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Your search keyword '"Murthy, S. Narasimha"' showing total 131 results
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131 results on '"Murthy, S. Narasimha"'

23. Overcoming challenges in dermal and transdermal delivery of herbal therapeutics with polymeric microneedles.

Author

V. M., Anusha, Suresh, Sarasija, Kumar, Avichal, K., Paranjyothy, N. M., Reena, Rangappa, Srinath, Murthy, S. Narasimha, and H.N., Shivakumar

Abstract

Natural products are generally preferred medications owing to their low toxicity and irritancy potential. However, a good number of herbal therapeutics (HT) exhibit solubility, permeability and stability issues that eventually affect oral bioavailability. Transdermal administration has been successful in resolving some of these issues which has lead in commercialization of a few herbal transdermal products. Polymeric Microneedles (MNs) has emerged as a promising platform in transdermal delivery of HT that face problems in permeating the skin. Several biocompatible and biodegradable polymers used in the fabrication of MNs have been discussed. MNs have been exploited for cutaneous delivery of HT in management of skin ailments like skin cancer, acne, chronic wounds and hypertrophic scar. Considering the clinical need, MNs are explored for systemic delivery of potent HT for management of diverse disorders like asthma, disorders of central nervous system and nicotine replacement as it obviates first pass metabolism and elicits a quicker onset of therapeutic response. MNs of HT have found good number of aesthetic applications in topical delivery of HT to the skin. Interestingly, MNs have emerged as an attractive option as a minimally invasive diagnostic aid in sampling biomarkers from plants, skin and ocular interstitial fluid. The review updates the progress made by MN technology of HT for multiple therapeutic interventions along with the future challenges. An attempt is made to illustrate the challenging formulation strategies employed in the fabrication of polymeric MNs of HT. Efforts are on to extend the potential applications of polymeric MNs to HT for diverse therapeutic applications. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Non-dermal applications of microneedle drug delivery systems.

Author

Panda, Apoorva, Matadh, V. Anusha, Suresh, Sarasija, Shivakumar, H. N., and Murthy, S. Narasimha

Abstract

Microneedles (MNs) are micron-scaled needles measuring 100 to 1000 μm that were initially explored for delivery of therapeutic agents across the skin. Considering the success in transcutaneous drug delivery, the application of microneedles has been extended to different tissues and organs. The review captures the application of microneedles to the oral mucosa, the eye, vagina, gastric mucosa, nail, scalp, and vascular tissues for delivery of vaccines, biologics, drugs, and diagnostic agents. The technology has created easy access to the poorly accessible segments of eye to facilitate delivery of monoclonal antibodies and therapeutic agents in management of neovascular disease. Microporation has been reported to drastically improve the drug delivery through the poorly permeable nail plate. Curved microneedles and spatially designed microneedle cuffs have been found to be capable of delivering stem cells and therapeutic macromolecules directly to the cardiac tissue and the vascular smooth muscle cells, respectively. Besides being minimally invasive and patient compliant, the technology has the potential to offer viable solutions to deliver drugs through impermeable barriers owing to the ability to penetrate several biological barriers. The technology has been successful to overcome the delivery hurdles and enable direct delivery of drug to the target sites, thus maximizing the efficacy thereby reducing the required dose. This review is an attempt to capture the non-dermatological applications of microneedles being explored and provides an insight on the future trends in the field of microneedle technology. Pictorial representation of different microneedle application. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Insight into hydroxyl radical-mediated cleavage of caged methylene blue: the role of Fenton's catalyst for antimalarial hybrid drug activation.

Author

Dao, Huy Minh, Husain, Islam, Shankar, Vijay Kumar, Khan, Shabana I., Murthy, S. Narasimha, and Jo, Seongbong

Subjects
METHYLENE blue, DRUG activation, REACTIVE oxygen species, CATALYSTS, HYDROXYL group, HEMOPROTEINS
Abstract

Methylene blue with a 10-N carbamoyl linkage was reported to be a hydroxyl radical triggered cleavable ligand. Probed by this platform, hemoproteins were demonstrated to be a much more efficient Fenton's catalyst than commonly used inorganic Fe(II) salts. The applicability of this ligand was demonstrated through the capability of being triggered by elevated reactive oxygen species levels at diseased tissue, with malaria-parasitized erythrocytes as an in vitro model. [ABSTRACT FROM AUTHOR]

Published
2020
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49. Methylene blue as a far-red light-mediated photocleavable multifunctional ligand.

Author

Dao, Huy Minh, Whang, Chang-Hee, Shankar, Vijay Kumar, Wang, Yan-Hong, Khan, Ikhlas A., Walker, Larry A., Husain, Islam, Khan, Shabana I., Murthy, S. Narasimha, and Jo, Seongbong

Subjects
FLUORESCENCE
Abstract

Methylene blue (MB) with a 10-N-carbamoyl linkage was discovered and developed as a multifunctional far-red (660 nm) photocleavable ligand capable of rendering a series of MB-conjugated compounds with off-to-on fluorescence switch properties through the controlled release of MB. [ABSTRACT FROM AUTHOR]

Published
2020
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