business.industry, Opportunistic infection, Fulminant, Brain tumor, medicine.disease, Pathology and Forensic Medicine, Pathogenesis, Cellular and Molecular Neuroscience, Pneumonia, Glioma, medicine, Neurology (clinical), business, Blastomycosis, Mycosis
Abstract

Except for isolated case reports, blastomycosis has not been identified as a significant problem in immunosuppressed patients. We describe an unusual case with blastomycotic infection of a cerebral glioma in a 56-year-old man who underwent radiotherapy for his tumor and died of fulminant blastomycotic pneumonia. This is believed to be the first reported case of Blastomyces dermatitidis infection of a cerebral glioma. The light microscopic and ultrastructural features of B. dermatitidis, the giant forms of which were encountered in our patient, are described, and the role of immuno-suppression due to steroid therapy in the pathogenesis of this fulminant infection are reviewed.

Published
1991
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12. Spontaneous remission of primary central nervous system lymphoma: report of 3 cases and discussion of pathophysiology

Author

M, Al-Yamany, A, Lozano, S, Nag, N, Laperriere, and M, Bernstein

Subjects
Adult, Lymphoma, Brain Neoplasms, Neoplasm Regression, Spontaneous, Recurrence, Humans, Female, Middle Aged, Tomography, X-Ray Computed, Magnetic Resonance Imaging
Abstract

Primary central nervous system lymphoma (PCNSL) is a relatively uncommon disease in which spontaneous remission is exceedingly rare. We are reporting three cases of primary CNS lymphoma with spontaneous regression in two to eight weeks, from the time of the initial diagnosis. The remission lasted for four years in the first case, two years in the second, and one year in the third case. Tissue diagnosis was made in the first two cases after relapse, and in the third case a biopsy was done at the initial presentation. The literature and the possible pathophysiological mechanisms of this interesting phenomenon are discussed.

Published
1999

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